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Effects of Pitavastatin on Lipoprotein Subfractions and Oxidized Low-density Lipoprotein in Patients with Atherosclerosis

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Current Medical Science 2020年第5期40卷 879-884页

作者： Rui-xia XU Yan ZHANG Yue ZHANG Ya-ru WU Xiao-lin LI Yuan-lin guo Geng LIU Qian DONG Jian-jun LI State Key Laboratory of Cardiovascular Disease Fu Wai Hospital National Center for Cardiovascular DiseaseChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100037China

It has been demonstrated that pitavastatin can significantly reduce low-density lipoprotein(LDL)cholesterol(LDL-C),but its impact on lipoprotein subfractions and oxidized low-density lipoprotein(oxLDL)has not been *** aim of the present study was to investigate the potential effects of pitavastatin on subfractions of LDL and high-density lipoprotein(HDL)as well as oxLDL in untreated patients with coronary atherosclerosis(AS).Thirty-six subjects were enrolled in this study.O f them,18 patients with AS were administered pitavastatin 2 mg/day for 8 weeks and 18 healthy subjects without therapy served as *** plasma lipid profile,lipoprotein subfractions and circulating oxLDL were determined at baseline and 8 weeks *** results showed that pitavastatin treatment indeed not only decreased LDL-C,total cholesterol(TC),triglycerides(TG)and apolipoprotein B(ApoB)levels,and increased HDL cholesterol(HDL-C),but also reduced the cholesterol concentration of all of the LDL subfractions and the percentage of intermediate and small LDL ***,pitavastatin could decrease plasma oxLDL ***,a more close correlation was found between oxLDL and LDL-C as well as LDL subfractions after pitavastatin *** concluded that a moderate dose of pitavastatin therapy not only decreases LDL-C and oxLDL concentrations but also improves LDL subfractions in patients with AS.

关键词： pitavastatin atherosclerosis lipoprotein subfraction low-density lipoprotein

Microglia and astrocytes mediate synapse engulfment in a MER tyrosine kinase-dependent manner after traumatic brain injury

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Neural Regeneration Research 2023年第8期18卷 1770-1776页

作者： Hui Shen Xiao-Jing Shi Lin Qi Cheng Wang Muyassar Mamtilahun Zhi-jun Zhang Won-Suk Chung guo-Yuan Yang Yao-Hui Tang Med-X Research Institute and School of Biomedical Engineering Shanghai Jiao Tong UniversityShanghaiChina Department of Biological Sciences Korea Advanced Institute of Science and TechnologyDaejeonSouth Korea

Recent studies have shown that microglia/macrophages and astrocytes can mediate synaptic phagocytosis through the MER proto-oncokinase in developmental or stroke models,but it is unclear whether the same mechanism is also active in traumatic brain *** this study,we established a mouse model of traumatic brain injury and found that both microglia/macrophages and astrocytes phagocytosed synapses and expression of the MER proto-oncokinase increased 14 days after *** knockout of MER in microglia/macrophages or astrocytes markedly reduced injury volume and greatly improved neurobehavioral *** addition,in both microglia/macrophages-specific and astrocytes-specific MER knock-out mice,the number of microglia/macrophage and astrocyte phagocytosing synapses was markedly decreased,and the total number of dendritic spines was *** study suggested that MER proto-oncokinase expression in microglia/macrophages and astrocytes may play an important role in synaptic phagocytosis,and inhibiting this process could be a new strategy for treating traumatic brain injury.

关键词： animal model astrocyte dendritic spines lysosome macrophage MER proto-oncokinase microglia neurologic function phagocytosis synapse engulfment traumatic brain injury

Testing the transfer functions for the Geonor T-200B and Chinese standard precipitation gauge in the central Qinghai-Tibet Plateau

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Journal of Mountain Science 2022年第7期19卷 1974-1987页

作者： ZHANG Le-le GAO Li-ming CHEN Ji ZHAO Lin CHEN Ke-long ZHAO Jing-yi LIU guo-jun SONG Ting-xi LI Yan-kun Key Laboratory of Tibetan Plateau Land Surface Processes and Ecological Conservation(Ministry of Education) Qinghai Normal UniversityXining810016China Qinghai Province Key Laboratory of Physical Geography and Environmental Process College of Geographical ScienceQinghai Normal UniversityXining810016China Academy of Plateau Science and Sustainability People’s Government of Qinghai Province and Beijing Normal UniversityXining810016China Beiluhe Observation and Research Station on Frozen Soil Engineering and Environment in Qinghai-Tibet Plateau Northwest Institute of Eco-environment and ResourcesChinese Academy of SciencesLanzhou730000China School of Geographical Sciences Nanjing University of Information Science and TechnologyNanjing210044China

