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Natural Convection of a Power-law Nanofluid in a Square Cavity with a Vertical Fin

Fluid Dynamics & Materials Processing 2024年第9期20卷 2091-2108页

作者： Amira M’hadbi Mohammed El Ganaoui haïkel Ben hamed Amenallah Guizani Khalid Chtaibi lERMAB Department of Transition and Energy Efficiency ProfessionsIUT H Poincaréde LongwyUniversity of LorraineLongwy54400France lPT Center for Energy Research and Technologies(Borj Cedria2084)University of Tunis El ManarTunis1068Tunisia lTI Department of Mechanical Engineering and ProductionIUTUniversity of Picardie Jules-VerneAmiens80025France

The behavior of non-Newtonian power-law nanofluids under free convection heat transfer conditions in a cooled square enclosure equipped with a heated fin is investigated *** particular,the impact of nanofluids,composed of water and Al_(2)O_(3),TiO_(2),and Cu nanoparticles,on heat transfer enhancement is *** aim of this research is also to analyze the influence of different parameters,including the rayleigh number(ra=10^(4)-10^(6)),nanoparticle volume fraction(φ=0%-20%),non-Newtonian power-law indexes(n=0.6-1.4),and fin dimensions(Ar=0.3,0.5,and 0.7).Streamlines and isotherms are used to depict flow and related heat transfer *** indicate that thermal performance improves with increasing rayleigh number,regardless of the nanoparticle type or nanofluid rheological *** suggests that the buoyancy force has a significant impact on heat transfer,particularly near the heat *** Nusselt number is more sensitive to variations in Cu nanoparticle volume fractions compared to Al₂O₃and TiO₂.Moreover,the average Nusselt numbers for power-law nanofluids with n1)are greater(smaller)than for Newtonian fluids due to the decrease(increase)in viscosity with increasing(decreasing)shear rate,at the same values of rayleigh number ra owing to the amplification(attenuation)of the convective ***,the most substantial enhancement is observed with Cu-water shear-thinning nanofluid,where the Nusselt number increases by 136%when changing from Newtonian to shear thinning behavior and by 154.9%when adding 16%nanoparticle volume ***,an even larger increase of 57%in the average Nusselt number is obtained on increasing the fin length from 0.3 to 0.7.

关键词： Heat transfer nanofluid non-Newtonian fluid natural convection

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Biodiversity responses to insular fragmentation in Amazonia: Two decades of research in the Balbina Hydroelectric Reservoir

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Zoological Research(Diversity and Conservation) 2024年第2期1卷 106-116页

作者： Ana Filipa Palmeirim Maíra Benchimol Danielle Storck-Tonon Anderson S.Bueno Isabel l.Jones Gilmar Klein Carlos A.Peres CIBIO Research Centre of Biodiversity and Genetic ResourcesInBIO Associated LabVairão CampusUniversity of PortoVairão 4485-661Portugal BIOPOlIS Program in Genomics Biodiversity and Land PlanningCIBIOVairão CampusUniversity of PortoVairão 4485-661Portugal laboratório de Ecologia AplicadaàConservação Universidade Estadual de Santa CruzIlhéusBahia 45662-900Brazil Programa de Pós-Graduação em Ambiente e Sistemas de Produção Agrícola(PPGASP) Universidade do Estado de Mato GrossoTangaráda SerraMato Grosso 78301-532Brazil Instituto Federal de Educação Ciência e Tecnologia FarroupilhaJúlio de CastilhosRio Grande do Sul 98130-000Brazil Biological and Environmental Sciences University of StirlingStirling FK94LAUK REBIO Uatumã/ICMBio Presidente FigueiredoAmazonas 69736-000Brazil Centre for Ecology Evolution and ConservationSchool of Environmental SciencesUniversity of East AngliaNorwich NR47TJUK JuruáInstitute ManausAmazonas 69057-060Brazil

As hydropower development expands across lowland tropical forests,flooding and concomitant insular fragmentation have become important threats to *** created insular landscapes serve as natural laboratories to investigate biodiversity responses to *** of these most iconic landscapes is the Balbina Hydroelectric Reservoir in Brazilian Amazonia,occupying>400000 ha and comprising>3500 forest ***,we synthesise the current knowledge on responses of a wide range of biological groups to insular fragmentation at *** has largely concentrated on a set of 22 islands and three mainland *** total,39 studies were conducted over nearly two decades,covering 17 vertebrate,invertebrate,and plant *** species responses varied according to taxonomic group,island area was consistently included and played a pivotal role in 66.7%of all studies examining patterns of species *** persistence was further affected by species traits,mostly related to species capacity to use/traverse the aquatic matrix or tolerate habitat degradation,as noted for species of vertebrates and orchid *** research is needed to improve our understanding of such effects on wider ecosystem *** Impact Assessments must account for changes in both the remaining habitat amount and configuration,and subsequent long-term species losses.

