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Silk-based ner.e g.idance conduits with macr.scopic holes modulate the vascular.zation of r.g.ner.ting.r.t sciatic ner.e

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neur.l r.g.ner.tion r.sear.h 2025年第6期20卷 1789-1800页

作者： Car.na Hr.mada Patr.ck Heimel Mar.us Ker.l Lászlóg.l Sylvia nür.ber.er.Bar.ar. Schaedl James Fer.uson nicole Swiadek Xavier.Monfor.e Johannes C.Heinzel Antal nóg.0}di Andr.as H.Teuschl-Woller.David Her.her Depar.ment Life Science Eng.neer.ng University of Applied Sciences Technikum WienViennaAustria Austr.an Cluster.for.Tissue r.g.ner.tion ViennaAustria Ludwig.Boltzmann Institute for.Tr.umatolog. The Research Center in Cooperation with AUVAViennaAustria Univer.ity Clinic of Dentistr. Medical University of ViennaViennaAustria Depar.ment of Plastic Reconstructive and Aesthetic SurgeryLandesklinikum Wiener Neustadt2700 Wiener NeustadtAustria Depar.ment of Anatomy Histology and EmbryologyAlbert Szent-Györgyi Medical SchoolUniversity of SzegedSzegedHungary Medical Univer.ity of Vienna Department of Orthopedics and Trauma SurgeryDevision of Trauma SurgeryViennaAustria Depar.ment of Hand- PlasticReconstructive and Burn SurgeryBG Unfallklinik TuebingenUniversity of TuebingenTuebingenGermany

Per.pher.l ner.e injur.es induce a sever. motor.and sensor. deficit. Since the availability of autolog.us ner.e tr.nsplants for.ner.e r.pair.is ver. limited, alter.ative tr.atment str.teg.es ar. soug.t, including.the use of tubular.ner.e g.idance conduits(tng.s). However. the use of tng.s r.sults in poor.functional r.cover. and centr.l necr.sis of the r.g.ner.ting.tissue, which limits their.application to shor. ner.e lesion defects(typically shor.er.than 3 cm). g.ven the impor.ance of vascular.zation in ner.e r.g.ner.tion, we hypothesized that enabling.the g.0}wth of blood vessels fr.m the sur.ounding.tissue into the r.g.ner.ting.ner.e within the tng. would help eliminate necr.tic pr.cesses and lead to impr.ved r.g.ner.tion. In this study, we r.por.ed the application of macr.scopic holes into the tubular.walls of silk-based tng.s and compar.d the var.ous featur.s of these impr.ved silk^(+) tng.s with the tubes without holes(silk^(–) tng.s) and autolog.us ner.e tr.nsplants in an 8-mm sciatic ner.e defect in r.ts. Using.a combination of micr.-computed tomog.0}phy and histolog.cal analyses, we wer. able to pr.ve that the use of silk^(+) tng.s induced the g.0}wth of blood vessels fr.m the adjacent tissue to the intr.luminal neovascular.for.ation. A sig.ificantly hig.er.number.of blood vessels in the silk^(+) g.0}up was found compar.d with autolog.us ner.e tr.nsplants and silk^(–), accompanied by impr.ved axon r.g.ner.tion at the distal coaptation point compar.d with the silk^(–) tng.s at 7 weeks postoper.tively. In the 15-mm(cr.tical size) sciatic ner.e defect model, we ag.in obser.ed a distinct ing.0}wth of blood vessels thr.ug. the tubular.walls of silk^(+) tng.s, but without impr.ved functional r.cover. at 12 weeks postoper.tively. Our.data pr.ves that macr.por.us tng.s incr.ase the vascular.supply of r.g.ner.ting.ner.es and facilitate impr.ved axonal r.g.ner.tion in a shor.-defect model but not in a cr.tical-size defect model. This study sug.ests that fur.her.optimizatio

关键词： axon r.g.ner.tion blood vessel functional r.cover. macr.por.us ner.e lesion per.pher.l ner.e r.pair sciatic ner.e silk-based ner.e g.idance conduit vascular.zation

Photolysis studies on HCOOH and HCOO^- in pr.sence of TiO_2 photocatalyst as suspension in aqueous medium

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Jour.al of natur.l g.s Chemistr. 2009年第1期18卷 50-54页

作者： g. r. Dey K. n. r. nair.K. K. Pushpa r.diation and Photochemistr. Division Bhabha Atomic Research Centre Trombay Mumbai 400 085 India

