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Anti-microtubule activity of the traditional Chinese medicine herb Northern Ban Lan(Isatis tinctoria)leads to glucobrassicin

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Journal of Integrative Plant Biology 2021年第12期63卷 2058-2074页

作者： Pingyin Guan Jianning Zhou Sergey Girel Xin Zhu Marian Schwab Kunxi Zhang qiyan wang-Müller Laurent Bigler Peter Nick Molecular Cell Biology Botanical InstituteKarlsruhe Institute of TechnologyFritz-Haber-Weg 4Karlsruhe 76131Germany Department of Chemistry University of ZürichWinterthurerstr.190CH-8057ZurichSwitzerland Research Institute of Organic Agriculture FiBL Ackerstrasse 113CH-5070FrickSwitzerland College of Horticulture China Agricultural UniversityBeijing 100193China Institute of Pharmaceutical Sciences of Western Switzerland University of GenevaRue Michel-Servet 1CH-1211Geneva 4Switzerland Swiss Chinese Herbal Medicine and Functional Food Innovation Center Mainaustrasse 21CH-8046ZurichSwitzerland

Traditional Chinese medicine(TCM)belongs to the most elaborate and extensive systems of plant-based *** herb Northern Ban Lan(Isatis tinctoria)is famous for its antiviral and anti-inflammatory *** numerous components isolated from *** have been characterized so far,their modes of action have remained ***,we show that extracts from *** exert antimicrotubular *** time-lapse microscopy in living tobacco BY-2(Nicotiana tabacum ***2)cellsexpressing greenfluorescentprotein-tubulin,weuse activity-guided fractionation to screen out the biologically active compounds of *** 54 fractions obtained from either leaves or roots of *** by methanol(MeOH/H_(2)O 8:2),or ethyl acetate extraction,one specific methanolic root fraction was selected,because it efficiently and rapidly eliminated *** combination of further purification with ultrahigh-performance liquid chromatography and high-resolution tandem mass spectrometry most of the bioactivity could be assigned to the glucosinolate compound *** can also affect microtubules and induce apoptosis in HeLa *** the light of these findings,the antiviral activity of Northern Ban Lan is discussed in the context of microtubules being hijacked by many viral pathogens for cell-to-cell spread.

关键词： anti-microtubule activity cytoskeleton glucobrassicin high-performance liquid chromatography(HPLC) high-resolution tandem mass spectrometry(HRMS/MS) Isatis tinctoria Northern Ban Lan traditional Chinese medicine(TCM)

DYNAMIC COHESIVENESS IN A COMMUNICATIVE ENGLISH CLASS

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Chinese Journal of Applied Linguistics 2001年第4期24卷 15-18页

作者： wang qiyan Fu Yanjun Northeast Normal University

One of the main features of a communicative English classis activities, organized by the teacher and conducted by studentsperforming certain functions and involving different topics. Theuse of activities has gained much attention. However, the linkbetween activities seems to have been ignored. This paper is anattempt to explore the role of cohesiveness between activities incommunicative teaching. The cohesiveness can be eithermechanical or dynamic. The key is that dynamic cohesivenesscontributes to the atmosphere and effectiveness of communicativeEnglish classroom teaching.

关键词： DYNAMIC COHESIVENESS IN A COMMUNICATIVE ENGLISH CLASS

Study of Water Flow in a Single Clay Crack

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Acta Geologica Sinica(English Edition) 1993年第4期67卷 443-451页

作者： Ge Zhonghua, Nanjing University, Nanjing, Jiangsu Fan Bingheng, Feng qiyan and wang Yonghong China University of Mining and Technology, Xuzhou, Jiangsu wang Xichuan Nanjing University Nanjing Jiangsu China

A model has been constructed to study water flow in a single clay crack, and a new concept of the critical rise rate of water level in the crack has been put forward. When the water level rises faster than this critical rate, the flow in a crack will increase, and vice versa. The flow in a crack is not in proportion to the water level. The maximium water flow in clay is 30-40 times smaller than that in a rock fissure under the same condition. In the process of water discharge, the flow in a crack will lessen gradually, and the crack will grow narrower by 3.0-4.0cm, with its depth reducing by over 50%.

关键词： clay crack water flow critical rise rate of water level expansion and collapse

Use of Qishen granule for the treatment of heart failure: A systematic review and meta-analysis of animal studies

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Journal of Traditional Chinese Medical Sciences 2020年第2期7卷 121-132页

作者： Junjie Liu Shuangjie Yang Wei wang Yili Zhang qiyan wang Xiaoli Sun Nannan Tan Kangjia Du Yong wang Huihui Zhao Dongzhimen Hospital Beijing University of Chinese MedicineBeijing100700China School of Traditional Chinese Medicine Beijing University of Chinese MedicineBeijing102488China School of Life Sciences Beijing University of Chinese MedicineBeijing102488China

Objective:To evaluate the effect of Qishen granule(QSG)on heart failure(HF)and the potential mechanisms involved in animal ***:Studies of QSG in animals with HF were identified by searches of eight databases up to August 1,*** authors independently reviewed each study and the Collaborative Approach to Metaanalysis and Review of Animal Data from Experimental Studies 10-item checklist was used for quality *** primary outcomes were indicators of left ventricular ejection fraction and/or left ventricular fractional *** secondary outcome measures were ventricular structure,hemodynamics,myocardial injury-related indicators,and the mechanisms whereby QSG ameliorates HF.A metaanalysis was performed and all the data were analyzed using RevMan 5.3 ***:Thirteen studies containing a total of 240 animals met the criteria for the *** quality score of the studies ranged from three to six *** meta-analysis showed a significant effect of QSG to improve cardiac function,inhibit ventricular remodeling,improve circulation,and attenuate myocardial *** possible mechanisms was identified to be suppression of the renin-angiotensinaldosterone system,which has anti-fibrotic,anti-apoptotic,anti-inflammatory,and anti-oxidative effects in the myocardium,the prevention of calcium overload,and the promotion of myocardial energy ***:Our review shows that QSG has a cardioprotective effect in animal models of ***,due to the relatively poor quality of the included studies and the differences between humans and animal models,the results should be interpreted with caution.

