检索结果-南通市图书馆

Amyloid-beta pathology-induced nanoscale synaptic disruption:the case of the GABA_B-GIRK assembly

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第5期20卷 1409-1410页

作者： rafael Lujan Alejandro martín-Belmonte Sergi Ferré Francisco Ciruela Synaptic Structure Laboratory Instituto de Biomedicina de la UCLM(IB-UCLM)Departamento de Ciencias MédicasInstituto de Investigación en Salud de Castilla-La Mancha(IDISCAM)Facultad de MedicinaUniversidad Castilla-La ManchaCampus BiosanitarioC/AlmansaAlbaceteSpain Integrative Neurobiology Section National Institute on Drug AbuseIntramural Research ProgramNational Institutes of HealthBaltimoreMDUSA pharmacology Unit Department of Pathology and Experimental TherapeuticsSchool of Medicine and Health SciencesInstitute of NeurosciencesUniversity of BarcelonaNeuropharmacology&Pain GroupNeuroscience ProgramBellvitge Institute for Biomedical ResearchL’Hospitalet de LlobregatSpain

Alzheimer's disease (AD) is characterized by an imbalance between excitatory and inhibitory brain networks,leading to aberrant homeostatic synaptic *** has progressively been recognized as syna ptopathy and syna ptic dysfunction has been identified as a key component of its pathogenesis (Schirinzi et al.,2020).Syna ptic dysfunction is believed to precede synapse loss,a primary biological correlate of cognitive decline in AD,inevita bly associated with neuronal death.

关键词： Alzheimer pathology

Evidences supporting the vascular etiology of post-double balloon enteroscopy pancreatitis: Study in porcine model

在线全文

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2017年第34期23卷 6201-6211页

作者： rafael Latorre Octavio López-Albors Federico Soria Esther Morcillo pilar Esteban Enrique pérez-Cuadrado-Robles Enrique pérez-Cuadrado-martínez Department of Anatomy and Comparative pathology University of Murcia Minimally Invasive Surgery Centre Jesús Usón Department of Gastroenterology Small Bowel UnitMorales Meseguer Hospital

Double balloon enteroscopy(DBE) is an endoscopic technique broadly used to diagnose and treat small bowel diseases. Among the associated complications of the oral DBE, post-procedure pancreatitis has taken the most attention due to its gravity and the thought that it might be associated to the technique itself and anatomical features of the pancreas. However, as the etiology has not been clarified yet, this paper aims to review the published literature and adds new results from a porcine animal model. Biochemical markers, histological sections and the vascular perfusion of the pancreas were monitored in the pig during DBE practice. A reduced perfusion of the pancreas and bowel, the presence of defined hypoxic areas and disseminated necrotic zones were found in the pancreatic tissue of pigs. All these evidences contribute to support a vascular distress as the most likely etiology of the post-DBE pancreatitis.

关键词： Double balloon enteroscopy pancreas Animal model pancreatitis pig

Repellent and Insecticidal Activity of Naphthoquinones from the Heartwood of Tectona grandis on Incisitermes marginipennis(Latreille)

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

phyton-International Journal of Experimental Botany 2023年第7期92卷 2165-2181页

作者： Crisanto Velázquez-Becerra Gu Yen Ambriz-Ortiz rafael Torres-martínez Mauro Manuel martínez-pacheco Facultad de Ingeniería en Tecnología de la Madera Universidad Michoacana de San Nicolás de HidalgoMoreliaMéxico Escuela Nacional de Estudios Superiores Unidad MoreliaMoreliaMéxico Instituto de Investigaciones Químico-Biológicas Universidad Michoacana de San Nicolás de HidalgoMoreliaMéxico

Wood is a lignocellulosic material that,because of its organic nature,is a source of nutrients for bacteria,fungi,and *** marginipennis(Latreille)is an interesting dry wood-boring *** it is an extremely destructive pest,difficult to control due to its cryptic lifestyle,and for its role in the biogeochemical cycle of carbon and other elements;it is a fundamental *** use of less toxic and eco-friendly substances is important for protecting domestic,cultural,and historical heritage made of wood or lignocellulosic *** aim of this study was to evaluate the biological activity of various naphthoquinones extracted from the heartwood of *** on ***,heartwood flour was used for Soxhlet-type extractions to isolate and characterize the heartwood compounds by thin-layer *** identify the heartwood compounds,nuclear magnetic resonance and gas chromatography coupled to a mass spectrometer were *** information obtained was supported using the Interactive Spectroscopy *** identified heartwood compounds were lapachol,tectoquinone,deoxylapachol,dehydro-α-lapachone,tectol and *** nymphal termites of *** as a biological model,the isolated and identified molecules were under three different tests(repellent,insecticide and protective)and their biological activity was individually *** results showed that the molecules obtained have a repellent-protective effect against ***,although not in all cases,these molecules have high percentages of mortality and decreased the weight loss of the treated material exposed to ***.

