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A small number of male-biased candidate pheromone receptors are expressed in large subsets of the olfactory sensory neurons in the antennae of drones from the European honey bee Apis mellifera

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Insect Science 2022年第3期29卷 749-766页

作者： Joerg fleischer Alexander rausch Kathrin Dietze Silvio Erler Sina Cassau Jurgen Krieger Martin Luther University Halle-Wittenberg Institute of Biologyl ZoologyDepartment of Animal PhysiologyHalle(Saale) Institute for Bee Protection Julius Kuhn Institute(JKI)-Federal Research Centre for Cultivated PlantsBraunschweigGermany

In the European honey bee(Apis mellifera),the olfactory system is essential for foraging and intraspecific communication via *** bees are equipped with a large repertoire of olfactory receptors belonging to the insect odorant receptor(Or)*** studies have indicated that the transcription level of a few Or types including Or11,a receptor activated by the queen-released pheromone compound(2£)-9-oxodecenoic acid(9-ODA),is significantly higher in the antenna of males(drones)than in female ***,the number and distribution of antennal cells expressing male-biased Ors is ***,we analyzed antennal sections from bees by in situ hybridization for the expression of the male-biased receptors Or11,Or18,and *** results demonstrate that these receptors are expressed in only moderate numbers of cells in the antennae of females(workers and queens),whereas substantially higher cell numbers express these Ors in ***,the reported male-biased transcript levels are due to sex-specific differences in the number of antennal cells expressing these *** analyses for Or11 and Or18 in drone antennae revealed expression in two distinct subsets of olfactory sensory neurons(OSNs)that in total account for approximately 69%of the Or-positive *** high percentages of OSNs expressing given receptors are reminiscent of male-biased Ors in moths that mediate the detection of female-released sex pheromone ***,our findings indicate remarkable similarities between male antennae of bees and moths and support the concept that male-biased Ors in bee drones serve the detection of female-emitted sex pheromones.

关键词： chemosensory odorant receptor olfaction pheromone detection sensilla placodea

Chatter identification of thin-walled parts for intelligent manufacturing based on multi-signal processing

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Advances in Manufacturing 2021年第1期9卷 22-33页

作者： Dong-Dong Li Wei-Min Zhang Yuan-Shi Li Feng Xue Jürgen fleischer School of Mechanical Engineering Tongji UniversityShanghai 201804People's Republic of China Bosch rexroth Endowed Chair for Automation&Electrification Solutions Sino-German College for Postgraduate StudyTongji UniversityShanghai 201804People's Republic of China China North Engine research Institute Tianjin 300400People's Republic of China WBK Institute of Production Science Karlsruhe Institute of TechnologyKarlsruhe 76131Germany

Machine chatter is still an unresolved and challenging issue in the milling process,and developing an online chatter identification and process monitoring system towards smart manufacturing is an urgent *** this paper,two indicators of chatter detection are *** is the real-time variance of milling force signals in the time domain,and the other one is the wavelet energy ratio of acceleration signals based on wavelet packet decomposition in the frequency ***,a novel classification concept for vibration condition,called slight chatter,is proposed and integrated successfully into the designed multi-classification support vector machine(SVM)***,a mapping model between image and chatter indicators is established via a distance threshold on the *** multi-SVM model is trained by the results of three signals as an *** data and detection accuracy of the SVM model are verified in actual *** identification accuracy of 96.66%has proved that the proposed solution is feasible and *** presented method can be used to select optimized milling parameters to improve machining process stability and strengthen manufacturing system monitoring.

