Individualized Traditional Chinese Medicine treatment vs antibiotics for recurrent urinary tract infections: a multicenter, randomized controlled study

作     者：GU Xiangchen QIU Meisi XIE Lin CHEN Min DENG Yueyi ZHANG Changming JIAN Guihua WANG Chen WANG Yi GU Xiangchen;QIU Meisi;XIE Lin;CHEN Min;DENG Yueyi;ZHANG Changming;JIAN Guihua;WANG Chen;WANG Yi

作者机构：Department of NephrologyYueyang Hospital of Integrated Traditional Chinese and Western Medicine Affiliated to Shanghai University of Traditional Chinese Medicine Department of NephrologyRizhao Hospital of Traditional Chinese Medicine Department of NephrologyLonghua Hospital Affiliated to Shanghai University of Traditional Chinese Medicine Department of NephrologyShanghai Municipal Traditional Chinese Medicine Hospital Affiliated to Shanghai University of Traditional Chinese Medicine Department of Nephrologythe Sixth People's Hospital Affiliated Shanghai Jiaotong University Department of NephrologyShuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine 

出 版 物：《Journal of Traditional Chinese Medicine》 (中医杂志(英文版))

年 卷 期：2024年第44卷第3期

页      面：524-529页

核心收录：

学科分类：1006[医学-中西医结合] 1002[医学-临床医学] 100602[医学-中西医结合临床] 10[医学] 

基　　金：TCM Guidance Project of Shanghai Science and Technology Commission:Study on TCM Syndrome Differentiation and Treatment Scheme for Chronic Urinary Tract Infection (No. 13401904600) 

主　　题：immunoglobulin A, secretory medicine, Chinese traditional quality of life randomized controlled trial syndrome differentiation urinary tract infections 

摘      要：OBJECTIVE: To systematically assess the effects of individualized Chinese medicines on recurrent urinary tract infections(rUTIs).METHODS: This study recruited 230 adult female patients in the remission phase of rUTIs from five hospitals in China. The patients were randomly allocated to two groups: an individualized Chinese medicine group(n = 114) and a control group(n = 116). Patients in the Chinese medicine group received individualized Chinese herbs, which were evaluated for syndrome *** in the control group received antibiotic treatment combined with a Chinese medicine placebo. The duration of treatment was three courses of four weeks each, with a three-month subsequent follow-up. UTI recurrence rate,Traditional Chinese Medicine(TCM) syndrome scores,36-item Short Form Survey(SF-36) score, and urine secretory immunoglobulin A(SIgA) were measured and analyzed before and after treatment in each group. RESULTS: Patients from the Chinese medicine group exhibited significant decreases in both short-and longterm UTI recurrence rates compared with the control group(P 0.05). The changes in TCM syndrome scores between the Chinese medicine and control groups were significant(P 0.05). The changes in the average SF-36 quality-of-life scores in the Chinese medicine group were also significantly higher than those in the control group after treatment(P 0.05). The Chinese medicine group also demonstrated a significant increase in urine SIg A expression. CONCLUSION: Taken together, compared to the oftenused long-term antimicrobial prophylaxis during the remission stage of r UTIs, treating patients with an individualized Chinese medicine decoction by syndrome differentiation could effectively reduce the recurrence rate, improve the patients TCM syndrome scores and quality of life, and enhance immunity, which in turn helps to prevent antibiotic resistance.