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Endovascular treatment of acute M1 occlusions due to underlying intracranial atherosclerotic severe stenosis

Chinese Neurosurgical Journal 2022年第4期8卷 215-220页

作者： Yazhou Yan Li Du Xiliang He qinghai huang Yuan Pan Tao Xin Stroke Center of 971 Hospital of PLA Qingdao 266071China Department of Neurosurgery of Changhai Hospital affiliated to the Naval Military Medical University ShanghaiChina

Background:Endovascular treatment(EVT)for acute ischemic stroke with an occlusion of the M1 segment due to intracranial atherosclerotic severe stenosis(ICASS)remains *** study aimed to evaluate the safety and efficacy of EVT for ICASS-related M1 acute ***:We retrospectively reviewed all patients with an ICASS-related M1 acute occlusion who underwent EVT at our institution between January 2015 and December *** presentation,baseline characteristics,angiographic and clinical results,technical feasibility,perioperative complications,and follow-up results were ***:Twenty-two patients with ICASS-related M1 acute occlusion were *** patients(36.4%)received bridging therapy,and the other 14 patients(63.6%)directly underwent *** patients(68.2%)treated with balloon dilations and stenting as rescue *** patients(27.3%)received single balloon angioplasty,and 5 of these patients were treated with staged *** case(4.5%)failed recanalization at the first EVT,and successful revascularization was achieved a month *** mean procedure time was 67.2±20.8 *** revascularization(mTICI≥2b)was achieved in 95.5%(21/22)of *** complications developed in two patients(9.1%)including one hemorrhagic event and one thromboembolic *** follow-up was available in 20 patients(90.9%)at an average of 8.6±3.0 *** degree of stenosis was worse(10-30%)in 6 cases(30%)compared with the initial *** favorable outcomes(mRS≤2)at 3-month follow-up was achieved in 19 patients(86.4%).Conclusions:ICASS-related occlusion in the M1 segment often required a rescue therapy including balloon angioplasty with/without stenting,and this treatment strategy was safe and *** single balloon angioplasty at the first EVT generally cannot achieve satisfactory results and often needed staged stenting treatment.

关键词： Endovascular treatment M1 occlusion Intracranial severe stenosis Rescue therapy

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Morphological predictors of posterior communicating artery aneurysms rupture

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Translational Neuroscience and Clinics 2015年第2期1卷 86-91页

作者： Nan Lv Yibin Fang Ying Yu Jinyu Xu Jianmin Liu qinghai huang Department of Neurosurgery Changhai HospitalSecond Military Medical University

Objective: The conflicting findings of previous morphological studies on intracranial aneurysm rupture may be caused by the different locations of aneurysms. We aimed to determine the independent risk factors of aneurysm rupture by focusing on only posterior communicating artery(Pcom A) aneurysms. Methods: In 89 PcomA aneurysms(58 ruptured, 31 unruptured), clinical and morphological characteristics were compared between the ruptured and unruptured groups. Multivariate logistic regression analysis was performed to determine the independent predictors for the rupture status of PcomA aneurysms. Results: In univariate analyses, the aneurysm dome size, aspect ratio, size ratio,dome‐to‐neck ratio, and inflow angle were significant parameters. With multivariate analyses, only the aneurysm dome size and inflow angle were significantly associated with the rupture status of PcomA aneurysms. Conclusions: Morphology was related with rupture of PcomA aneurysms. The aneurysm dome size and inflow angle were found to be the independent parameters characterizing the rupture status of PcomA aneurysms.

关键词： intracranial aneurysm posterior communicating artery rupture morphology

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侨批:中国信用文化之珍品

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征信 2013年第10期31卷 1-5页

作者：晏露蓉黄清海中国人民银行福州中心支行福建福州350001 中国银行福建省分行福建福州350001

2013年6月19日,由福建、广东两省联合推荐、国家档案局申报的"侨批档案"成功入选《世界记忆名录》。侨批是海外华侨寄给国内眷属的书信与汇款的合称。侨批业盛行于19世纪中期,直至20世纪70年代末归口银行管理,历时150余年。侨批具有国... 详细信息

2013年6月19日,由福建、广东两省联合推荐、国家档案局申报的"侨批档案"成功入选《世界记忆名录》。侨批是海外华侨寄给国内眷属的书信与汇款的合称。侨批业盛行于19世纪中期,直至20世纪70年代末归口银行管理,历时150余年。侨批具有国际汇兑工具、流通货币载体、个人信用产品等金融属性。侨批"银信合一"的特征,使其不同于一般的金融产品,它是富有情感的金融产品,蕴含着忠义孝悌的中华传统文化价值。同时,侨批业经营者坚守"见利不忘义、灵活要守信"的经商原则,体现了信义经商的传统文化价值。侨批是中华民族,更是世界的记忆遗产,它所体现的信用文化和精神值得我们永久记忆和传承。

关键词：侨批档案侨批业金融属性信用文化世界记忆遗产

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AMD3100 accelerates reendothelialization of neointima formation in rabbit saccular aneurysm after flow diverter treatment

AMD3100 accelerates reendothelialization of neointima format...

