检索结果-南通市图书馆

神经损伤与功能重建 2023年第6期18卷 F0003-F0003页

作者： Synphane Gibbs-Shelton Jordan Benderoth Ronald P Gaykema Justyna Straub Kenneth A Okojie Joseph O Uweru Dennis H lentferink Binita rajbanshi Maureen N Cowan Brij Patel Anthony Brayan Campos-Salazar Edward Perez-reyes Ukpong B Eyo 杜一星(编译) Brain Immunology and Glia Center University of VirginiaCharlottesvilleVirginiaUSA Department of Pharmacology University of VirginiaCharlottesvilleVirginiaUSA Department of Neuroscience University of VirginiaCharlottesvilleVirginiaUSA Neuroscience Graduate Program University of VirginiaCharlottesvilleVirginiaUSA 不详

癫痫发病率高,影响各年龄层次,包括年轻人和老年人。目前临床上使用的抗癫痫药物都是根据已知的以神经元为中心的机制研发,但有约1/3的患者对现有药物的治疗无效。因此,有必要对癫痫产生和持续的其他替代和补充机制进行研究。神经炎症,... 详细信息

癫痫发病率高,影响各年龄层次,包括年轻人和老年人。目前临床上使用的抗癫痫药物都是根据已知的以神经元为中心的机制研发,但有约1/3的患者对现有药物的治疗无效。因此,有必要对癫痫产生和持续的其他替代和补充机制进行研究。神经炎症,广义上定义为中枢神经系统中免疫细胞和分子的激活。研究发现,神经炎症促进癫痫的发生,但参与该病理生理过程的特定细胞尚不清楚。小胶质细胞是大脑的主要炎症细胞。因为既往研究使用的方法对小胶质细胞的特异性较低,或者存在固有的混淆,所以小胶质细胞的作用一直存在争议。使用一种选择性靶向小胶质细胞的方法(以避免上述副作用),我们发现了小胶质细胞在限制化学惊厥、电性和高热性癫痫发作方面有广泛有益作用,并进一步发现小胶质细胞对控制癫痫发作的作用。

关键词： CSF1R PlX3397 炎症小胶质细胞癫痫发作

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

差异蛋白组学方法识别热休克蛋白27作为动脉粥样硬化的潜在标志物

引用

世界核心医学期刊文摘（心脏病学分册） 2005年第3期1卷 30-30页

作者： Martin-Ventura J.l. Duran M.C. Blanco-Colio l.M. J. Egido 王亭忠 Vascular Research laboratory Fundacion Jimenez Diaz Avenida Reyes Cat olicos 2 28040 Madrid Spain Dr.

Background-We hypothesized that normal and pathological vessel walls display a differential pattern of secreted proteins. We have recently set up the conditions for comparing secretomes from carotid atherosclerotic plaques and control arteries using a proteomic approach to assess whether differentially secreted proteins could represent markers for atherosclerosis. Methods andResults-Normal endartery segments and different regions of endarterectomy pieces (noncomplicated/ complicated plaques) were incubated in protein-free medium, and the released proteinswere analyzed by 2D electrophoresis(2-DE). Among the differently secreted proteins, we have identified heat shock protein-27(HSP27). Surprisingly, compared with control arteries, HSP27 release was drastically decreased in atherosclerotic plaques and barely detectable in complicated plaque supernatants. HSP27 was expressed primarily by intact vascular cells of normal arteries and carotid plaques (immunohistochemistry). Plasma detection of soluble HSP27 showed that circulating HSP27 levels are significantly decreased in the blood of patients with carotid stenosis relative to healthy subjects(0.19 [0.1 to 1.95] versus 83[71.8 to 87.8]) ng/ml, Plusions-HSP27 secretion is decreased in complicated atherosclerotic plaques, and sHSP27 plasma levels are decreased in atherosclerotic patients compared with healthy subjects. Plasma sHSP27 levels could be a potential index of atherosclerosis, although further validation is needed in large patient cohorts.

