Knockout of Sirt2 alleviates traumatic brain injury in mice

作     者：Wei Wang Qiu-Yuan Gong Lin Cai Yao Jing Dian-Xu Yang Fang Yuan Hao Chen Heng-Li Tian Wei Wang;Qiu-Yuan Gong;Lin Cai;Yao Jing;Dian-Xu Yang;Fang Yuan;Hao Chen;Heng-Li Tian

作者机构：Department of NeurosurgeryShanghai Jiao Tong University Affiliated Sixth People’s HospitalShanghai Jiao Tong UniversityShanghaiChina 

出 版 物：《Neural Regeneration Research》 (中国神经再生研究（英文版）)

年 卷 期：2023年第18卷第2期

页      面：350-356页

核心收录：

学科分类：1002[医学-临床医学] 100210[医学-外科学(含：普外、骨外、泌尿外、胸心外、神外、整形、烧伤、野战外)] 10[医学] 

基　　金：supported by the National Nature Science Foundation of China Nos.81671207 and 81974189(both to HLT) 

主　　题：blood-brain barrier caspase-1 cerebral edema neuroinflammation neuroprotection NLRP3 pyroptosis Sirt2 tightjunction protein traumatic brain injury 

摘      要：Sirtuin 2(SIRT2)inhibition or Sirt2 knocko ut in animal models protects against the development of neurodegenerative diseases and cerebral ***,the role of SIRT2 in traumatic brain injury(TBI)remains *** this study,we found that knockout of Sirt2 in a mouse model of TBI reduced brain edema,attenuated dis ruption of the blood-brain barrie r,decreased expression of the nucleotide-binding oligomerization domain-like receptor protein 3(NLRP3)inflammasome,reduced the activity of the effector caspase-1,reduced neuroinflammation and neuronal pyroptosis,and improved neurological *** kout of Sirt2 in a mechanical stretch injury cell model in vitro also decreased expression of the NLRP3 inflammasome and *** findings suggest that knockout of Sirt2 is neuro protective against TBI;***2 could be a novel to rget for TBI treatment.