Cancer stem cells,plasticity,and drug resistance
作者机构：Center for Complexity and BiosystemsDepartment of Environmental Science and PolicyUniversity of Milanvia Celoria 26Milano 20133Italy CNR-Consiglio Nazionale delle RicercheIstituto di BiofisicaVia de Marini 6Genova 16149Italy
出 版 物：《Cancer Drug Resistance》 (癌症耐药（英文）)
年 卷 期：2020年第3卷第2期
页 面：140-148页
学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学]
基 金：The project was supported by funded from the Center for Complexity and Biosystems of UniMI The research leading to these results has received funding from AIRC under IG 2019-ID.23141 project-P.I.La Porta Caterina
主 题：Melanoma drug resistance epithelial-mesenchymal transition precision medicine tumor plasticity
摘 要：Melanoma is a highly aggressive tumor and almost always fatal when ***,we discuss recent findings on the mechanisms of resistance of human cutaneous *** achieve a precision medicine approach,the heterogeneity and plasticity of tumor cells are two crucial aspects to be investigated in *** fact,to understand the mechanisms that cells use to acquire a resistant phenotype after chemotherapy or how resistant cells inside the tumor are selected,it is the most important issue for a successful *** new therapeutic strategies are trying to go in this direction,we discuss here the state of the art of the research and the clinical impact of these *** also discuss and suggest future research directions to develop approaches able to define the best concentration and time of exposure of the drug or the cocktails of drugs for each specific patient based on his/her biological features.
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