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Adaptive Sensor-Fault Tolerant Control of Unmanned Underwater Vehicles With Input Saturation

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IEEE/CAA Journal of Automatica Sinica 2024年第4期11卷 907-918页

作者： Xuerao Wang qingling Wang Yanxu Su Yuncheng ouyang Changyin Sun the School of Artificial Intelligence the Engineering Research Center of Autonomous Unmanned System Technologyand the Anhui Provincial Engineering Research Center for Unmanned System and Intelligent TechnologyMinistry of EducationAnhui UniversityHefei 230601China the School of Automation Southeast UniversityNanjing 210096China

This paper investigates the tracking control problem for unmanned underwater vehicles(UUVs)systems with sensor faults,input saturation,and external disturbance caused by waves and ocean currents.An active sensor fault-tolerant control scheme is proposed.First,the developed method only requires the inertia matrix of the UUV,without other dynamic information,and can handle both additive and multiplicative sensor faults.Subsequently,an adaptive fault-tolerant controller is designed to achieve asymptotic tracking control of the UUV by employing robust integral of the sign of error feedback method.It is shown that the effect of sensor faults is online estimated and compensated by an adaptive estimator.With the proposed controller,the tracking error and estimation error can asymptotically converge to zero.Finally,simulation results are performed to demonstrate the effectiveness of the proposed method.

关键词： Asymptotic stability fault-tolerant control input saturation robust integral of the sign of error unmanned underwater vehicle

Space-confined microwave synthesis of ternary-layered BiOCl crystals with high-performance ultraviolet photodetection

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InfoMat 2020年第3期2卷 593-600页

作者： Lixing Kang Xuechao Yu Xiaoxu Zhao qingling ouyang Jun Di Manzhang Xu Dan Tian Weiliang Gan Calvin CIAng Shoucong Ning Qundong Fu Jiadong Zhou R.G.Kutty Ya Deng Pin Song Qingsheng Zeng Stephen J.Pennycook Jun Shen Ken-T.Yong Zheng Liu School of Materials Science and Engineering Nanyang Technological UniversitySingapore CINTRA CNRS/NTU/THALES Singapore Centre for OptoElectronics and Biophotonics School of Electrical and Electronic EngineeringNanyang Technological UniversitySingapore School of Physical and Mathematical Sciences Nanyang Technological UniversitySingapore Department of Materials Science and Engineering National University of SingaporeSingapore Chongqing Institute of Green and Intelligent Technology Chinese Academy of SciencesChongqingChina

In recent years,two-dimensional(2D)ternary materials have attracted wide attention due to their novel properties which can be achieved by regulating their chemical composition with a very great degree of freedom and adjustable space.However,as for the precise synthesis of 2D ternary materials,great challenges still lie ahead that hinder their further development.In this work,we demonstrated a simple and reliable approach to synthesize 2D ternary-layered BiOCl crystals through a microwave-assisted space-confined process in a short time(<3 minutes).Their ultraviolet(UV)detection performance was analyzed systematically.The photodetectors based on the as-obtained BiOCl platelets demonstrate high sensitivity to 266-nm laser illumination.The responsivity is calculated to be8 A/W and the response time is up to be18 ps.On the other hand,the device is quite stable after being exposed in the ambient air within 3 weeks and the response is almost unchanged during the measurement.The facile and fast synthesis of single crystalline BiOCl platelets and its high sensitivity to UV light irradiation indicate the potential optoelectronic applications of 2D BiOCl photodetectors.

关键词： 2D materials bismuth oxyhalide microwave synthesis UV photodetector

Aggregation-induced emission （ALE） dye loaded polymer nanoparticles for gene silencing in pancreatic cancer and their in vitro and in vivo biocompatibility evaluation

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Nano Research 2015年第5期8卷 1563-1576页

作者： Rui Hu Chengbin Yang Yucheng Wang Guimiao Lin Wei Qin qingling ouyang Wing-Cheung Law Quoc Toan Nguyen Ho Sup Yoon Xiaomei Wang Ken-Tye Yong Ben Zhong Tang School of Electrical and Electronic Engineering Nanyang Technological University Singapore 639798 Singapore The Engineering Lab of Synthetic Biology and the Key Lab of Biomedical Engineering School of Medicine Shenzhen University Shenzhen 518060 China Department of Chemistry The Hang Kong University of Science and Technology Clear Water Bay Kowloon Hang Kong China Department of Industrial and Systems Engineering The Hang Kong Polytechnic University Hung Ham Kowloon Hang Kong China Division of Structural Biology & Biochemistry School of Biological Sciences Nanyang Technological University Singapore 539798 Singapore

Comparing the regeneration potential between PLLA/Aragonite and PLLA/ Vaterite pearl composite scaffolds in rabbit radius segmental bone defects

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Bioactive Materials 2020年第4期5卷 980-989页

作者： Qianli Huang Yuansheng Liu Zhengxiao ouyang qingling Feng State Key Laboratory of Powder Metallurgy Central South UniversityChangsha410083PR China State Key Laboratory of New Ceramics and Fine Processing School of Materials Science and EngineeringTsinghua UniversityBeijing100084PR China Public Security College Northwest University of Political Science and LawXi'an710122PR China Department of Orthopedics The Second Xiangya HospitalCentral South UniversityChangsha410083PR China

