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法律起源的经济后果(上)

管理世界 2010年第7期26卷 156-166,179页

过去10年里,经济学家发表的大量研究表明,一国法律的历史起源与它的法规、规范在多个方面高度关联,同时亦与其经济结果密切相关。本文总结了此领域的研究成果并试图给出一个统一的解析。对于"法律起源是重要的"这一经验性结论的反对意见... 详细信息

过去10年里,经济学家发表的大量研究表明,一国法律的历史起源与它的法规、规范在多个方面高度关联,同时亦与其经济结果密切相关。本文总结了此领域的研究成果并试图给出一个统一的解析。对于"法律起源是重要的"这一经验性结论的反对意见,我们也给予了评述。最后,我们对本研究在经济改革中的应用进行了评估。

关键词：法律起源经济后果经济学家历史起源研究成果经济改革经验性

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投资者保护与公司治理

研究生法学 2008年第4期23卷 133-146页

作者： rafael la porta Florencio Lopez-de-Silanes Andrei Shleifer Robert Vishny 缪因知哈佛大学经济系哈佛大学肯尼迪政府学院芝加哥大学商学院北京大学法学院 2006级博士研究生100871

近期研究表明,各国上市公司所有权的集中程度、资本市场的广度与深度、红利(分配)政策以及企业获得外部融资的途径存在着巨大差异。其中,投资者(股东与债权人)在多大程度上受到了法律的保护、以免受公司经理和控股股东剥夺,是对这些差... 详细信息

近期研究表明,各国上市公司所有权的集中程度、资本市场的广度与深度、红利(分配)政策以及企业获得外部融资的途径存在着巨大差异。其中,投资者(股东与债权人)在多大程度上受到了法律的保护、以免受公司经理和控股股东剥夺,是对这些差异的解释中的一个通用要素。我们阐述了各国法律以及执法效率的差异,讨论了这些差异可能的起因,概述了它们的影响,并评估了公司治理改革的可能策略。在理解公司治理及其改革上,人们习惯把金融体制分为以银行为中心的体制和以市场为中心的体制。我们认为,与这种方法相比,基于法律的进路更富有成效。

关键词：投资者保护公司治理法律

Impact of data balancing a multiclass dataset before the creation of association rules to study bacterial vaginosis

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Intelligent Medicine 2024年第3期4卷 188-199页

作者： Freddy de la Cruz-Ruiz Juana Canul-Reich rafael Rivera-López Erick de la Cruz-Hernández Academic Division of Science and Technology of the Information Juárez Autonomous University of TabascoLa Esmeralda DistrictTabascoMexico Department of Systems National Technological Institute of MexicoTechnological Institute of VeracruzVeracruzMexico Multidisciplinary Academic Division of Comalcalco Juárez Autonomous University of TabascoTabascoMexico

Background Bacterial vaginosis is a polymicrobial syndrome in which the homeostasis exerted by the latobacillus species that protect the vaginal mucosa has been *** study explored the data balancing process with the intention of improving the quality of association *** article aimed to balance the unbalanced multiclass dataset to improve association rule *** A dataset with 201 observations and 58 variables was analyzed.A preconstructed dataset was *** authors collected the data between August 2016 and October 2018 in Tabasco,*** study population comprised sexually active women ages 18 to 50 who underwent gynecological inspection at the infectious and metabolic diseases research laboratory at the Universidad Juarez Autonoma de *** determine the best κ-value,the random-forest algorithm was used and the balancing was performed with the synthetic minority over-sampling technique(SMOTE),random over-sampling examples(ROSE),and adaptive syntetic sampling approach for imbalanced learning(ADASYN)*** Apriori algorithm created the rules and to select rules with statistical significance,the ***(),***(),and ***()functions and quality metric Fisher’s exact tes were *** biological validation was carried out by the expert(bacteriologist).Results The ADASYN algorithm at K=9 the out of the bag(OOB)error was zero,this was the best𝐾-*** the balancing process the ADASYN algorithm show best the *** the dataset balanced with ADASYN,the apriori algorithm created the association rules and the selection with the quality metric Fisher’s exact test,and the biological validation reported 13 ***-bacteria Atopobium vaginae,Gardnerella vaginalis,Megasphaera filotipo 1,Mycoplasma hominis and Ureaplasma parvum were detected by the apriori algorithm from the balanced *** Balancing may improve the creation of association rules to efficiently model the bacteria that cause bac

