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Physical and biochemical changes in ultra-rapid air chilled broiler muscle and quality of marinated chicken breast filets

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Food Bioscience 2022年第2期46卷 315-320页

作者： rakesh k.singh Neeraj Sharma Department of Food Science and Technology University of Georgia100 Cedar StreetFood Science BuildingAthensGA30602USA

The effect of ultra-rapid chilling in air at-20℃ over water-immersion chilling on broiler carcasses was investigated for physical and biochemical ***-eight eviscerated carcasses were divided into two groups,one group were subjected to air chilling and other to water-immersion chilling,and samples were drawn at time periods of 1,3 and 24 h post-chill to analyze for pH,ratios of adenine:inosine nucleotide(R-values),expressible moisture,cook yield,tenderness and ***-rapid air chilled carcasses showed significant differences(Pk yield at chosen post-chill time intervals over the carcasses chilled using water-immersion *** was concluded that air chilled carcasses had higher pH and expressible moisture,but the R-values,and shear values did not show significant differences,and only slight difference in color of carcasses processed by the two chilling *** a separate experiment with 108 commercially processed carcasses,quality attributes of pre-rigor marinated breast filets were studied after subjecting the carcasses to air chilling and water-immersion *** filets from air and water chilled carcass aged for 1,3,and 24 h were tumble marinated for 25 min in a Sodium Tri Polyphosphate(STPP)and NaCl solution with different pick up levels of 10,15 and 20%.After measuring marinade absorption,filets were aged at 2℃ for 24 *** differences were observed between the air and water chilling treatments in terms of marinade retention at different marinade target levels(10,15 and 20%)and time intervals(24,27 and 47 h)but cook yield of air chilled marinated fillet was *** conclusion,processors using further-processing operations that debone meat may find that AC to be more suitable alternative for cooling poultry carcasses because fillet color,marination yield,and tenderness were not affected,but cook yield was improved.

关键词： Air chilling Poultry Fillet Chicken meat Marination

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Visceral leishmaniasis: An immunological viewpoint on asymptomatic infections and post kala azar dermal leishmaniasis

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Asian Pacific Journal of Tropical Medicine 2018年第2期11卷 98-108页

作者： Neeraj Tiwari Dhiraj kishore Surabhi Bajpai rakesh k.singh Department of Biochemistry Institute of ScienceBanaras Hindu University Department of Medicine Institute of Medical SciencesBanaras Hindu University Department of Bioscience and Biotechnology Banasthali University

Elimination of visceral leishmaniasis is a priority programme in Indian *** World Health Organization has set a new target to eliminate kala-azar by the year 2020 as previous target elimination year(2015) has *** elimination programme has successfully curbed the rate of infection in endemic regions; however, there are still few challenges in its *** current drug control regime is extremely limited and comprises only two(amphotericin B and miltefosine) drugs, which are also susceptible for parasites ***, these drugs do not produce sterile cure, and cured patients may develop post kala-azar dermal leishmaniasis even after a decade of cure leaving behind a potent source of parasitic reservoirs for further disease transmission.A significant proportion of endemic population remain seropositive but aymptomatic for many years without any clinical symptom that serve as latent parasitic *** lack of tools to identify live parasites in asymptomatic infections and there association in disease transmission, parameters of sterile cure along with post kala-azar dermal leishmaniasis progression remain a major threat in its *** this review, we discuss the potential of host immune inhibitory mechanisms to identify immune correlates of protective immunity to understand the mystery of asymptomatic infections, sterile cure and post kala azar dermal leishmaniasis.

关键词： Visceral leishmaniasis Immune response Asymptomatic infection Sterile cure Post kala-azar dermal leishmaniasis

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Micronization enhanced extractability of polyphenols and anthocyanins in tart cherry puree

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Food Bioscience 2022年第6期50卷 676-684页

作者： Nishtha Lukhmana Fanbin kong rakesh k.singh Department of Food Science and Technology The University of Georgia100 Cedar StreetAthensGA30602-2610USA

Tart cherries(Prunus cerasus L.)are the richest in phenolic compounds,among all the members of drupe family of *** reduce the inherent sourness of the cherries,thermal processing or filtration steps are *** processes lead to changes in pH,and exposure to temperature enhances oxidation leading to degradation of *** the present study,Megatron®and high-pressure homogenization(HPH)were employed to produce micronized puree,which was analyzed for polyphenolic,flavonoid and anthocyanin contents using various *** methods of micronization lead to breakage of cell wall structure facilitating enhanced release of bioactives from the cellular matrix and thus higher antioxidant *** presence of functional groups was corroborated by FTIR spectrophotometric analysis,and reversed phase HPLC for the presence and relative amounts of various polyphenols and *** was a significant increase(p<0.05)of in the extractability of polyphenols with HPH(285.05 GAEμg/g)in comparison with the non-micronized samples(166.80 GAEμg/g).The changes in anthocyanins and flavonoids were also significant(p<0.05),thus confirming the impact of micronization on the antioxidant release in tart cherries.

