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Machine learning aided design of perovskite oxide materials for photocatalytic water splitting

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Journal of Energy Chemistry 2021年第9期30卷 351-359页

作者： qiuling tao Tian Lu Ye Sheng Long Li Wencong Lu Minjie Li Department of Chemistry College of SciencesShanghai UniversityShanghai 200444China Materials Genome Institute Shanghai UniversityShanghai 200444China

Suffering from the inefficient traditional trial-and-error methods and the huge searching space filled by millions of candidates, discovering new perovskite visible photocatalysts with higher hydrogen production rate(RH_(2)) still remains a challenge in the field of photocatalytic water splitting(PWS). Herein, we established structural-property models targeted to RH_(2) and the proper bandgap(Eg) via machine learning(ML) technology to accelerate the discovery of efficient perovskite photocatalysts for PWS. The Pearson correlation coefficients(R) of leave-one-out cross validation(LOOCV) were adopted to compare the performances of different algorithms including gradient boosting regression(GBR), support vector regression(SVR), backpropagation artificial neural network(BPANN), and random forest(RF). It was found that the BPANN model showed the highest R values from LOOCV and testing data of 0.9897 and 0.9740 for RH_(2),while the GBR model had the best values of 0.9290 and 0.9207 for Eg. Furtherly, 14 potential PWS perovskite candidates were screened out from 30,000 ABO3-type perovskite structures under the criteria of structural stability, Eg, conduction band energy, valence band energy and RH_(2). The average RH_(2) of these14 perovskites is 6.4% higher than the highest value in the training data set. Moreover, the online web servers were developed to share our prediction models, which could be accessible in http://***/ocpmdm/material_api/ahfga3d9puqlknig(E_g prediction) and http://***/ocpmdm/material_api/i0 ucuyn3 wsd14940(RH_(2) prediction).

关键词： Perovskite Machine learning Online web service Photocatalytic water splitting Bandgap Hydrogen production rate

Correlation between the cumulative analgesic effect of electroacupuncture intervention and synaptic plasticity of hypothalamic paraventricular nucleus neurons in rats with sciatica

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Neural Regeneration Research 2013年第3期8卷 218-225页

作者： qiuling Xu tao Liu Shuping Chen Yonghui Gao Junying Wang Lina Qiao Junling Liu Hainan Medical University Institute of Acu-moxibustion China Academy of Chinese Medical Sciences

In the present study, a rat model of chronic neuropathic pain was established by ligation of the sciatic nerve and a model of learning and memory impairment was established by ovariectomy to investigate the analgesic effect of repeated electroacupuncture stimulation at bilateral Zusanfi （ST36） and Yanglingquan （GB34）. In addition, associated synaptic changes in neurons in the paraventricular nucleus of the hypothalamus were examined. Results indicate that the thermal pain threshold （paw withdrawal latency） was significantly increased in rats subjected to 2-week electroacupuncture intervention compared with 2-day electroacupuncture, but the analgesic effect was weakened remarkably in ovariectomized rats with chronic constrictive injury. 2-week electroacupuncture intervention substantially reversed the chronic constrictive injury-induced increase in the synaptic cleft width and thinning of the postsynaptic density. These findings indicate that repeated electroacupuncture at bilateral Zusanfi and Yanglingquan has a cumulative analgesic effect and can effectively relieve chronic neuropathic pain by remodeling the synaptic structure of the hypothalamic paraventricular nucleus.

关键词： neural regeneration acupuncture and moxibustion Chronic neuropathic pain electroacupuncture acupuncture analgesia cumulative effect synaptic plasticity hypothalamus learning and memory neurobiology grants-supported paper photographs-containing paper neuroregeneration

Energy beam-based direct and assisted polishing techniques for diamond:A review

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International Journal of Extreme Manufacturing 2024年第1期6卷 93-124页

作者： Zhuo Li Feng Jiang Zhengyi Jiang Zige Tian Tian Qiu tao Zhang qiuling Wen Xizhao Lu Jing Lu Hui Huang Institute of Manufacturing Engineering Huaqiao UniversityXiamen 361021People’s Republic of China School of Mechanical MaterialsMechatronic and Biomedical EngineeringUniversity of WollongongWollongongNSW 2522Australia College of Mechanical Engineering and Automation Huaqiao UniversityXiamen 361021People’s Republic of China State Key Laboratory of High Performance Tools Huaqiao UniversityXiamen 361021People’s Republic of China

