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基于纹影成像技术的可视化口罩密合性检测装置的设计与应用

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东华大学学报（自然科学版） 2024年第4期50卷 156-162页

作者：管晓宁韩佳祥林婧任祥岭高晓东王璐东华大学纺织学院上海东华大学纺织面料技术教育部重点实验室上海东华大学纺织行业生物医用纺织材料及技术重点实验室上海复旦大学附属中山医院感染管理科上海

口罩佩戴不当造成的泄漏会显著降低口罩的有效性。现有的口罩密合性测试结果仅判断佩戴口罩过程中是否存在气体泄漏,但无法精确指出气流泄露部位,也不能实时调整口罩佩戴方式。为此,利用纹影成像技术设计口罩密合性检测装置。该技术利... 详细信息

口罩佩戴不当造成的泄漏会显著降低口罩的有效性。现有的口罩密合性测试结果仅判断佩戴口罩过程中是否存在气体泄漏,但无法精确指出气流泄露部位,也不能实时调整口罩佩戴方式。为此,利用纹影成像技术设计口罩密合性检测装置。该技术利用气流对光波的扰动,将肉眼看不到的气流变化转化为可见的图像,从而实现气流的可视化。利用口罩密合性检测装置可观测不同口罩、不同佩戴个体下的口罩气流泄露情况,同时测量泄露气流的纹影面积。使用该装置测试头模或真人佩戴口罩时的密合性,结果显示:头模佩戴医用外科口罩时泄露气流的纹影最明显;不同个体佩戴同类口罩时泄露气流也存在纹影差异。采用医用外科口罩对装置有效性进行验证,数据显示正确佩戴口罩时口罩边缘气流泄漏率为36.83%。

关键词：纹影成像技术密合性测试装置可视化口罩

Chemical chaperone delivered nanoscale metal–organic frameworks as inhibitor of endoplasmic reticulum for enhanced sensitization of thermo-chemo therapy

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Chinese Chemical Letters 2022年第3期33卷 1604-1608页

作者： Xiaoyan Ma Qiong Wu Longfei Tan Changhui Fu xiangling ren Qijun Du Lufeng Chen Xianwei Meng Laboratory of Controllable Preparation and Application of Nanomaterials Technical Institute of Physics and ChemistryChinese Academy of SciencesBeijing 100190China Graduate School of Bio-Applications and Systems Engineering Tokyo University of Agriculture and TechnologyKokyo 184-8588Japan CAS Key Laboratory of Cryogenics Technical Institute of Physics and ChemistryBeijing 100190China First Clinical Medical School and First Hospital Shanxi Medical UniversityTaiyuan 030001China

Thermotherapy and chemotherapy have received extensive attention to tumor treatment. However, thermal tolerance and drug resistance severely limit clinical effect of tumor therapy owing to endoplasmic reticulum(ER) stress. Reducing thermal tolerance and drug resistance of tumors is an urgent challenge to be solved. In this work, we design a nanoplatform of PBA-Dtxl@MIL-101 as an ER inhibitor. Amino functionalized Fe-metal organic framework(MIL-101) nanoparticles are synthesized as p H and microwave(MW) dual stimuli-responsive drug delivery system. Then, the chemical chaperones of 4-phenylbutyric acid(PBA) and antineoplastic drug Docetaxel(Dtxl) were successfully loaded into MIL-101 nanoparticles to form PBA-Dtxl@MIL-101 nanoparticles. Furthermore, PBA-Dtxl@MIL-101 nanoparticles exhibit inhibitor effect of ER stress through upregulating caspase 9 proteins and reduce thermal tolerance by downregulating HSP 90. It was demonstrated that the therapy sensitized by PBA-Dtxl@MIL-101 nanoparticles obviously destroyed tumor cells, showing simultaneously enhanced thermo-chemo therapy.

