克雅病试用喹纳克林未显示显著效果

作     者：Hak S. Brandel J.P. Salomon D. 张玉龙 

作者机构：Raymond Escourolle Neuropathol. Lab. INSERM U360 Salpêtrière Hospital 47 bd de l'Hpital 75651 Paris Cedex 13 France Dr. 

出 版 物：《世界核心医学期刊文摘（神经病学分册）》 (Digest of the World Core Medical Journals:Clinical Neurology)

年 卷 期：2005年第1卷第5期

页      面：46-46页

学科分类：1002[医学-临床医学] 100204[医学-神经病学] 10[医学] 

主　　题：纳克 朊病毒 

摘      要：Quinacrine has been reported as an antiprion agent and proposed as an immedia tely applicable treatment for Creutzfeldt-Jakob disease (CJD). The authors rep ort the results of an open compassionate procedure to which 32 CJD patients had access. In some genotypic subgroups, a slight but nonsignificant increase in sur vival was observed, likely due to biased inclusion of longterm surviving patient s. There was no pathologic evidence of a beneficial effect of quinacrine treatme nt.