Diamond is a highly valuable material with diverse industrial applications,particularly in the fields of semiconductor,optics,and high-power ***,its high hardness and chemical stability make it difficult to realize high-efficiency and ultra-low damage machining of *** address these challenges,several polishing methods have been developed for both single crystal diamond(SCD)and polycrystalline diamond(PCD),including mechanical,chemical,laser,and ion beam processing *** this review,the characteristics and application scope of various polishing technologies for SCD and PCD are ***,various energy beam-based direct and assisted polishing technologies,such as laser polishing,ion beam polishing,plasma-assisted polishing,and laser-assisted polishing,are *** current research progress,material removal mechanism,and infuencing factors of each polishing technology are *** some of these methods can achieve high material removal rates or reduce surface roughness,no single method can meet all the ***,the future development prospects and application directions of different polishing technologies are presented.

关键词： single crystal diamond polycrystalline diamond energy beam polishing technology material removal mechanism influencing factors

Clinical Benefit of Epidermal Growth Factor Receptor-Tyrosine Kinase Inhibitors Plus Radiotherapy for Epidermal Growth Factor Receptor-Mutated Metastatic Non-Small Cell Lung Cancer: A Retrospective Analysis on Real World Data

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肿瘤预防与治疗 2019年第5期32卷 385-394页

作者： Wang Ranlin Li tao Lv Jiahua Sun Chang Shi qiuling Department of Oncology The Affiliated Hospital of Southwest Medical UniversityLuzhou 646000SichuanChina Department of Radiation Oncology Sichuan Cancer Hospital & InstituteSichuan Cancer CenterSchool of MedicineUniversity of Electronic Science and Technology of ChinaChengdu 610041 China Department of Symptom Research The University of Texas MD Anderson Cancer Center1515 Holcombe Blvd. HoustonTexas 77030USA

Objective: To investigate the benefit of epidermal growth factor receptor( EGFR) tyrosine kinase inhibitors( TKIs)with radiotherapy in patients with EGFR mutation-positive metastatic non-small cell lung cancer( NSCLC),compared with TKIs ***: A total of 103 patients with stage Ⅳ EGFR-mutated NSCLC treated from February 2015 to May 2017 at Sichuan Cancer Hospital were analyzed retrospectively. Fifty patients were treated with EGFR-TKIs( gefitinib or erlotinib) plus radiotherapy( the TKI +RT group) and 53 patients received EGFR-TKIs alone( the TKI group). Tumor response,survival and toxicities were compared between the two groups. Results: Median follow-up time was 11. 7 months( 2. 8-36. 3 months). The overall response rate( ORR) and disease control rate( DCR) in the TKI + RT group vs the TKI group were 62% vs 37. 7%( P = 0. 014) and 88% vs 75. 5%( P =0. 101),respectively. The median progression-free survival( PFS) and median overall survival( OS) in the TKI + RT group were superior to those of the TKI group( 18. 87 months vs 12. 80 months,P = 0. 035 and 23. 10 months vs 18. 30 months,P = 0. 011). OS rates in the TKI + RT group and the TKI group were 56. 0% vs 35. 8% at year 1( P = 0. 04) and 16. 0% vs 3. 8% at year 2( P =0. 036). Multivariate Cox model found that TKI + RT related to significantly better OS( hazard ratio = 0. 209;95% CI,0. 066 to0. 661;P = 0. 008) than TKI alone. Adverse events did not differ significantly between the two groups( P > 0. 050). Conclusion:Compared with EGFR-TKIs alone,EGFR-TKIs combined with radiotherapy was well tolerated and showed benefit in tumor response and survival for EGFR mutation-positive metastatic NSCLC patients.