关键词： habitat loss Hydropower dams landbridge local extinctions Species-area relationships Species diversity Tropical forests

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Posterior reversible encephalopathy syndrome in a patient with metastatic breast cancer:A case report

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World Journal of Clinical Cases 2022年第7期10卷 2281-2285页

作者： Chae Hyun Song Seung Jun lee ha ra Jeon department of Physical Medicine and Rehabilitation National Health Insurance Service Ilsan HospitalGoyang-si Gyeonggi-do 10444South Korea department of Physical Medicine and Rehabilitation National Health Insurance Service Ilsan HospitalGoyang-si Gyeonggi-do ASI/KR/KS009/GoyangSouth Korea

BACKGROUND Posterior reversible encephalopathy syndrome(PRES)is a neurotoxic encephalopathic state with clinical symptoms such as headache,altered consciousness,visual disturbances,and *** edema occurs predominantly in the posterior occipital and parietal lobes of the *** is caused by various diseases,and its mechanism remains ***,it can be easily diagnosed based on characteristic lesions on magnetic resonance *** SUMMARY A 51-year-old woman with unremarkable past medical history presented with progressively worsening back pain since 2 *** examinations revealed paralumbar muscle tenderness,a large lesion on the right breast and several masslike lesions on both *** blood pressure(BP)was elevated(150/90 mmHg),and did not respond to antihypertensive *** the seventh day of hospitalization,she exhibited a confused mental status and generalized tonicclonic *** magnetic resonance imaging,bilateral cortical and subcortical edema of the occipital lobes,suggestive of PRES,was *** serum calcium was 15.8 mg/*** two days of treatment with nicardipine,elcatonin,and zolendronic acid,her BP was 130/91 mmHg and serum calcium was 10.1 mg/*** patient regained consciousness and her mental status ***-positron emission tomography revealed right breast cancer with extensive *** Although rare,hypercalcemia can lead to PRES by causing uncontrolled *** diagnosis can help prevent severe mental disturbances and even death.

关键词： Posterior reversible encephalopathy syndrome Breast cancer Hypercalcemia Hypertension Case report

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Extensive pollen immigration and no evidence of disrupted mating patterns or reproduction in a highly fragmented holm oak stand

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Journal of Plant Ecology 2014年第4期7卷 384-395页

作者： Joaquín Ortego raúl Bonal Alberto Muñoz JoséMiguel Aparicio Grupo de Investigación de la Biodiversidad Genética y Cultural Instituto de Investigación en Recursos Cinegéticos-IREC(CSICUCLMJCCM)Ronda de Toledo s/nE-13005 Ciudad RealSpain departamento de Ecología Evolutiva Museo Nacional de Ciencias Naturales(CSIC)C/JoséGutiérrez Abascal 2E-28006 MadridSpain departamento de Didáctica de las Ciencias Experimentales Facultad de EducaciónUniversidad Complutense de MadridC/Rector Royo Villanova s/nE-28040 MadridSpain Centre de Recerca Ecològica i Aplicacions Forestals(CREAF) Cerdanyola del VallèsE-08193 BarcelonaSpain

