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β-环糊精清除乳脂中胆固醇的研究

饲料博览 2010年第3期 44-44页

作者： alonso L Cuesta P Fontecha j juarez M Gilliland S E

试验旨在研究4℃条件下通过加入β-环糊精,从商业规模的散装牛奶搅拌罐内清除经过巴氏杀菌的不均质牛奶中的胆固醇的最适条件(β-环糊精浓度,搅拌时间,保温时间)。在4℃条件下添加不同水平的β-环糊精(0.4%,0.6%,0.8%和1%)20min后,对胆... 详细信息

试验旨在研究4℃条件下通过加入β-环糊精,从商业规模的散装牛奶搅拌罐内清除经过巴氏杀菌的不均质牛奶中的胆固醇的最适条件(β-环糊精浓度,搅拌时间,保温时间)。在4℃条件下添加不同水平的β-环糊精(0.4%,0.6%,0.8%和1%)20min后,对胆固醇的清除可达65.42%～95.31%。在牛奶中添加β-环糊精0.6%与0.8%、1%的添加水平对胆固醇的清除无显著差异,处理时间为6h对牛奶中胆固醇的清除效果最好。在4℃条件下处理20min后,牛奶(不搅拌)中的β-环糊精和胆固醇形成复合体以沉淀形式存在,可经离心除去。β-环糊精添加水平为0.6%的牛奶经分离后,大约有0.35%的β-环糊精残留在脱脂部分,0.1%的β-环糊精存在于乳脂中,剩余的与胆固醇络合的β-环糊精可通过分离器清除。单个脂肪酸和甘油三酯成分在对照组和添加β-环糊精0.6%组间无显著差异。

关键词： β-环糊精清除胆固醇巴氏彻底灭菌牛奶

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GRADE指南：Ⅸ.证据质量升级

中国循证医学杂志 2011年第12期11卷 1459-1463页

作者： Gordon H.Guyatt Andrew D.Oxman Shahnaz Sultan Paul Glasziou Elie A.Akl Pablo alonso-Coello David Atkins Regina Kunz jan Brozek Victor Montori Roman jaeschke David Rind Philipp Dahm joerg Meerpohl Gunn Vist Elise Berliner Susan Norris Yngve Falck-Ytter M.Hassan Murad Holger j.Schünemann 代表GRADE工作组李幼平杨晓妍李玲王应强机构不详

证据质量升级的最常见原因是效应量大。当方法学严谨的观察性研究表明风险至少降低或增加2倍时,GRADE建议考虑将证据质量升高1级;当风险至少降低或增加5倍时,考虑将证据质量升高2级。当存在剂量-反应关系,或所有合理的混杂、偏倚会降低... 详细信息

证据质量升级的最常见原因是效应量大。当方法学严谨的观察性研究表明风险至少降低或增加2倍时,GRADE建议考虑将证据质量升高1级;当风险至少降低或增加5倍时,考虑将证据质量升高2级。当存在剂量-反应关系,或所有合理的混杂、偏倚会降低明显的治疗效应,或混杂、偏倚使得结果无效为假效应时,系统评价作者和指南制定者也可考虑升高证据质量。其他考虑因素包括起效迅速、潜在的疾病(状态)趋势以及间接证据。

关键词： GRADE 指南证据等级观察性研究效应量大偏倚风险

成人看电视时间长短与中央血流动力学参数及桡动脉增强指数相关

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中华高血压杂志 2013年第7期21卷 698-698页

作者： Recio-Rodriguez jI Gomez-Marcos MA Patino-alonso MC Romaguera-Bosch M Grandes G Menendez-Suarez M Lema-Bartolome j Gonzalez-Viejo N Agudo-Conde C Garcia-Ortiz L 罗冬梅叶鹏 EVIDENT Group

该研究探讨成人看电视时间与中央血流动力学参数及桡动脉增强指数的相关性。方法：从参加初级保健中心的人群中，随机抽取732人作为研究对象。受试者通过自答问卷报告躺着或坐着看电视的时间。用系在腰部的计步器计算体力活动程度，应... 详细信息

该研究探讨成人看电视时间与中央血流动力学参数及桡动脉增强指数的相关性。方法：从参加初级保健中心的人群中，随机抽取732人作为研究对象。受试者通过自答问卷报告躺着或坐着看电视的时间。用系在腰部的计步器计算体力活动程度，应用脉搏波监测仪软件（A—PulseCASP）推测中央血流动力学参数和75次／min心率校正的外周增强指数（peripheralaugmentationindex，PAIx75）。

关键词：血流动力学参数看电视时间增强指数桡动脉中央成人长短保健中心

第一产程中应用哌替啶治疗难产:一项随机对照试验

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世界核心医学期刊文摘（妇产科学分册） 2005年第4期1卷 8-8页

