Fabrication of microwave-sensitized nanospheres of covalent organic framework with apatinib for tumor therapy

作     者：Qijun Du Jian Zou Zhongbing Huang Shimei Li Longfei Tan Xiangling Ren Guangfu Yin Yongfa Zheng Xianwei Meng Qijun Du;Jian Zou;Zhongbing Huang;Shimei Li;Longfei Tan;Xiangling Ren;Guangfu Yin;Yongfa Zheng;Xianwei Meng

作者机构：College of Biomedical EngineeringSichuan UniversityChengdu 610065China Laboratory of Controllable Preparation and Application of NanomaterialsCAS Key Laboratory of CryogenicsTechnical Institute of Physics and ChemistryChinese Academy of SciencesBeijing 100190China Sichuan Kangcheng Biotechnology Co.Ltd.Chengdu 610041China Department of OncologyRenmin Hospital of Wuhan UniversityWuhan 430060China 

出 版 物：《Chinese Chemical Letters》 (中国化学快报（英文版）)

年 卷 期：2023年第34卷第5期

页      面：427-432页

核心收录：

学科分类：1002[医学-临床医学] 07[理学] 070205[理学-凝聚态物理] 08[工学] 080501[工学-材料物理与化学] 0805[工学-材料科学与工程（可授工学、理学学位）] 100214[医学-肿瘤学] 10[医学] 0702[理学-物理学] 

基　　金：supported by the National Key Research and Development Program of China(No.2018YFC1106800) National Natural Science Foundation of China(No.81703035) Sichuan Science&Technology Program(No.2020YFSY0018) 

主　　题：Covalent organic framework Antiangiogenesis Tumor therapy Microwave hyperthermia Hollow spheres 

摘      要：A new nanocomposite of hollow covalent organic framework(COF)conjugated with the apatinib(AP)and loading microwave-sensitizer(ionic liquid,IL)was prepared by layer by layer(LBL)method and hyaluronic acid(HA)coating,named as COF-AP-IL@*** loading rate in COF hollow-spheres(~30 nm shell thickness)was~40.3%,due to the interactions of hydrogen andπ-πbonds between AP and COF shell,and acidic environment destroyed COF structure,promoting AP *** sensitization of loaded IL in COF hollow-spheres could enhance the microwave heat-effect,and combined AP therapeutic ability,leading to their higher inhibitation on tumor,due to targeting ability of HA and the local release of apatinib.88.9%of inhibition rate of COF-AP-IL@HA under microwave on the in vivo tumor was significantly higher than those without microwave(12.3%)and COF-IL@HA with microwave(37.5%),indicating a synergism of sensitized microwave hyperthermia and AP therapy on the reduced expression of VEGF via the downregulation pathway of hypoxia inducible *** results indicated that COF-AP-IL@HA was potential to the application in the combination therapy of tumor of the sensitized microwave hyperthermia and apatinib.