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T cell responses in respiratory viral infections and chronic obstructive pulmonary disease

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Chinese Medical Journal 2021年第13期134卷 1522-1534页

作者： Shouxiong Huang Quan HE Linfu Zhou Department of Environmental and Public health Sciences University of Cincinnati College of MedicineImmunology Graduate ProgramCincinnati Children's HospitalCincinnatiOH 45249USA Department of Respiratory and Critical Care Medicine The First Affiliated HospitalNanjing Medical UniversityNanjingJiangsu 210029China

Respiratory viruses are major human pathogens that cause approximately 200 million pneumonia cases annually and induce various comorbidities with chronic obstructive pulmonary disease(COPD),resulting in significant health concerns and economic burdens.Clinical manifestations in respiratory viral infections and inflammations vary from asymptomatic,mild,to severe,depending on host immune cell responses to pathogens and interactions with airway epithelia.We critically review the activation,effector,and regulation of T cells in respiratory virus infections and chronic inflammations associated with COPD.Crosstalk among T cells,innate immune cells,and airway epithelial cells is discussed as essential parts of pathogenesis and protection in viral infections and COPD.We emphasize the specificity of peptide antigens and the functional heterogeneity of conventional CD4^(+) and CD8^(+) T cells to shed some light on potential cellular and molecular candidates for the future development of therapeutics and intervention against respiratory viral infections and inflammations.

关键词： Chronic obstructive pulmonary disease Coronavirus disease 2019 Inflammation Respiratory virus T cells

Application of Fourier transform ion cyclotron resonance mass spectrometry in molecular characterization of dissolved organic matter

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Science China Earth Sciences 2022年第12期65卷 2219-2236页

作者： Chen he Ding he Chunmao CheN quan SHI State Key Laboratory of heavy Oil Processing China University of PetroleumBeijing 102249China Department of Ocean Science and Hong Kong Branch of the Southern Marine Science and Engineering Guangdong Laboratory(Guangzhou) The Hong Kong University of Science and TechnologyHong Kong 999077China

Dissolved organic matter(DOM)plays an important role in the global carbon cycle,and an in-depth analysis of its chemical composition is fundamental to the study of its environmental and biogeochemical behavior and significance.DOM is a complex mixture of organic substances,and determining its molecular composition is a long-standing challenge in the field of analytical chemistry.The development and application of Fourier transform ion cyclotron resonance mass spectrometry(FT-ICR MS)has enabled the identification of the chemical composition of DOM at the molecular level.This paper summarizes progress made in the molecular characterization of DOM based on the FT-ICR MS technique,including DOM sample pretreatment methods,mass spectrometry ionization techniques,data acquisition,data processing and presentation,and molecular structure characterization.Focusing on the work done by the instrument at the State Key Laboratory of heavy Oil Processing in the China University of Petroleum,Beijing,we introduce applications of FT-ICR MS in the fields of earth science,environmental science and engineering,and look ahead to further research directions in the future.

关键词： Dissolved organic matter FT-ICR MS Molecular composition Recalcitrant dissolved organic matter High resolution mass spectrometry

Numerical Research on the Cold Start-up Strategy of a PEMFC Stack from-30℃

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Journal of Thermal Science 2023年第3期32卷 898-910页

作者： LEI Le he Pu he Peng TAO Wen-quan Shaanxi Collaborative Innovation Center for PEMFC Performance Improvement Key Laboratory of Thermal Fluid Science and Engineering of MOESchool of Energy and Power EngineeringXi’an Jiaotong UniversityXi'an 710049China

The cold start-up of the PEMFC(proton exchange membrane fuel cell)stack from sub-zero temperature is considered one of the significant obstacles to its expansive commercial applications.In the cold start-up process,with the progress of hydrogen/oxygen chemical reaction,the produced water will freeze into ice,occupying the pores of the porous electrode,thus leading to a rapid deterioration of output performance and even making the cold start-up fail.In this work,a one-dimensional numerical model is adopted to study a cold start-up process of the PMEFC stack starting from-30℃.The stepwise-changed current loading mode is employed in the process.An assisted preheating method is used to explore an optimal operating condition for a successful cold start-up.The numerical results are validated by comparing the numerical result with the experimental data in reference,and they agree with the experimental data very well.The results show that the optimal heating power in the studied range is 100 W.As the initial current slope increased,the current peak value increased,but the cold start-up process failed.Also,the start-up time and ice volume fraction are highly dependent on the initial current slope.The optimal initial current slope is 0.7 A/s.Besides,a higher initial current slope will cause a significant inner ohmic resistance.The resistance of CLa(catalyst layer of the anode)is the key and primary part of the total ohmic resistance.The details of the research and the analyzed results will help design the cold start-up strategy for the PEMFC stack start-up from-30℃.