Accurately measuring precipitation is integral for understanding water cycle processes and assessing climate change in the Qinghai–Tibet Plateau(QTP).The Geonor T-200B weighing precipitation gauge with a single Alter shield(Geonor)and the Chinese standard precipitation gauge(CSPG)are widely used for measuring precipitation in the ***,their measurements need to be adjusted for wetting loss,evaporation loss and windinduced *** existing transfer functions for adjusting the Geonor-recorded and three transfer functions for adjusting the CSPG-recorded precipitation at hourly,daily or event scale has been proposed based on the precipitation intercomparison experiments conducted at a single site in different *** latest transfer functions for the Geonor(which are referred to as K2017a and K2017b)at the half-hour time scale based on the precipitation intercomparison experiments at multiple stations in the northern hemisphere were provided in the World Meteorological Organization Solid Precipitation Intercomparison ***,the applicability of these transfer functions in the QTP has not been ***,the current study carried out a precipitation measurement intercomparison experiment between August 2018 and September 2020 at a site in Beiluhe in central *** performance of these transfer functions at this site was also evaluated on the basis of mean bias(MB),root mean squared error(RMSE)and relative total catch(RTC).The results are as follows:First,the unadjusted RTC values of the Geonor for rain,mixed(snow mixed with rain),snow and hail are 92.06%,85.35%,64.11% and 91.82%,respectively,and the unadjusted RTC values of the CSPG for the same precipitation types are 92.59%,81.32%,46.43% and 95.56%,***,K2017a has the most accurate adjustment results for the Geonor-recorded snow and mixed precipitation at the half-hour time scale,and the post-adjustment RTC values increased to 98.25% and 98.23%,respectively.M2007e

关键词： Precipitation observation errors Transfer function Geonor T-200B CSPG Qinghai-Tibet Plateau

Advantages of Chinese Medicine for Patients with Acquired Immunodeficiency Syndrome in Rural Central China

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Chinese Journal of Integrative Medicine 2018年第12期24卷 891-896页

作者： XU Qian-lei guo Hui-jun JIN Yan-tao WANG Jian JIANG Zi-qiang LI Zheng-wei CHEN Xiu-min LIU Ying XU Li-ran Department of Acquired Immune Deficiency Syndrome Treatment and Research Center the First Affiliated Hospital of Henan University of Traditional Chinese MedicineZhengzhou 450000China Henan Key Laboratory of Viral Diseases Control with Traditional Chinese Medicine Zhengzhou 450000China Traditional Chinese Medicine Center for Acquired Immune Deficiency Syndrome Prevention and Treatment China Academy of Traditional Chinese MedicineBeijing 100700China

Objective： To analyze the effect of Chinese medicine （CM） on mortality and quality of life （QOL） of acquired immunodeficiency syndrome （AIDS） patients treated with combined antiretroviral therapy （cART）. Methods： A random sample of AIDS patients enrolled in the National Chinese Medicine Treatment Trial Program （NCMTP） that met the inclusion criteria was included in this study. NCMTP patients were included as the CM＋cART group, and those not in the NCMTP were included as the cART group. Survival from September 2004 to September 2012 was analyzed by retrospective cohort study. QOL was analyzed by cross-sectional study. Results： The retrospective cohort study included 528 AIDS patients, 322 in the CM＋cART group and 206 in the cART group. After 8 years, the mortality in the CM＋cART group was 3.3/100 person-years, which was lower than the cART group of 5.3/100 person-years （P〈0.05）. The hazard ratio （HR） for mortality in the cART group was 1.6 times that of the CM＋cART group by Cox proportional hazard model analysis. After controlling for gender, age, marital status, education, and CD4＋ T-cell count, the HR was 1.9 times higher in the cART group compared with the CM＋cART group （P〈0.05）. The cross-sectional study investigated 275 AIDS patients. The mean scores of all QOL domains except spirituality/personal beliefs were higher in the CM＋cART group than in the cART group （P〈0.05）. Conclusions： For AIDS patients, CM could help to prolong life, decrease mortality, and improve QOL. However, there were limitations in the study, so prospective studies should be carded out to confirm our primary results.