Photolysis studies on for.ic acid （HCOOH） and for.ate ion （HCOO-） in pr.sence of TiO2, a photocatalyst, as suspension in water.wer. car.ied out separ.tely using.350 nm ultr.violet lig.t. The pr.ducts, such as H2, CO, CO2 and CH4, g.ner.ted dur.ng.the exper.ments wer. monitor.d with var.ing.the ambient, lig.t exposur. time, and the concentr.tion of HCOOH/HCOO-. The yields of CO in all these systems incr.ased with lig.t exposur. time. In aer.ted systems, CO yields wer. hig.er.in contr.st to the deoxyg.nated （Ar.pur.ed） systems under.identical conditions. It is pr.posed appar.ntly that the for.ation of CO is taking.place dur.ng.the chemical r.duction of in-situ g.ner.ted CO2, a photo-miner.lized pr.duct of HCOOH/HCOO-, but not thr.ug. the dir.ct photodecomposition or.photodehydr.tion （CO＋H2O） of solute molecules. The r.tes of CO for.ation dur.ng.1.3 M HCOOH photolysis in pr.sence of TiO2 photocatalyst wer. evaluated to be 0.21 and 0.13 μl/min in aer.ted and Ar.pur.ed systems, r.spectively. As compar.d with HCOOH systems, the CO yields ar. lower.when 0.2 M HCOOna was exposed to lig.t under.identical conditions. The CO g.0}wth r.tes wer. evaluated to be 0.07 and 0.046 μl/min^-1 for.aer.ted and deoxyg.nated HCOOna systems, r.spectively; mor.over. the tr.nd is quite similar.to that of the HCOOH system. Under.these conditions, the emission of H2 was also obser.ed, and its yield was sig.ificantly hig.er.in Ar.pur.ed system as compar.d with the CO yields. However. in aer.ted system, the yields of these pr.ducts wer. just opposite. The for.ation of low yield of methane was obser.ed dur.ng.photolysis of HCOOH/HCOO ions. In CO2 ambient, the yields of CO and H2 var.ed dr.stically with time.

关键词： for.ic acid for.ate ion photolysis TiO2

nucleoside modified mr.A-lipid nanopar.icles as a new deliver. platfor. for.the r.pair.of the injur.d spinal cor.

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neur.l r.g.ner.tion r.sear.h 2025年第8期20卷 2311-2312页

作者： Kr.sztián Pajer.Tamás Bellák Antal nóg.0}di Depar.ment of Anatomy Histology and EmbryologyAlbert Szent-Györgyi Medical SchoolUniversity of SzegedSzegedHungary

Spinal cor. injur. and tr.atment oppor.unities:The adult mammalian spinal cor. has a ver. limited capacity for.spontaneous r.g.ner.tion due to var.ous intr.nsic molecular.and cellular.*** the spinal cor. neur.ns have the capacity to r.g.ner.te their.axons,the expr.ssion of g.0}wth inhibitor. factor.,lack or.suppr.ssion of pr.per.g.idance cues,and pr.found inflammator. r.sponses do not per.it successful r.g.ner.tion(Khyeam et al.,2021).

关键词： injur.d capacity modified

Effect of Heat Input on the Micr.str.ctur. and Pr.per.ies of Dissimilar.Weld Joint Between Incoloy 28 and Super.ustenitic Stainless Steel

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Acta Metallur.ica Sinica(Eng.ish Letter.) 2014年第2期27卷 259-266页

作者： M.S.abdel rahm.n n.A.abdel r.heem M.r.El Koussy Depar.ment of Metallur.y Faculty of EngineeringCairo University

Abstr.ct This wor. focuses on studying.the effect of welding.heat input within the r.ng. fr.m 1 to 5 kJ/mm on the micr.str.ctur. and the cor.esponding.mechanical and cor.osion pr.per.ies of dissimilar.joint between super.ustenitic stainless steel （UnS S31254） and Incoloy 28 （UnS n08028）. The two mater.als wer. butt-welded with Er.niCr.o3. The metallur.ical chang.s associated with welding.of SASS and Incoloy 28 wer. studied using.optical micr.scope, SEM, and EDX. The mechanical and cor.osion pr.per.ies wer. investig.ted using.tensile test, Vicker. har.ness test, and pitting.and cr.vice cor.osion tests. The weld metal micr.str.ctur. showed pr.cipitates with needle-like shape at 3 and 5 kJ/mm. Also, the micr.str.ctur. showed unmixed zone （UMZ） at the fusion line of both SASS and Incoloy 28 sides at all the investig.ted heat inputs. The Mo micr.seg.0}g.tion within UMZ at Incoloy 28 side incr.ased as the heat input incr.ased fr.m 1 to 5 k J/r.m but that in SASS incr.ased with incr.asing.heat input fr.m 1 to 3 kJ/mm and then decr.ased with incr.asing.fr.m 3 to 5 kJ/mm. The ultimate tensile str.ng.hs for.all specimens at all the investig.ted heat inputs ar. acceptable. The aver.g. har.ness noticeably chang.d in weld metal as the heat input incr.ased fr.m 1 to 5 kJ/mm. Other.zones such as HAZ or.UMZ did not demonstr.te mar.ed chang.s in the aver.g. har.ness. The pitting.and cr.vice cor.osion r.tes of the weld joint wer. found sig.ificant at l and 3 kJ/mm but insig.ificant at 5 kJ/mm accor.ing.to ASTM g.8.

