临床试验中复合终点的有效性

作     者：Victor M Montori Gaietà Permanyer-Miralda Ignacio Ferreira-González Jason W Busse Valeria Pacheco-Huergo Dianne Bryant Jordi Alonso Elie A Akl Antònia Domingo-Salvany Edward Mills Holger J Schünemann Roman Jaeschke Gordon H Guyatt 杜昕 

作者机构：epartment ofMedicine MayoClinic Collegeof MedicineRochesterMN 55905 USAassistant professor Cardiology ServiceEpidemiology UnitHospital GeneralVall d'HebronBarcelona 08035 Spainsenior consultant Department de Medicina UniversitatAutònoma de BarcelonaHospital GeneralVall d'Hebronresearch fellow Department ofClinical Epidemiologyand BiostatisticsMcMaster UniversityHamiltonON L8N 3Z5 Canadaresearch associate Primary Care Centre TuróEAP VilapicinaInstitut Catalàde la SalutBarcelona Spaingeneral practitioner Department ofClinical Epidemiologyand BiostatisticsMcMaster UniversityHamiltonON L8N 3Z5instructor Health Services Research UnitInstitut Municipald'InvestigacióMèdica BarcelonaSpainhead Department ofMedicine andof Social andPreventive MedicineUniversity atBuffalo BuffaloNY 14214 USAresearchassistant professor Health Services Research UnitInstitut Municipald'InvestigacióMèdica BarcelonaSpain senior scientist Department ofResearchCanadian Collegeof Naturopathic Medicine TorontoCanada M2K 1E2director ofresearch Department ofMedicine andof Social andPreventive MedicineUniversity atBuffalo BuffaloNY 14214 USAassociate professor Department of Medicine McMaster Universityclinical professor Department ofClinical Epidemiologyand BiostatisticsMcMaster UniversityHamiltonON L8N 3Z5professor 

出 版 物：《英国医学杂志中文版》 (The BMJ Chinese Edition)

年 卷 期：2005年第8卷第5期

页      面：315-318页

学科分类：1007[医学-药学(可授医学、理学学位)] 1006[医学-中西医结合] 100706[医学-药理学] 100602[医学-中西医结合临床] 10[医学] 

基　　金：VMMisaMayoFoundationScholar.JWBisfundedbyaCanadianInstitutesofHealthresearchfellowshipaward.GPMandJAarepartiallysupportedbyfundsfromtheFondodeInvestigacinSanitaria.EMisfundedbyanOntarioHIVTreatmentNetworkresearchaward 

主　　题：随机临床试验 终点 复合 临床实践 

摘      要：采用复合终点作为随机临床试验的主要结局指标有时会掩盖各个终点事件间的巨大差别，在临床实践中如何参照这些临床试验的结果呢？