关键词： Naphthoquinones dry wood termite Incisitermes marginipennis wood preservatives

3′-UTR of the SARS-CoV-2 genome as a possible source of piRNAs

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Genes & Diseases 2023年第3期10卷 668-670页

作者： María Teresa Hernández-Huerta Laura pérez-Campos Mayoral Carlos Alberto Matias-Cervantes Carlos Romero Díaz Eli Cruz parada Eduardo pérez-Campos Mayoral rafael Baltiérrez-Hoyos Margarito martínez Cruz Gabriel Mayoral Andrade Eduardo pérez-Campos CONACyT Faculty of Medicine and SurgeryAutonomous University“Benito Juárez”of Oaxaca(UABJO)Oaxaca 68020Mexico Research Center Faculty of Medicine UNAM-UABJOAutonomous University“Benito Juárez”of Oaxaca(UABJO)Oaxaca 8020Mexico National Technology of Mexico/IT Oaxaca Oaxaca de JuárezOaxaca 68030Mexico

SARS-CoV-2 is the causal agent of the COVID-19 pandemic. This is a single-stranded RNA beta-coronavirus that is comprised of a 5′ and 3′-untranslated region (UTR) in its non-coding RNA (ncRNA) region. The p-element-induced wimpy testis (pIWI)-interacting RNAs (piRNAs) are ncRNA sequences that bind to transposons and interfere with the translation of new genes. Here, we search for short sequences in the non-coding regions, corresponding to 28 nucleotides (nt). These start from a uracil and have a conserved region of at least 10 nt of homology with the previously reported piRNAs. The aim of this work was to identify piRNA-like sequences in the 3′-UTR of SARS-CoV-2 from the reported Wuhan patient's genome sequence (GenBank: MN908947.3).

关键词： piRNA sequences piRNAs

Analysis of Naval Ship Evacuation Using Stochastic Simulation Models and Experimental Data Sets

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Computer Modeling in Engineering & Sciences 2020年第3期122卷 971-995页

作者： Roberto Bellas Javier martínez Ignacio Rivera Ramón Touza MiguelGómez rafael Carreño University of Vigo Vigo36310Spain. Spanish Navy Madrid28033Spain.

The study of emergency evacuation in public spaces,buildings and large ships may present parallel characteristic in terms of complexity of the layout but there are also significant differences that can hinder passengers to reach muster stations or the *** are many hazards on a ship that can cause an emergency evacuation,the most severe result in loss of *** safe and effective evacuation of passengers from ships in an emergency situation becomes ***,computer simulation has become an indispensable technology in various fields,among them,the evacuation models that recently evolved incorporating human behavioral *** this work,an analysis of evacuation in a Landing Helicopter Dock(LHD)ship was *** routes specified by the ship’s procedures were introduced in the model and the six emergency scenarios of the Naval Ship Code were *** crew and embarked troops were introduced with their different evacuation behavior,in addition,walking speeds were extracted from data set collected in experiments conducted at other *** the results of the simulations,the longest time was chosen and confidence intervals constructed to determine the total evacuation ***,results show that evacuation time meets regulatory requirements and the usefulness and low cost of the evacuation simulation for testing and refining possible ships’layouts and emergency scenarios.

关键词： Evacuation modeling confidence intervals naval ship IMO NATO NSC.

SARS-CoV-2 spike RBD-specific IgA and IgG antibodies in breast milk after vaccination with the protein subunit vaccine Abdala

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Infectious Medicine 2022年第4期1卷 253-261页

作者： Maylin pérez-Bernal Carlos Hernández rafael Ibargollín Midalis martínez Migdiala Soria Magali Delgado Onel Valdivia DayamíDorta Andy Domínguez Enrique pérez Yeosvany Cabreraa Research&Development Department Center for Genetic Engineering and BiotechnologyCircunvalante NorteOlivos IIISancti SpiritusCuba Neonatology Service General Hospital“Camilo Cienfuegos”128 Bartolome MasoSancti SpiritusCuba production Department Center for Genetic Engineering and BiotechnologyCircunvalante NorteOlivos IIISancti SpiritusCuba

