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Particuology 2024年第8期91卷 249-259页

作者： Dhayananth Natarajan Kalaichelvi Ponnusamy radhakrishnan thota karunakaran Department of Chemical Engineering National Institute of TechnologyTiruchirappalli620015TamilnaduIndia

The polymer on modulating the crystal's habit is an evolving research in pharmaceutical *** study demonstrates the crystal habit modification of chlorzoxazone(CHZ)by heterogeneous crystallization(HC)in the binary solvent acetonitrile-ethanol(A-E(1:1))in the presence of polyvinylpyrrolidine(PVP)at concentrations of 0.50,0.75,and 1.00 wt%.The A-E(1:1)and PVP in HC experiments influenced to change the shape of crystals from needle to plate shape and reduced the crystal size producing a lower aspect ratio(in the range of 1.5-2.3).In the presence of PVP,the CHZ size distribution is 65-78μm which tends to enhance the powder flow-ability of CHZ crystals and as the PVP concentration increases,the nucleation rate *** solubility of size-reduced CHZ crystals at different pH is found to be improved by 1.2-1.4 ***,HC is deemed effective in modifying the physicochemical attributes of CHZ.

关键词： Chlorzoxazone Polyvinylpyrrolidine Heterogeneous crystallization Crystal habit modification Aspect ratio

A Resource-Efficient Communication Architecture for Chip Multiprocessors on FPGAs

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Journal of Computer Science & Technology 2011年第3期26卷 434-447页

作者： Maggie Swetha thota Department of Electrical and Computer Engineering Villanova University

Significant advances in field-programmable gate arrays （FPGAs） have made it viable to explore innovative multiprocessor solutions on a single FPGA chip. For multiprocessors, an efficient communication network that matches the needs of the target application is always critical to the overall performance. Wormhole packet-switching network-on-chip （NoC） solutions are replacing conventional shared buses to deal with scalability and complexity challenges coming along with the increasing number of processing elements （PEs）. However, the quest for high performance networks has led to very complex and resource-expensive NoC designs, leaving little room for the real computing force, i.e., PEs. Moreover, many techniques offer very small performance gains or none at all when network traffic is light while increasing the resource usage of routers. We argue that computation is still the primary task of multiprocessors and sufficient resources should be reserved for PEs. This paper presents our novel design and implementation of a resource-efficient communication network for multiprocessors on FPGAs. We reduce not only the required number of routers for a given number of PEs by introducing a new PE-router topology, but also the resource requirement of each router. Our communication network relies on the NEWS channels to transfer packets in a pipelined fashion following the path determined by the routing network, The implementation results on various Xilinx FPGAs show good performance in the typical range of network load for multiprocessor applications.

关键词： chip multiprocessors FPGA network on chip mesh topology resource efficient

Systematic Implementation of Innovation Best Practices:thota Framework for Innovation

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创新与创业管理 2011年第1期 110-134页

作者： Hamsa thota Innovation Business Development Inc.St.Simons IslandGAUSA

The Product Development and Management Association(PDMA)comparative performance assessment studies(CPAS)teach us that the new product development(NPD)and innovation management practices continue to ***,advances in the practice of NPD and innovation did not yield significant increases in new product success ***,the PDMA 2003 CPAS reported a significant difference in the success rates for top performing businesses versus the"rest".This paper summarizes innovation practices of top performing businesses from CPAS and compares them with the practices of PDMA Outstanding Corporate Innovator(OCI)Award winning *** paper verifies that what the top performers say they do in research surveys is actually what the outstanding corporate innovators do in *** paper then raises the question of how underperforming companies can implement key learnings from the best to improve their own innovation *** development of thota framework for innovation as a systematic framework to help underperformers implement the best practices is *** a case study,the implementation of the thota framework for innovation is illustrated with BMW,an OCI award winning *** thota Framework for Innovation is based on three organizing principles and eight *** businesses can improve their innovation performance by internalizing the three organizing principles and rigorously implementing eight actions specified in the thota framework for innovation.

