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Guided bone regeneration in long-bone defect with a bilayer mineralized collagen membrane

Collagen and Leather 2024年第1期5卷 85-100页

作者： Fuli Peng Xuelei Zhang Yilei Wang Rui Zhao Zhiwei Cao Siyu Chen Yunxuan Ruan Jingjing Wu Tianxi Song Zhiye qiu Xiao Yang Yi Zeng Xiangdong zhu jian Pan Xingdong Zhang Department of Orthopedics West China HospitalOrthopedic Research InstituteSichuan University National Engineering Research Center for Biomaterials Sichuan University Chengdu Integrated TCM and Western Medicine Hospital Chengdu First People's Hospital Department of Inspection School of MedicineJiangsu University State Key Laboratory of Oral Diseases and National Center for Stomatology and National Clinical Research Center for Oral Diseases Department of Oral and Maxillofacial SurgeryWest China Hospital of StomatologySichuan University State Key Laboratory of New Ceramics and Fine Processing Key Laboratory of Advanced Materials of Ministry of EducationSchool of Materials Science and EngineeringTsinghua University

Bone regeneration for large,critical-sized bone defects remains a clinical challenge *** bone regeneration(GBR) is a promising technique for the repair of multiple bone defects,which is widely used in oral and maxillofacial bone defects but is still unsatisfied in the treatment of long bone ***,we successfully fabricated a bilayer mineralized collagen/collagen(MC/Col)-GBR membrane with excellent osteoinductive and barrier function by coating the MC particles prepared via in situ biomimetic mineralization process on one side of a sheet-like pure collagen *** aim of the present study was to investigate the physicochemical properties and biological functions of the MC/Col film,and to further evaluate its bone regeneration efficiency in large bone defect *** infrared spectra and X-ray diffraction patterns confirmed the presence of both hydroxyapatite and collagen phase in the MC/Col film,as well as the chemical interaction between *** microscope,scanning electron microscopy and atomic force microscope showed the uniform distribution of MC particles in the MC/Col film,resulting in a rougher surface compared to the pure Col *** quantitative analysis of surface contact angle,light transmittance and tensile strength demonstrated that the MC/Col film have better hydrophilicity,mechanical properties,light-barrier properties,*** vitro macrophage co-culture experiments showed that the MC/Col film can effectively inhibit macrophage proliferation and fusion, reducing fibrous capsule *** vivo bone repair assessment of a rabbit critical segmental radial defect proved that the MC/Col film performed better than other groups in promoting bone repair and regeneration due to their unique dual osteoinductive/barrier *** findings provided evidence that MC/Col film has a great clinical potential for effective bone defect repair.

关键词： Mineralized collagen Collagen Guided bone regeneration Artificial periosteum Bone defect repair

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Safety and efficacy of omalizumab for antihistamine-resistant chronic urticaria in children:a case series and literature review

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World Journal of Pediatrics 2024年第3期20卷 294-298页

作者： Wei-Fang zhu Chen Wang jian-Jun Qiao Lan-Juan Li Department of Dermatology First Affiliated HospitalZhejiang University School of MedicineHangzhou 310003China State Key Laboratory for Diagnosis and Treatment of Infectious Diseases National Clinical Research Center for Infectious DiseasesCollaborative Innovation Center for Diagnosis and Treatment of Infectious DiseasesThe First Affiliated HospitalZhejiang University School of MedicineHangzhou 310003China

Chronic urticaria(CU)is a common skin disease characterized by the occurrence of wheals,with or without angioedema,lasting more than 6 *** prevalence of CU is about 0.7%[1],but higher in children,with an incidence of 1.38%[1].The occurrence of severe pruritus and unpredictable wheals may severely impact patients'quality of life,cause psychological problems,including sleep disorders and depression,and lead to economic burden due to limitation on daily life and work[2,3].

关键词： edema prevalence children

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Individualized Traditional Chinese Medicine treatment vs antibiotics for recurrent urinary tract infections: a multicenter, randomized controlled study

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Journal of Traditional Chinese Medicine 2024年第3期44卷 524-529页

作者： GU Xiangchen qiu Meisi XIE Lin CHEN Min DENG Yueyi ZHANG Changming jian Guihua WANG Chen WANG Yi Department of Nephrology Yueyang Hospital of Integrated Traditional Chinese and Western Medicine Affiliated to Shanghai University of Traditional Chinese MedicineShanghai 200437China Department of Nephrology Rizhao Hospital of Traditional Chinese MedicineShanghai 200437China Department of Nephrology Longhua Hospital Affiliated to Shanghai University of Traditional Chinese MedicineShanghai200032China Department of Nephrology Shanghai Municipal Traditional Chinese Medicine Hospital Affiliated to Shanghai University of Traditional Chinese MedicineShanghai 200071China Department of Nephrology the Sixth People's Hospital Affiliated Shanghai Jiaotong UniversityShanghai 200233China Department of Nephrology Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese MedicineShanghai 201203China