Background:COVID-19 vaccines that trigger a strong secretory antibody response in breast milk may achieve effective passive protection of vulnerable newborns and breastfed infants of immunized *** aim of this work was to investigate the presence of SARS-CoV-2 spike RBD-specific IgA and IgG antibodies in breast milk,5 and 9 weeks after vaccination with 3 doses of the protein subunit vaccine Abdala,compared to those found in breast milk from COVID-19-recovered women,collected at least 40 days after the ***:SARS-CoV-2 spike RBD-specific IgA and IgG antibodies were semi-quantified by indirect ELISA,using a homemade standard generated by pooling twenty breast milk samples with high absorbance values according to preliminary *** validity of the standard curves was proved following the European Medicines Agency *** breast milk samples from 2 unvaccinated women who had not been infected with COVID-19 were included as negative *** neutralizing antibodies was assessed by a SARS-CoV-2 surrogate virus neutralization ***:High levels of anti-RBD IgA antibodies were detected in breast milk samples 9 weeks after vaccination and anti-RBD IgG antibodies rise from the fifth to the ninth *** the post-COVID-19 time that was evaluated,the IgG-type response was notably higher compared to both post-vaccination *** antibody titers were similar in breast milk from vaccinated and COVID-19 recovered ***:This is the first report about the immune response in breast milk after the administration of a COVID-19 protein subunit vaccine,which could provide analogous protection to that conferred by SARS-CoV-2 *** implies a potential passive immunity that breastfed infants receive from their mothers vaccinated with Abdala.

关键词： Abdala vaccine IgA IgG Neutralizing antibody titers SARS-CoV-2

Resilience to structural and molecular changes in excitatory synapses in the hippocampus contributes to cognitive function recovery in Tg2576 mice

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Neural Regeneration Research 2024年第9期19卷 2068-2074页

作者： Carolina Aguado Sara Badesso Josémartínez-Hernández Alejandro martín-Belmonte Rocío Alfaro-Ruiz Miriam Fernández Ana Esther Moreno-martínez Mar Cuadrado-Tejedor Ana García-Osta rafael Luján Synaptic Structure Laboratory Instituto de Investigación en Discapacidades Neurológicas(IDINE)Department of Medical SciencesFacultad de MedicinaUniversidad de Castilla-La ManchaCampus BiosanitarioAlbaceteSpain Gene Therapy for Neurological Disease program Center for Applied Medical Research(CIMA)University of NavarraInstituto de Investigación Sanitaria de Navarra(IdiSNA)PamplonaSpain pharmacology Unit Department of Pathology and Experimental TherapeuticsFaculty of Medicine and Health SciencesInstitute of NeurosciencesUniversity of BarcelonaBarcelonaSpain Neuropharmacology and pain Group Neuroscience ProgramInstitut d’InvestigacióBiomèdica de BellvitgeIDIBELLL’Hospitalet de LlobregatSpain Department of pathology Anatomy and PhysiologySchool of MedicineUniversity of NavarraPamplonaSpain UniversitéGrenoble Alpes Grenoble Institut des NeurosciencesGrenobleFrance

plaques of amyloid-β(Aβ)and neurofibrillary tangles are the main pathological characteristics of Alzheimer’s disease(AD).However,some older adult people with AD pathological hallmarks can retain cognitive *** the factors that lead to this cognitive resilience to AD offers promising prospects for identifying new therapeutic *** hypothesis focuses on the contribution of resilience to changes in excitatory synapses at the structural and molecular levels,which may underlie healthy cognitive performance in aged AD *** the Morris Water Maze test,we selected resilient(asymptomatic)and cognitively impaired aged Tg2576 *** the enzyme-linked immunosorbent assay showed similar levels of Aβ42 in both experimental groups,western blot analysis revealed differences in tau pathology in the pre-synaptic supernatant *** further investigate the density of synapses in the hippocampus of 16-18 month-old Tg2576 mice,we employed stereological and electron microscopic *** findings indicated a decrease in the density of excitatory synapses in the stratum radiatum of the hippocampal CA1 in cognitively impaired Tg2576 mice compared with age-matched resilient Tg2576 and non-transgenic ***,through quantitative immunoelectron microscopy in the hippocampus of impaired and resilient Tg2576 transgenic AD mice,we uncovered differences in the subcellular localization of glutamate ***,the density of GluA1,GluA2/3,and mGlu5 in spines and dendritic shafts of CA1 pyramidal cells in impaired Tg2576 mice was significantly reduced compared with age-matched resilient Tg2576 and non-transgenic ***,the density of GluA2/3 in resilient Tg2576 mice was significantly increased in spines but not in dendritic shafts compared with impaired Tg2576 and non-transgenic *** subcellular findings strongly support the hypothesis that dendritic spine plasticity and synaptic machinery in the hippocampus play cr

