Recent advances and perspectives in next generation sequencing application to the genetic research of type 2 diabetes
Recent advances and perspectives in next generation sequencing application to the genetic research of type 2 diabetes作者机构：Laboratory of Biobanking and Genomic Medicine of Institute of Translation BiomedicineSt.Petersburg State UniversitySt.Petersburg 199034Russia Department of Genomic MedicineD.O.Ott Research Institute of ObstetricsGynaecology and ReproductologySt.Petersburg 199034Russia Bioinformatics InstituteSt.Petersburg 194021Russia Department of Genetics and BiotechnologySt.Petersburg State UniversitySt.Petersburg 199034Russia Department of GeneticsCity Hospital No.40St.Petersburg 197706Russia Institute of Living SystemsImmanuel Kant Baltic Federal UniversityKaliningrad 236016Russia
出 版 物：《World Journal of Diabetes》 (世界糖尿病杂志（英文版）（电子版）)
年 卷 期：2019年第10卷第7期
页 面：376-395页
核心收录：
基 金：Supported by D.O.Ott Research Institute of Obstetrics Gynaecology and Reproductology project 558-2019-0012(АААА-А19-119021290033-1)of FSBSI
主 题：Type 2 diabetes Next-generation sequencing Epigenetics Genome-wide association study Microbiome
摘 要：Type 2 diabetes(T2D)mellitus is a common complex disease that currently affects more than 400 million people worldwide and has become a global health ***-throughput sequencing technologies such as whole-genome and whole-exome sequencing approaches have provided numerous new insights into the molecular bases of *** advances in the application of sequencing technologies to T2D research include,but are not limited to:(1)Fine mapping of causal rare and common genetic variants;(2)Identification of confident genelevel associations;(3)Identification of novel candidate genes by specific scoring approaches;(4)Interrogation of disease-relevant genes and pathways by transcriptional profiling and epigenome mapping techniques;and(5)Investigation of microbial community alterations in patients with *** this work we review these advances in application of next-generation sequencing methods for elucidation of T2D pathogenesis,as well as progress and challenges in implementation of this new knowledge about T2D genetics in diagnosis,prevention,and treatment of the disease.
维普期刊数据库