关键词： Particle size Antioxidants Polyphenols High-pressure homogenization Bioaccessibility

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Corrigendum to“Assessing the impact of 4-oxo-2-nonenal on lactate dehydrogenase activity and myoglobin redox stability”[Food Bioscience 43(2021)101306]

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Food Bioscience 2022年第2期46卷 1040-1040页

作者： Samuel A.Gonzalez Ronald B.Pegg rakesh k.singh Anand Mohan Department of Food Science and Technology College of Agricultural and Environmental SciencesUniversity of Georgia100 Cedar StreetAthensGA30602-2610United States

The authors regret a spelling error in the name of the first author.“Samuel ***”should read“Samuel A Gonzalez”.The authors would like to apologise for any inconvenience caused.

关键词： none Bioscience Cor

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pyGWBSE:a high throughput workflow package for GW-BSE calculations

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npj Computational Materials 2023年第1期9卷 2127-2136页

作者： Tathagata Biswas Arunima k.singh Department of Physics Arizona State UniversityTempe 85287 AZUSA

We develop an open-source python workflow package,pyGWBSE to perform automated first-principles calculations within the GW-BSE(Bethe-Salpeter)***-BSE is a many body perturbation theory based approach to explore the quasiparticle(QP)and excitonic properties of *** approximation accurately predicts bandgaps of materials by overcoming the bandgap underestimation issue of the more widely used density functional theory(DFT).BSE formalism produces absorption spectra directly comparable with experimental *** package achieves complete automation of the entire multi-step GW-BSE computation,including the convergence tests of several parameters that are crucial for the accuracy of these *** is integrated with Wannier90,to generate QP bandstructures,interpolated using the maximally-localized wannier *** also enables the automated creation of databases of metadata and data,including QP and excitonic properties,which can be extremely useful for future material discovery studies in the field of ultra-wide bandgap semiconductors,electronics,photovoltaics,and photocatalysis.

关键词： automated python enable

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Chemical hardness-driven interpretable machine learning approach for rapid search of photocatalysts

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npj Computational Materials 2021年第1期7卷 1850-1862页

作者： Ritesh kumar Abhishek k.singh Materials Research Centre Indian Institute of ScienceBangaloreKarnataka 560012India

Strategies combining high-throughput(HT)and machine learning(ML)to accelerate the discovery of promising new materials have garnered immense attention in recent *** knowledge of new guiding principles is usually scarce in such studies,essentially due to the‘black-box’nature of the ML ***,we devised an intuitive method of interpreting such opaque ML models through SHapley Additive exPlanations(SHAP)values and coupling them with the HT approach for finding efficient 2D watersplitting *** developed a new database of 30992D materials consisting of metals connected to six ligands in an octahedral geometry,termed as 2DO(octahedral 2D materials)*** ML models were constructed using a combination of composition and chemical hardness-based features to gain insights into the thermodynamic and overall *** importantly,it distinguished the target properties of the isocompositional 2DO materials differing in bond connectivities by combining the advantages of both elemental and structural *** interpretable ML regression,classification,and data analysis lead to a new hypothesis that the highly stable 2DO materials follow the HSAB *** most stable 2DO materials were further screened based on suitable band gaps within the visible region and band alignments with respect to standard redox potentials using the GW method,resulting in 21 potential ***,HfSe_(2)and ZrSe_(2)were found to have high solar-tohydrogen efficiencies reaching their theoretical *** proposed methodology will enable materials scientists and engineers to formulate predictive models,which will be accurate,physically interpretable,transferable,and computationally tractable.