Aims Forest fragmentation and reduced tree population densities can poten-tially have negative impacts on mating patterns,offspring genetic diversity and reproductive *** aim of the present study is to test these hypotheses comparing an extremely fragmented,low tree density(~0.02 trees/ha)holm oak(Quercus ilex l.)stand from Central spain with a nearby high tree density stand(~50 trees/ha).Methods We genotyped adult trees and seeds from the low-density stand(436 seeds from 15 families)and the high-density stand(404 seeds from 11 families)using nine microsatellite *** these data,we performed paternity analyses,determined pollen flow,mating patterns and pollen pool structure,and estimated progeny genetic diversity in both *** also studied seed set and production and performed a pollen supplementation experiment to determine whether reduced tree density has limited foreign pollen *** Findings We have found extensive pollen immigration(>75%)into the low tree density stand and monte Carlo simulations revealed that pollen moves larger distances than expected from null models of random *** patterns and differentiation of pollen pools were similar in the high-density stand and the low-density stand but we found higher inter-annual differentiation of pollen pools in the *** genetic diversity and self-fertilization rates did not dif-fer between the low-density stand and the high-density *** set rates were significantly lower in the low-density stand than in the high-density stand and experimental cross-pollen supplementation evidenced that foreign pollen availability is indeed a limiting factor in the ***,seed crops did not differ between the low-density stand and the high-density stand,indicating that limitation of foreign pollen is not likely to be of great concern in terms of reduced seed production and potential *** forest regeneration due to other ecological and human fac

关键词： forest fragmentation genetic diversity paternity analyses pollen dispersal pollen pool structure selfing tree density

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Crossing the Rivers by Touching the Stones:Alternative Approaches in Technical and Vocational Education and Training From the People’s Republic of China and the Republic of Korea

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ECNU Review of Education 2023年第4期6卷 654-676页

作者：哈巍杨钋 Youngsup Choi Sungsup ra Ryotaro hayashi Conor McCutcheon Peking University Korea University of Technology and Education Asian development Bank New York University

Purpose:This study aims to answer the following questions:(1)Why have attempts to transplant Western vocational education models failed?(2)Is there anything we can learn from the experiences of Eastern Asian countries when developing their own vocational education models?design/Approach/Methods:This study reviews the history of transplanting Western skill formation schemes into developing countries,an often-failed die-hard practice supported by both bilateral and multilateral ***:Our findings suggest that developing countries should design their technical and vocational education and training systems based on their unique cultural,sociological,and economic *** offers two alternative pathways based on the experiences of the People’s Republic of China and the Republic of ***/Value:These East Asian examples could broaden the perspectives of policymakers in developing countries aspiring to develop functional skill formation schemes.

关键词： Comparative education East Asia international development skill formation technical and vocational education and training

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肠道菌群代谢产物氧化三甲胺对肾小球系膜细胞和肾小管上皮细胞NF-κB/MAPK信号通路的影响

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中国生物制品学杂志 2024年第8期37卷 932-937页

作者：宋月娟杨波冯强生哈小琴联勤保障部队第九四○医院检验科甘肃兰州730050

目的探讨肠道菌群代谢产物氧化三甲胺(trimethylamine oxide,TMAO)对人肾小球系膜细胞HMC和肾小管上皮细胞HK-2核因子-κB(nuclear factor-kappa B,NF-κB)/丝裂原活化蛋白激酶(mitogen activated protein kinase,MAPK)信号通路的影响,为通过肠道菌群治疗和预防肾损伤提供理论依据。方法用TMAO处理HMC和HK-2细胞,并设未处理或TMAO处理0 h对照组,Real-time PCR法检测炎性反应因子MCP-1、Il-6、TNF-α和Il-1β基因mRNA的转录水平,Western blot法检测NF-κB和MAPK信号通路相关蛋白的表达。并用NF-κB抑制剂BAY11-7082处理HMC和HK-2细胞,验证TMAO的促炎作用。结果与对照组相比,HMC和HK-2细胞TMAO处理组炎性反应因子MCP-1、Il-6、TNF-α和Il-1βmRNA转录水平均明显上升(t=33.349,P=0.001),TMAO对两种细胞有明显的促炎作用;TMAO可激活HMC和HK-2细胞的NF-κB及MAPK信号通路,引起炎性反应,造成对肾脏的损伤。结论TMAO含量的增高可激活HMC和HK-2细胞NF-κB/MAPK信号通路,刺激两种细胞释放炎性反应因子,从而导致肾损伤的发生和发展。

关键词：氧化三甲胺肾损伤信号通路人肾小球系膜细胞人肾小管上皮细胞

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Electroacupuncture for abdominal pain relief in patients with acute pancreatitis:A three-arm randomized controlled trial

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Journal of Integrative Medicine 2023年第6期21卷 537-542页