关键词： Chatter Milling force Acceleration Wavelet packet decomposition Multi-sensor

Seasonality of PSII thermostability and water use e ffi ciency of in situ mountainous Norway spruce(Picea abies)

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Journal of Forestry research 2023年第1期34卷 197-208页

作者： Peter Petrik Anja Petek-Petrik Alena Konopkova Peter.fleischer Srdjan Stojnic Ina Zavadilova Daniel Kurjak Global Change research Institute Czech Academy of SciencesBrnoCzech Republic Department of Vegetation Ecology Institute of Botany CASBrnoCzech Republic Faculty of Forestry Technical University of ZvolenZvolenSlovakia Institute of Forest Ecology Slovak Academy of SciencesZvolenSlovakia Institute of Lowland Forestry and Environment University of Novi SadNovi SadSerbia

The stability of monocultural,even-aged spruce forests at lower altitudes in Central Europe is seriously threatened by the prospects of global climate *** thermostability and water use efficiency of their photo synthetic apparatus might play a vital role in their successful *** this study,photo systemⅡ(PSⅡ)performance(OJIP transient,rapid light curves)and thermostability were analyzed in Norway spruce(Picea abies(L.)Karst.)throughout the growing season of the exceptionally warm year 2018(May-September)in the Western Carpathians,*** measurements were accompanied by analysis of pigment concentrations in the *** addition,gas-exchange temperature curves were produced weekly from June until September to obtain intrinsic water use *** the beginning of the growing season,needles exposed to heat stress showed significantly higher basal fluorescence and lower quantum yield,performance index,critical temperature thresholds of PSII inactivation and nonphotochemical yield in comparison to other *** overall thermostability(heat-resistance)of PSII peaked in July and August,reflected in the lowest basal fluorescence and the highest quantum yield of PSII,critical temperature thresholds and yield of non-photochemical quenching under heat ***,the ratio between chlorophyll and carotenoids was the highest in August and had a positive impact on PSII ***,the high-temperature intrinsic water use efficiency was significantly higher during July and August than in *** show that15-year-old trees of Picea abies at 840 m *** acclimative seasonal responses of PSII thermostability and intrinsic water use efficiency during an exceptionally warm *** results suggest that mountainous *** at lower altitudes can acclimate their photosynthetic apparatus to higher temperatures during summer.

关键词： Heat stress Photosynthesis Non-photochemical quenching Pigments Intrinsic water use efficiency

Hepatitis B among Inuit: A review with focus on Greenland Inuit

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World Journal of Hepatology 2015年第9期7卷 1265-1271页

作者： Karsten fleischer rex Stig Andersen Henrik Bygum Krarup Department of Internal Medicine Queen Ingrid’s Hospital Arctic Health research Centre Clinical Institute Aalborg University Hospital Greenland Centre for Health research Institute of Nursing and Health Science University of Greenland Department of Geriatric and Internal Medicine Aalborg University Hospital Section of Molecular Diagnostics Clinical Biochemistry Aalborg University Hospital

Hepatitis B virus(HBV) infection is a disease with a highly variable course. Chronic HBV infection may cause end-stage liver disease including cirrhosis and hepatocellular carcinoma, which is the 3rd most common cause of cancer related death due to the poor prognosis. The prevalence of HBV infection is low in many countries. Still, it remains important due to the potential consequences of the disease. HBV is endemic in the Arctic with serologic markers of chronic HBV infection in up to 29% of the population in some areas in Greenland. Interestingly, Inuit populations rarely show signs of liver disease despite the fact that around half of all Inuit has been exposed to HBV and around 8% of Inuit are chronically infected with HBV. These findings have been consistent in surveys conducted for more than four decades among Arctic Inuit. We thus review HBV infection in the Arctic with focus on Greenland Inuit and compared with Inuit in Canada, Alaska and Siberia. The aspects described include epidemiology and monitoring of the disease, as well as treatment and the risk of liver cancer.

关键词： Hepatitis B Hepatitis D Monitoring disease Prevention Liver cancer Inuit Greenland Arctic

Stress kinase inhibition modulates acute experimental pancreatitis

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World Journal of Gastroenterology 2001年第2期7卷 259-265页

作者： F.fleischer r.Dabew B.Goke ACC Wagner Department of Gastroenterology InselspitalUniversity of BernSwitzerland