关键词： acquired immunodeficiency syndrome mortality quality of life Chinese medicine

The safety of esophagojejunostomy via a transorally inserted-anvil method vs extracorporeal anastomosis using a circular stapler during total gastrectomy for Siewert type 2 adenocarcinoma of the esophagogastric junction

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Gastroenterology Report 2020年第3期8卷 242-251,I0002页

作者： Xin-Hua Chen Yan-Feng Hu jun Luo Yue-Hong Chen Hao Liu Tian Lin Hao Chen guo-Xin Li Jiang Yu Department of General Surgery Nanfang HospitalSouthern Medical UniversityGuangzhouGuangdongP.R.China

Background:Intracorporeal esophagojejunostomy via a transorally inserted-anvil method during laparoscopic total gastrectomy(LTG)for upper gastric cancer has been demonstrated to be feasible,but the use of this assessment exclusively for Siewert type 2 adenocarcinoma of the esophagogastric junction(AEG)has not been ***:A total of 428 consecutive gastric-cancer patients who underwent LTG in Nanfang Hospital from January 2008 to December 2016 were *** these patients,98 were classified as Siewert type 2 *** patients underwent intracorporeal esophagojejunostomy through either a transorally inserted-anvil method(n=27)or extracorporeal anastomosis usinga circular stapler(n=71).After generating propensity scores with covariates that were associated with developing anastomotic leakage,26 patients who underwent esophagojejunostomy via the transorally inserted-anvil method(transoral group)were 1:1 matched with 26 patients who underwent the procedure via extracorporeal anastomosis using a circular stapler(extracorporeal group).The safety after 30 days post-operatively was compared between the two ***:The transoral group and extracorporeal group were balanced regarding the baseline *** operative time,reconstruction duration,number of dissected lymph nodes,length of the proximal resectionmargins,estimated blood loss,intra-operative complication rate,and post-operative recovery course were not significantly different between the two *** mean anvil-insertion completion time(9.763.0 vs 13.462.0minutes,Pjunostomy through a transorally inserted-anvil method may be a potentially safe approach to simplify

关键词： adenocarcinoma of the esophagogastric junction laparoscopic total gastrectomy esophagojejunostomy anastomotic leakage

Evaluation of grain breakage sensitivity of maize varieties mechanically-harvested by combine harvester

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International Journal of Agricultural and Biological Engineering 2020年第5期13卷 8-16页

作者： Yizhou Wang Lulu Li Shang Gao Yanan guo guoqiang Zhang Bo Ming Ruizhi Xie jun Xue Peng Hou Keru Wang Shaokun Li Institute of Crop Sciences Chinese Academy of Agricultural SciencesKey Laboratory of Crop Physiology and EcologyMinistry of Agriculture and Rural AffairsBeijing 100081China

A high grain breakage rate is the main problem that occurs during mechanical maize harvest in *** breakage sensitivity of different varieties was significantly different,and the breakage resistance is ***,breakage resistant variety screening can help improve the field production efficiency and provide references for breeding *** this study,42 varieties of maize were harvested with the same mechanical parameters and the same manipulator on a range of harvest dates at experimental stations in Xinxiang,Henan Province,in 2017 and Changji,Xinjiang Province,in 2018 to determine the sensitivity of grain moisture content on grain breakage rate during machine harvest for different *** integral value of the grain breakage rate curve corresponding to the range of 15%to 30%grain moisture content was used as an index that expressed the sensitivity of maize grains to breakage depending on grain moisture content(BSW).Forty-two varieties were categorized as having weak,intermediate,or strong *** the same four varieties in the two stations,Lianchuang 825 and Lianchuang 808 were classified as sensitive and fragile varieties,Shandan 650 was classified as an intermediate variety,Zeyu 8911 was divided into weak sensitive and breakage-resistance varieties in Xinxiang and intermediate varieties in *** BSW classification results at the two experimental sites were generally consistent,indicating that breakage sensitivity due to moisture content may be a relatively stable genetic *** study suggested that the integral method for determining BSW can be used to assess the resistance of different maize varieties to grain breakage during mechanical *** integral method was used to identify twelve breakage-resistant varieties in Xinxiang Station,and six breakage-resistant varieties in Changji *** study provides a method for screening maize varieties that are suited to mechanical grain harvesting and for studying t

关键词： maize mechanical grain harvest breakage resistance integral method varieties classification

Evaluation of high-risk factors and the diagnostic value of alpha-fetoprotein in the stratification of primary liver cancer

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World Journal of Clinical Cases 2022年第26期10卷 9264-9275页

作者： Hong-Bin Jiao Wei Wang Meng-Nan guo Ya-Li Su De-Quan Pang Bao-Lin Wang jun Shi Jing-Hua Wu Clinical Laboratory Tangshan Maternal and Child Health Care HospitalNorth China University of Science and TechnologyTangshan 063000Hebei ProvinceChina Department of Oncology Tangshan Maternal and Child Health Care HospitalNorth China University of Science and TechnologyTangshan 063000Hebei ProvinceChina Clinical Laboratory Tangshan Nanhu HospitalTangshan 063000Hebei ProvinceChina