关键词： aging Alzheimer´s disease cognitive hippocampus immunoelectron microscopy resilience synapse

Children with obesity have poorer circadian health as assessed by a global circadian health score

在线全文

学校读者我要写书评

暂无评论

World Journal of pediatrics 2024年第8期20卷 787-800页

作者： María Rodríguez-martín Nuria martínez-Lozano Vicente Santaclara-Maneiro Antonio Gris-peñas Diego Salmerón rafael Ríos Asta Tvarijonaviciute marta Garaulet Department of physiology Regional Campus of International ExcellenceUniversity of Murcia30100MurciaCPSpain Biomedical Research Instituteof Murcia IMIB-Arrixaca-UMUUniversity Clinical Hospital30120MurciaSpain Health Area of Lorca LorcaMurciaSpain Health and Social Sciences Department University ofMurciaMurciaSpain Consortium for Biomedical Research in Epidemiology and public Health MadridSpain Interdisciplinary Laboratory of Clinical Analysis(Interlab-UMU) University of MurciaMurciaSpain Division of Sleep and Circadian Disorders Brigham and Women's Hospital(BWH)and Division of Sleep MedicineHarvard Medical SchoolBostonMA 02115USA

Background Circadian health refers to individuals’well-being and balance in terms of their circadian *** is influenced by external *** adults,a close relationship between circadian-related alterations and obesity has been ***,studies in children are scarce,and circadian health and its association with obesity have not been evaluated *** aimed to assess whether circadian health differed between children with and without obesity as determined by a global circadian score(GCS)in a school-age *** Four hundred and thirty-two children(7–12 years)were recruited in ***-invasive tools were used to calculate the GCS:(1)7-day rhythm of wrist temperature(T),activity(A),position(p),an integrative variable that combines T,A,and p(TAp);(2)cortisol;and(3)7-day food and sleep *** mass index,body fat percentage,waist circumference(WC),melatonin concentration,and cardiometabolic marker levels were *** Circadian health,as assessed by the GCS,differed among children with obesity,overweight,and normal weight,with poorer circadian health among children with *** with obesity and abdominal obesity had 3.54 and 2.39 greater odds of having poor circadian health,respectively,than did those with normal weight or low *** percentage of rhythmicity,a marker of the robustness of the TAp rhythm,and the amplitude,both components of the GCS,decreased with increasing *** lifestyle behaviors were involved in the association between circadian health and obesity,particularly protein intake(p=0.024),physical activity level(p=0.076)and chronotype(p=0.029).Conclusions The GCS can capture the relationship between circadian health and obesity in school-age *** intake,physical activity level,and chronotype were involved in this *** intervention based on improving circadian health may help to prevent childhood obesity.

关键词： Children Chronodisruption Circadian Lifestyle Obesity

Supercritical synthesis of platinum-modified titanium dioxide for solar fuel production from carbon dioxide

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Chinese Journal of Catalysis 2017年第4期38卷 636-650页

作者： Susana Tostón rafael Camarillo Fabiola martínez Carlos Jiménez Jesusa Rincón University of Castilla‐La Mancha Department of Chemical Engineering Faculty of Environmental Sciences and Biochemistry Avda. Carlos III s/n 45071 Toledo Spain

This paper investigates the properties of TiO2‐based photocatalysts synthesised under ***,the characteristics of pt dispersed on TiO2catalysts obtained in supercriticalCO2are discussed and compared with those of commercial *** photocatalytic activity of thesynthesised catalysts in the CO2photoreduction reaction to produce solar fuel is *** mainconclusion of the study is that photocatalysts with better or similar features,including high surfacearea,crystallisation degree,hydroxyl surface concentration,pore volume,absorbance in the visiblerange and methane production rate,to those of commercial TiO2may be produced for the reductionof CO2to fuel by synthesis in supercritical media.

关键词： Titanium dioxide platinum photocatalyst Metal dispersion Carbon dioxide photoreduction