作者： Sosa C.G. Balaguer E. alonso j.G. 程广艳 Dept. Obstet. Gynecol. Dept. N. Pereira Rossell Hospital Sch. of Med. University of Uruguay Montevideo Uruguay Dr

Objective This study was undertaken to evaluate whether the administration of meperidine decreases the length of labor in patients with a diagnosis of dystocia during the first stage of labor. Study design Women with term singleton pregnancies who received a diagnosis of dystocia and required an active management of labor were randomly assigned to receive either 100 mg of meperidine or placebo. The primary outcome measure was length of labor. Results Four hundred seven pregnant women were included. There were no significant statistical differences between meperidine and placebo groups in length of labor and operative delivery rates such as forceps and cesarean section by intentiontotreat analysis. Low Apgar scores, umbilical artery acidosis, and admission to neonatal care units were increased in the meperidine group. Conclusion Because of the absence of any benefits in patients with dystocia in labor and the presence of harmful effects on neonatal outcomes, meperidine should not be used during labor for this specific indication.

关键词：第一产程随机对照试验足月单胎产钳助娩手术分娩脐动脉剖宫产术新生儿监护病房安慰剂产时

加速度计和7d体力活动回顾评估血压昼夜节律模式与体育锻炼程度

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中华高血压杂志 2014年第8期22卷 798-798页

作者： García-Ortiz L Recio-Rodríguez jI Puig-Ribera A Lema-Bartolomé j Ibáez-jalón E González-Viejo N Guenaga-Saenz N Agudo-Conde C Patino-alonso MC Gomez-Marcos MA EVIDENT Group

客观测量和自我评估的体力活动与24h动态血压昼夜节律的相关性尚不完全清楚。方法：选取健康人群进行横断面队列研究。研究者从EVIDENT研究中选取1345例患者[年龄（55±14）岁;女性占59.3%]。采用7d体力活动回顾（physical activity rec... 详细信息

客观测量和自我评估的体力活动与24h动态血压昼夜节律的相关性尚不完全清楚。方法：选取健康人群进行横断面队列研究。研究者从EVIDENT研究中选取1345例患者[年龄（55±14）岁;女性占59.3%]。采用7d体力活动回顾（physical activity recall,PAR）问卷[代谢当量/（h·周）]和活动变化记录仪-GT3X加速度计（次/min）计算7d的体力活动;用桡动脉压力计测量动态动脉血压。结果：加速度计和7dPAR显示,

关键词：体力活动血压昼夜节律模式加速度计自我评估体育锻炼动态血压昼夜节律队列研究健康人群

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阴茎特发性皮肤钙质沉着症

世界核心医学期刊文摘（皮肤病学分册） 2005年第1期1卷 38-38页

作者： S'anchez-Merino j.M. Bouso-MonteroM. Fern'andez-Flores A. Garca-alonso j. 刘超

Calcification of the skin occurs in three main forms: dystrophic; metastatic; and *** calcinosis cutis of the penis is a rare event and only 4 cases have been *** we present another case in a 19-year-old man and discu... 详细信息

关键词：皮肤钙质沉着症营养障碍文章报道

ST段抬高的急性心肌梗死溶栓后24h内常规介入治疗与缺血指导下的保守治疗的比较(GRACIA-1):随机对照试验

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世界核心医学期刊文摘（心脏病学分册） 2005年第2期1卷 10-10页

作者： Fernandez Avilés F. alonso j.j. Castro Beiras A. Prof. F. 王亭忠 Fernandez Avilés Inst. de Ciencias del Corazón Hospital Universi tario Valladolid Spain

Background In patients with ST segment elevated myocardial infarction (STEMI) , early post thrombolysis routine angioplasty has been discouraged because of i ts association with high incidence of events. The GRACIA 1 trial was designed t o reassess the benefits of an early postthrombolysis interventional approach in the era of stents and new antiplatelet agents. Methods 500 patients with thrombo lysed STEMI (with recombinant tissue plasminogen activator) were randomly assign ed to angiography and intervention if indicated within 24 h of thrombolysis, or to an ischaemia guided conservative approach. The primary endpoint was the comb ined rate of death, reinfarction, or revascularisation at 12 months. Analysis wa s by intention to treat. Findings Invasive treatment included stenting of the cu lprit artery in 80%(199 of 248) patients, bypass surgery in six (2%), non cul prit artery stenting in three, and no intervention in 40 (16%). Predischarge re vascularisation was needed in 51 of 252 patients in the conservative group. By c omparison with patients receiving conservative treatment, by 1 year, patients in the invasive group had lower frequency of primary endpoint (23 [9%] vs 51 [ 21 %], risk ratio 0.44 [95%CI 0.28-0.70], p=0.0008), and they tended to have red uced rate of death or reinfarction (7%vs 12%, 0.59 [0.33-1.05], p=0.07). In de x time in hospital was shorter in the invasive group, with no differences in maj or bleeding or vascular complications. At 30 days both groups had a similar inci dence of cardiac events. In hospital incidence of revascularisation induced by spontaneous recurrence of ischaemia was higher in patients in the conservative g roup than in those in the invasive group. Interpretation In patients with STEMI, early post thrombolysis catheterisation and appropriate intervention is safe a nd might be preferable to a conservative strategy since it reduces the need for unplanned in hospital revascularisation, and improves 1-year clinical outcome.