关键词： Radiotherapy Non-small cell lung cancer Epidermal growth factor receptor-tyrosine kinase inhibitor Effectiveness

Ultrasound diagnosis about branchial cyst in parotid

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International English Education Research 2014年第2期 97-100页

作者： Shi qiuling Hui Luo Yang Jiao tao Liu Jun Lu Second Affiliated Hospital of Jinan University (Shenzhen People's Hospital) Shenzhen Guangdong China

Study the audiovideo picture characteristic of gill slit and cyst in the parotid gland, canvass the diagnosis value of the supersound in this disease. Carry on comprehensive analysis to the audiovideo picture materials of cyst patient of gill slit in 39 parotid glands as diagnosed definitely by operation pathology. Divide into 3 kinds of types based on different echoes within gill slit and cyst in the parotid gland： Bag echo type, mixs echo type, real low echo type. Among them the number of ultrasonic suggestion is correct 28, accounts for 71.8%; Misdiagnose 11, accounts for 28.2%.Check and play an important role in diagnosis of this disease in conclusion supersound. Meanwhile, should improve the understanding of gill slit and cyst in mixing echo type and real low echo type parotid gland, in order to improve the correct rate of suggestion to these 2 kinds of types of the supersound.

关键词： Gill slit and cyst in parotid gland supersound diagnosed Picture dividing type of the audiovideo

健脾化湿法调控肝脏脂质输出基因甲基化治疗非酒精性脂肪性肝病的理论探讨

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临床肝胆病杂志 2019年第3期35卷 661-664页

作者：刘涛徐秋玲海南医学院海口571101

非酒精性脂肪性肝病(NAFLD)是糖尿病、心脑血管疾病最常见危险因素,随着生活水平提高,NAFLD患病率急剧上升。微粒体甘油三酯转移蛋白(MTP)是肝脏脂质向外转运的关键酶,MTP启动子甲基化水平增加,是NAFLD肝脏脂质沉积重要因素。中医认为... 详细信息

非酒精性脂肪性肝病(NAFLD)是糖尿病、心脑血管疾病最常见危险因素,随着生活水平提高,NAFLD患病率急剧上升。微粒体甘油三酯转移蛋白(MTP)是肝脏脂质向外转运的关键酶,MTP启动子甲基化水平增加,是NAFLD肝脏脂质沉积重要因素。中医认为“脾气散精”,MTP脂质转运功能可能是“脾气散精”的表现形式之一,临床研究表明,健脾化湿法是治疗NAFLD的重要原则。本文通过综述相关文章,分析健脾化湿法可能通过调控MTP启动子甲基化水平,提高NAFLD肝脏MTP水平,促进肝脏脂质外流,减轻NAFLD脂质沉积,达到改善NAFLD的作用。

关键词：非酒精性脂肪性肝病健脾化湿法 DNA甲基化脂蛋白类,LDL 综述

大黄素抑制NAFLD大鼠肝脏TLR4信号表达的研究

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中药新药与临床药理 2016年第2期27卷 201-205页

作者：刘涛徐秋玲赵岩海南医学院海南海口571101 厦门大学附属第一医院福建厦门361003

目的探讨大黄素改善非酒精性脂肪肝(NAFLD)大鼠模型肝脏脂质沉积的机制。方法大鼠随机分为正常对照组,NAFLD模型组,大黄素低、中、高(20,40,80 mg·kg^(-1))剂量组,每组8只。采用高脂诱导的方法建立NAFLD大鼠模型,采用HE染色法检测肝脏... 详细信息

目的探讨大黄素改善非酒精性脂肪肝(NAFLD)大鼠模型肝脏脂质沉积的机制。方法大鼠随机分为正常对照组,NAFLD模型组,大黄素低、中、高(20,40,80 mg·kg^(-1))剂量组,每组8只。采用高脂诱导的方法建立NAFLD大鼠模型,采用HE染色法检测肝脏病理变化,酶联免疫法检测血清TNF-α、IL-1含量,实时定量PCR法和免疫组化染色法检测TLR4信号的表达。结果 NAFLD组大鼠呈现典型的肝细胞脂滴空泡,部分肝细胞有单核细胞浸润,与正常对照组比较,血清TNF-α、IL-1增高(P<0.05),肝脏TLR4、My D88、TRAF-6的基因表达增高(P<0.05)。与NAFLD模型组比较,大黄素各剂量组对NAFLD大鼠肝脏脂滴空泡均有显著改善,抑制血清TNF-α、IL-1分泌(P<0.05),并抑制肝脏TLR4的表达(P<0.05),大黄素中、高剂量组抑制肝脏My D88和TRAF-6的表达(P<0.05)。结论大黄素改善NAFLD模型肝脏脂质沉积的机制与抑制肝脏TLR4信号有关。

