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Urolithin A alleviates blood-brain barrier disruption and attenuates neuronal apoptosis following traumatic brain injury in mice

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Neural Regeneration Research 2022年第9期17卷 2007-2013页

作者： qiu-yuan gong Lin Cai Yao Jing Wei Wang Dian-Xu Yang Shi-Wen Chen Heng-Li Tian Department of Neurosurgery Shanghai Jiao Tong University Affiliated Sixth People’s HospitalShanghaiChina

Urolithin A(UA)is a natural metabolite produced from polyphenolics in foods such as pomegranates,berries,and *** is neuroprotective against Parkinson’s disease,Alzheimer’s disease,and cerebral ***,its effect against traumatic brain injury remains *** this study,we established adult C57BL/6J mouse models of traumatic brain injury by controlled cortical impact and then intraperitoneally administered *** found that UA greatly reduced brain edema;increased the expression of tight junction proteins in injured cortex;increased the immunopositivity of two neuronal autophagy markers,microtubule-associated protein 1A/B light chain 3A/B(LC3)and p62;downregulated protein kinase B(Akt)and mammalian target of rapamycin(mTOR),two regulators of the phosphatidylinositol 3-kinase(PI3K)/Akt/mTOR signaling pathway;decreased the phosphorylation levels of inhibitor of NFκB(IκB)kinase alpha(IKKα)and nuclear factor kappa B(NFκB),two regulators of the neuroinflammation-related Akt/IKK/NFκB signaling pathway;reduced blood-brain barrier permeability and neuronal apoptosis in injured cortex;and improved mouse neurological *** findings suggest that UA may be a candidate drug for the treatment of traumatic brain injury,and its neuroprotective effects may be mediated by inhibition of the PI3K/Akt/mTOR and Akt/IKK/NFκB signaling pathways,thus reducing neuroinflammation and enhancing autophagy.

关键词： autophagy blood-brain barrier cerebral edema controlled cortical impact model neuronal apoptosis neuropharmacology neuroprotection tight junction protein traumatic brain injury urolithin A

Potassium and calcium channels in different nerve cells act as therapeutic targets in neurological disorders

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Neural Regeneration Research 2025年第5期20卷 1258-1276页

作者： Qing qiu Mengting Yang Danfeng gong Haiying Liang Tingting Chen Department of Pharmacology School of PharmacyNantong UniversityNantongJiangsu ProvinceChina Jiangsu Province Key Laboratory of Inflammation and Molecular Drug Target NantongJiangsu ProvinceChina Department of Pharmacy Longyan First Affiliated Hospital of Fujian Medical UniversityLongyanFujian ProvinceChina

The central nervous system, information integration center of the body, is mainly composed of neurons and glial cells. The neuron is one of the most basic and important structural and functional units of the central nervous system, with sensory stimulation and excitation conduction functions. Astrocytes and microglia belong to the glial cell family, which is the main source of cytokines and represents the main defense system of the central nervous system. Nerve cells undergo neurotransmission or gliotransmission, which regulates neuronal activity via the ion channels, receptors, or transporters expressed on nerve cell membranes. Ion channels, composed of large transmembrane proteins, play crucial roles in maintaining nerve cell homeostasis. These channels are also important for control of the membrane potential and in the secretion of neurotransmitters. A variety of cellular functions and life activities, including functional regulation of the central nervous system, the generation and conduction of nerve excitation, the occurrence of receptor potential, heart pulsation, smooth muscle peristalsis, skeletal muscle contraction, and hormone secretion, are closely related to ion channels associated with passive transmembrane transport. Two types of ion channels in the central nervous system, potassium channels and calcium channels, are closely related to various neurological disorders, including Alzheimer's disease, Parkinson's disease, and epilepsy. Accordingly, various drugs that can affect these ion channels have been explored deeply to provide new directions for the treatment of these neurological disorders. In this review, we focus on the functions of potassium and calcium ion channels in different nerve cells and their involvement in neurological disorders such as Parkinson's disease, Alzheimer's disease, depression, epilepsy, autism, and rare disorders. We also describe several clinical drugs that target potassium or calcium channels in nerve cells and could be u

