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Comparative study of the chitooligosaccharides effect on the proliferation inhibition and radiosensitization of three types of human gastric cancer cell line

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Asian Pacific Journal of Tropical Medicine 2016年第6期9卷 581-585页

作者： Yang Luo Liang deng qiu-ju deng Li Wen Department of Gastroenterology the First Affiliated Hospital of Chongqing Medical University Department of Genetics Beijing Cancer Hospital Department of Cardiology First Affiliated Hospital of Chongqing Medical University

Objective:To observe the chitooligosaccharides(COS) effect on the proliferation inhibition and radiosensitivity of three types of human gastric cancer cell ***:CCK-8 assay was employed to obtain the inhibition ratio of COS on BGC823 cells,MKN45 cells and SGC7901 cells at 48 h after treatment and the proliferation-inhibition curve was drawn with the inhibition ratio of COS on three types of *** clonogenic assay was used to detect the cell viability of 0,1,2,4,6 and 8 Gy(6 dose grades) in RAY group and RAY+COS group after X-ray,and the cell survival curve was used to analyze the sensitization enhancement ratio of *** cytometry was employed to detect cell cycle and apoptosis rate in control group,RAY group and RAY+COS group after 48 h ***:COS inhibited the proliferation of three types of *** inhibition rate was positively correlated with the concentration of COS,and the susceptibility of MKN45 cells,SGC7901 cells and BGC823 cells to COS decreased in *** cell viability decreased gradually with the increasing radiation dose in RAY group and RAY+COS group(P<0.01).The cell viabilities of RAY+COS group were lower than those of RAY group at all the dose grades under X-ray exposure(P<0.01),and the sensitization enhancement ratios of COS on BGC823 cells,MKN45 cells and SGC7901 cells were 1.06,1.28 and 1.15 *** controlled trials,apoptosis rate and percentage in the G_2/M phase of three types of cells in RAY+COS group were higher than those in control group and RAY group,and percentage in the S phase and the G_0/G_1 phase in RAY+COS group were lower than those in the other two groups(P<0.01).Conclusions:COS can inhibit the proliferation of three types of human gastric cancer cells and enhance the radiosensitivity by inducing apoptosis and G_2/M phase arrest.

关键词： Chitooligosaccharides Gastric cancer Radiotherapy radiosensitization Cell cycle Apoptosis

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Association of cardiometabolic multimorbidity with all-cause and cardiovascular disease mortality among Chinese hypertensive patients

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Journal of Geriatric Cardiology 2024年第2期21卷 211-218页

作者： Luo-Xi XIAO Zi-Yu WANG Jiang-Tao LI Hai-Mei WANG Yi-Ming HAO Pan ZHOU Yu-Lin HUANG qiu-ju deng Yong-Chen HAO Na YANG Li-Zhen HAN Zhao YANG Ping-Ping JIA Yue QI Jing LIU Center for Clinical and Epidemiologic Research Beijing Anzhen HospitalCapital Medical UniversityBeijing Institute of HeartLung and Blood Vessel DiseasesBeijing Municipal Key Laboratory of Clinical EpidemiologyBeijingChina

BACKGROUND Hypertension usually clusters with multiple ***,the association between cardiometabolic multimorbidity(CMM)and mortality in hypertensive patients is *** study aimed to investigate the association between CMM and all-cause and cardiovascular disease(CVD)mortality in Chinese patients with *** The data used in this study were from the China National Survey for Determinants of Detection and Treatment Status of Hypertensive Patients with Multiple Risk Factors(CONSIDER),which comprised 5006 participants aged 19–91 *** was defined as the presence of one or more of the following morbidities:diabetes mellitus,dyslipidemia,chronic kidney disease,coronary heart disease,and *** proportional hazard models were used to calculate the hazard ratios(HR)with 95%CI to determine the association between the number of CMMs and both all-cause and CVD *** Among 5006 participants[mean age:58.6±10.4 years,50%women(2509 participants)],76.4%of participants had at least one *** mortality rate was 4.57,4.76,8.48,and 16.04 deaths per 1000 person-years in hypertensive patients without any comorbidity and with one,two,and three or more morbidities,*** the fully adjusted model,hypertensive participants with two cardiometabolic diseases(HR=1.52,95%CI:1.09–2.13)and those with three or more cardiometabolic diseases(HR=2.44,95%CI:1.71–3.48)had a significantly elevated risk of all-cause *** findings were similar for CVD mortality but with a greater increase in risk *** In this study,three-fourths of hypertensive patients had *** with two or more comorbidities was associated with a significant increase in the risk of all-cause and cardiovascular mortality among hypertensive patients,suggesting more intensive treatment and control in this high-risk patient group.