Mussel-derived nacre and pearl,which are natural composites composed CaCO3 platelets and interplatelet organic matrix,have recently gained interest due to their osteogenic potential.The crystal form of CaCO3 could be either aragonite or vaterite depending on the characteristics of mineralization template within pearls.So far,little attention has been paid on the different osteogenic capacities between aragonite and vaterite pearl.In the current work,aragonite or vaterite pearl powders were incorporated into poly-L-lactic acid(PLLA)scaffold as bio-functional fillers for enhanced osteogenesis.In intro results revealed that PLLA/aragonite scaffold possessed stronger stimulatory effect on SaOS-2 cell proliferation and differentiation,evidenced by the enhanced cell viability,alkaline phosphatase activity,collagen synthesis and gene expressions of osteogenic markers including osteocalcin,osteopotin and bone sialoprotein.The bone regeneration potential of various scaffolds was evaluated in vivo employing a rabbit critical-sized radial bone defect model.The X-ray and micro-CT results showed that significant bone regeneration and bridging were achieved in defects implanted with composite scaffolds,while less bone formation and non-bridging were found for pure PLLA group.Histological evaluation using Masson's trichrome and hematoxylin/eosin(H&E)staining indicated a typical endochondral bone formation process conducted at defect sites treated with composite scaffolds.Through three-point bending test,the limbs implanted with PLLA/aragonite scaffold were found to bear significantly higher bending load compared to other two groups.Together,it is suggested that aragonite pearl has superior osteogenic capacity over vaterite pearl and PLLA/aragonite scaffold can be employed as a potential bone graft for bone regeneration.

关键词： Composite scaffold Aragonite Vaterite Segmental bone defect Bone regeneration

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奥马珠单抗治疗中重度哮喘的初步临床观察

中华结核和呼吸杂志 2021年第7期44卷 611-618页

作者：吴鹏辉董聪谢佳星张筱娴刘杰欧阳铭马健娟黄伟华欧昌星李靖张清玲广州医科大学附属第一医院国家呼吸医学中心国家呼吸系统疾病临床医学研究中心呼吸疾病国家重点实验室广州呼吸健康研究院呼吸与危重症医学科510120 广州医科大学附属第一医院国家呼吸医学中心国家呼吸系统疾病临床医学研究中心呼吸疾病国家重点实验室广州医科大学附属第一医院变态反应科510120

目的:探讨奥马珠单抗在中国真实世界临床实践中治疗中重度哮喘的疗效、安全性及管理特点。方法:回顾性分析2018年3月至2020年4月在广州医科大学附属第一医院接受奥马珠单抗治疗至少4个月的中重度哮喘患者79例,男30例,女49例,年龄14~76岁... 详细信息

目的:探讨奥马珠单抗在中国真实世界临床实践中治疗中重度哮喘的疗效、安全性及管理特点。方法:回顾性分析2018年3月至2020年4月在广州医科大学附属第一医院接受奥马珠单抗治疗至少4个月的中重度哮喘患者79例,男30例,女49例,年龄14~76岁,中位年龄50岁。比较患者治疗前后的临床表现、血嗜酸性粒细胞计数、呼出气一氧化氮(FeNO)、肺功能、口服糖皮质激素剂量及不良反应等。两两前后比较采用配对t检验或非参数配对Wilcoxon分析,组间比较用非参数独立样本Mann-Whitney分析,计数资料组间比较采用卡方检验或Fisher检验分析。结果:奥马珠单抗治疗4个月后,哮喘患者哮喘控制评分(ACT)从17.0(13.0,19.0)分升至20.0(18.0,24.0)分(P<0.001);急性发作次数从1.0(0,1.0)次/4个月减至0(0,1.0)次/4个月(P<0.001);呼气峰流速(PEF)变异率从16.5(13.8,27.3)%降低至10.4(6.0,16.2)%(P<0.001);PEF占预计值%从71.7(51.4,91.6)%升高至87.5(65.2,105.5)%(P<0.001);FEV 1占预计值%从73.6(53.9,90.8)%升高至80.6(68.7,91.8)%(P=0.007);口服糖皮质激素(OCS)维持剂量从12.0(10.0,20.0)mg/d减至5.0(0,17.5)mg/d(P=0.001)。治疗总体应答率达74.7%,其中过敏性哮喘治疗应答率(77.3%)较非过敏性哮喘(25.0%)高(P=0.019)。5例完成1年期治疗资料显示,治疗1年后ACT评分、急性发作次数、PEF占预计值%、PEF变异率及OCS维持剂量较治疗前仍有改善。共有3例(3.8%)患者共发生不良反应3次(0.6%)。分层分析显示,奥马珠单抗治疗4个月后,达到推荐治疗剂量(足剂量)组ACT评分改善程度及PEF变异率下降程度[3.0(1.0,8.0)分,6.5(3.5,15.8)%]均较未达到推荐治疗剂量(不足剂量)组[1.0(-0.3,3.0)分,2.9(1.5,5.0)%]明显,差异均有统计学意义(P<0.05),且足剂量组治疗应答率(80.0%)较不足剂量组(50.0%)高(P=0.019)。治疗有效但治疗时间不足1年停药的主要原因为经济因素(70.3%),其次是患者认为症状已改善不需继续用药(21.9%)及疗效不及预期(7.8%)。结论:应用奥马珠单抗治疗中重度过敏性哮喘,初步观察具有良好疗效,不良反应少。足剂量组治疗应答率更高。经济因素是奥马珠单抗治疗有效但治疗时间不足1年停药的主要原因。

关键词：哮喘治疗学奥马珠单抗