关键词： astrocytes calcium channels central nervous system extracellular ion concentration microglia neurological disorders neurons potassium channels

Recent progress on photoactive nonprecious transition-metal complexes

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Science China Chemistry 2025年第1期 46-95页

作者： Zhong-Liang gong Hong-Jie Zhang Yan Cheng Jianxun Liu Yuhan Ai Yaqin Li Zhihui Feng Qiong Zhang Shaolong gong Yong Chen Chang-Jiang Yao yuan-yuan Zhu Liang-Jin Xu Yu-Wu Zhong CAS Key Laboratory of Photochemistry Institute of Chemistry Chinese Academy of Sciences State Key Laboratory of Structural Cemistry Fujian Institute of Research on the Structure of Matter Chinese Academy of Sciences School of Chemistry and Chemical Engineering Anhui Key Laboratory of Advanced Catalytic Materials and Reaction EngineeringHefei University of Technology State Key Laboratory of Explosion Science and Safety Protection School of Mechatronical Engineering Beijing Institute of Technology College of Chemistry and Molecular Sciences Hubei Key Lab on Organic and Polymeric Optoelectronic Materials Wuhan University School of Chemistry and Chemical Engineering Anhui University Key Laboratory of Photochemical Conversion and Optoelectronic Materials & CAS-HKU Joint Laboratory on New Materials Technical Institute of Physics and Chemistry Chinese Academy of Sciences

Photoactive complexes of nonprecious transition metals, mainly including those in the first-row and partially the second-row of the Periodic table of elements, have received increasing attention in view of their low cost and long-term sustainability. They are recognized as promising alternatives to noble transition metal complex congeners that have been extensively studied in optoelectronic devices, artificial photosynthesis, photocatalysis, biodiagnostics, and therapeutics, etc. This review is devoted to a comprehensive summary on the classical and recent advances on photoactive nonprecious transition metal complexes, including photoactive Zr, V, Cr, Mo, and W complexes, Mn complexes and hybrids, Fe, Co, Ni, and Cu complexes, and Zn and Cd complexes and hybrids. A particular focus is given on the molecular design, modulation of photophysical and photochemical properties, and applications of the representative and lately-developed nonprecious metal complexes. In addition, a perspective on the future development in this field is provided at the end of this review.

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Molecule‑Level Multiscale Design of Nonflammable Gel Polymer Electrolyte to Build Stable SEI/CEI for Lithium Metal Battery

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Nano-Micro Letters 2025年第1期17卷 404-423页

作者： Qiqi Sun Zelong gong Tao Zhang Jiafeng Li Xianli Zhu Ruixiao Zhu Lingxu Wang Leyuan Ma Xuehui Li Miaofa yuan Zhiwei Zhang Luyuan Zhang Zhao Qian Longwei Yin Rajeev Ahuja Chengxiang Wang Key Laboratory for Liquid‑Solid Structural Evolution and Processing of Materials(Ministry of Education) School of Materials Science and EngineeringShandong UniversityJinan 250061People’s Republic of China Condensed Matter Theory Department of Physics and AstronomyUppsala UniversityUppsala 75120Sweden

