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Association between calcium sensing receptor gene polymorphisms and chronic pancreatitis in a Us population:Role of serine protease inhibitor Kazal 1type and alcohol

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World Journal of Gastroenterology 2008年第28期14卷 4486-4491页

作者： Venkata Muddana Janette Lamb Julia B Greer Beth Elinoff Robert H Hawes Peter B Cotton Michelle A Anderson randall E Brand Adam slivka David C Whitcomb Division of Gastroenterology Hepatology and NutritionDepartment of MedicineUniversity of Pittsburgh Medical CenterPittsburgh PA 15213United States Digestive Disorder Center Medical University of South CarolinaCharleston SC 29403United States Department of Medicine University of Michigan Medical CenterAnn Arbor MI 48109United States Department of medicine Northwestern Universityand Currently at University of Pittsburgh Medical CenterPittsburgh PA 15213United States Division of Gastroenterology Hepatology and NutritionDepartment of MedicineUniversity of Pittsburgh Medical CenterPittsburgh PA 15213United States Department of Human GeneticsUniversity of PittsburghPittsburgh PA 15213United States

AIM： To test the hypothesis that calcium sensing receptor （CAsR） polymorphisms are associated with chronic pancreatitis （CP）, and to determine whether serine protease inhibitor Kazal 1type （sPINK1） N34s or alcohol are necessary co-factors in its etiology. METHODs： Initially, 115 subjects with pancreatitis and 66 controls were evaluated, of whom 57 patients and 21 controls were predetermined to carry the high-risk sPINK1 N34s polymorphism. We sequenced CAsR gene exons 2, 3, 4, 5 and 7, areas containing the majority of reported polymorphisms and novel mutations. Based on the initial results, we added 223 patients and 239 controls to analyze three common nonsynonymous single nucleotide polymorphisms （sNPs） in exon 7 （A986s, R990G, and Q1011E）. REsULTs： The CAsR exon 7 R990G polyrnorphism was significantly associated with CP （OR, 2.01; 95% CI, 1.12-3.59; P = 0.015）. The association between CAsR R990G and CP was stronger in subjects who reported moderate or heavy alcohol consumption （OR, 3.12; 95% CI, 1.14-9.13; P = 0.018）. There was no association between the various CAsR genotypes and sPINK1 N34s in pancreatitis. None of the novel CAsR polymorphisms reported from Germany and India was detected. CONCLUsION： Our United states-based study confirmed an association of CAsR and CP and for the first time demonstrated that CAsR R990G is a significant risk factor for CP. We also conclude that the risk of CP with CAsR R990G is increased in subjects with moderate to heavy alcohol consumption.

关键词： Calcium sensing receptor serine protease inhibitor Kazal llype Chronic pancreatitis Alcohol

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利益相关者之间的和谐(英文)

利益相关者之间的和谐(英文)

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北京论坛（2007）文明的和谐与共同繁荣——人类文明的多元发展模式

作者： randall Morck Bernard Yeung University of Alberta stern New York University

Corporate governance matters because how corporations allocate the nation’s capital matters. Many developed economies mandate that corporations be run for their public *** is not because shareholders are superior to employees,bankers,bondholders,customers,suppliers,or other ***,it is because poor governance usually harms public shareholders before other *** engineered disclosure rules make corporations transparent,so poor governance quickly depresses share prices,alarming shareholders who demand corrective measures. Ideally,all this happens before the problem grows large enough to harm other stakeholders. Governing corporations for shareholders really amounts to ’using’ shareholders as early warning alarms and automatic correction *** sound government policies are necessary,for this works if corporations are rendered transparent and public shareholders are empowered to force *** stakeholders cannot fulfill this role as well because shareholders’ wealth is more directly linked to the their corporation’s economic efficiency.

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腹股沟淋巴结清扫术中保留隐静脉以减少外阴癌患者并发症的发生率

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世界核心医学期刊文摘（妇产科学分册） 2006年第9期2卷 54-55页

作者： Dardarian T.s. Gray H.J. Morgan M.A. T.C. randall 李奎 Department of Obstetrics and Gynecology Pennsylvania Hospital Spruce Building 801 Spruce Street Philadelphia PA 19107 United States