AIM: To examine the role of p38 during acute experimental cerulein pancreatitis. METHODS: rats were treated with cerulein with or without a specific JNK inhibitor (CEP1347) and/or a specific p38 inhibitor (SB203580) and pancreatic stress kinase activity was determined. Parameters to assess pancreatitis included trypsin, amylase, lipase, pancreatic weight and histology. rESULTS: JNK inhibition with CEP1347 ameliorated pancreatitis, reducing pancreatic edema. In contrast, p38 inhibition with SB203580 aggravated pancreatitis with higher trypsin levels and, with induction of acinar necrosis not normally found after cerulein hyperstimulation. Simultaneous treatment with both CEP1347 and SB203580 mutually abolished the effects of either compound on cerulein pancreatitis. CONCLUSION: Stress kinases modulate pancreatitis differentially. JNK seems to promote pancreatitis development, possibly by supporting inflammatory reactions such as edema formation while its inhibition ameliorates pancreatitis. In contrast, p38 may help reduce organ destruction while inhibition of p38 during induction of cerulein pancreatitis leads to the occurrence of acinar necrosis.

关键词： Acute Disease Animals Caerulein Carbazoles Enzyme Inhibitors Imidazoles Indoles Mitogen-Activated Protein Kinases inhibitors Models, Animal Necrosis Pancreatitis Pyridines rats Trypsin p38 Mitogen-Activated Protein Kinases

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进给系统振动特性研究及新型加减速控制策略

振动．测试与诊断 2019年第1期39卷 160-167,228页

作者：罗亮张为民 Jürgen fleischer 同济大学机械与能源工程学院上海201804 同济大学中德学院上海201804 同济大学先进制造技术中心上海201804 卡尔斯鲁厄理工学院生产技术研究所德国卡尔斯鲁厄76131

不平滑的运动指令导致数控机床进给过程中产生振动。本研究基于滚珠丝杠进给系统集中质量动力学模型,建立了伺服电机扭矩激励与进给系统响应的理论模型,分析了运动指令加速度曲线功率谱与进给系统振动响应的相关关系。针对加减速策略中... 详细信息

不平滑的运动指令导致数控机床进给过程中产生振动。本研究基于滚珠丝杠进给系统集中质量动力学模型,建立了伺服电机扭矩激励与进给系统响应的理论模型,分析了运动指令加速度曲线功率谱与进给系统振动响应的相关关系。针对加减速策略中存在的加加速曲线开始点和结束点不连续而引入振动激励的问题,提出一种类余弦加加速加减速控制策略,实现了加加速全过程的平滑过渡。以某滚珠丝杠进给实验台架为例,建立并实验验证了该台架的集中质量动力学模型,在此基础上建立了加减速控制策略激励特性分析的仿真模型,对加减速控制策略的激励特性进行了对比分析。仿真结果表明,类余弦加加速策略的激励特性最小,其工作台响应的功率密度是有限加加速策略的万分之一,是正弦加加速策略的1%。

关键词：滚珠丝杠进给系统集中质量模型加减速策略类余弦加加速

Brain network correlates of epilepsy occurrence in multiple sclerosis and neuroinflammation

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Neural regeneration research 2023年第8期18卷 1717-1718页

作者： Dumitru Ciolac Gabriel Gonzalez-Escamilla Yaroslav Winter Vinzenz fleischer Matthias Grothe Sergiu Groppa Department of Neurology Focus Program Translational NeuroscienceRhine Main Neuroscience Network(rmn2)University Medical Center of the Johannes Gutenberg University MainzMainzGermany State University of Medicine and Pharmacy“Nicolae Testemitanu” ChisinauRepublic of Moldova Department of Neurology Institute of Emergency MedicineChisinauRepublic of Moldova Mainz Comprehensive Epilepsy and Sleep Medicine Center Department of NeurologyJohannes Gutenberg University MainzMainzGermany Department of Neurology Philipps-UniversityMarburgGermany Department of Neurology Heinrich Heine UniversityDüsseldorfGermany

Multiple sclerosis(MS),the most common inflammatory condition of the central nervous system in young adults,is characterized by immunemediated demyelination and neurodegeneration that translate into heterogeneous clin... 详细信息

关键词： epilepsy inflammation sclerosis

滚珠丝杠进给系统动态特性集中质量建模与仿真

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农业机械学报 2015年第12期46卷 370-377页