关键词：差异蛋白组学血管细胞颈动脉斑块分泌型蛋白免疫组化法颈动脉硬化旋切电泳分析队列研究质中

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

The domestication of Cucurbita argyrosperma as revealed by the genome of its wild relative

引用

Horticulture Research 2021年第1期8卷 1287-1300页

作者： Josue Barrera-Redondo Guillermo Sanchez-de la Vega Jonas A.Aguirre-liguori Gabriela Castellanos-Morales Yocelyn T.Gutierrez-Guerrero Xitlali Aguirre-Dugua Erika Aguirre-Planter Maud I.Tenaillon rafael lira-Saade luis E.Eguiarte Departamento de Ecologia Evolutiva Instituto de EcologiaUniversidad Nacional Autonoma de MexicoCircuito Exterior s/n Anexo al Jardin Botanico04510 Ciudad de MexicoMexico Department of Ecology and Evolutionary Biology University of CaliforniaIrvineCA 92697USA Departamento de Conservacion de la Biodiversidad El Colegio de la Frontera SurVillahermosaCarretera Villahermosa‐Reforma km 15.5 Rancheria El Guineo 2ªseccion86280 VillahermosaTabascoMexico Genetique Quantitative et Evolution-le Moulon Universite Paris-SaclayInstitut National de Recherche pour l’Agriculturel’Alimentation et l’EnvironnementCentre National de la Recherche ScientifiqueAgroParisTechGif-sur-Yvette 91190France UBIPRO Facultad de Estudios Superiores IztacalaUniversidad Nacional Autonoma de MexicoAv.de los Barrios#1Col.Los Reyes IztacalaTlalnepantlaEdo.de Mex 54090Mexico

Despite their economic importance and well-characterized domestication syndrome,the genomic impact of domestication and the identification of variants underlying the domestication traits in Cucurbita species(pumpkins and squashes)is currently *** argyrosperma,also known as cushaw pumpkin or silver-seed gourd,is a Mexican crop consumed primarily for its seeds rather than fruit *** makes it a good model to study Cucurbita domestication,as seeds were an essential component of early Mesoamerican diet and likely the first targets of human-guided selection in pumpkins and *** obtained population-level data using tunable Genotype by Sequencing libraries for 192 individuals of the wild and domesticated subspecies of *** across *** also assembled the first high-quality wild Cucurbita *** genomic analyses revealed several structural variants and presence/absence of genes related to *** results indicate a monophyletic origin of this domesticated crop in the lowlands of *** found evidence of gene flow between the domesticated and wild subspecies,which likely alleviated the effects of the domestication *** uncovered candidate domestication genes that are involved in the regulation of growth hormones,plant defense mechanisms,seed development,and *** presence of shared selected alleles with the closely related species Cucurbita moschata suggests domestication-related introgression between both taxa.

关键词： Cucurbita likely pump

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

面部肉芽肿继发于德美蒂(充填剂)微植入体:1例个案报道和注射不同的永久性填充材料引起的肉芽肿的组织病理鉴别诊断

引用

世界核心医学期刊文摘（皮肤病学分册） 2006年第12期2卷 51-页

作者： Vargas-Machuca I. Gonzlez-Guerra E. Angulo J. l. Requena 任建文 Department of Dermatology Fundación Jiménez Daz Avda. Reyes Católicos 2 28040-Madrid Spain Dr.

Wrinkle reduction and the correction of skin defects using injectable aesthetic microimplants are now widely performed by dermatologists and plastic surgeons. In recent years, dermal filler substances containing polymer particle suspensions such as Bioplastique, Artecoll, and Dermalive are the most commonly used materials. These microimplants are permanent, non-biodegradable, and generally well tolerated, although various adverse reactions are still possible. We describe here a patient with facial granulomas secondary to Dermalive injections for correction of naso-labial folds and wrinkles. The particular shape of the injected particles allows for correct identification of the implanted material. Therefore, histopathologic examination is the best means to obtain the correct diagnosis of foreign body granuloma and to identify the type of filler particles. We discuss the histopathologic differential diagnosis among the granulomas secondary to the most commonly used aesthetic permanent filler materials.

关键词：肉芽肿炎症植入体植入物面部永久性德美填充材料继发

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：