关键词： new product development product innovation product innovation performance harmo-nized innovation best innovation practice implementing innovation innovation culture innovation process innovation tool and method comparative performance assessment study outstanding corpo-rate innovator thota framework for innovation

Cryotherapy in the management of premalignant and malignant conditions of the esophagus

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World Journal of Gastroenterology 2018年第43期24卷 4862-4869页

作者： Pooja Lal Prashanthi N thota Department of Internal Medicine Cleveland Clinic Department of Gastroenterology Digestive Disease Surgery InstituteCleveland Clinic

Endoscopic cryotherapy is a relatively new thermal ablative modality used for the treatment of neoplastic lesions of the esophagus. It relies on cycles of rapid cooling and thawing to induce tissue destruction with a cryogen(liquid nitrogen or carbon dioxide) leading to intra and extra-cellular damage. Surgical treatment was once considered the standard therapeutic intervention for neoplastic diseases of the esophagus and is associated with considerable rates of morbidity and mortality. Several trials that evaluated cryotherapy in Barrett's esophagus(BE) associated neoplasia showed reasonable efficacy rates and safety profile. Cryotherapy has also found applications in the treatment of esophageal cancer, both for curative and palliative intent. Cryotherapy has also shown promising results as salvage therapy in cases refractory to radiofrequency ablation treatment. Cryoballoon focal ablation using liquid nitrogen is a novel mode of cryogen delivery which has been used for the treatment of BE with dysplasia and squamous cell carcinoma. Most common side effects of cryotherapy reported in the literature include mild chest discomfort, esophageal strictures and bleeding. In conclusion, cryotherapy is an effective and safe method for the treatment of esophageal neoplastic processes, ranging from early stages of low grade dysplasia to esophageal cancer.

关键词： Esophageal cancer Barrett's esophagus Palliative therapy Cryotherapy

Design,synthesis,characterization,cytotoxic and structure activity relationships of novel Ru(Ⅱ) complexes

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Chinese Chemical Letters 2015年第6期26卷 721-726页

作者： Sreekanth thota Srujana Vallala Rajeshwar Yerra Eliezer J.Barreiro National Institute for Science and Technology on Innovation on Neglected Diseases (INCT/IDN) Center for Technological Development in Health (CDTS)Fundao Oswaldo CruzMinistério da SadeAv.Brasil 4036Prédio da Expanso8° AndarSala 814Manguinhos21040-361 Rio de JaneiroRJBrazil Programa de Desenvolvimento de Frmacos Instituto de Ciências BiomédicasUniversidade Federal do Rio de Janeiro S.R. College of Pharmacy Department of Pharmaceutical Chemistry & Toxicology

Platinum containing compounds have shown antineoplastic potential, but their clinical applications have been limited by high toxicity. Ruthenium containing complexes have long been known to be well suited for biological applications, and have long been utilized as replacements to popular platinum based-drugs. Here, we report a novel series of ruthenium（ll） arene compounds bearing thiosemicarba- zone and isonicotinylhydrazone ligands with potent anticancer activity their structure activity relationships and apoptosis was studied. The cytotoxic activity of the new ruthenium（ll） arene compounds has been evaluated in several cell lines （Molt 4/C8, LI 210, CEM, HL60 and BEL7402）. Among them, ten complexes were found to be excellent in vitro growth inhibitory activity against various cell lines with IC50 in the sub-micromolar range.

关键词： Cytotoxic Ligand Ruthenium compounds Structure activity relationships

Lymphocytic esophagitis: Still an enigma a decade later

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World Journal of Gastroenterology 2017年第6期23卷 949-956页

作者： Carol Rouphael Ilyssa O Gordon Prashanthi N thota Department of General Internal Medicine Cleveland Clinic Foundation Department of Pathology Cleveland Clinic Foundation Department of Gastroenterology and Hepatology Digestive Disease and Surgery InstituteCleveland Clinic Foundation

Lymphocytic esophagitis (LE) is a clinicopathologic entity first described by Rubio et al in 2006. It is defined as peripapillary intraepithelial lymphocytosis with spongiosis and few or no granulocytes on esophageal biopsy. This definition is not widely accepted and the number of lymphocytes needed to make the diagnosis varied in different studies. Multiple studies have described potential clinical associations and risk factors for LE, such as old age, female gender and smoking history. This entity was reported in inflammatory bowel disease in the pediatric population but not in adults. Other associations include gastroesophageal reflux disease and primary esophageal motility disorders. The most common symptom is dysphagia, with a normal appearing esophagus on endoscopy, though esophageal rings, webs, nodularities, furrows and strictures have been described. Multiple treatment modalities have been used such as proton pump inhibitors and topical steroids. Esophageal dilation seems to be therapeutic when dysphagia is present along with esophageal narrowing secondary to webs, rings or strictures. The natural history of the disease remains unclear and needs to be better delineated. Overall, lymphocytic esophagitis seems to have a chronic and benign course, except for two cases of esophageal perforation in the literature, thought to be secondary to this entity.