作者：罗亮张为民周敏剑 Jurgen fleischer 同济大学机械与能源工程学院上海201804 同济大学中德学院上海201804 同济大学中德先进制造技术中心上海201804 卡尔斯鲁厄理工大学生产技术研究所德国卡尔斯鲁厄76131

为了研究高速滚珠丝杠进给系统的动态特性,提出一种改进的集中质量建模方法,该方法考虑了滚珠丝杠进给系统基座的质量、柔性及进给系统部件间反向间隙对系统动态特性的影响,并完善了滚珠丝杠进给系统集中质量模型等效参数的计算方法。以... 详细信息

为了研究高速滚珠丝杠进给系统的动态特性,提出一种改进的集中质量建模方法,该方法考虑了滚珠丝杠进给系统基座的质量、柔性及进给系统部件间反向间隙对系统动态特性的影响,并完善了滚珠丝杠进给系统集中质量模型等效参数的计算方法。以MAG某加工中心X轴滚珠丝杠进给系统为实验对象,对该集中质量模型建模方法进行实验验证,仿真结果与实测结果具有相同数量的特征频率,且特征频率的误差在5%以内。滚珠丝杠进给系统的仿真分析表明,螺母位置改变引起的进给系统固有频率变化将影响伺服系统的稳定性,滚珠丝杠进给系统中的反向间隙会激励部件产生高频振动,给进给系统带来不利影响。

关键词：滚珠丝杠进给系统动态特性反向间隙集中质量

Antidiabetic effect of Chrysophyllum albidum is mediated by enzyme inhibition and enhancement of glucose uptake via 3T3-L1 adipocytes and C2C12 myotubes

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Asian Pacific Journal of Tropical Biomedicine 2020年第9期10卷 387-396页

作者： Benjamin Kingsley Harley rita Akosua Dickson Isaac Kingsley Amponsah robert A Ngala Dorice Berkoh Theophilus Christian fleischer Department of Pharmacognosy and Herbal Medicine School of PharmacyUniversity of Health and Allied SciencesHoGhana Department of Pharmacognosy Faculty of Pharmacy and Pharmaceutical SciencesCollege of Health SciencesKwame Nkrumah University of Science and TechnologyKumasiGhana Department of Molecular Medicine School of Medical SciencesCollege of Health SciencesKwame Nkrumah University of Science and TechnologyKumasiGhana Department of Basic and Applied Biology School of SciencesUniversity of Energy and Natural ResourcesSunyaniGhana

Objective:To investigate the in vivo and in vitro antidiabetic potential of Chrysophyllum ***:The effects of oral treatment with hydro-ethanolic extract(125,250 and 500 mg/kg)of the stem bark of Chrysophyllum albidum and glibenclamide for 21 d on glucose level,serum enzyme markers for liver function,lipid profile,total protein,serum urea,serum creatinine,and body weight were evaluated in experimental diabetic rats administered with 45 mg/kg of *** vitro assays including glucose uptake in C2 C12 cells and 3 T3-L1 adipose tissues,α-glucosidase andα-amylase inhibition were employed to evaluate the possible mechanism of hypoglycemic action of the *** and nitric oxide radical antioxidant activity of the extract was also ***:The increased levels of blood glucose,triglycerides,lowdensity lipoprotein,total cholesterol,serum aspartate,and alanine transaminases,creatinine,and urea in the diabetic animals were reduced significantly(Pr treatment with Chrysophyllum albidum *** decreased total protein and high-density lipoprotein concentrations were normalized after *** addition,the extract significantly(Preased the transport of glucose in 3 T3-L1 cells and C2 C12 myotubes and exhibited considerable potential to inhibitα-amylase andα-*** also demonstrated potent antioxidant action by scavenging considerably DPPH and nitric oxide ***:Chrysophyllum albidum stem bark extract exhibits considerable antidiabetic effect by stimulating glucose uptake and utilization in C2 C12 myotubes and 3 T3-L1 adipocytes as well as inhibiting the activities ofα-amylase andα-glucosidase.

关键词： Antidiabetic C2C12 myotubes α-glucosidase inhibition α-amylase inhibition Glucose uptake Chrysophyllum albidum