Evaluation of high-risk factors and the diagnostic value of alpha-fetoprotein in the stratification of primary liver cancer

作     者：Hong-Bin Jiao Wei Wang Meng-Nan Guo Ya-Li Su De-Quan Pang Bao-Lin Wang Jun Shi Jing-Hua Wu 

作者机构：Clinical LaboratoryTangshan Maternal and Child Health Care HospitalNorth China University of Science and TechnologyTangshan 063000Hebei ProvinceChina Department of OncologyTangshan Maternal and Child Health Care HospitalNorth China University of Science and TechnologyTangshan 063000Hebei ProvinceChina Clinical LaboratoryTangshan Nanhu HospitalTangshan 063000Hebei ProvinceChina 

出 版 物：《World Journal of Clinical Cases》 (世界临床病例杂志)

年 卷 期：2022年第10卷第26期

页      面：9264-9275页

核心收录：

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

基　　金：Supported by High-End Talent Funding Project in Hebei Province,No.A202003005 Hebei Provincial Health Commission Office,No.G2019074 Science and Technology Research Project of Hebei Higher Education Institutions(ZD2018090) Natural Science Foundation of Hebei Province,No.H2019209355 

主　　题：Primary liver cancer Stratification Risk factors Alpha-fetoprotein Receiver operating characteristic curve Diagnostics 

摘      要：BACKGROUND Alpha-fetoprotein(AFP)is one of the diagnostic standards for primary liver cancer(PLC);however,AFP exhibits insufficient sensitivity and specificity for diagnosing *** To evaluate the effects of high-risk factors and the diagnostic value of AFP in stratified *** In total,289 PLC cases from 2013 to 2019 were selected for ***,the contributions of high-risk factors in stratifying PLC were compared according to the following criteria:Child–Pugh score,clinical stage of liver cirrhosis,tumor size,and Barcelona Clinic Liver Cancer(BCLC)***,the diagnostic value of AFP was evaluated in different stratifications of PLC by receiver operating characteristic *** PLC cases in which AFP played little role,the diagnostic values of carcinoembryonic antigen(CEA),carbohydrate antigen 19-9(CA 19-9),gamma-glutamyl transferase(GGT),and AFP were *** The roles of high-risk factors differed in stratified *** incidence of smoking and drinking history was higher in PLC with Child–Pugh scores of C(P0.700].However,these measures were meaningless(AUC0.600)in small hepatomas and BCLC A stage PLC,but could be replaced by the combined detection of CEA,CA 19-9,GGT,and AFP(AUC=0.810 and 0.846,respectively).CONCLUSION Stratification of PLC was essential for precise diagnoses and benefited from evaluating AFP levels.