关键词： Lymphocytic esophagitis intraepithelial lymphocytes spongiosis gastroesophageal reflux disease CD4 T-cells dysphagia inflammatory bowel disease esophageal rings proton pump inhibitors esophageal dilation

Reservoir quality evaluation using sedimentological and petrophysical characterization of deep-water turbidites:A case study of Tariki Sandstone Member,Taranaki Basin,New Zealand

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Energy Geoscience 2023年第1期4卷 13-32页

作者： Surya Tejasvi thota Md Aminul Islam Mohamed Ragab Shalaby Department of Geosciences Faculty of ScienceUniversiti Brunei DarussalamJalanTungku LinkGadong1410Brunei Darussalam

The current study aims to ascertain the reservoir characteristics of the Tariki Sandstone Member of the Otaraoa Formation,Taranaki Basin,New *** study was carried out by integrating the comprehensive petrophysical evaluation,sedimentological and petrographic studies,as well as well log analysis by using data from six *** porosity-permeability relationship is used to divide the samples of the Tariki Sandstone Member into reservoir and non-reservoir facies.A thorough petrophysical analysis shows that the maximum porosity values fluctuate between 16.6%and 22.1%,while permeability ranges from 102 mD to 574 mD,which indicates fair to good reservoir ***,the Tariki sandstone represents six hydraulic flow units with a high reservoir quality index and flow zone indicator representing good reservoir *** pore size varies between nano and megapores with dominant *** on the sedimentological and petrographic analysis,the Tariki Sandstone Member is classified as a combination of subarkose,arkose,and lithic arkose with fine to medium and moderately to moderately well-sorted *** main diagenetic factor affecting the reservoir quality is cementation,which occupied all the pores with *** the bright side,the secondary pores are developed due to the dissolution of calcite cement and few *** well log analysis demonstrates the presence of low clay volume ranging from 0.3%to 3.1%,fair to good effective porosity values between 13.6%and 15.9%,net pay thickness from 18.29 m to 91.44 m,and hydrocarbon saturation from 56%to 77.9%.The findings from this study revealed that the Tariki Sandstone Member possesses fair to good reservoir quality and hydrocarbon potential,which indicate submarine fans as appealing hydrocarbon *** study can be used in similar depositional environments elsewhere in the world.

关键词： Reservoir quality Tariki sandstone Petrophysical analysis Petrophysical parameter

Long-term esophageal and respiratory outcomes in children with esophageal atresia and tracheoesophageal fistula

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Gastroenterology Report 2016年第4期4卷 310-314,I0002页

作者： Richard H.Cartabuke Rocio Lopez Prashanthi N.thota Department of Internal Medicine Cleveland ClinicClevelandOHUSA Department of Biostatistics Cleveland ClinicClevelandOHUSA Department of Gastroenterology and Hepatology Cleveland ClinicClevelandOHUSA

Objectives:Few studies have evaluated the long-term complications and outcomes of esophageal atresia with or without tracheoesophageal fistula(EA/TEF)beyond *** aim of our study was to characterize the esophageal and respiratory morbidity of EA/TEF through evaluation of clinical symptoms,diagnostic testing and therapeutic intervention at a tertiary care ***:Patients with congenital EA/TEF evaluated from 2011 to 2014 were *** characteristics,type and mode of repair of EA/TEF,clinical symptoms,radiographic,endoscopic,bronchoscopic and medication use data were ***:A total of 43 patients were *** median age of this predominantly Caucasian population was 8 years(interquartile range:3,20).Twenty(62.5%)had type C(EA with distal TEF)***-one(48.8%)patients had heartburn,19(44.1%)had acid regurgitation,and 31(72.1%)had dysphagia to *** swallow in 26 patients revealed strictures in 17(65.4%),dysmotility in 20(76.9%)and recurrent fistulas in four patients(15.4%).Thirty patients underwent upper endoscopy,of which 21(70.0%)had a stricture,and six(20.0%)had recurrent fistula requiring surgical ***(18.6%)patients underwent *** evaluation showed cough and choking in 31(72.1%)patients and dyspnea and wheezing in 32(53.4%)*** respiratory infections were reported in 19(44.2%).*** findings included tracheomalacia in 86.7% and restrictive lung disease in 54.5%of ***:There is a high burden of residual esophageal and pulmonary pathology in patients with EA/*** follow-up is required to monitor both the clinical symptoms and treatment responses.