The risk of flammability is an unavoidable issue for gel polymer electrolytes(GPEs).Usually,flameretardant solvents are necessary to be used,but most of them would react with anode/cathode easily and cause serious interfacial instability,which is a big challenge for design and application of nonflammable ***,a nonflammable GPE(SGPE)is developed by in situ polymerizing trifluoroethyl methacrylate(TFMA)monomers with flame-retardant triethyl phosphate(TEP)solvents and LiTFSI–LiDFOB dual lithium *** is strongly anchored to PTFMA matrix via polarity interaction between-P=O and-CH_(2)CF_(3).It reduces free TEP molecules,which obviously mitigates interfacial reactions,and enhances flame-retardant performance of TEP *** TEP molecules are also inhibited in solvation of Li^(+),leading to anion-dominated solvation sheath,which creates inorganic-rich solid electrolyte interface/cathode electrolyte interface *** coordination structure changes Li^(+)transport from sluggish vehicular to fast structural transport,raising ionic conductivity to 1.03 mS cm^(-1) and transfer number to 0.41 at 30℃.The Li|SGPE|Li cell presents highly reversible Li stripping/plating performance for over 1000 h at 0.1 mA cm^(−2),and 4.2 V LiCoO_(2)|SGPE|Li battery delivers high average specific capacity>120 mAh g^(−1) over 200 *** study paves a new way to make nonflammable GPE that is compatible with Li metal anode.

关键词： Anchoring effect Nonflammable gel electrolyte In situ cross-linked Electrode-electrolyte interface Li metal battery

Reconstruction characteristics of gut microbiota from patients with type 1 diabetes affect the phenotypic reproducibility of glucose metabolism in mice

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Science China Life Sciences 2025年第1期 176-188页

作者： Zhiyi Wang Mengxue gong yuanyuan Fang Huijuan yuan Chenhong Zhang State Key Laboratory of Microbial Metabolism School of Life Sciences and BiotechnologyShanghai Jiao Tong University Department of Endocrinology Henan Provincial People's HospitalPeople's Hospital of Zhengzhou University

The human microbiota-associated(HMA) mice model, especially the germ-free(GF)-humanized mice, has been widely used to probe the causal relationships between gut microbiota and human diseases such as type 1 diabetes(T1D). However, most studies have not clarified the extent to which the reconstruction of the human donor microbiota in recipient mice correlates with corresponding phenotypic reproducibility. In this study, we transplanted fecal microbiota from five patients with T1D and four healthy people into GF mice, and microbiota from each donor were transplanted into 10 mice. Mice with similar microbiota structure to the donor exhibited better phenotypic reproducibility. The characteristics of the microbial community assembly of donors also influenced the phenotypic reproducibility in mice, and individuals with a higher proportion of stochastic processes showed more severe disorders. Microbes enriched in patients with T1D had a stronger colonization potential in mice with impaired glucose metabolism, and microbiota functional features related to T1D were better reproduced in these mice. This indicates that assembly traits and colonization efficacy of microbiota influence phenotypic reproducibility in GF-humanized mice. Our findings provide important insights for using HMA mice models to explore links between gut microbiota and human diseases.

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Reducing Synchronization Cost for Single-Level Store in Mobile Systems

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Journal of Computer Science & Technology 2016年第4期31卷 836-848页

作者： yuan-Chao Xu Hu Wan Ke-Ni qiu Tao Li Wei-gong Zhang College of Information Engineering Capital Normal University Beijing 100048 China State Key Laboratory of Computer Architecture Institute of Computing Technology Chinese Academy of Sciences Beijing 100190 China Department of Electrical and Computer Engineering University of Florida Gainesville FL 32611 U.S.A.

Emerging byte-addressable non-volatile memory technologies, such as phase change memory （PCM） and spin- transfer torque RAM （STT-RAM）, offer both the byte-addressability of memory and the durability of storage, thus making it feasible to build single-level store systems. To ensure the consistency of persistent data structures in the presence of power failures or system crashes, it requires flushing cache lines to persistent memory frequently, thus incurring non-trivial synchronization overhead. To mitigate this issue, we propose two techniques. First, we use non-volatile STT-RAM as scratchpad memory on chip to store recovery information, thereby eliminating synchronization cost in the logging phase due to the avoidance of off-chip logging operations. Second, we present an adaptive synchronization policy based on caching modes in terms of data access patterns, thereby eliminating unnecessary synchronization cost in the checkpoint phase. Evaluation results indicate that the two techniques improve the overall performance from 2.15x to 2.39x compared with conventional transactional persistent memory.

