3′-UTR of the SARS-CoV-2 genome as a possible source of piRNAs

作     者：María Teresa Hernández-Huerta Laura Pérez-Campos Mayoral Carlos Alberto Matias-Cervantes Carlos Romero Díaz Eli Cruz Parada Eduardo Pérez-Campos Mayoral Rafael Baltiérrez-Hoyos Margarito Martínez Cruz Gabriel Mayoral Andrade Eduardo Pérez-Campos María Teresa Hernández-Huerta;Laura Pérez-Campos Mayoral;Carlos Alberto Matias-Cervantes;Carlos Romero Díaz;Eli Cruz Parada;Eduardo Pérez-Campos Mayoral;Rafael Baltiérrez-Hoyos;Margarito Martínez Cruz;Gabriel Mayoral Andrade;Eduardo Pérez-Campos

作者机构：CONACyTFaculty of Medicine and SurgeryAutonomous University“Benito Juárez”of Oaxaca(UABJO)Oaxaca 68020Mexico Research CenterFaculty of Medicine UNAM-UABJOAutonomous University“Benito Juárez”of Oaxaca(UABJO)Oaxaca 8020Mexico National Technology of Mexico/IT OaxacaOaxaca de JuárezOaxaca 68030Mexico 

出 版 物：《Genes & Diseases》 (基因与疾病（英文）)

年 卷 期：2023年第10卷第3期

页      面：668-670页

核心收录：

学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学] 

基　　金：supported by Faculty of Medicine of the Autonomous University Benito Juarez of Oaxaca Mexico the National Technology of Mexico(TecNM)/IT Oaxaca and CONACYT 

主　　题：piRNA sequences piRNAs 

摘      要：SARS-CoV-2 is the causal agent of the COVID-19 pandemic. This is a single-stranded RNA beta-coronavirus that is comprised of a 5′ and 3′-untranslated region (UTR) in its non-coding RNA (ncRNA) region. The P-element-induced wimpy testis (PIWI)-interacting RNAs (piRNAs) are ncRNA sequences that bind to transposons and interfere with the translation of new genes. Here, we search for short sequences in the non-coding regions, corresponding to 28 nucleotides (nt). These start from a uracil and have a conserved region of at least 10 nt of homology with the previously reported piRNAs. The aim of this work was to identify piRNA-like sequences in the 3′-UTR of SARS-CoV-2 from the reported Wuhan Patient s genome sequence (GenBank: MN908947.3).