关键词： Bacterial vaginosis Data balancing Random forest Synthetic minority over-sampling technique

High-resolution multi-scale air pollution system:Evaluation of modelling performance and emission control strategies

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Journal of Environmental Sciences 2024年第3期137卷 65-81页

作者： Diogo Lopes Joana Ferreira Sandra rafael Ka In Hoi Xin Li Yuan Liu Ka-Veng Yuen Kai Meng Mok Ana Isabel Miranda Department of Environment and Planning&CESAM University of AveiroAveiroPortugal Department of Civil&Environmental Engineering Faculty of Science and TechnologyUniversity of MacaoMacao SARChina

A high percentage of the world's population lives in areas where air pollutant concentrations exceed the World Health Organization *** work aims to develop and test,a high-resolution multi-scale air pollution modelling system by integrating a set of adequate *** system is able to provide detailed air pollutant concentrations in urban areas and support air quality management strategies through a better identification of different atmospheric *** also allows furthering the design and assessment of air pollution control measures for a specific *** evaluate its performance and suitability,the system was applied to the Macao Special Administrative Region(SAR),China,one of the most densely populated areas on earth,during a winter period when this area is affected by high levels of Particulate Matter(PM).Although the developed system tends to underestimate the PM concentrations,it revealed a good performance in reproducing the temporal and spatial air pollution *** exceedances of the Chinese air quality standards were calculated and high population exposure to PM pollution was *** tested urban atmospheric emission reduction scenarios have shown air quality improvements,indicating that emission reduction measures at urban level should focus on the domestic ***,it is crucial to implement joint pollution prevention strategies with neighbouring regions to improve the air quality in Macao *** approach developed in this work can support policymakers in defining new strategies to reduce atmospheric pollution in urban areas.

关键词： Urban areas High-resolution emission inventory Particulate matter Population exposure

Prognostic Factors for Mortality in Severe Traumatic Brain Injury at HGZ 46, Villahermosa, Tabasco, Period from March 1, 2021 to December 31, 2022

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Open Journal of Emergency Medicine 2024年第1期12卷 1-9页

作者： América del Carmen Flores Jiménez Eduardo Guillermo Aguilar López rafael Blanco De la Vega Pérez Juan Manuel Hernández Vázquez Emergency Room at General Zone Hospital #46 (HGZ46) “Dr. Bartolomé Reynés Berezaluce” from Mexican Institute of Social Security Tabasco Mexico Intensive Care Unit at General Zone Hospital #46 (HGZ46) “Dr. Bartolomé Reynés Berezaluce” from Mexican Institute of Social Security Tabasco Mexico

Introduction: A traumatic brain injury (TBI) is caused by a forceful bump, blow, or jolt to the head or body, or by an object that pierces the skull and interrupts the normal function of the brain. Severe TBI is estimated at 73 cases per 100,000 people. The mortality of severe TBI can be reduced if a timely diagnosis and treatment of the injuries are made through prognostic factors. Objective: To determine the prognostic factors related to mortality in severe traumatic brain injury at the Hospital General de Zona No. 46. Material and Methods: Retrospective, cross-sectional and descriptive study in beneficiaries admitted to the Hospital General de Zona (HGZ) No. 46 of the Mexican Institute of Social Security (IMSS by its acronym in Spanish), with a diagnosis of severe TBI;the possible prognostic factors related to mortality of severe TBI were obtained from their records. Measures of central tendency and chi square were used for data analysis. Results: The study sample consisted of 60 subjects diagnosed with severe traumatic brain injury, of which 5 (8%) were women and 55 (92%) were men, and all 60 (100%) patients died. The average age of the sample was 26 with a standard deviation of 9 years. The variables that had a p value less than or equal to 0.05 were: Mydriasis, seizures, Hyperglycemia, Normoglycemia, Hypothermia and Hypotension. This means that these variables were associated with mortality. Conclusion: Statistical significance is demonstrated in prognostic factors of mortality in severe traumatic brain injury with p < 0.05 in the case of mydriasis, seizures, hyperglycemia, normoglycemia, hypothermia and hypotension.