OBJECTIVE: To systematically assess the effects of individualized Chinese medicines on recurrent urinary tract infections(rUTIs).METHODS: This study recruited 230 adult female patients in the remission phase of rUTIs from five hospitals in China. The patients were randomly allocated to two groups: an individualized Chinese medicine group(n = 114) and a control group(n = 116). Patients in the Chinese medicine group received individualized Chinese herbs, which were evaluated for syndrome *** in the control group received antibiotic treatment combined with a Chinese medicine placebo. The duration of treatment was three courses of four weeks each, with a three-month subsequent follow-up. UTI recurrence rate,Traditional Chinese Medicine(TCM) syndrome scores,36-item Short Form Survey(SF-36) score, and urine secretory immunoglobulin A(SIgA) were measured and analyzed before and after treatment in each group. RESULTS: Patients from the Chinese medicine group exhibited significant decreases in both short-and longterm UTI recurrence rates compared with the control group(P < 0.05). The changes in TCM syndrome scores between the Chinese medicine and control groups were significant(P < 0.05). The changes in the average SF-36 quality-of-life scores in the Chinese medicine group were also significantly higher than those in the control group after treatment(P < 0.05). The Chinese medicine group also demonstrated a significant increase in urine SIg A expression. CONCLUSION: Taken together, compared to the oftenused long-term antimicrobial prophylaxis during the remission stage of r UTIs, treating patients with an individualized Chinese medicine decoction by syndrome differentiation could effectively reduce the recurrence rate, improve the patients' TCM syndrome scores and quality of life, and enhance immunity, which in turn helps to prevent antibiotic resistance.

关键词： urinary tract infections medicine Chinese traditional syndrome differentiation quality of life immunoglobulin A secretory randomized controlled trial

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Effect of alumina occurrence form on metallurgical properties of hematite and magnetite pellets

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Journal of Iron and Steel Research International 2024年第4期31卷 797-809页

作者： jian Pan Chen-mei Tang Cong-cong Yang De-qing zhu Zheng-qi Guo Wei-qun Huang School of Minerals Processing and Bioengineering Central South UniversityChangsha 410083HunanChina Exploration and Development of Geology and Mineral Resources Co. Ltd.Nanchang 330030JiangxiChina

The effect of alumina occurrence form on the metallurgical properties of both hematite and magnetite pellets was investigated at the same Al_(2)O level of 2 wt.%,including reduction index(RI),low-temperature reduction disintegration index(RDI),reduction swelling index(RSI),and high-temperature softening-dripping *** mineralogy of fired pellets was also studied to reveal the influence of alumina occurrence form on the phase composition and *** the results,the alumina occurrence form presents tremendous impacts on the metallurgical perfor-mance of both magnetite and hematite *** of all alumina occurrence forms contributes to inferior reducibility of pellets,especially in the case of gibbsite for magnetite pellets with a RI of 58.4%and kaolinite for hematite pellets with a RI of 56.8%.However,addition of all alumina occurrence forms improves the RDI of magnetite pellets,while there is no significant difference among various alumina occurrence *** contrast,alumina occurrence forms have little influence on the RDI of hematite *** presence of free alumina,gibbsite,and kaolinite tends to improve the RSI of hematite and magnetite pellets,whereas hercynite gives the opposite trend with a RSI of 25.6%.For softening-dripping performance of magnetite pellets,all alumina occurrence forms contribute to narrower softening-melting ***,alumina,gibbsite,and kaolinite give narrower softening-dripping interval,at 229,217,and 88℃,respectively,whereas addition of hercynite results in the largest melting range at 276℃ due to its high melting *** hematite pellets,free alumina,gibbsite,and hercynite tend to enlarge melting range,whereas kaolinite contributes to lower dripping temperature of 1148℃ and narrow softening-dripping interval of 88℃ due to the formation of a greater amount of slag phase at high temperatures.

关键词： Oxidized pellet Magnetite Hematite Alumina occurrence form Metallurgical performance Blast furnace

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Butterfly taxonomic and functional diversity in the urban green spaces of Hefei city

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Journal of Forestry Research 2024年第5期35卷 47-62页

作者： Haicong Zeng Yan zhu Junyao Zhang Chenliang Li jian Zhang Hui Liu jianan Wang Dexian Zhao The College of Forestry and Landscape Architecture Anhui Agricultural UniversityHefei 230036People’s Republic of China Anhui Hefei Urban Ecosystem National Observation and Research Station Hefei 230036People’s Republic of China School of Urban Construction Anhui Xinhua UniversityHefei 230001People’s Republic of China