作者： Dong Kee Jang Jun Kyu lee Chan Yung Jung Kyung Ho Kim ha ra Kang Yeon Sun lee Jong Hwa Yoon Kwang Ro Joo Min Kyu Chae Yong Hyeon Baek Byung-Kwan Seo Sang Hyub lee Chiyeon lim department of Internal Medicine Seoul Metropolitan Government Boramae Medical CenterSeoul National University College of MedicineSeoul 07061Republic of Korea department of Internal Medicine Dongguk University Ilsan HospitalDongguk University College of MedicineGoyang 10326Republic of Korea department of Acupuncture and Moxibustion Dongguk University Ilsan Oriental HospitalCollege of Korean MedicineDongguk UniversityGoyang 10326Republic of Korea department of Korean Medicine Dongguk UniversityGoyang 10326Republic of Korea department of Acupuncture and Moxibustion College of Korean MedicineDongguk UniversityGyeongju 38067Republic of Korea department of Gastroenterology Kyung Hee University Hospital at GangdongSeoul 05278Republic of Korea department of Acupuncture and Moxibustion Kyung Hee University Korean Medicine Hospital at GangdongSeoul 05278Republic of Korea department of Internal Medicine and liver Research Institute Seoul National University HospitalSeoul National University College of MedicineSeoul 03080Republic of Korea department of Biostatistics College of MedicineDongguk UniversityGoyang 10326Republic of Korea

Background: Electroacupuncture(EA) may reduce the severity of acute pancreatitis(AP) and provide additional pain relief in patients with chronic pancreatitis. However, the ability of EA to relieve pain in patients with AP has not been well ***: This study was undertaken to compare the pain-relieving effects of EA and conventional treatment in patients with ***, setting, participants and interventions: This study was conducted using a randomized, controlled,three-arm, parallel-group and multi-center design. Patients diagnosed with AP were randomly and equally assigned to EA1, EA2 or control groups. All participants received conventional standard-of-care therapy for AP. local EA alone was administered in EA1, and local plus distal EA was given in *** EA included two abdominal acupoints, while distal EA included twelve peripheral acupoints. EA groups underwent one session of EA daily for 4 days(days 1–4), or until pain was resolved or *** outcome measures: The primary outcome measure was the change in the visual analogue scale(VAS;0–100) pain score between baseline and day ***: Eighty-nine participants were randomized into EA1, EA2 and control groups, and 88(EA1, 30;EA2, 29;control, 29) were included in the full-analysis set. VAS score change(median [interquartile range]) on day 5 was(12.3 ± 22.5) in the EA1 group,(10.3 ± 21.5) in the EA2 group, and(8.9 ± 15.2) in the control group. There were not significant differences in the change in VAS score among treatments(P = 0.983). However, time to food intake was significantly shorter in the EA group(EA1 + EA2) than in the control group(median 2.0 days vs 3.0 days), with a hazard ratio of 0.581(P = 0.022;95% CI,0.366–0.924). No significant adverse events ***: EA treatment did not significantly reduce pain after 4 days of treatment in patients with AP-associated abdominal pain but significantly reduced time to first food intake.

关键词： Acute pancreatitis Electroacupuncture Pain management Abdominal pain randomized controlled trial

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自然杀伤细胞在流感中的作用机制研究进展

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重庆医学 2024年第7期53卷 1084-1088页

作者：张研李刚张茜哈小琴吴涛中国人民解放军联勤保障部队第九四〇医院血液科兰州730050 甘肃中医药大学第一临床医学院兰州730000 中国人民解放军联勤保障部队第九四〇医院检验科兰州730050

流行性感冒病毒(简称流感病毒)每年引起较高的人群发病率和死亡率,对全球公共卫生安全构成严重威胁。流感病毒经过不断进化,具有躲避宿主免疫反应和逃避疫苗保护的能力。因此,有必要开发针对宿主细胞机制的药物或疫苗以降低重症率和死... 详细信息

流行性感冒病毒(简称流感病毒)每年引起较高的人群发病率和死亡率,对全球公共卫生安全构成严重威胁。流感病毒经过不断进化,具有躲避宿主免疫反应和逃避疫苗保护的能力。因此,有必要开发针对宿主细胞机制的药物或疫苗以降低重症率和死亡率。自然杀伤细胞(NK细胞)能够在非致敏状态下迅速杀伤病毒感染的宿主细胞,并具有免疫调节及记忆效应,为流感病毒的防治带来了希望。该文就NK细胞及其免疫激活在流感中的作用机制进行综述,为流感防治的新型药物或疫苗研究提供依据。