关键词： Traumatic Brain Injury Prognostic Factors Mortality Severity

Amyloid-beta pathology-induced nanoscale synaptic disruption:the case of the GABA_B-GIRK assembly

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Neural Regeneration Research 2025年第5期20卷 1409-1410页

作者： rafael Lujan Alejandro Martín-Belmonte Sergi Ferré Francisco Ciruela Synaptic Structure laboratory Instituto de Biomedicina de la UCLM(IB-UCLM)Departamento de Ciencias MédicasInstituto de Investigación en Salud de Castilla-La Mancha(IDISCAM)Facultad de MedicinaUniversidad Castilla-La ManchaCampus BiosanitarioC/AlmansaAlbaceteSpain Integrative Neurobiology Section National Institute on Drug AbuseIntramural Research ProgramNational Institutes of HealthBaltimoreMDUSA Pharmacology Unit Department of Pathology and Experimental TherapeuticsSchool of Medicine and Health SciencesInstitute of NeurosciencesUniversity of BarcelonaNeuropharmacology&Pain GroupNeuroscience ProgramBellvitge Institute for Biomedical ResearchL’Hospitalet de LlobregatSpain

Alzheimer's disease (AD) is characterized by an imbalance between excitatory and inhibitory brain networks,leading to aberrant homeostatic synaptic *** has progressively been recognized as syna ptopathy and syna ptic dysfunction has been identified as a key component of its pathogenesis (Schirinzi et al.,2020).Syna ptic dysfunction is believed to precede synapse loss,a primary biological correlate of cognitive decline in AD,inevita bly associated with neuronal death.

关键词： Alzheimer pathology

The first record of dermochelyid turtles in the Eocene of Tierra del Fuego:new insights on the evolution of the Weddellian faunas

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Advances in Polar Science 2024年第1期35卷 63-77页

作者： Paula BONA Juliana STERLI Marcelo Saúl de la FUENTE Eduardo OLIVERO Marta S.FERNÁNDEZ Marcelo REGUERO División Paleontología Vertebrados Museo de La Plata-Anexo IIFacultad de Ciencias Naturales y MuseoUniversidad Nacional de La PlataLa Plata B1900FWAArgentina Consejo Nacional de Investigaciones Científicas y Técnicas(CONICET) Ciudad Autónoma de Buenos Aires C1425FQBArgentina Museo Paleontológico Egidio Feruglio Trelew U9100Argentina Instituto de Evolución Ecología Histórica y Ambiente-CONICETSan Rafael CP5600Argentina Centro Austral de Investigaciones Científicas-CONICET Universidad Nacional de Tierra del FuegoUshuaia CP 9410Argentina División Paleontología Vertebrados Museo de La PlataUniversidad Nacional de La PlataLa Plata B1900FWAArgentina

The Antarctic Paleogene marine fossil record has been the key to reconstructing the evolution of the Weddellian Sea and final dismemberment of Southern *** this context,Eocene marine vertebrates from Seymour(Marambio)Island have provided valuable *** present the first Eocene record of marine reptiles from the southern Atlantic Coast of South *** corresponds to several postcranial turtle remains represented by a proximal end of the right humerus,three caudal and one thoracic vertebrae,a fragment of the left pubis,and ten ossicles of the dorsal carapace,coming from the Leticia Formation(late-mid Eocene)at Cabo Tiburones,Tierra del Fuego,*** materials show severalfeatures such as the size and general morphology of the humerus and vertebrae,and the presence of relatively small,irregular,smooth,and unkeeled ossicles,which allow us to assign them to Dermochelyidae *** are a cosmopolitan group ofcryptodiran turtles,registered from the late Cretaceous up to the recent,with some physiological-biological peculiarities(e.g.,endothermy and an exclusive jellyfish-based diet)and characterized by the presence of an osseous carapace formed by *** new finding from the Leticia Formation is an addition to the scarce and extremely fragmentary record of Eocene dermochelyids from the southern seas like those from the la Meseta and Submeseta formations(Antarctica)and the Waihao and Burnside formations(New Zealand).This new information allows us to discuss the presence of these turtles in such high latitudes in the past and its implication in the evolution of the Weddellian fauna.

