Catalyst-free electrochemical S_(N)Ar of electron-rich fluoroarenes using carboxylic acids

作     者：Anzai Shi Yaowen Liu Ranran Zhang Zile Zhu Youai Qiu 

作者机构：State Key Laboratory and Institute of Elemento-Organic ChemistryFrontiers Science Center for New Organic MatterCollege of ChemistryNankai University94 Weijin RoadTianjin 300071China 

出 版 物：《eScience》 (电化学与能源科学（英文）)

年 卷 期：2024年第4卷第5期

页      面：120-131页

学科分类：081704[工学-应用化学] 08[工学] 0817[工学-化学工程与技术] 

基　　金：Financial support from National Key R&D Program of China(2022YFA1503200) National Natural Science Foundation of China(Grant No.22371149,22188101) the Fundamental Research Funds for the Central Universities(No.63223015) Frontiers Science Center for New Organic Matter,Nankai University(Grant No.63181206) Nankai University are gratefully acknowledged 

主　　题：Electrochemistry DefluorinationElectrochemical S_(N)Ar Catalyst-free process Carboxylic acids 

摘      要：Herein,an electrochemically driven catalyst-free nucleophilic aromatic substitution(S_(N)Ar)of electron-rich fluoroarenes with carboxylic acids as weak nucleophiles under mild conditions was reported.A series of highly valuable ester derivatives were obtained in a direct and rapid *** transformation features commercially available reagents and an exceptionally broad substrate scope with good functional group tolerance,using cheap and abundant electrodes and completed within a short reaction ***-scale synthesis and complex biorelevant compounds ligation further highlighted the potential utility of the *** mechanistic investigations and density functional theory(DFT)calculations verified the feasibility of the proposed pathway of this transformation.