关键词： cold start-up IPEMFCstack stepwise-changed current loading mode preheating

High-entropy intermetallics:from alloy design to structural and functional properties

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Rare Metals 2022年第6期41卷 1989-2001页

作者： Hang Wang quan-Feng he Yong Yang Department of Mechanical Engineering City University of Hong KongHong Kong 999077China Department of Materials Science and Engineering.City University of Hong Kong Hong Kong 999077China Department of Advanced Design and System Engineering.City University of Hong Kong Hong Kong 999077China

Conventional intermetallics are strong but brit-tle.However,multi-principal element intermetallics,also termed as high-entropy intermetallics(heIs)in the recent high-entropy alloy literature,are strong but malleable,some of which even show appreciable ductility and fracture toughness at room temperature.In this article,we provide a focused review on the recent researches on heIs,from the fundamentals,such as the concept of heIs,the formation rules to the structural and functional properties of heIs.The results hitherto reported clearly show that the heIs with distinct properties could be a promising material for future structural and functional applications.

关键词： Internetallics High-entropy alloys Phase formation Mechanical properties Functional properies

Thermal-force control ability under variation of electromagnetic stick structure parameters in RPECT

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Journal of Iron and Steel Research(International) 2024年第1期31卷 224-236页

作者： Ting-song Yang Wen-quan Sun Feng-shan Du An-rui he quan Yang National Engineering Research Center of Advanced Rolling and Intelligent Manufacturing University of Science and Technology BeijingBeijing100083China Institute of Engineering and Technology University of Science and Technology BeijingBeijing100083China College of Mechanical Engineering Yanshan UniversityQinhuangdao066004HebeiChina

Thermal-force driving of roll profile electromagnetic control technology(RPECT),which can be used to adjust the roll profile,can be affected by the sequential temperature rise between the electromagnetic stick(ES)and electromagnetic control roll.Due to the limited space of ES and induction coil,the cross-sectional area of induction coil can be inevitably affected by changing the size of the ES induction zone,which can further change the energy input under the same electromagnetic parameters,the temperature rising effect and the bulging ability.To investigate this phenomenon,the effects of the radius of the induction zone on the thermal-force contribution ratio,the heating ability of ES and the temperature distribution were analyzed through an electromagnetic-thermal-structural finite element model.To ensure that the results are applicable to RPECT,the thermal energy conversion ability and thermal-force roll crown control ability under different lengths of the induction zone were analyzed.It was found that whether the current density regulation mode or the current frequency regulation mode is adopted,the cases with 20 or 25 mm radius of the induction zone have the great thermal energy conversion ability and the good thermal-force roll crown control ability.The reasonable adjustment of the length of the induction zone can reduce the radius required for the maximum energy efficiency regulation.Combined with the results of the simulation analysis,the optimization of ES based on the control ability maximization requirement is achieved,which provides the base for the design and configuration of ES in RPECT.

关键词： Roll profile electromagnetic control technology Electromagnetic stick Electromagnetic control roll Induction area Thermal-force driving

Driver-Centric Velocity Prediction With Multidimensional Fuzzy Granulation

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IEEE/CAA Journal of Automatica Sinica 2023年第2期10卷 547-549页

作者： Ji Li quan Zhou Xu he Hongming Xu IEEE the Department of Mechanical Engineering University of BirminghamBirmingham B152TTUK

Dear Editor,This letter deals with a real-world problem regarding chaotic time series prediction, where a driver-centric velocity prediction model is presented for vehicle intelligent control and advanced driver assistance,i.e., multi-dimension fuzzy predictor. Inspired by fuzzy granulation technology, a finite-state Markov chain(MC) is reinforced to capture probabilities of the transitions between velocity and acceleration and present signals that vary in a continuous range.