关键词： marine reptiles sea turtles Dermochelyidae Paleogene la Meseta Formation Submeseta Formation Leticia Formation

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Resilience to structural and molecular changes in excitatory synapses in the hippocampus contributes to cognitive function recovery in Tg2576 mice

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Neural Regeneration Research 2024年第9期19卷 2068-2074页

作者： Carolina Aguado Sara Badesso JoséMartínez-Hernández Alejandro Martín-Belmonte Rocío Alfaro-Ruiz Miriam Fernández Ana Esther Moreno-Martínez Mar Cuadrado-Tejedor Ana García-Osta rafael Luján Synaptic Structure laboratory Instituto de Investigación en Discapacidades Neurológicas(IDINE)Department of Medical SciencesFacultad de MedicinaUniversidad de Castilla-La ManchaCampus BiosanitarioAlbaceteSpain Gene Therapy for Neurological Disease Program Center for Applied Medical Research(CIMA)University of NavarraInstituto de Investigación Sanitaria de Navarra(IdiSNA)PamplonaSpain Pharmacology Unit Department of Pathology and Experimental TherapeuticsFaculty of Medicine and Health SciencesInstitute of NeurosciencesUniversity of BarcelonaBarcelonaSpain Neuropharmacology and Pain Group Neuroscience ProgramInstitut d’InvestigacióBiomèdica de BellvitgeIDIBELLL’Hospitalet de LlobregatSpain Department of Pathology Anatomy and PhysiologySchool of MedicineUniversity of NavarraPamplonaSpain UniversitéGrenoble Alpes Grenoble Institut des NeurosciencesGrenobleFrance

Plaques of amyloid-β(Aβ)and neurofibrillary tangles are the main pathological characteristics of Alzheimer’s disease(AD).However,some older adult people with AD pathological hallmarks can retain cognitive *** the factors that lead to this cognitive resilience to AD offers promising prospects for identifying new therapeutic *** hypothesis focuses on the contribution of resilience to changes in excitatory synapses at the structural and molecular levels,which may underlie healthy cognitive performance in aged AD *** the Morris Water Maze test,we selected resilient(asymptomatic)and cognitively impaired aged Tg2576 *** the enzyme-linked immunosorbent assay showed similar levels of Aβ42 in both experimental groups,western blot analysis revealed differences in tau pathology in the pre-synaptic supernatant *** further investigate the density of synapses in the hippocampus of 16-18 month-old Tg2576 mice,we employed stereological and electron microscopic *** findings indicated a decrease in the density of excitatory synapses in the stratum radiatum of the hippocampal CA1 in cognitively impaired Tg2576 mice compared with age-matched resilient Tg2576 and non-transgenic ***,through quantitative immunoelectron microscopy in the hippocampus of impaired and resilient Tg2576 transgenic AD mice,we uncovered differences in the subcellular localization of glutamate ***,the density of GluA1,GluA2/3,and mGlu5 in spines and dendritic shafts of CA1 pyramidal cells in impaired Tg2576 mice was significantly reduced compared with age-matched resilient Tg2576 and non-transgenic ***,the density of GluA2/3 in resilient Tg2576 mice was significantly increased in spines but not in dendritic shafts compared with impaired Tg2576 and non-transgenic *** subcellular findings strongly support the hypothesis that dendritic spine plasticity and synaptic machinery in the hippocampus play cr

关键词： aging Alzheimer´s disease cognitive hippocampus immunoelectron microscopy resilience synapse

Cancer stem cells,plasticity,and drug resistance

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Cancer Drug Resistance 2020年第2期3卷 140-148页

作者： Maria Chiara Lionetti Maria Rita Fumagalli Caterina A.M.la porta Center for Complexity and Biosystems Department of Environmental Science and PolicyUniversity of Milanvia Celoria 26Milano 20133Italy CNR-Consiglio Nazionale delle Ricerche Istituto di BiofisicaVia de Marini 6Genova 16149Italy

Melanoma is a highly aggressive tumor and almost always fatal when ***,we discuss recent findings on the mechanisms of resistance of human cutaneous *** achieve a precision medicine approach,the heterogeneity and plasticity of tumor cells are two crucial aspects to be investigated in *** fact,to understand the mechanisms that cells use to acquire a resistant phenotype after chemotherapy or how resistant cells inside the tumor are selected,it is the most important issue for a successful *** new therapeutic strategies are trying to go in this direction,we discuss here the state of the art of the research and the clinical impact of these *** also discuss and suggest future research directions to develop approaches able to define the best concentration and time of exposure of the drug or the cocktails of drugs for each specific patient based on his/her biological features.

关键词： Melanoma drug resistance epithelial-mesenchymal transition precision medicine tumor plasticity