Objectives. To compare short- and long- term morbidity associatedwith saphenous vein sparing versus ligation during inguinal lymphadenectomy for vulvar carcinoma. Methods. A retrospective evaluation of patients with carcinoma of the vulva that underwent inguinal lymphadenectomy was performed. Operative reports were evaluated and patients were divided into those who had sparing of the saphenous vein versus ligation. Postoperative short- and long- term complications were compared between the two groups using Pearson chi squared analysis. Results. There were a total of 49 inguinal lymphadenectomies performed on 29 patients. The saphenous vein was spared in 18 (37% ) groin dissections compared to 31(63% ) in which the saphenous vein was ligated. The two groups were similar in regards to clinical characteristics. All patients received closed suction drains and prophylactic antibiotics. Median number of nodes dissected was similar. Cellulitis was more common in the vein- ligated group compared to the vein- spared group (45% vs. 0% ; P ssections where the saphenous vein was ligated versus 0% in dissections where the vein was spared (P = short- term edema (≤ 6 months)was similar between vein- ligated and veinspared groups (67% vs. 72% , P subsequently, chronic lymphedema ( > 6 months) persisted in 38% of the vein- ligated group compared to 11% in the vein- spared group (P sease was similar in both groups (19.3% vs. 22.2% P sions. Routine preservation of the saphenous vein during inguinal lymphadenectomy for vulvar carcinomamay reduce the incidence of wound cellulitis, wound breakdown, and chronic lymphedema.

关键词：腹股沟淋巴结清扫术发生率隐静脉外阴癌并发症术中癌患者预防性应用抗生素

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采用时间-密度曲线测量弹性蛋白酶诱导的动脉瘤模型的量化参数:血流导向支架与传统动脉瘤支架比较的初步结果

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国际医学放射学杂志 2013年第2期 201-202页

作者： T. struffert s. ott M. Kowarschik F. Bender E. Adamek T. Engelhorn 李宁 Department of Neuroradiology University of Erlangen-Nuremberg Schwabachanlage 6 91054 Erlangen Germany

研究背景采用量化参数评估血流导向支架(FD)的有效性是可行的。对经支架[neuroform(NF)]和引流器(FD)[管道栓塞装置(pipelineembolisationdevice,PED)]治疗后的弹性蛋白酶诱导的兔动脉瘤模型进行时间-密度曲线(TDC)测量及量化参数计算... 详细信息

研究背景采用量化参数评估血流导向支架(FD)的有效性是可行的。对经支架[neuroform(NF)]和引流器(FD)[管道栓塞装置(pipelineembolisationdevice,PED)]治疗后的弹性蛋白酶诱导的兔动脉瘤模型进行时间-密度曲线(TDC)测量及量化参数计算。方法 16例弹性蛋白酶诱导的兔动脉瘤采用FD(n=9)或NF(n=5)治疗。分别于治疗前及治疗后行血管造影并生成TDC。计算达峰时间(TTP)、半峰全宽(FWHM)及代表流入(IF)流出(OF)的曲线平均斜率。结果治疗前的平均值分别为TTP=0.8s,FWHM=1.2s,IF=153.5及OF=-54.9。经PED治疗后,TTP及FWHM均延长,分别为1.8s和47.8s。IF及OF随即延迟,分别为31.2s和-11.5s。经NF治疗后各值略有改变(TTP=1.1s,FWHM=1.8s,IF=152.9,OF=-33.2)。结论采用兔动脉瘤模型生成TDC是可行的。描述PED及NF血流动力学效应的参数可以计算出,并且使用器械不同参数不同。这些参数或许可以作为动脉瘤闭塞的预测指标。要点①可脱性弹簧圈现在已取代外科手术广泛应用于治疗颅内动脉瘤。②动脉瘤的时间-密度曲线能够提示降低动脉瘤内血流的效果。③目前时间-密度曲线可以通过软件模型进行测量。④经血流导向支架或传统支架治疗后的时间-密度曲线是不同的。⑤可以计算时间-密度曲线的参数,并且可以作为预测参数。

关键词：时间-密度曲线颅内动脉瘤血流导向支架血管造影血管内治疗

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Recent advances and perspectives in next generation sequencing application to the genetic research of type 2 diabetes

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World Journal of Diabetes 2019年第7期10卷 376-395页

作者： Yulia A Nasykhova Yury A Barbitoff Elena A serebryakova Dmitry s Katserov Andrey s Glotov Laboratory of Biobanking and Genomic Medicine of Institute of Translation Biomedicine St.Petersburg State UniversitySt.Petersburg 199034Russia Department of Genomic Medicine D.O.Ott Research Institute of ObstetricsGynaecology and ReproductologySt.Petersburg 199034Russia Bioinformatics Institute St.Petersburg 194021Russia Department of Genetics and Biotechnology St.Petersburg State UniversitySt.Petersburg 199034Russia Department of Genetics City Hospital No.40St.Petersburg 197706Russia Institute of Living systems Immanuel Kant Baltic Federal UniversityKaliningrad 236016Russia

Type 2 diabetes(T2D)mellitus is a common complex disease that currently affects more than 400 million people worldwide and has become a global health ***-throughput sequencing technologies such as whole-genome and whole-exome sequencing approaches have provided numerous new insights into the molecular bases of *** advances in the application of sequencing technologies to T2D research include,but are not limited to:(1)Fine mapping of causal rare and common genetic variants;(2)Identification of confident genelevel associations;(3)Identification of novel candidate genes by specific scoring approaches;(4)Interrogation of disease-relevant genes and pathways by transcriptional profiling and epigenome mapping techniques;and(5)Investigation of microbial community alterations in patients with *** this work we review these advances in application of next-generation sequencing methods for elucidation of T2D pathogenesis,as well as progress and challenges in implementation of this new knowledge about T2D genetics in diagnosis,prevention,and treatment of the disease.