关键词： letter acceleration chaotic

TSR:A User-friendly R Shiny Application for Assessment of Optimal Blood Product Selection in ABO-incompatible hematopoietic Stem Cell Transplantation

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当代医学科学(英文) 2023年第4期43卷 716-722页

作者： Juan WANG Lin-feng DENG quan ZHANG Lei he Department of Blood Transfusion Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China Department of Laboratory Medicine Hubei Provincial Hospital of Integrated Chinese&Western MedicineWuhan 430015China

Objective:Patients undergoing hematopoietic stem cell transplant(HSCT)need frequent transfusions,until their red blood cells(RBCs)and platelets start to recover.The safe transfusion for patients who receive ABO-incompatible HSCT is essential to the transplant process.To date,there is no user-friendly tool to choose the right blood product for transfusion treatment,despite the number of guidelines and expert advice on the subject.Methods:R/shiny is a powerful programming language for clinical data analysis and visualization.It can create interactive web applications that work in real-time.The web application named TSR was built using R programming,simplifying blood transfusion practice for ABO-incompatible HSCT witha one-click solution.Results:The TSR is divided into four main tabs.The home tab provides an overview of the application,while RBC,plasma and platelet transfusion tabs offer tailored suggestions for blood product selection in each category.Unlike traditional methods that rely on treatment guidelines and specialist consensus,TSR leverages the power of the R/Shiny interface to extract critical content based on user-specified parameters,providing an innovative approach to improve transfusion support.Conclusion:The present study highlights that the TSR enables real-time analysis,and promotes transfusion practice byoffering a unique and efficient one-key output for blood product selection to ABO-incompatible HSCT.TSR has the potential to become a widely-utilized tool for transfusion services,providing a reliable and user-friendly solution that enhances transfusion safety in clinical practice.

关键词： transfusion practice peripheral blood stem cell transplant transfusion risks

Real-Time Monitoring of Dynamic Chemical Processes in Microbial Metabolism with Optical Sensors

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Chinese Journal of Chemistry 2023年第15期41卷 1836-1840页

作者： Na Chen Di Cheng Tianpei he quan Yuan Institute of Molecular Medicine Renmin Hospital of Wuhan UniversityCollge of Chemistry and Molecular SciencesWuhan UniversityWuhanHubei 430072China Molecular Science and Biomedicine Laboratory(MBL) State Key Laboratory of Chemo/Biosensing and ChemometricsCollege of Chemistry and Chemical EngineeringHunan UniversityChangshaHunan 410082China

Monitoring microbial metabolism is vital for revealing the mechanism of disease related to microbial metabolism and providing guidance for biomanufacturing processes optimization.However,it remains a grand challenge to offer real-time insights into microbial metabolism owing to the complex and dynamic process.In this paper,the recent advances and prospects of optical biosensors including the organic,genetic coding and inorganic optical biosensors are briefly described for real-time monitoring of dynamic microbial metabolism.This paper points out that challenges remain in microbial heterogeneity.We believe that this work will inspire the application of developing new methods for single cell real-time analysis.

关键词： Real-time Microbial metabolism Dynamic Monitoring Optical biosensor

An efficient single atom catalysts Os/P_(3)C sheet for ammonia borane dehydrogenation

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Chinese Chemical Letters 2022年第6期33卷 3281-3286页

作者： Chaozheng he quan Zhang Jinrong Huo Ling Fu Shaanxi Key Laboratory of Optoelectronic Functional Materials and Devices School of Materials Science and Chemical EngineeringInstitute of Environment and Energy CatalysisXi’an Technological UniversityXi’an 710021China School of Sciences Xi’an Technological UniversityXi’an 710021China College of Resources and Environmental Engineering Tianshui Normal UniversityTianshui 741001China

Ammonia borane(NH_(3)BH_(3),AB)has been considered to be a promising chemical hydrogen storage material.Based on density functional theory,a series of transition metal atoms supported P_(3)C(P_(3)C_O)sheet is systematically investigated to screen out the most promising catalyst for dehydrogenation of AB.The results indicate that the Os/P_(3)C and Os/P_(3)C_O could be an efficient single atom catalyst(SACs)and the stepwise reaction pathway with free energy barrier of 2.07 and 1.54 e V respectively.Remarkably,the rate constant further quantitatively confirmed the real situation of the first step of dehydrogenation of AB on the Os/P_(3)C and Os/P_(3)C_O substrates.We found that k_(f1)at 400 K is equivalent to k_(f2)at 800 K,which greatly improves the temperature of the first step of AB dehydrogenation on P_(3)C_O.We hope this work can provide a promising method for the design of catalysts for AB dehydrogenation reactions on the surface of two-dimensional materials(2D).

关键词： Ammonia borane Two-dimensional materials Dehydrogenation Single atom catalyst Microkinetic model