关键词： Metal–organic frameworks Biodegradable Chemotherapy Thermotherapy Microwave

Fabrication of microwave-sensitized nanospheres of covalent organic framework with apatinib for tumor therapy

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Chinese Chemical Letters 2023年第5期34卷 427-432页

作者： Qijun Du Jian Zou Zhongbing Huang Shimei Li Longfei Tan xiangling ren Guangfu Yin Yongfa Zheng Xianwei Meng College of Biomedical Engineering Sichuan UniversityChengdu 610065China Laboratory of Controllable Preparation and Application of Nanomaterials CAS Key Laboratory of CryogenicsTechnical Institute of Physics and ChemistryChinese Academy of SciencesBeijing 100190China Sichuan Kangcheng Biotechnology Co. Ltd.Chengdu 610041China Department of Oncology Renmin Hospital of Wuhan UniversityWuhan 430060China

A new nanocomposite of hollow covalent organic framework(COF)conjugated with the apatinib(AP)and loading microwave-sensitizer(ionic liquid,IL)was prepared by layer by layer(LBL)method and hyaluronic acid(HA)coating,named as COF-AP-IL@HA.AP loading rate in COF hollow-spheres(~30 nm shell thickness)was~40.3%,due to the interactions of hydrogen andπ-πbonds between AP and COF shell,and acidic environment destroyed COF structure,promoting AP release.Microwave sensitization of loaded IL in COF hollow-spheres could enhance the microwave heat-effect,and combined AP therapeutic ability,leading to their higher inhibitation on tumor,due to targeting ability of HA and the local release of apatinib.88.9%of inhibition rate of COF-AP-IL@HA under microwave on the in vivo tumor was significantly higher than those without microwave(12.3%)and COF-IL@HA with microwave(37.5%),indicating a synergism of sensitized microwave hyperthermia and AP therapy on the reduced expression of VEGF via the downregulation pathway of hypoxia inducible factor.These results indicated that COF-AP-IL@HA was potential to the application in the combination therapy of tumor of the sensitized microwave hyperthermia and apatinib.

关键词： Covalent organic framework Antiangiogenesis Tumor therapy Microwave hyperthermia Hollow spheres

Sensitive detection of dopamine and quinone drugs based on the quenching of the fluorescence of carbon dots

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Science Bulletin 2016年第20期61卷 1615-1623页

作者： xiangling ren Jiejie Ge Xianwei Meng Xiaozhong Qiu Jun ren Fangqiong Tang Laboratory of Controllable Preparation and Application of Nanomaterials Key Laboratory of Photochemical Conversion and Optoelectronic Materials Technical Institute of Physics and Chemistry Chinese Academy of Sciences Beijing 100190China Department of Anatomy Guangdong Provincial Key Laboratory of Construction and Detection in Tissue Engineering Southern Medical University Guangzhou 510515 China

In this work,we demonstrated that the quinone structure can quench the fluorescence of the carbon dots(CDs).The sensitive determination of dopamine(DA) was studied primarily based on this principle.DA would be transformed into DA quinone under alkaline conditions,which resulted in fluorescence quenching of the CDs.A good linear range from 5 nmol/L to 0.4 mmol/L was obtained and the detection limit was 1 nmol/L.Moreover,the quenching effect of quinone structure on the fluorescence of CDs was confirmed by Fourier transform infrared spectra,time-correlated single-photon counting and X-ray photoelectron spectroscopy.Remarkably,CDs were firstly applied to detect the quinone drugs quantitatively which contained typical quinone structure based on the quenching mechanism.More than this,the sensing platform was demonstrated to provide credible selectivity and satisfactory stability in human serum solution with good liner range.Hence,our practical application and mechanism have showed great potential for diagnostic purposes.