关键词： Qishen granule Heart failure Systematic review Animal model Traditional Chinese medicine

China's Human Rights Cause and Non-Governmental Organizations

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The Journal of Human Rights 2009年第6期8卷 15-18页

作者： wang qiyan JIANG ZHIQIANG Policy Research Center Ministry of Civil Affairs

Non-governmental organizations （NGOs） are a major force in promoting modern human rights cause. NGO plays an important and indispensable supplementary role in the system of human rights protection led by the government. In developing human rights, it is imperative to display the advantages of NGOs in protecting and developing the right to survival and development.

关键词： China’s Human Rights Cause and Non-Governmental Organizations NGO

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生态农业和有机农业的创新

中国生态农业学报（中英文） 2021年第3期29卷 423-430页

作者： Urs Niggli qiyan wang-Muller Helga Willer Jacques Fuchs Research Institute of Organic Agriculture(FiBL) Vienna A-1010Austria Research Institute of Organic Agriculture(FiBL) Frick CH-5070Switzerland Swiss Chinese Herbal Medicine and Functional Food Innovation Center(SwissHerbs) Zürich CH-8008Switzerland

现代农业系统在明显提高产量、保证粮食安全的同时,也对人类健康和地球的可持续性产生了影响。在持续不断的严重环境破坏和自然资源毁坏的背景下,建立可持续的农业生产方式至关重要。生态农业和有机农业是减少生态可持续性和生产力及社... 详细信息

现代农业系统在明显提高产量、保证粮食安全的同时,也对人类健康和地球的可持续性产生了影响。在持续不断的严重环境破坏和自然资源毁坏的背景下,建立可持续的农业生产方式至关重要。生态农业和有机农业是减少生态可持续性和生产力及社会可持续之间权衡关系的重要方法。这两种农业方法都属生态集约化范畴,均具有减少环境污染的巨大潜力;然而,生态农业和有机农业常导致产量降低。虽然产量降低带来的损失可以通过改变人们的饮食习惯来弥补(如减少食物浪费、减少食用精饲料喂养的肉类),但是,由于全球的发展趋势与之相反,因此本文探讨了通过科学研究寻求新的解决方案前景来提高低投入农业系统作物产量的可能性。为权衡生产力与可持续发展的关系,使生态农业和有机农业有助于粮食安全,我们对未来研究提出5点建议:1)农场和田地的景观设计与复合种植模式、2)数字化技术的应用、3)以农田低投入为目标的作物育种、4)农业废弃物的高质量循环利用和5)非化学作物保护。

关键词：生态农业生产力有机农业系统导向性研究

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国民时间资产和闲暇活动核算研究

统计研究 2000年第11期17卷 29-34页

作者：王琪延日本环日本海经济研究所

A preliminary research about people’s life on the measure of time is made in this *** the basis of predecessors’ researches,it puts forward the accounting concepts of people’s time asset and leisure activity\,accou... 详细信息

关键词：国民时间资产闲暇活动核算

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中国城市职工生活时间分配研究

统计研究 1998年第6期15卷 41-44页

作者：王琪延中国人民大学

对于如何认识时间，如何安排和利用时间，特别是闲暇时间，以改善人们的社会生活，促进人类的物质文明与精神文明建设，则是人类社会发展中的重要课题。我国城市职工的工作时间及闲暇时间的多寡，闲暇活动的丰富程度以及闲暇设施的满足... 详细信息

对于如何认识时间，如何安排和利用时间，特别是闲暇时间，以改善人们的社会生活，促进人类的物质文明与精神文明建设，则是人类社会发展中的重要课题。我国城市职工的工作时间及闲暇时间的多寡，闲暇活动的丰富程度以及闲暇设施的满足程度如何，特别是１９９２年“五一”...

关键词：中国城市职工生活时间分配

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外部不确定因素对我国旅游企业动态影响研究

旅游学刊 2020年第12期35卷 24-37页

作者：王琪延高旺中国人民大学统计学院北京100872

近年来,多种不确定事件频发给我国旅游业带来了不可预知的冲击。文章借助时变参数向量自回归模型,结合财务数据,分析了经济政策、地缘风险、金融压力3种不确定因素对我国旅游企业的动态影响。研究发现,经济政策不确定性对景区类企业影... 详细信息

近年来,多种不确定事件频发给我国旅游业带来了不可预知的冲击。文章借助时变参数向量自回归模型,结合财务数据,分析了经济政策、地缘风险、金融压力3种不确定因素对我国旅游企业的动态影响。研究发现,经济政策不确定性对景区类企业影响最大,特别是“非典”疫情带来的不确定性产生了长期显著的负向效应;地缘风险会对旅行社类企业造成明显的下行冲击,在近期趋于增强,而对景区和酒店类企业存在一定的正面影响;金融压力加剧会给景区和旅行社类企业带来较强的不良影响,金融压力缓和对两类企业发展有积极作用;高度不确定性事件爆发后,旅游企业会表现出明显的时变滞后响应,通常在1年以上。该研究结论有助于提高旅游业对不确定性因素的认识,同时也为如何应对复杂多变的外部环境提供政策启示。

关键词：旅游经济政策不确定性地缘风险金融压力时变参数向量自回归模型