Design,synthesis,characterization,cytotoxic and structure activity relationships of novel Ru(Ⅱ) complexes

作     者：Sreekanth Thota Srujana Vallala Rajeshwar Yerra Eliezer J.Barreiro 

作者机构：National Institute for Science and Technology on Innovation on Neglected Diseases (INCT/IDN)Center for Technological Development in Health (CDTS)Fundao Oswaldo CruzMinistério da SadeAv.Brasil 4036Prédio da Expanso8° AndarSala 814Manguinhos21040-361 Rio de JaneiroRJBrazil Programa de Desenvolvimento de FrmacosInstituto de Ciências BiomédicasUniversidade Federal do Rio de Janeiro S.R. College of PharmacyDepartment of Pharmaceutical Chemistry & Toxicology 

出 版 物：《Chinese Chemical Letters》 (中国化学快报（英文版）)

年 卷 期：2015年第26卷第6期

页      面：721-726页

核心收录：

学科分类：081704[工学-应用化学] 07[理学] 070304[理学-物理化学(含∶化学物理)] 08[工学] 0817[工学-化学工程与技术] 0703[理学-化学] 

基　　金：supported by National Council for Scientific and Technological Development (CNPq) Coordenao de Aperfeioamento de Pessoal de Nível Superior (CAPES) Oswaldo Cruz Foundation (Fiocruz) Department of Science and Technology,New Delhi,India [No.SR/WOS-A/LS-562/2011) dated 27/03/2012] 

主　　题：Cytotoxic Ligand Ruthenium compounds Structure activity relationships 

摘      要：Platinum containing compounds have shown antineoplastic potential, but their clinical applications have been limited by high toxicity. Ruthenium containing complexes have long been known to be well suited for biological applications, and have long been utilized as replacements to popular platinum based-drugs. Here, we report a novel series of ruthenium（ll） arene compounds bearing thiosemicarba- zone and isonicotinylhydrazone ligands with potent anticancer activity their structure activity relationships and apoptosis was studied. The cytotoxic activity of the new ruthenium（ll） arene compounds has been evaluated in several cell lines （Molt 4/C8, LI 210, CEM, HL60 and BEL7402）. Among them, ten complexes were found to be excellent in vitro growth inhibitory activity against various cell lines with IC50 in the sub-micromolar range.