关键词： crash consistency synchronization cost persistent memory power failure mobile system

Automatic Search of Threshold Implementations of 4-Bit S-Boxes Resisting DPA

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Chinese Journal of Electronics 2017年第1期26卷 93-100页

作者： LIU Bozhong gong Zheng qiu Weidong School of Information Security Shanghai Jiao Tong University School of Computer Science South China Normal University State Key Laboratory of Information Security Institute of Information Engineering Chinese Academy of Sciences

The threshold implementation method of Substitution box(S-box) has been proposed by Nikova et al. for resisting first-order Differential power attacks with glitches. To lower the time complexity for a threshold implementation of a specific non-linear function, one needs to decompose the function first and then search possible share methods for it. However, the time complexity for this search process is still non-trivial. In this paper, an effective method of searching threshold implementations of4-bit S-boxes is proposed. It mainly consists of two *** the decomposing stage, an efficient way of decomposing an S-box is introduced. For the sharing stage, the search complexity is lowered by the technique of time memory trade-off. As a result, threshold implementations of various lightweight block ciphers’ S-boxes are given. Moreover, our method is applied to each 4-bit involutive S-box and some candidates of threshold implementations are presented.

关键词： S-box Differential power attacks Threshold implementation Time memory trade-off

Substituent Effect on Infrared Spectra and Thermodynamic Properties of Polynitroamino Substituted Cyclopentane and Cyclohexane

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Chinese Journal of Chemical Physics 2008年第6期21卷 526-534页

作者： Ling qiu Xue-dong gong He-ming Xiao Institute for Computation in Molecular and Material Science School of Chemical Engineering Nanfing University of Science and Technology Nanjing 210094 China Key Laboratory of Nuclear Medicine Ministry of Health Jiangsu Institute of Nuclear Medicine Wuxi 214063 China

Density functional theory method was employed to study the effect of the nitroamino group as a substituent in cyclopentane and cyclohexane, which usually construct polycyclic or caged nitramines. Based on the optimized molecular structures of two groups of monocyclic nitramines at the B3LYP/6-31G^＊＊ level, the infrared （IR） spectra were obtained and assigned by harmonic vibrational analysis. The calculated results agree reasonably with the available experimental data. According to the principles of statistic thermodynamics, thermodynamic properties were derived from the IR spectra, which were linearly correlated with the number of nitroamino groups as well as the temperature. The contributions of nitroamino groups to thermodynamic properties are in accord with the group additivity.

关键词： Density functional theory Substituent effect Monocyclic nitramine Infrared spectrum Thermodynamic property

“劳淋病”古代中医药文献记载及现代治疗现状

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陕西中医 2025年第1期46卷 142-144,F0003页

作者：袁港龚学忠上海中医药大学附属市中医医院肾病科上海201401

“劳淋病”常因劳倦而发,迁延不愈,是临床常见难治性疾病,其现代医学病名对应的是复发性尿路感染。现代医学的主流治疗劳淋的抗生素疗法仍存在诸多局限性,中医药疗法历史悠久、潜力巨大、优势显著。本文通过整理中国古代关于淋证的记载... 详细信息

“劳淋病”常因劳倦而发,迁延不愈,是临床常见难治性疾病,其现代医学病名对应的是复发性尿路感染。现代医学的主流治疗劳淋的抗生素疗法仍存在诸多局限性,中医药疗法历史悠久、潜力巨大、优势显著。本文通过整理中国古代关于淋证的记载以及近年来中医药治疗劳淋的相关文献,从历代文献记载、现代医家对于劳淋的认识、中医验方、中医外治法等方面进行概括总结,对未来研究进行展望,以期为劳淋的临床治疗提供些许参考。

关键词：劳淋病复发性尿路感染肾虚湿热辨证论治外治法