关键词： hypertensive patients morbidity

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Constraining the Earth-mass Primordial Black Hole Mergers Model of the Non-repeating FRBs Using the First CHIME/FRB Catalog

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Research in Astronomy and Astrophysics 2024年第9期24卷 76-82页

作者： Min Meng qiu-ju Huang Can-Min deng Guangxi Key Laboratory for Relativistic Astrophysics School of Physical Science and TechnologyGuangxi UniversityNanning 530004China

In this paper,we upgrade the constraints for the Earth-mass primordial black hole mergers model based on the first Canadian Hydrogen Intensity Mapping Experiment(CHIME)/fast radio burst(FRB)*** the null hypothesis that the observed non-repeating FRBs originate from Earth-mass primordial black hole mergers,we find that how the charges were distributed in the primordial black hole population is well described by a double powerlaw function with typical charge value of law function with typical charge value of q_(c)/10^(-5)=1.60_(-0.28)^(+0.28),where the power-law index α_(1)=2.33_(-0.18)^(+0.15) for q

关键词： black hole physics (stars:)gamma ray burst:general (cosmology:)dark matter

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Impacts of Platform’s Omnichannel Coupons on Multichannel Suppliers

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Journal of Systems Science and Systems Engineering 2023年第1期32卷 71-99页

作者： Yue Zhang Xiaojian Hu ju Zhao ju qiu School of Management Hefei University of TechnologyHefei230009China Key Laboratory of Process Optimization and Intelligent Decision-Making Ministry of EducationHefei230009China

While coupons that can be redeemed only in online channels have been issued by e-commerce platforms for decades, a new type of platform’s coupons, i.e., omnichannel coupons, which can be redeemed in both online and store channels, is gaining popularity with the rise of the omnichannel retail mode. It is interesting to explore the conditions under which omnichannel coupons are more advantageous to platforms and multichannel suppliers that sell products through platforms and physical stores. Two game models are developed in two cases where an e-commerce platform offers single channel coupons or omnichannel coupons for a multichannel supplier. Two scenarios are considered: one in which a consumer’s valuation of a product that fits his or her need is homogeneous and another in which the valuation is heterogeneous. Equilibrium outcomes show that under the homogeneous scenario, the product price and coupon face value in both coupon modes increase with the product’s fit probability when the cross-selling revenue is high, while decrease with the product’s fit probability when the cross-selling revenue is low. However, under the heterogeneous scenario, the price in both modes increases with the product’s fit probability only when the supplier’s loss from returns is low and the cross-selling revenue is high, and the coupon face value always decreases with the product’s fit probability. Compared with single channel coupons, omnichannel coupons may lead to a higher product price under certain conditions. Furthermore, omnichannel coupons can lead to higher total demand and benefit both the platform and the supplier if and only if the product’s fit probability is low and the supplier’s loss from returns is high. An extension shows that the platform’s preference for omnichannel coupons is weakened when the supplier offers a partial refund policy.

关键词： Omnichannel coupon promotion e-commerce platform game theory

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ILC3-derived OX40L is essential for homeostasis of intestinal Tregs in immunodeficient mice

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Cellular & Molecular Immunology 2020年第2期17卷 163-177页

作者： Tian deng Caixia Suo Jiali Chang Rui Yang Jingyu Li Ting Cai ju qiu CAS Key Laboratory of Tissue Microenvironment and Tumor Shanghai Jiao Tong University School of Medicine(SJTUSM)&Shanghai Institutes for Biological Sciences(SIBS)Chinese Academy of Sciences(CAS)Shanghai 200031China CAS Key Laboratory of Tissue Microenvironment and Tumor Shanghai Institutes for Biological SciencesUniversity of Chinese Academy of SciencesChinese Academy of SciencesShanghai 200031China

OX40L is one of the co-stimulatory molecules that can be expressed by splenic lymphoid tissue inducer(Lti)cells,a subset of group 3 innate lymphoid cells(ILC3s).OX40L expression in subsets of intestinal ILC3s and the molecular regulation of OX40L expression in ILC3s are ***,we showed intestinal ILC3s marked as an OX40L high population among all the intestinal leukocytes and were the dominant source of OX40L in Rag1–/–*** ILC3 subsets expressed OX40L,and NCR–ILC3s were the most abundant source of *** expression of OX40L in ILC3s could be upregulated during *** addition to tumor necrosis factor(TNF)-like cytokine 1A(TL1A),which has been known as a trigger for OX40L,we found that Poly(I:C)representing viral stimulus promoted OX40L expression in ILC3s via a cell-autonomous ***,we demonstrated that IL-7-STAT5 signaling sustained OX40L expression by *** regulatory T cells(Tregs),most of which expressed OX40,had defective expansion in chimeric mice,in which ILC3s were specifically deficient for OX40L ***,co-localization of Tregs and ILC3s was found in the cryptopatches of the intestine,which suggests the close interaction between ILC3s and *** study has unveiled the crosstalk between Tregs and ILC3s in mucosal tissues through OX40–OX40L signaling,which is crucial for the homeostasis of intestinal Tregs.