关键词： esophageal atresia tracheoesophageal fistula gastroesophageal reflux disease(GERD) esophageal dysmotility aspiration pneumonia

Gender,medication use and other factors associated with esophageal motility disorders in non-obstructive dysphagia

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Gastroenterology Report 2018年第3期6卷 177-183,I0002页

作者： Afrin Kamal Sampurna Shakya Rocio Lopez Prashanthi N.thota Department of Gastroenterology and Hepatology Digestive Diseases and Surgical InstituteCleveland Clinic9500 Euclid AvenueClevelandOH 44195USA Department of Qualitative Health Sciences Cleveland Clinic9500 Euclid AvenueClevelandOH 44195USA

Background:High-resolution esophageal manometry(HREM)is the diagnostic test of choice for evaluation of nonobstructive *** regarding the predictors of esophageal dysmotility are ***,our aim was to study the prevalence of and factors associated with esophageal motility disorders in patients with non-obstructive ***:We performed a retrospective review of all patients with non-obstructive dysphagia who underwent HREM in a tertiary center between 1 January 2014 and 31 December *** obtaining IRB approval(16–051),clinical records were scrutinized for demographic data,symptoms,medication use,upper endoscopic findings and esophageal pH *** plots were classified per Chicago Classification version *** outcome was prevalence of esophageal motility disorders;secondary outcomes assessed predictive ***:In total,155 patients with non-obstructive dysphagia(55616 years old,72%female)were *** diagnosis was normal in 49%followed by ineffective esophageal motility in 20%,absent contractility in 7.1%,achalasia type II in 5.8%,outflow obstruction in 5.2%,jackhammer esophagus in 4.5%,distal esophageal spasm in 3.9%,fragment peristalsis in 1.9%,achalasia type I in 1.9%,and achalasia type III in 0.6%.Men were five times more likely to have achalasia than women[odds ratio(OR)5.3,95%confidence interval(CI):2.0–14.2;P=0.001].Patients with erosive esophagitis(OR 2.9,95%CI:1.1–7.7;P=0.027)or using calcium channel blockers(OR 3.0,95%CI:1.2–7.4;P=0.015)were three times more likely to have hypomotility ***:From this study,we concluded that HREM diagnosis per Chicago Classification version 3.0 was normal in 49%of patients with non-obstructive *** gender,erosive esophagitis and use of calcium channel blockers were predictive of esophageal motility disorders.

关键词： Impaired swallowing high-resolution esophageal manometry esophageal motility disorders

NADPH oxidase family proteins:signaling dynamics to disease management

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Cellular & Molecular Immunology 2022年第6期19卷 660-686页

作者： Rizwana Begum Shilpa thota Abubakar Abdulkadir Gagandeep Kaur Prathyusha Bagam Sanjay Batra Present address:Department of Environmental Medicine University of RochesterSchool of Medicine and DentistryRochesterNY14642USA Laboratory of Pulmonary Immunotoxicology Department of Environmental ToxicologySouthern University and A&M CollegeBaton RougeLA70813USA Present address:Division of Systems Biology National Center for Toxicological ResearchJeffersonAR72079USA

Reactive oxygen species(ROS)are pervasive signaling molecules in biological *** humans,a lack of ROS causes chronic and extreme bacterial infections,while uncontrolled release of these factors causes pathologies due to excessive *** phagocytes such as neutrophils(PMNs),eosinophils,monocytes,and macrophages use superoxide-generating NADPH oxidase(NOX)as part of their arsenal of antimicrobial mechanisms to produce high levels of *** is a multisubunit enzyme complex composed of five essential subunits,two of which are localized in the membrane,while three are localized in the *** resting phagocytes,the oxidase complex is unassembled and inactive;however,it becomes activated after cytosolic components translocate to the membrane and are assembled into a functional *** NOX isoforms play a variety of roles in cellular differentiation,development,proliferation,apoptosis,cytoskeletal control,migration,and *** studies have identified NOX as a major contributor to disease pathologies,resulting in a shift in focus on inhibiting the formation of potentially harmful free ***,a better understanding of the molecular mechanisms and the transduction pathways involved in NOX-mediated signaling is essential for the development of new therapeutic agents that minimize the hyperproduction of *** current review provides a thorough overview of the various NOX enzymes and their roles in disease pathophysiology,highlights pharmacological strategies,and discusses the importance of computational modeling for future NOX-related studies.

关键词： NADPH oxidase Reactive oxygen species Inflammation Inhibitors In silico