关键词： Type 2 diabetes Next-generation sequencing Epigenetics Genome-wide association study Microbiome

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霍桑传

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丛书名：科学大师传记丛书

1999年

作者：（美）兰德尔·斯图尔特（randall stewart）赵庆庆译

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ACP-103,a potent 5-HT2A Receptor Inverse Agonist,as an Adjunctive Therapy in schizophrenia

ACP-103,a potent 5-HT2A Receptor Inverse Agonist,as an Adjun...

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第十五届国际药理学大会

作者： Vanover Kimberly E. Lameh Jelveh Gardell Luis R. ott Thomas R. Ma Jian-Nong Burstein Ethan s. van Kammen Daniel Davis Robert E. Weiner David M. Brann Mark R. ACADIA Pharmaceuticals ACADIA Pharmaceuticals ACADIA Pharmaceuticals ACADIA Pharmaceuticals ACADIA Pharmaceuticals ACADIA Pharmaceuticals ACADIA Pharmaceuticals ACADIA Pharmaceuticals ACADIA Pharmaceuticals ACADIA Pharmaceuticals

＜正＞ ACP- 103 is a potent and selective 5 - HT2A receptor inverse agonist,with nanomolar potency at 5 - HT2A receptors and 7-50 fold lower potency at 5 -HT2C receptors in a variety of in vitro assays. ACP - 103 lacks significant activity at D2 and over 50 other human receptors at concentrations up to 10 uM. In mice. ACP - 103 was a potent inhibitor of head - twitch behaviors induced by 5 - HT2 agonist DOI, and enhanced haloperidol - or risperidone - mediated decreases in dizocilpine - or amphetamine - induced hyperactivity. ACP - 103 also reduced haloperidol - or risperidone - induced catalepsy and hyperprolactinemia in rats. The ability of ACP - 103 to reduce neuroleptic - induced side effects in animals was extended into the clinic. Initial clinical studies indicate that ACP - 103 was generally safe and well tolerated,had a long plasma half - life,and occupied 5 -HT2A receptors in human brain after oral administration. Moreover. ACP- 103 administration reduced haloperidol - induced hyperprolactinemia in healthy volunteers,and haloperidol - induced akathisia in both healthy volunteers and schizophrenic subjects. Based on these observations. ACP - 103 may have potential as an adjunctive therapy in schizophrenia with a wide therapeutic index.

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室外空气污染、早产和低出生体重：世界卫生组织孕产妇和围产期保健全球调查分析

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环境与职业医学 2014年第12期31卷 988-993页

作者： Nancy L.Fleischer Mario Merialdi Aaron van Donkelaar Felipe Vadillo-Ortega randall V.Martin Ana Pilar Betran Jo?o Paulo souza Marie s.O'Neill 王晓宇汪源金泰廙 University of south Carolina Arnold school of Public Health Department of Reproductive Health and Research World Health Organization Department of Physics and Atmospheric science Dalhousie University school of Medicine Universidad NacionalA utónoma de México Instituto Nacional de Medicina Genomica Harvard-smithsonian Center for Astrophysics Cambridge University of Michigan school of Public Health

[背景]吸入细颗粒物（颗粒物直径≤2.5μm,PM2.5）能诱发氧化应激和炎症反应,并有可能导致早产和其他不良的围产期结局。[目的]检测2004—2008年,世界卫生组织在全球22个国家中进行的孕产妇和围产期保健调查中,室外PM2.5是否与不良妊娠... 详细信息