关键词：非酒精性脂肪肝 TLR4信号炎性反应大黄素

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基于深度学习的面料密度回归预测

纺织高校基础科学学报 2024年第1期37卷 34-41页

作者：毋涛王娟车秋凌西安工程大学计算机科学学院陕西西安710600 安踏(中国)有限公司创新研发部福建晋江362200

在实际面料设计和质量检测过程中,人工检测面料密度通常需要耗费大量的时间与人力资源,效率十分低下。为了解决这一问题,提出一种基于深度学习的面料密度回归预测方法。首先,基于迁移学习在改进后的VGG19上进行训练,在卷积层后面加入自... 详细信息

在实际面料设计和质量检测过程中,人工检测面料密度通常需要耗费大量的时间与人力资源,效率十分低下。为了解决这一问题,提出一种基于深度学习的面料密度回归预测方法。首先,基于迁移学习在改进后的VGG19上进行训练,在卷积层后面加入自适应平均池化层使输入图像大小不受限制,在全连接层加入SVD矩阵分解来减少计算时间。其次,删除分类层,将全连接层的输出作为最终模型的输出结果。在训练过程中,选用均方差损失函数,以某纺织企业提供的面料为数据集,进行对比实验和结果分析。结果表明:提出的方法相较于传统方法更加智能化,其面料密度计算误差约为5%,准确率为95.5%,具有一定的可行性。

关键词：面料密度深度学习迁移学习回归预测 VGG19

Single-cell transcriptomic landscape of human blood cells

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National Science Review 2021年第3期8卷 42-52页

作者： Xiaowei Xie Mengyao Liu Yawen Zhang Bingrui Wang Caiying Zhu Chenchen Wang Qing Li Yingying Huo Jiaojiao Guo Changlu Xu Linping Hu Aiming Pang Shihui Ma Lina Wang Wenbin Cao Shulian Chen qiuling Li Sudong Zhang Xueying Zhao Wen Zhou Hongbo Luo Guoguang Zheng Erlie Jiang Sizhou Feng Lixiang Chen Lihong Shi Hui Cheng Sha Hao Ping Zhu tao Cheng State Key Laboratory of Experimental Hematology and National Clinical Research Center for Blood Diseases Institute of Hematology and Blood Diseases HospitalChinese Academy of Medical Sciences &Peking Union Medical College Center for Stem Cell Medicine and Department of Stem Cell & Regenerative Medicine Chinese Academy of Medical Sciences and Peking Union Medical College Cancer Research Institute School of Basic Medical Science Central South University School of Life Sciences Zhengzhou University

High throughput single-cell RNA-seq has been successfully implemented to dissect the cellular and molecular features underlying ***,an elaborate and comprehensive transcriptome reference of the whole blood system is ***,we profiled the transcriptomes of 7551 human blood cells representing 32 immunophenotypic cell types,including hematopoietic stem cells,progenitors and mature blood cells derived from 21 healthy *** high sequencing depth and coverage,we constructed a single-cell transcriptional atlas of blood cells(ABC) on the basis of both protein-coding genes and long noncoding RNAs(lncRNAs),and showed a high consistence between ***,putative lncRNAs and transcription factors regulating hematopoietic cell differentiation were *** common transcription factor regulatory networks were activated in neutrophils and monocytes,lymphoid cells dramatically changed their regulatory networks during ***,we showed a subset of nucleated erythrocytes actively expressing immune signals,suggesting the existence of erythroid precursors with immune ***,a web portal offering transcriptome browsing and blood cell type prediction has been ***,our work provides a transcriptional map of human blood cells at single-cell resolution,thereby offering a comprehensive reference for the exploration of physiological and pathological hematopoiesis.

关键词： human hematopoietic cells lncRNAs transcription factor single-cell RNA-seq