Urbanization has profound impacts on ecological environments. Green spaces are a vital component of urban ecosystems and play a crucial role in maintaining ecological balance and enhancing sustainability. This study aimed to investigate the community composition characteristics of butterflies in urban green spaces within the context of rapid urbanization. Simultaneously, it explored the status and differences in butterfly taxonomic diversity, functional diversity, and functional traits among different types of urban green spaces, regions, and urban gradients to provide relevant insights for further improving urban green space quality and promoting biodiversity conservation. We conducted a year-long survey of 80 green spaces across different urban regions and ring roads within Hefei City, Anhui Province, with monthly sampling intervals over 187 transects. A total of 4822 butterflies, belonging to 5 families, 17 subfamilies, 40 genera, and 55 species were identified. The species richness, Shannon, Simpson, functional richness, and Rao's quadratic entropy indices of butterflies in urban park green spaces were all significantly higher than those in residential and street green spaces(P < 0.05). Differences in butterfly diversity and functional traits among different urban regions and ring roads were relatively minor, and small-sized, multivoltine, and long flying duration butterflies dominated urban green spaces. Overall, these spaces offer more favorable habitats for butterflies. However, some residential green spaces and street green spaces demonstrate potential for butterfly conservation.

关键词： Urban green space planning Rapid urbanization Butterfly functional traits Green space types Urban biodiversity

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Electronic structures and Mott state of epitaxial TaS_(2) monolayers

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Science China(Physics,Mechanics & Astronomy) 2024年第5期67卷 91-97页

作者： Qichao Tian Chi Ding Xiaodong qiu Qinghao Meng Kaili Wang Fan Yu Yuyang Mu Can Wang jian Sun Yi Zhang National Laboratory of Solid State Microstructure School of PhysicsNanjing UniversityNanjing 20093China Collaborative Innovation Center of Advanced Microstructures Nanjing UniversityNanjing 210093China School of Physics and Electronic Sciences Changsha University of Science and TechnologyChangsha 410114China Hefei National Laboratory Hefei 230088China

Layered material TaS2hosts multiple structural phases and exotic correlated quantum states,including charge density wave(CDW),superconductivity,quantum spin liquid,and Mott insulating ***,we synthesized TaS_(2)monolayers in H and T phases using the molecular beam epitaxial(MBE)method and studied their electronic structures via angle-resolved photoemission spectroscopy(ARPES).We found that the H phase TaS_(2)(H-TaS_(2))monolayer is metallic,with an energy band crossing the Fermi *** contrast,the T phase TaS_(2)(T-TaS_(2))monolayer shows an insulated energy gap at the Fermi level,while the normal calculated band structure implies it should be metallic without any band ***,by considering Hubbard interaction potential U,further density functional theory(DFT)calculation suggests that monolayer T-TaS_(2)could be a CDW Mott insulator,and the DFT+U calculation matches well with the ARPES *** significantly,the temperature-dependent ARPES result indicates that the CDW Mott state in the T-TaS_(2)monolayer is more robust than its bulk counterpart and can persist at room *** results reveal that the dimensional effect can enhance the CDW Mott state and provide valuable insights for further exploring the exotic properties of monolayer TaS2.

关键词： temperature monolayer state

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Cell Mechanics Regulates the Dynamic Anisotropic Remodeling of Fibril Matrix at Large Scale

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Research 2024年第3期2023卷 401-415页

作者： Mingxing Ouyang Yanling Hu Weihui Chen Hui Li Yingbo Ji Linshuo qiu Linlin zhu Baohua Ji Bing Bu Linhong Deng Institute of Biomedical Engineering and Health Sciences School of Medical and Health Engineering and School of PharmacyChangzhou UniversityChangzhou213164China Institute of Biomechanics and Applications Department of Engineering MechanicsZhejang UniversityHangzhou310027China.

Living tissues often have anisotropic and heterogeneous organizations, in which developmental processes are coordinated by cells and extracellular matrix modeling. Cells have the capability of modeling matrix in long distance;however, the biophysical mechanism is largely unknown. We investigated the dynamic remodeling of collagen I (COL) fibril matrix by cell contraction with designed patterns of cell clusters. By considering cell dynamic contractions, our molecular dynamics simulations predicted the anisotropic patterns of the observed COL bundling in experiments with various geometrical patterns without spatial limitation. The pattern of COL bundling was closely related to the dynamic remodeling of fibril under cell active contraction. We showed that cell cytoskeletal integrity (actin filaments and microtubules), actomyosin contractions, and endoplasmic reticulum calcium channels acting as force generations and transductions were essential for fiber bundling inductions, and membrane mechanosensory components integrin and Piezo played critical roles as well. This study revealed the underlying mechanisms of the cell mechanics-induced matrix remodeling in large scales and the associated cellular mechanism and should provide important guidelines for tissue engineering in potential biomedical applications.