[背景]吸入细颗粒物（颗粒物直径≤2.5μm,PM2.5）能诱发氧化应激和炎症反应,并有可能导致早产和其他不良的围产期结局。[目的]检测2004—2008年,世界卫生组织在全球22个国家中进行的孕产妇和围产期保健调查中,室外PM2.5是否与不良妊娠结局相关。[方法]以有新生儿出生的各医疗诊所周围50 km为半径的圆弧缓冲区计算室外PM2.5的长期均值（2001—2006年）。应用广义估计方程确定诊所的PM2.5水平与个体的早产和低出生体重之间的相关性,调整个人、诊所和国家水平的季节性因素及潜在的混杂因素。另外还对各国中的相关性进行了研究。[结果]在所有国家中,调整季节性因素后,PM2.5与早产无关联,但是与低出生体重相关[PM2.5的第四个四分位数段（〉20.2μg/m3）与第一个四分位数（〈6.3μg/m3）相比,比值比（OR）=1.22;95%CI：1.07-1.39]。中国是PM2.5测量值范围最大的国家,早产和低出生体重均仅与PM2.5的最高四分位数段相关,提示可能存在阈值效应（PM2.5≥36.5μg/m3与PM2.5〈12.5μg/m3相比,早产和低出生体重比值比分别为：OR=2.54;CI：1.42-4.55和OR=1.99;CI：1.06-3.72）。[结论]室外PM2.5浓度与低出生体重相关,但与早产不相关。在快速发展的国家中,例如中国,最高的空气污染水平可能与两个结局都相关。

关键词：低出生体重世界卫生组织围产期保健空气污染保健调查孕产妇早产室外

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美國專利訴訟綜述及最新發展(上)

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中国专利与商标 2019年第2期 82-96页

作者： Thomas L Jarvis Cyrus T Frelinghuysen randall R Rader 郝元王維多 Winston & strawn事務所ITC業務部 Winston & strawn事務所 Rader集團清華-微軟創新與知識產權研究中心北京市環球律師事務所

一、概述美國擁有高度發達的專利訴訟制度,主要是因爲其在技術研發方面的歷史性投資,以及在國内外生産的産品擁有龐大且利潤豐厚的市場。美國專利是基於在美國專利商標局(UsPTO)的申請進行審查授予。如果侵權産品是進口的且相關專利已... 详细信息

一、概述美國擁有高度發達的專利訴訟制度,主要是因爲其在技術研發方面的歷史性投資,以及在國内外生産的産品擁有龐大且利潤豐厚的市場。美國專利是基於在美國專利商標局(UsPTO)的申請進行審查授予。如果侵權産品是進口的且相關專利已經被國内行業使用,那麽這些專利可以在美國地區法院或美國國際貿易委員會予以執行。在UsPTO,所有的美國專利都面臨潜在的授權後有效性的挑戰。雖然專利訴訟的數量隨着時間的推移而變化,但保護開發新技術所必需的投資之需求和保障競争者可獲得的利潤之需求表明:美國專利訴訟將繼續受到重大關注。

关键词：衡平法 UsPTO 禁止反言 LLC

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慕尼黑随访研究:基于内窥镜或组织学检查疑似Barrett食管的临床意义

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世界核心医学期刊文摘（胃肠病学分册） 2005年第3期1卷 35-36页

作者： Meining A. ott R. Becker I. T. Rsch 杨瑗 Central Interdisciplinary Department of Gastroenterology CharitéUniversity Hospitals Berlin Germany Prof.

Background: The incidence of distal oesophageal adenocarcinoma is rising, with chronic reflux and Barretts oesophagus being considered risk factors. Reliable detection of Barretts oesophagus during upper endoscopy is therefore mandatory but requires both endoscopy and histology for confirmation. Appropriate management of patients with endoscopic suspicion but negative on histology, or vice versa, or of patients with no endoscopic suspicion but with a biopsy diagnosis of intestinal metaplasia at the gastro oesophageal junction, has not yet been studied prospectively. Patients and methods: In a prospective multicentre study, 929 patients (51%male, mean age 50 years) referred for upper gastrointestinal endoscopy were included; 59%had reflux symptoms. The endoscopic aspect of the Z line and any suspicion of Barretts oesophagus were noted, and biopsies were taken in all patients from the Z line (n = 4), gastric cardia (n = 2), and body and antrum (n = 2 each). Biopsies positive for specialised intestinal metaplasia (sIM) were reviewed by a reference pathologist for a final Barretts oesophagus diagnosis. All patients with endoscopic and/or histological suspicion of Barretts oesophagus were invited for a follow up endoscopy; the remaining cases (no endoscopic or histological suspicion of Barretts oesophagus) were followed clinically. Results: Of 235 patients positive for Barretts oesophagus on endoscopy and/or histology, 63%agreed to undergo repeat endoscopy (mean follow up period 30.5months). 46%of patients with an endoscopic Barretts oesophagus diagnosis but no histological confirmation (group A) showed the same distribution, a further 42%did not have Barretts oesophagus, and 11%had confirmed Barretts oesophagus on both endoscopy and biopsy on follow up. In the group with a histological Barretts oesophagus diagnosis but negative on initial endoscopy (group B), follow up showed the same in 26%whereas 46%had no Barretts oesophagus, and confirmed Barretts oesop

关键词： Barrett 组织学检查随访研究反流症状消化道内镜检查不典型增生肠化生阴性患者胃贲门组织学诊断

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