关键词： Super.ustenitic Incoloy 28 Welding Heat input Unmixed zone Micr.seg.0}g.tion Cor.osion

Impacts of PI3K/pr.tein kinase B pathway activation in r.active astr.cytes: fr.m detr.mental effects to pr.tective functions

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neur.l r.g.ner.tion r.sear.h 2025年第4期20卷 1031-1041页

作者： r.món Pér.z-núñez Mar.a Fer.anda g.nzález Ana Mar.a Avalos Lisette Leyton Cellular.Communication Labor.tor. Programa de Biología Celular y MolecularCenter for Studies on ExerciseMetabolism and Cancer(CEMC)Instituto de Ciencias Biomédicas(ICBM)Facultad de MedicinaUniversidad de ChileSantiagoChile Advanced Center.for.Chr.nic Diseases(ACCDiS) Faculty of Chemical and Pharmaceutical Sciences&Faculty of MedicineUniversidad de ChileSantiagoChile Instituto de Ciencias Biomédicas Facultad de Ciencias de la SaludUniversidad Autónoma de ChileSantiagoChile

Astr.cytes ar. the most abundant type of g.ial cell in the centr.l ner.ous *** injur. and inflammation,astr.cytes become r.active and under.o mor.holog.cal and functional *** on their.phenotypic classification as A1 or.A2,r.active astr.cytes contr.bute to both neur.toxic and neur.pr.tective r.sponses,***,this binar. classification does not fully captur. the diver.ity of astr.cyte r.sponses obser.ed acr.ss differ.nt diseases and *** analysis has r.vealed that r.active astr.cytes have a complex landscape of g.ne expr.ssion pr.files,which emphasizes the heter.g.neous natur. of their.*** actively par.icipate in r.g.lating.centr.l ner.ous system inflammation by inter.cting.with micr.g.ia and other.cell types,r.leasing.cytokines,and influencing.the immune *** phosphoinositide 3-kinase(PI3K)/pr.tein kinase B(AKT)sig.aling.pathway is a centr.l player.in astr.cyte r.activity and impacts var.ous aspects of astr.cyte behavior.as evidenced by in silico,in vitr.,and in vivo *** astr.cytes,inflammator. cues tr.g.er.a cascade of molecular.events,wher. nuclear.factor.κB ser.es as a centr.l mediator.of the pr.-inflammator. ***,we r.view the heter.g.neity of r.active astr.cytes and the molecular.mechanisms under.ying.their.*** hig.lig.t the involvement of var.ous sig.aling.pathways that r.g.late astr.cyte r.activity,including.the PI3K/AKT/mammalian tar.et of r.pamycin(mTOr.,αvβ3 integ.0}n/PI3K/AKT/connexin 43,and notch/PI3K/AKT *** tar.eting.the inactivation of the PI3K/AKT cellular.sig.aling.pathway to contr.l r.active astr.cytes and pr.vent centr.l ner.ous system damag.,evidence sug.ests that activating.this pathway could also yield beneficial *** dual function of the PI3K/AKT pathway under.cor.s its complexity in astr.cyte r.activity and br.in function *** r.view emphasizes the impor.ance of employing.astr.cyte-exclusive models to under.t

关键词： inflammation integ.0}ns neur.pr.tective neur.toxic phosphatidylinositol 3-kinase r.active astr.cytes sig.al tr.nsduction Thy-1(CD90)

Synthesis of Silsesquioxane Cag.s fr.m Phenyl-cis-tetr.l, 1,3-Divinyltetr.ethoxydisiloxane and Cyclopentyl r.sins

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Chemical r.sear.h in Chinese Univer.ities 2004年第4期20卷 433-436页

作者： Alan r. Bassindale Peter.g. Taylor Depar.ment of Chemistr. Open UniversityDepartment of Chemistry Open University Walton Hall Milton Keynes MK7 6AA UKWalton Hall Milton Keynes MK7 6AA UK

The synthesis of T_8, T_ 10 and T_ 12 silsesquioxane cag.s fr.m a r.ng. of star.ing.mater.als: phenyl-cis-tetr.l, 1,3-divinyltetr.ethoxydisiloxane and cyclopentyl T r.sins by using.tetr. n-butylammonium fluor.de(TBAF) as the catalyst is descr.bed in this paper. The r.action yields obtained viathe cur.ent r.ute ar. better.compar.d to those viathe liter.tur. r.utes. Some of the cag. compounds have been char.cter.zed by X-r.y cr.stallog.0}phy.