关键词： intuitive formulate visible

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Diagenesis,facies and palaeocurrent analysis of Upper Rewa Sandstone around Sagar,Central India

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Journal of Palaeogeography 2023年第4期12卷 546-563页

作者： Gaurav k.singh Ashish k.Rai Arvind k.singh Department of Applied Geology Dr.Harisingh Gour VishwavidyalayaSagar 470003Madhya PradeshIndia Geological Survey of India ShillongIndia

The stratigraphic surface represented by a major contact between the Archean Bundelkhand Granite and the extensive Proterozoic Vindhyan sediments is a regional basement cover *** crystalline—sedimentary interface reflects an intense weathering of continental crust during marine *** time-transgressive sand deposition events ***,Rewa and Bhander are mainly witnessed during the entire Vindhyan ***,the Upper Rewa Sandstone comprises one of these events in the Vindhyan *** progress has been made in interpreting these sandstones as a function of entirely marine process to a combination of tidal—fluvio—eolian *** the results have so far been attained on the basis of sedimentary facies,provenance,palaeocurrent analysis,and some of petrography.A distinct differentiation between marine and fluvial components of the Upper Rewa Sandstone still remains ***,we use diagenesis as a parameter for the first time along with facies and palaeocurrent analysis to acquire a clear comprehension of marine-and fluvial-dominated *** present study spans 27 square kilometer area covering 15 stratigraphic sections with a collection of 571directional data from the facies specific sedimentary structures,and 28 samples obtained for the thin section *** lower unit of the Upper Rewa Sandstone shows facies association typical of tidal environment,along with polymodal *** rocks are well sorted and dominantly lithified by authigenic *** development of a complex of syntaxial,passive pore fills,and grain replacive cements reflect normally pressured nature of the lower unit *** upper unit of the Upper Rewa Sandstone however,reveals a facies pattern resembling fluvial processes and unimodal palaeocurrent *** exhibit poor sorting,siliceous,and ferruginous matrix,and development of intense ***,pressure solution is a dominant mode of l

关键词： Palaeocurrent Diagenesis Facies Upper Rewa Sandstone Vindhyan Basin

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Excitonic effects in absorption spectra of carbon dioxide reduction photocatalysts

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npj Computational Materials 2021年第1期7卷 1752-1761页

作者： Tathagata Biswas Arunima k.singh Department of Physics Arizona State UniversityTempeAZ 85287USA

The formation and disassociation of excitons play a crucial role in any photovoltaic or photocatalytic ***,excitonic effects are seldom considered in materials discovery studies due to the monumental computational cost associated with the examination of these ***,we study the excitonic properties of nearly 50 photocatalysts using state-of-the-art Bethe–Salpeter ***~50 materials were recently recognized as promising photocatalysts for CO_(2) reduction through a data-driven screening of 68,860 ***,we propose three screening criteria based on the optical properties of these materials,taking excitonic effects into account,to further down select six ***,we study the correlation between the exciton binding energies obtained from the Bethe–Salpeter formalism and those obtained from the computationally much lessexpensive Wannier–Mott model for these chemically diverse~50 *** work presents a paradigm towards the inclusion of excitonic effects in future materials discovery for solar-energy harvesting applications.

关键词： materials properties dioxide

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Inflammation and retinal degenerative diseases

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Neural Regeneration Research 2023年第3期18卷 513-518页

作者： Geetika kaur Nikhlesh k.singh Integrative Biosciences Center Wayne State UniversityDetroitMIUSA Department of Ophthalmology Visual and Anatomical SciencesWayne State University School of MedicineDetroitMIUSA

Vision is an ability that depends on the precise structure and functioning of the *** kind of stress or injury can disrupt the retinal architecture and leads to vision impairment,vision loss,and *** system and immune response function maintain homeostasis in the *** genetic,metabolic,and environmental factors may alter retinal homeostasis,and these events may initiate various inflammatory *** prolonged inflammatory state may contribute to the initiation and development of retinal disorders such as glaucoma,age-related macular degeneration,diabetic retinopathy,and retinitis pigmentosa,which pose a threat to *** the current review,we attempted to provide sufficient evidence on the role of inflammation in these retinal ***,this review paves the way to focus on therapeutic targets of the disease,which are found to be promising.

关键词： age-related macular degeneration diabetic retinopathy glaucoma retina retinal degeneration retinitis pigmentosa

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RBFOX2: a key factor in suppressing PDAC metastasis through regulation of alternative splicing events

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Signal Transduction and Targeted Therapy 2023年第10期8卷 4431-4432页

作者： Laura Urbach Shiv k.singh Department of Gastroenterology Gastrointestinal Oncology and EndocrinologyUniversity Medical Center GottingenGottingenGermany Clinical Research Unit 5002 KFO5002University Medical Center GöttingenGottingenGermany

A new study published in Nature by Jbara et *** identified the splicing factor“RBFOX2,”which halts metastatic spread of pancreatic ductal adenocarcinoma(PDAC)through regulating alternative splicing events.1 The results of the study provide new insights into the molecular mechanisms underlying the start of metastatic spread of PDAC *** study also indicates that pathways involved in splicing modulation could be targeted for potential therapeutic interventions in an advanced-stage PDAC.

关键词： metastasis al. metastatic

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