BACKGROUND Alpha-fetoprotein(AFP)is one of the diagnostic standards for primary liver cancer(PLC);however,AFP exhibits insufficient sensitivity and specificity for diagnosing *** To evaluate the effects of high-risk factors and the diagnostic value of AFP in stratified *** In total,289 PLC cases from 2013 to 2019 were selected for ***,the contributions of high-risk factors in stratifying PLC were compared according to the following criteria:Child–Pugh score,clinical stage of liver cirrhosis,tumor size,and Barcelona Clinic Liver Cancer(BCLC)***,the diagnostic value of AFP was evaluated in different stratifications of PLC by receiver operating characteristic *** PLC cases in which AFP played little role,the diagnostic values of carcinoembryonic antigen(CEA),carbohydrate antigen 19-9(CA 19-9),gamma-glutamyl transferase(GGT),and AFP were *** The roles of high-risk factors differed in stratified *** incidence of smoking and drinking history was higher in PLC with Child–Pugh scores of C(P0.700].However,these measures were meaningless(AUC<0.600)in small hepatomas and BCLC A stage PLC,but could be replaced by the combined detection of CEA,CA 19-9,GGT,and AFP(AUC=0.810 and 0.846,respectively).CONCLUSION Stratification of PLC was essential for precise diagnoses and benefited from evaluating AFP levels.

关键词： Primary liver cancer Stratification Risk factors Alpha-fetoprotein Receiver operating characteristic curve Diagnostics

TNM staging of colorectal cancer should be reconsidered by T stage weighting

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World Journal of Gastroenterology 2014年第17期20卷 5104-5112页

作者： jun Li Bao-Cai guo Li-Rong Sun Jian-Wei Wang Xian-Hua Fu Su-Zhan Zhang Graeme Poston Ke-Feng Ding Department of Surgical Oncology Second Affiliated Hospitaland The Key Laboratory of Cancer Prevention and InterventionChina National Ministry of EducationZhejiang University College of Medicine Department of Applied Mathematics School of Statistics and MathematicsZhejiang Gongshang UniversityXiasha University Town Department of Surgery Aintree University HospitalLiverpool L9 7ALUnited Kingdom

AIM: To verify that the T stage has greater weight than the N stage in the staging of colorectal cancer.

关键词： Colorectal cancer Neoplasm staging Cluster analysis Survival analysis Observational study

植物种类对由建筑垃圾构筑而成的三层土覆盖层系统防渗特性的影响研究（英文）

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2019年第1期20卷 1-9页

作者： Charles W.W.NG Bang-wen LU jun-jun NI Yun-min CHEN Rui CHEN Hao-wen guo Department of Civil and Environmental Engineering Hong Kong University of Science and Technology Department of Civil Engineering Zhejiang University Department of Urban and Civil Engineering Shenzhen Graduate School Harbin Institute of Technology

目的:为提高资源重复利用率,建筑垃圾常常被回收、粉碎并重新应用在土木工程建设中。本文旨在将回收建筑垃圾骨料应用于三层土覆盖层系统,并研究植物对其防渗特性的影响。创新点:1.提出一种由建筑垃圾构筑而成的三层土覆盖层系统;2.对... 详细信息

目的:为提高资源重复利用率,建筑垃圾常常被回收、粉碎并重新应用在土木工程建设中。本文旨在将回收建筑垃圾骨料应用于三层土覆盖层系统,并研究植物对其防渗特性的影响。创新点:1.提出一种由建筑垃圾构筑而成的三层土覆盖层系统;2.对比灌木、草以及裸土3种工况下该覆盖层的防渗特性。方法:1.采用一维土柱渗透试验研究由建筑垃圾构筑而成的三层土覆盖层系统的防渗特性。2.分别模拟灌木、草和裸土3种植被覆盖情况。3.移栽植物并养护,而后进行降雨试验,对比3种植被覆盖层的吸力响应及水分渗入。结论:1.在干旱条件下,蒸腾作用的大小顺序为:灌木>草>裸土,因为植物可以将更多的水分从覆盖层中释放到大气中;2.在极端降雨条件下,相比裸土覆盖层,植被覆盖层可以更好地保持吸力并阻止渗滤液的产生,且灌木比草效果更佳;3.在极端降雨条件下,由建筑垃圾构筑而成的植被型三层土覆盖系统是一种理想覆盖层,可以在湿润地区有效防止雨水下渗而进入垃圾体。

关键词：回收骨料吸力三层土覆盖系统植物种类土壤含水率