关键词： Carbon dots Quinone structure Detection Dopamine Quinone drugs

Metal-Organic Frameworks-Based Fluorescent Nanocomposites for Bioimaging in Living Cells and in vivo

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Chinese Journal of Chemistry 2021年第2期39卷 473-487页

作者： Meijia Liu xiangling ren Xianwei Meng Hongbo Li Experimental Center of Advanced Materials School of Materials Science&EngineeringBeijing Institute of TechnologyBeijing100081 China Laboratory of Controllable Preparation and Application of Nanomaterials Technical Institute of Physics and ChemistryChinese Academy of SciencesBeijing100190 China

Metal-organic frameworks(MOFs)as a class of porous functional materials have attracted more and more attention for biomedical applications.To date,MOFs have been developed for bioimaging based on a series of advantages such as the large surface areas,high porosity,fluorescence functionalities and good biocompatibility.It is worth noting that organic or inorganic fluorescent materials such as fluorescent dyes,quantum dots,metal nanoclusters and nanosheets can combine MOFs or be encapsulated in MOFs to form fluorescent nanocomposites for excellent imaging function.Importantly,excellent imaging capabilities are of great significance in living cells and in vivo for detection,diagnosis and cancer therapy.In this review,we focus on the recent research of the bioimaging in living cells and in vivo based on various MOF-based nanocomposites and their potential biological clinical applications.

关键词： Metal-organic frameworks Fluorescent material Nanostructures Fluorescence Bioimaging

Enhanced antibacterial activity of silica nanorattles with ZnO combination nanoparticles against methicillin-resistant Staphylococcus aureus

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Science Bulletin 2017年第17期62卷 1207-1215页

作者： Qianqian Chai Qiong wu Tianlong Liu Longfei Tan Changhui Fu xiangling ren Yue Yang Xianwei Meng Laboratory of Controllable Preparation and Application of Nanomaterials CAS Key Laboratory of CryogenicsTechnical Institute of Physics and ChemistryChinese Academyof SciencesBeijing 100190China University of Chinese Academy of Sciences Beijing 100049China

Silica nanorattles(SNs) with zinc oxide(ZnO) combination nanoparticles are reported to inhibit methicillin-resistant Staphylococcus aureus(MRSA) for the first time. SNs loaded with ZnO nanoparticles,which can produce free radicals, can cause severe damage to bacteria. ZnO nanoparticles not only provide free radicals in the combined nanostructures, which can inhibit the growth of bacteria, but also form nanorough surfaces with an irregular distribution of spikes on the SNs, which can enhance their adhesion to bacteria. Nanorough silica shell surfaces maintain the high activity and stability of small-sized ZnO nanoparticles and gather ZnO nanoparticles together to enhance production, which improves the efficiency of free radicals against the cytomembranes of bacterial cells. The enhanced adhesion of ZnO@SN nanoparticles to MRSA cells shortens the effective touching distance between free radicals and MRSA, which also improves antibacterial activity. As we expected, the ZnO@SN nanoparticles exhibit a better antibacterial effect than free ZnO nanoparticles against MRSA in vitro and in vivo. We also demonstrate that SNs loaded with ZnO nanoparticles can accelerate wound healing in MRSA skin inflammation models. This method of multilevel functionalization will be potentially applicable to the antibacterial field.

关键词： ZnO纳米粒子氧化锌纳米颗粒纳米二氧化硅金黄色葡萄球菌抗菌活性纳米氧化锌 MRSA 自由基对

Preparation and enhanced properties of ZrMOF@CdTe nanoparticles with high-density quantum dots

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Frontiers of Materials Science 2020年第2期14卷 155-162页

作者： Xin LIU xiangling ren Longfei TAN Wenna GUO Zhongbing HUANG Xianwei MENG College of Materials Science and Engineering Sichuan UniversityChengdu 610065China Laboratory of Controllable Preparation and Application of Nanomaterials CAS Key Laboratory of CryogenicsTechnical Institute of Physics and ChemistryChinese Academy of SciencesBeijing 100190China

