Near infra-red light treatment of Alzheimer's disease
作者机构：Med-X Research Institute and School of Biomedical Engineering Shanghai Jiao Tong University1954 Huashan Road Shanghai 200030P.R.China Zhejiang BrainHealth Medical Technology Co.Ltd 332 Wangjiang RoadHangzhou 310002P.R.China Department of Neurosurgery General Hospital of PLA 28 Fuxing Road Beijing 100853P.R.China
出 版 物：《Journal of Innovative Optical Health Sciences》 (创新光学健康科学杂志（英文）)
年 卷 期：2018年第11卷第1期
页 面：57-64页
核心收录：
基 金：supported by grants awarded by the National Major Scientic Research Program of China(Grant No.2011CB910404) the National Nature Science Foundation of China(Grant No.61227017) the State Key Basic Research Development Program of China(2012CB518103) National Outstanding Young Scientist Award of China(61425006)
主 题：Alzheimer's disease near infra-red light transgenic mouse model Moris water maze immunofluorescence analysis
摘 要：Alzheimers disease(AD)is a chronic neurodegenerative *** symptoms include memoryand spatial learning dificulties,language disorders,and loss of motivation,which get worse overtime,eventually ending in *** ffective treatments are available for AD,*** only attenuate symptoms temporarily and are associated with severe side ***-red(NIR)light has been studied for a long *** investigated the effect of NIR on ADusing a transgenic mouse model,which was obtained by co-injecting two vectors carrying ADmutations in amyloid precursor protein(APP)and presenilin-i(PSEN1)into C57BL/6J *** irradiation equipment consisted of an accommodating box and an LED *** wave-length of NIR light emitted from LED was between 1040 nm and 1090 *** power densitydelivered at the level of the mice was approximately 15 mW/cm^(2),Firstly,we treated the micewith NIR for 40 days,Then,the irradiation was suspended for 28 ***,another 15 daystreatment was brought to *** conducted Morris water maze and immunofluorescenceanalysis to evaluate the effects of *** analysis was based on mea-suring the quantity of plaques in mouse brain slices,Our results show that NIR light improvesmemory and spatial learning ability and reduces plaques *** light represents apotential treatment for AD.
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