Use of Qishen granule for the treatment of heart failure: A systematic review and meta-analysis of animal studies

作     者：Junjie Liu Shuangjie Yang Wei Wang Yili Zhang Qiyan Wang Xiaoli Sun Nannan Tan Kangjia Du Yong Wang Huihui Zhao Junjie Liu;Shuangjie Yang;Wei Wang;Yili Zhang;Qiyan Wang;Xiaoli Sun;Nannan Tan;Kangjia Du;Yong Wang;Huihui Zhao

作者机构：Dongzhimen HospitalBeijing University of Chinese MedicineBeijing100700China School of Traditional Chinese MedicineBeijing University of Chinese MedicineBeijing102488China School of Life SciencesBeijing University of Chinese MedicineBeijing102488China 

出 版 物：《Journal of Traditional Chinese Medical Sciences》 (中医科学杂志（英文）)

年 卷 期：2020年第7卷第2期

页      面：121-132页

学科分类：1007[医学-药学(可授医学、理学学位)] 100506[医学-中医内科学] 1006[医学-中西医结合] 1005[医学-中医学] 1002[医学-临床医学] 10[医学] 100602[医学-中西医结合临床] 

基　　金：the National Natural Science Foundation of China(81973697) the National Key R&D Program of China(2017YFC1700102) 

主　　题：Qishen granule Heart failure Systematic review Animal model Traditional Chinese medicine 

摘      要：Objective:To evaluate the effect of Qishen granule(QSG)on heart failure(HF)and the potential mechanisms involved in animal ***:Studies of QSG in animals with HF were identified by searches of eight databases up to August 1,*** authors independently reviewed each study and the Collaborative Approach to Metaanalysis and Review of Animal Data from Experimental Studies 10-item checklist was used for quality *** primary outcomes were indicators of left ventricular ejection fraction and/or left ventricular fractional *** secondary outcome measures were ventricular structure,hemodynamics,myocardial injury-related indicators,and the mechanisms whereby QSG ameliorates HF.A metaanalysis was performed and all the data were analyzed using RevMan 5.3 ***:Thirteen studies containing a total of 240 animals met the criteria for the *** quality score of the studies ranged from three to six *** meta-analysis showed a significant effect of QSG to improve cardiac function,inhibit ventricular remodeling,improve circulation,and attenuate myocardial *** possible mechanisms was identified to be suppression of the renin-angiotensinaldosterone system,which has anti-fibrotic,anti-apoptotic,anti-inflammatory,and anti-oxidative effects in the myocardium,the prevention of calcium overload,and the promotion of myocardial energy ***:Our review shows that QSG has a cardioprotective effect in animal models of ***,due to the relatively poor quality of the included studies and the differences between humans and animal models,the results should be interpreted with caution.