关键词： Group 3 innate lymphoid cells OX40L Regulatory T cells Intestinal immunity

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Experimental Study on Mean Overtopping of Sloping Seawall Under Oblique Irregular Waves

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China Ocean Engineering 2017年第3期31卷 350-356页

作者： WANG deng-ting ju Lie-hong ZHU Jia-ling WANG Zhen SUN Tian-ting CHEN Wei-qiu Nanjing Hydraulic Research Institute Nanjing 210029 China College of Harbour Coastal and Offshore Engineering Hohai University Nanjing 210098 China

In this paper, domestic and abroad research progresses and related calculation formulae of the mean overtopping discharge are summarized. Through integral physical model experiments, the relation between the wave direction and the overtopping discharge on the top of the sloping dike is focused on and put into analysis and discussion; and a modified formula for mean overtopping discharges under oblique irregular waves is proposed. The study shows that the mean overtopping discharge generally goes down as the relative wave obliquity fl increases for a fixed measurement point and the mean overtopping discharge generally increases as the wave steepness H/L decreases （the cycle increases） for a fixed relative wave obliquity.

关键词： mean overtopping discharge oblique wave sloping dike

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On the stochastic dynamics of molecular conformation

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2007年第9期8卷 1401-1407页

作者： deng Mao-lin ZHU Wei-qiu Department of Mechanics State Key Laboratory of Fluid Power Transmission and Control Zhejiang University Hangzhou 310027 China

An important functioning mechanism of biological macromolecules is the transition between different conformed states due to thermal fluctuation. In the present paper, a biological macromolecule is modeled as two strands with side chains facing each other, and its stochastic dynamics including the statistics of stationary motion and the statistics of conformational transition is studied by using the stochastic averaging method for quasi Hamikonian systems. The theoretical results are confirmed with the results from Monte Carlo simulation.

关键词： Biological macromolecule Thermal fluctuation Stationary statistics Transition time Stochastic averaging method

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The Nonorientable Genus of the Join of Two Cycles

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Acta Mathematica Sinica,English Series 2013年第12期29卷 2305-2320页

作者： deng ju MA Han REN School of Sciences Nantong University Department of Mathematics East China Normal University

In this paper, we show that the nonorientable genus of Cm ＋ Cn, the join of two cycles Cm and Cn, is equal to [（（m-2）（n-2））/2] if m = 3, n ≡ 1 （mod 2）, or m ≥ 4, n ≥ 4, （m, n）（4, 4）. We determine that the nonorientable genus of C4 ＋C4 is 3, and that the nonorientable genus of C3 ＋Cn is n/2 if n ≡ 0 （mod 2）. Our results show that a minimum nonorientable genus embedding of the complete bipartite graph Km,n cannot be extended to an embedding of the join of two cycles without increasing the genus of the surface.

关键词： Surface nonorientable genus of a graph the join of two graphs

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Minor and Minimum Cycle Bases of a 3-connected Planar Graph

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Acta Mathematica Sinica,English Series 2009年第4期25卷 649-656页

作者： deng ju MA Han REN Department of Mathematics East China Normal University Shanghai 200241 P.R. China School of Science Nantong University Jiangsu Province Nantong 226007 P. R. China Department of Mathematics East China Normal University Shanghai 200241 P. R. China

In this paper, we prove that if any set of ｜E（G）｜- ｜V（G）｜＋ 1 facial cycles of a 3-connected planar graph G embedded in the plane doesn＇t form a minimum cycle base of G, then any minimum cycle base of G contains a separating cycle, and G has a minor isomorphic to T6, where T6 is the graph obtained from the complete graph K6 by deleting a path with four edges.

关键词： cycle space minimum cycle base 3-connected planar graph

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Investigation on Relationships among Deformation,Texture and Properties of TA16 Alloy Tube

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Journal of Materials Science & Technology 2001年第1期17卷 151-152页

作者： Weilu WU Zhentao YU ju deng Northwest institute for Nonferrous Metal Research P.O.Box 51 Xi’an 710016China

The relationships among the deformation, texture and properties of TA16 alloy tube were investigated, an optimum processing parameter was obtained. High Q (the ratio of reduction of diameter to reduction of wall thickness) values increase tensile, flaring properties and reduce flattening; high Q values increase tensile strength, flattening, flaring. and decrease tensile elonga. tion. The main circular textures of rolling tubes are basal (0001) and pyramidal {1015}, {1014}, {1013} etc., and the main axial textures are prism {1010} and pyramidal {1120}, {2131}, {2021} etc. under different Q and E values. There are greater changes in the grain size under different E values, compared with that under different Q values.

关键词： processing parameter tensile strength wall thickness grain size

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