关键词：流感,人流感病毒自然杀伤细胞综述

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Methylsulfonylmethane suppresses hepatic tumor development through activation of apoptosis

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World Journal of Hepatology 2014年第2期6卷 98-106页

作者： Joo-Hyun Kim Hye-Jun Shin Hye-lin ha Young-Ho Park Tae-Ho Kwon Mi-ra Jung Hyung-Bae Moon Eun-Sang Cho Hwa-Young Son Dae-Yeul Yu Aging Research Center Korea Research Institute of Bioscience and Biotechnology College of Veterinary Medicine Chungnam National University Wonkwang University College of Medicine

AIM:To investigate the effect of methylsulfonylmethane(MSM), recently reported to have anti-cancer effects, in liver cancer cells and transgenic mice. METHODS: Three liver cancer cell lines, HepG2, Huh7-Mock and Huh7-H-rasG12V, were used. Cell growth was measured by Cell Counting Kit-8 and soft agar assay. Western blot analysis was used to detect caspases, poly(ADP-ribose) polymerase(PARP), and B-cell lymphoma2(Bcl-2) expressions. For in vivo study, we administered MSM to H-ras12V transgenic mice for 3 mo. RESUlTS: MSM decreased the growth of HepG2, Huh7-Mock and Huh7-H-rasG12V cells in a dose-dependent manner. That was correlated with significantly increased apoptosis and reduced cell numbers in MSM treated cells. Cleaved caspase-8, cleaved caspase-3 and cleaved PARP were remarkably increased in the liver cancer cells treated with 500 mmol/l of MSM; however, Bcl-2 was slightly decreased in 500 mmol/l. liver tumor development was greatly inhibited in the H-ras12V transgenic mice treated with MSM, compared to control, by showing reduced tumor size and number. Cleaved PARP was significantly increased in non-tumor treated with MSM compared to control. CONClUSION: liver injury was also significantly attenuated in the mice treated with MSM. Taken together, all the results suggest that MSM has anti-cancer effects through inducing apoptosis in liver cancer.

关键词： Methylsulfonylmethane Anti-cancer effects liver cancer cells Transgenic mice Hepatic tumorigenesis

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增加CT对桡骨远端骨折分型的可靠性及可重复性评价

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中华老年骨科与康复电子杂志 2024年第5期10卷 264-272页

作者：张峻赵建民姚晓克吉浩宇越瑞祥内蒙古医科大学附属医院骨科呼和浩特010000 解放军总医院第一医学中心骨科北京100853 成都市第一人民医院骨科成都610000 乌兰察布市中心医院普通外科集宁012000

目的对桡骨远端骨折的主要分型系统进行一致性检验,为临床医生选择分型系统提供重要指导。方法2014年1月1日至2018年6月31日,回顾性研究我院220例桡骨远端骨折患者。三名观察者随机选择并评估了50例患者在T1、T2、T3和T4四个不同时间节... 详细信息

目的对桡骨远端骨折的主要分型系统进行一致性检验,为临床医生选择分型系统提供重要指导。方法2014年1月1日至2018年6月31日,回顾性研究我院220例桡骨远端骨折患者。三名观察者随机选择并评估了50例患者在T1、T2、T3和T4四个不同时间节点的AO/OTA、Frykman、Fernández和Universal分型的放射学数据。时间节点T1和T2用于基于DR确定每个观察者的观察者内重复性。时间节点T3和T4用于基于DR和CT+2D确定每个观察者的观察者间重复性。Cohen’s kappa用于计算一致性。结果基于DR和DR+CT的观察者间信度Kappa值:AO/OTA分型0.14 vs.0.32;AO/OTA分组0.18 vs.0.35;Frykman 0.34 vs.0.29;Fernández 0.31vs.0.22;Universal 0.27 vs.0.30。观察者内重复性Kappa值:AO/OTA分型0.47 vs.0.67;AO/OTA分组0.48 vs.0.67;Frykman 0.70 vs.0.66;Fernández 0.59 vs.0.58;Universal 0.60 vs.0.59。结论CT+2D检查的增加可能不会改善Frykman分型、Fernández分型和Universal分型的观察者一致性结果。AO/OTA分型和AO/OTA分组的观察者一致性结果可以得到改善。

关键词：桡骨远端骨折骨折分型

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