关键词： contraction Dynamic Matrix

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Breeding exceptionally fragrant soybeans for soy milk with strong aroma

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Journal of Integrative Plant Biology 2024年第4期66卷 642-644页

作者： Hongtao Xie Minglei Song Xuesong Cao Qingfeng Niu jianhua zhu Shasha Li Xin Wang Xiaomu Niu jian-Kang zhu Bellagen Biotechnology Co.Ltd. Jinan 250000China Institute of Advanced Biotechnology and School of Life Sciences Southern University of Science and TechnologyShenzhen 518055China School of Life Sciences Anhui Agricultural UniversityHefei 230036China Shandong Normal University Jinan 250000China

Soybean(Glycine max(L.)Merr.)is a major source of vegetable protein and oil in human diet and animal *** seeds have been extensively used in various food products and *** quality,particularly the aroma,affects cooking and eating,and ultimately influences consumer *** milk is particularly popular in China and has been gaining popularity in many other countries in the world.

关键词： exceptional soybean cooking

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An Optimized System of Random Forest Model by Global Harmony Search with Generalized Opposition-Based Learning for Forecasting TBM Advance Rate

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Computer Modeling in Engineering & Sciences 2024年第3期138卷 2873-2897页

作者： Yingui qiu Shuai Huang Danial Jahed Armaghani Biswajeet Pradhan Annan Zhou jian Zhou School of Resources and Safety Engineering Central South UniversityChangsha410083China School of Civil and Environmental Engineering University of Technology SydneyNew South WalesAustralia Centre for Advanced Modelling and Geospatial Information Systems School of Civil and Environmental EngineeringFaculty of Engineering and Information TechnologyUniversity of Technology SydneyNew SouthWalesAustralia Civil and Infrastructure Engineering Discipline School of EngineeringRoyal Melbourne Institute of Technology(RMIT)MelbourneVictoria3001Australia

As massive underground projects have become popular in dense urban cities,a problem has arisen:which model predicts the best for Tunnel Boring Machine(TBM)performance in these tunneling projects?However,performance level of TBMs in complex geological conditions is still a great challenge for practitioners and *** the other hand,a reliable and accurate prediction of TBM performance is essential to planning an applicable tunnel construction *** performance of TBM is very difficult to estimate due to various geotechnical and geological factors and machine *** previously-proposed intelligent techniques in this field are mostly based on a single or base model with a low level of ***,this study aims to introduce a hybrid randomforest(RF)technique optimized by global harmony search with generalized oppositionbased learning(GOGHS)for forecasting TBM advance rate(AR).Optimizing the RF hyper-parameters in terms of,e.g.,tree number and maximum tree depth is the main objective of using the GOGHS-RF *** the modelling of this study,a comprehensive databasewith themost influential parameters onTBMtogetherwithTBM AR were used as input and output variables,*** examine the capability and power of the GOGHSRF model,three more hybrid models of particle swarm optimization-RF,genetic algorithm-RF and artificial bee colony-RF were also constructed to forecast TBM *** of the developed models was performed by calculating several performance indices,including determination coefficient(R2),root-mean-square-error(RMSE),and mean-absolute-percentage-error(MAPE).The results showed that theGOGHS-RF is a more accurate technique for estimatingTBMAR compared to the other applied *** newly-developedGOGHS-RFmodel enjoyed R2=0.9937 and 0.9844,respectively,for train and test stages,which are higher than a pre-developed ***,the importance of the input parameters was interpreted through the SHapley Additive exPlanations(SHA

关键词： Tunnel boring machine random forest GOGHS optimization PSO optimization GA optimization ABC optimization SHAP

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Catalyst-free electrochemical S_(N)Ar of electron-rich fluoroarenes using carboxylic acids

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eScience 2024年第5期4卷 120-131页

作者： Anzai Shi Yaowen Liu Ranran Zhang Zile zhu Youai qiu State Key Laboratory and Institute of Elemento-Organic Chemistry Frontiers Science Center for New Organic MatterCollege of ChemistryNankai University94 Weijin RoadTianjin 300071China

Herein,an electrochemically driven catalyst-free nucleophilic aromatic substitution(S_(N)Ar)of electron-rich fluoroarenes with carboxylic acids as weak nucleophiles under mild conditions was reported.A series of highly valuable ester derivatives were obtained in a direct and rapid *** transformation features commercially available reagents and an exceptionally broad substrate scope with good functional group tolerance,using cheap and abundant electrodes and completed within a short reaction ***-scale synthesis and complex biorelevant compounds ligation further highlighted the potential utility of the *** mechanistic investigations and density functional theory(DFT)calculations verified the feasibility of the proposed pathway of this transformation.

关键词： Electrochemistry DefluorinationElectrochemical S_(N)Ar Catalyst-free process Carboxylic acids

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