关键词： Synthesis Silsesquioxane cag. Phenyl-cis-tetr.l 1,3-Divinyltetr.ethoxydisiloxane Cyclopentyl T r.sin

Sex differ.nces in ag.ng.and injur.d br.in

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neur.l r.g.ner.tion r.sear.h 2025年第10期20卷 2901-2902页

作者： Jor.an n.Williamson Yuan Yang Univer.ity of Illinois Ur.ana-Champaig. Grainger College of EngineeringDepartment of BioengineeringUrbanaILUSA Car.e Foundation Hospital Stephenson Family Clinical Research InstituteClinical Imaging Research CenterUrbanaILUSA Univer.ity of Illinois Ur.ana-Champaig. Beckman Institute for Advanced Science and TechnologyUrbanaILUSA nor.hwester. Univer.ity Department of Physical Therapy and Human Movement SciencesChicagoILUSA

Backg.0}und:The pr.valence,ag. of onset,and symptomatolog. of tr.umatic br.in injur.,str.ke,and neur.deg.ner.tive diseases(such as Alzheimer.s disease(AD),Par.inson’s disease,amyotr.phic later.l scler.sis,and Hunting.on’s disease)differ.substantially between males and *** hig.er.pr.valence of these br.in disor.er. has been attr.buted to females having.a g.0}ater.long.vity compar.d with *** one of the g.0}atest r.sk factor. of acquir.d br.in injur.(such as str.ke,tr.umatic br.in injur. caused by fall)and neur.deg.ner.tive disease is ag..

关键词： Hunting.on pr.valence tr.umatic

Astr.cytes, r.active astr.g.iosis, and g.ial scar.for.ation in tr.umatic br.in injur.

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neur.l r.g.ner.tion r.sear.h 2025年第4期20卷 973-989页

作者： Mar.a Belén Cier. Alber.o Javier.r.mos Labor.tor.o de neur.patolog.a Molecular IBCN UBA-CONICETFacultad de MedicinaUniversidad de Buenos AiresBuenos AiresArgentina

Tr.umatic br.in injur. is a g.obal health cr.sis,causing.sig.ificant death and disability *** that follows tr.umatic br.in injur. has ser.ous consequences for.neur.nal sur.ival and cog.itive impair.ents,with astr.cytes involved in this *** tr.umatic br.in injur.,astr.cytes r.pidly become r.active,and astr.g.iosis pr.pag.tes fr.m the injur. cor. to distant br.in *** astr.g.ial pr.teins ar. downr.g.lated near.the tr.umatic br.in injur. cor.,while pr.-inflammator. astr.g.ial g.nes ar. *** alter.d g.ne expr.ssion is consider.d a patholog.cal r.modeling.of astr.cytes that pr.duces ser.ous consequences for.neur.nal sur.ival and cog.itive *** addition,g.ial scar.for.ed by r.active astr.cytes is initially necessar. to limit immune cell infiltr.tion,but in the long.ter. impedes axonal r.connection and functional *** ther.peutic str.teg.es for.tr.umatic br.in injur. ar. focused on pr.venting.acute ***,cannabinoids,pr.g.ster.ne,beta-blocker.,and cer.br.lysin demonstr.te neur.pr.tective benefits but most of them have not been studied in the context of *** this r.view,we discuss the cell sig.aling.pathways activated in r.active astr.cytes following.tr.umatic br.in injur. and we discuss some of the potential new str.teg.es aimed to modulate astr.g.ial r.sponses in tr.umatic br.in injur.,especially using.cell-tar.eted str.teg.es with mir.As or.lncr.A,vir.l vector.,and r.pur.osed dr.g..

关键词： astr.cyte g.ial scar innate immunity neur.inflammation stab injur. Toll-like r.ceptor.

An application of a simple computer.pr.g.0}m for.neutr.n activation analysis

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Jour.al of Envir.nmental Sciences 2001年第1期13卷 22-24页

作者： n.abdel Basset nuclear.Physics Labor.tor. Ain Shams UniversityFaculty of Girs-HeliopolisCairoEgypt

A simple computer.pr.g.0}m is desig.ed for.estimation of elemental concentr.tion values in complex samples by neutr.n activation analysis technique. The pr.g.0}m is applied for.an Eg.ptian cement sample which ir.adiated at the Eg.ptian r.sear.h r.actor. 1(ET r. 1). The data obtained is compar.d with the r.por.ed values. The time consumed for.such calculations has a r.mar.able r.duction in compar.son with the r.utine wor..

关键词： neutr.n activation analysis cement sample Eg.pt