ZrMOF@CdTe nanoparticles(NPs)with high fluorescence were synthe-sized by hydrothermal method.The morphology,particle size distribution,compositions,fluorescence properties and stability of the synthesized ZrMOF@CdTe were analyzed via the characterization by TEM,ICP-AES and fluorescence spectrophotometry,and the effects of the reaction time and pH value on the fluorescent property of ZrMOF@CdTe NPs were discussed.The results show that ZrMOFs could maintain its morphology and structure well during the process of loading CdTe quantum dots.With the increase of the loading reaction time,the red-shifted emission peaks of ZrMOF@CdTe NPs appear,and their fluorescence gradually changes from green to red color.With the increase of the pH value and temperature of the hydrothermal reaction,the fluorescence of ZrMOF@CdTe NPs was also consistent with the red-shifted change.The fluorescent property of ZrMOF@CdTe NPs could be remained for more than 3 months.Therefore,ZrMOF@CdTe NPs synthesized by the hydrothermal method have the characteristics of simple operation,adjustable fluorescent color and high stability,and the potential application in the fields of biological detection and sensing is expected.

关键词： hydrothermal synthesis ZrMOF@CdTe nanoparticles quantum dots metal-organic framework

Preparation and properties of covalent organic framework nanoparticles with high drug loading

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Frontiers of Materials Science 2021年第3期15卷 465-470页

作者： Jian ZOU xiangling ren Longfei TAN Zhongbing HUANG Li GOU Xianwei MENG College of Biomedical Engineering Sichuan UniversityChengdu 610065China Laboratory of Controllable Preparation and Application of Nanomaterials CAS Key Laboratory of CryogenicsTechnical Institute of Physics and ChemistryChinese Academy of SciencesBeijing 100190China

With the rapid development of nanotechnology,nano-drug carrier systems in biomedicine have received extensive attention from researchers.By adsorbing or coating the drug in/on a nano-sized carrier,this system improves the drug’s stability and selectivity in the body,reducing the toxicity and side effects of the drug.Thus these carrier systems have broad application prospects in the field of biomedicine.A common nano-drug carrier system includes inorganic nano-carriers,organic nano-carriers,and metal nano-carriers.Inorganic nano-carriers have the advantages of good stability,controllable size,larger specific surface area,and unique photothermal electromagnetic properties.

关键词： coating stability loading

Nanoscale metal organic frameworks inhibition of pyruvate kinase of M2

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Chinese Chemical Letters 2021年第10期32卷 3087-3089页

作者： xiangling ren Xinyuan Huang Qiong Wu Longfei Tan Changhui Fu Yi Chen Xianwei Meng Laboratory of Controllable Preparation and Application of Nanomaterials Technical Institute of Physics and ChemistryChinese Academy of SciencesBeijing 100190China Key Laboratory of Photochemical Conversion and Optoelectronic Materials Technical Institute of Physics and ChemistryChinese Academy of SciencesBeijing 100190China CAS Key Laboratory of Cryogenics Technical Institute of Physics and ChemistryChinese Academy of SciencesBeijing 100190China University of Chinese Academy of Sciences Beijing 100049China

Tumor cells usually show abnormally high glycolysis rate to maintain the dynamic balance of energy.The growth of tumor cells can be affected by inhibiting the activity of pyruvate kinase(especially M2-type isozyme,PKM2),the rate limiting enzyme of glycolysis.This is helpful to the treatment of tumor.Herein,metal organic frameworks(MOFs) were found to inhibit the activity of PKM2.Nanoscale ZIF-8 was synthesized by standing and ultrasonic method,respectively.The ZIF-8 has the performance of inhibiting PKM2.Further research showed that the inhibition ability was attributed to zinc ion in ZIF-8.Interestingly,the IC_(50) of ZIF-8 on PKM2 was one percent of that of zinc ion.This novel enzyme inhibitor is expected to be used in cancer therapy.

关键词： Metal organic frameworks Pyruvate kinase Glycolysis Lactate dehydrogenase Inhibition