Microglia and astrocytes mediate synapse engulfment in a MER tyrosine kinase-dependent manner after traumatic brain injury

作     者：Hui Shen Xiao-Jing Shi Lin Qi Cheng Wang Muyassar Mamtilahun Zhi-Jun Zhang Won-Suk Chung Guo-Yuan Yang Yao-Hui Tang Hui Shen;Xiao-Jing Shi;Lin Qi;Cheng Wang;Muyassar Mamtilahun;Zhi-Jun Zhang;Won-Suk Chung;Guo-Yuan Yang;Yao-Hui Tang

作者机构：Med-X Research Institute and School of Biomedical EngineeringShanghai Jiao Tong UniversityShanghaiChina Department of Biological SciencesKorea Advanced Institute of Science and TechnologyDaejeonSouth Korea 

出 版 物：《Neural Regeneration Research》 (中国神经再生研究（英文版）)

年 卷 期：2023年第18卷第8期

页      面：1770-1776页

核心收录：

学科分类：0710[理学-生物学] 1002[医学-临床医学] 1001[医学-基础医学(可授医学、理学学位)] 100210[医学-外科学(含：普外、骨外、泌尿外、胸心外、神外、整形、烧伤、野战外)] 10[医学] 

基　　金：supported by the National Key R&D Program of China,No.2019YFA0112000(to YHT) the National Natural Science Foundation of China,Nos.82071284(to YHT),81974179(to ZJZ) Shanghai Rising-Star Program,No.21QA1405200(to YHT) the Scientific Research and Innovation Program of Shanghai Education Commission,No.2019-01-07-00-02-E00064(to GYY) Scientific and Technological Innovation Act Program of Shanghai Science and Technology Commission,No.20JC1411900(to GYY) the Notional Research Foundation of Korea,Nos.2020M3E5D9079912(to WSC),2021R1A2C3005704(to WSC),2022M3E5E8081188(to WSC) the Korea Health Technology R&D Project,No.HU20C0290(to WSC) 

主　　题：animal model astrocyte dendritic spines lysosome macrophage MER proto-oncokinase microglia neurologic function phagocytosis synapse engulfment traumatic brain injury 

摘      要：Recent studies have shown that microglia/macrophages and astrocytes can mediate synaptic phagocytosis through the MER proto-oncokinase in developmental or stroke models,but it is unclear whether the same mechanism is also active in traumatic brain *** this study,we established a mouse model of traumatic brain injury and found that both microglia/macrophages and astrocytes phagocytosed synapses and expression of the MER proto-oncokinase increased 14 days after *** knockout of MER in microglia/macrophages or astrocytes markedly reduced injury volume and greatly improved neurobehavioral *** addition,in both microglia/macrophages-specific and astrocytes-specific MER knock-out mice,the number of microglia/macrophage and astrocyte phagocytosing synapses was markedly decreased,and the total number of dendritic spines was *** study suggested that MER proto-oncokinase expression in microglia/macrophages and astrocytes may play an important role in synaptic phagocytosis,and inhibiting this process could be a new strategy for treating traumatic brain injury.