关键词：急性心肌梗死 GRACIA-1 ST段抬高介入治疗随机对照试验再梗死支架术心血管事件血管成形术血管重建术

Outcomes of critically ill cancer patients with Acinetobacter baumannii infection

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World journal of Critical Care Medicine 2015年第3期4卷 258-264页

作者： Silvio A ?amendys-Silva Paulina Correa-García Francisco j García-Guillén María O González-Herrera Américo Pérez-alonso julia Texcocano-Becerra Angel Herrera-Gómez Patricia Cornejo-juárez Abelardo Meneses-García Department of Critical Care Medicine Instituto Nacional de Cancerología Department of Critical Care Medicine Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán Division of Education and Research Hospital de la Mujer Department of Infectious Diseases Instituto Nacional de Cancerología

AIM: To describe the intensive care unit(ICU) outcomes of critically ill cancer patients with Acinetobacter baumannii(AB) ***: This was an observational study that included 23 consecutive cancer patients who acquired AB infections during their stay at ICU of the National Cancer Institute of Mexico(INCan), located in Mexico City. Data collection took place between january 2011, and December 2012. Patients who had AB infections before ICU admission, and infections that occurred during the first 2 d of ICU stay were excluded. Data were obtained by reviewing the electronic health record of each patient. This investigation was approved by the Scientific and Ethics Committees at INCan. Because of its observational nature, informed consent of the patients was not ***: Throughout the study period, a total of 494 critically ill patients with cancer were admitted to the ICU of the INCan, 23(4.6%) of whom developed AB infections. Sixteen(60.9%) of these patients had hematologic malignancies. Most frequent reasons for ICU admission were severe sepsis or septic shock(56.2%) and postoperative care(21.7%). The respiratory tract was the most frequent site of AB infection(91.3%). The most common organ dysfunction observed in our group of patients were the respiratory(100%), cardiovascular(100%), hepatic(73.9%) and renal dysfunction(65.2%). The ICU mortality of patients with 3 or less organ system dysfunctions was 11.7%(2/17) compared with 66.6%(4/6) for the group of patients with 4 or more organ system dysfunctions(P = 0.021). Multivariate analysis identified blood lactate levels(BLL) as the only variable independently associated with inICU death(OR = 2.59, 95%CI: 1.04-6.43, P = 0.040). ICU and hospital mortality rates were 26.1% and 43.5%, ***: The mortality rate in critically ill patients with both HM, and AB infections who are admitted to the ICU is high. The variable most associated with increased mortality was a BLL ≥ 2.6 mmol/L in

关键词： Outcomes Cancer patients Acinetobacter baumannii Intensive care Critical care

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饲粮中的脂肪对猪肉食用品质的影响

饲料博览 2012年第10期22卷 6-6页

作者： alonso V Najes L M Provincial L Guillén E Gil M Roncalés P Beltrán j A 不详

为比较不同的饮食的脂肪来源对猪肉的肉质、脂肪酸组成和感官特性的影响,试验选用皮特兰×长×大白猪43头,饲喂基础日粮不添加脂肪(对照组),或辅以不同来源的脂肪:添加动物脂肪(1%的AF1组,3%的AF3组)、大豆油(1%SBO1组)、钙皂的棕榈油(1... 详细信息

为比较不同的饮食的脂肪来源对猪肉的肉质、脂肪酸组成和感官特性的影响,试验选用皮特兰×长×大白猪43头,饲喂基础日粮不添加脂肪(对照组),或辅以不同来源的脂肪:添加动物脂肪(1%的AF1组,3%的AF3组)、大豆油(1%SBO1组)、钙皂的棕榈油(1%CaSPO1组)。试验结果显示,在饲粮中补充外源脂肪对肉的pH、颜色、剪切力值、感官特性或饱和脂肪酸(SFA)没有显着影响(P>0.05)。饲喂SBO1组猪具有最低比例的单不饱和脂肪酸(MUFA)和最高比例的多不饱和脂肪酸(PUFA)。结果显示,这些不同的脂肪来源可以以试验水平添加到饲粮中,对猪肉食用品质无不利影响。用主成分分析法(PCA)发现,饲喂不同脂肪对猪肉的影响也没有显著差异。

关键词：食物中的脂肪猪肉品质脂肪酸组合物感官分析