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第十三届中国医师协会神经外科医师年会

作者： Zifu Li Xinggen Fang Jiahao Zhou Guoquan Jiang Rui Zhao qinghai huang Jianmin Liu Neurosurgery Department Changhai HospitalSecond Military Medical University Neurosurgery Department Yijishan Hospital

Purpose To investigate the role of AMD3100 that acts as an antagonist of SDF-1/CXCR4 in the neointima repair in rabbit saccular aneurysm after flow diverter（FD）*** and Methods Saccular aneurysm models of New Zealand White Rabbits were established by using porcine pancreatic *** weeks later,FDs of Tubridge were implanted into the saccular aneurysm *** the treated models were divided into two groups:AMD3100 group was subcutaneously injected with AMD3100 5 mg/kg per day,while control group was injected with *** and four weeks after FD treatment,morphology and thickness of the neointima were investigated by using hard tissue section and masson trichrome ***,scanning electron microscope（SEM）was used to detect the number of endothelial-like cells and fluorescence quantitative PCR was used to determine mRNA expression level of molecular biomarkers of the neointima,such as KDR,VE-cadherin,CD34,*** At two and four weeks after FD treatment,SEM results showed that AMD3100 group had more endothelial-like cells than that in control group in the *** trichrome staining showed that the intima in the AMD3100 group was more intact than that in the control ***,the PCR results demonstrated the increased m RNA expression level of KDR,VE-cadherin,Tie2 in the neointima in AMD3100 group compared with control *** Interval use of AMD3100 promotes the neointima repair of rabbit saccular aneurysm and facilitates the endothelialization of the neointima after FD treatment.

关键词： AMD3100 endothelial-like cells flow diverter treatment saccular aneurysm rabbit

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LncRNA NR＿120420 Promotes Apoptosis after Acute Cerebral Infarction by Regulating NF-κB

LncRNA NR＿120420 Promotes Apoptosis after Acute Cerebral In...

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第十三届中国医师协会神经外科医师年会

作者： Chunou Tian Zifu Li Lei Zhang Dongwei Dai qinghai huang Jianmin Liu Bo Hong Department of Neurosurgery Changhai HospitalSecond Military Medical University Department of Neurosurgery Number 422 Hospital of PLA

Objectives:Stroke is seriously harmful to the patient and has a huge impact on *** stroke accounts for 80% of all *** effect of current drug treatment for acute cerebral infarction is not *** study intends to explore whether the two lncRNAs candidates from our previous study(NR20420 and lnc-GCH1-2:3)regulate apoptosis after cerebral infarction and the specific mechanisms by which they exert regulatory ***:1,Co-expression analysis was performed with the lncRNAs microarray of our previous study,followed by functional prediction and pathway prediction;2,The changes of lncRNAs candidate in SH-SY5 Y cells were detected by quantitative PCR after they were treated with oxygen glucose deprivation(OGD)for 0,4,8,12 hours and reperfused for 24 hours after OGD for 4,8,12 hours *** changes of corresponding lncRNAs in SH-SY5 Y cells were detected by quantitative PCR after they were transfected with the designed six si RNAs respectively;3,The cell models were established by OGD for 8 hours after they were transfected with the four siRNAs with the qualified knockdown *** cell viability of them was measured by CCK8 assay,and the apoptosis of them was detected by TUNEL staining and flow cytometry analysis;*** changes of protein expression of p-P65,p65,p-ERK,ERK,p-AKT and AKT were detected by Western blotting after knockdown of NR20420;5,The cell models were treated with and without PDTC after they were transfected with *** the cell viability and apoptosis of them was ***:1,GO analysis showed the differentially expressed lncRNAs after acute cerebral infarction mainly involved the negative regulation of NF-κB transcription factor activity and the positive regulation of programmed cell *** analysis showed that they mainly involved apoptosis;2,The expression of these two lncRNAs candidate in OGD-treated cells *** expression was highest after OGD for 8 hours and then gradually d

关键词： Acute Cerebral Infarction apoptosis NF-κB lncRNA NR120420

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Elevated expression of Two Circulating LncRNAs predicts poor prognosis for acute Cerebral Infarction

Elevated expression of Two Circulating LncRNAs predicts poor...

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第十三届中国医师协会神经外科医师年会

Objectives:Stroke would bring a heavy burden on individuals and *** and accurate diagnosis could improve the treatment effect of acute cerebral infarction(ACI).Cerebral infarction still lacked reliable *** a few studies had shown that peripheral whole blood lncRNAs expression had the potential to be biomarkers of cerebral *** study aimed to explore the relationship between lncRNAs expression and the classification,prognosis of ***:Differentially expressed lncRNAs in the peripheral whole blood from the acute cerebral infarction patients were identified using microarray and the selected lncRNAs were further verified by quantitative polymerase chain reaction(qPCR).Lastly,the clinical outcome evaluated by 3-month modified Rankin Score(mRS),stroke classification classified by Oxford Community Stroke Project(OCSP)criteria,and the expression characteristics of specific lncRNAs were analyzed in ACI ***:The microarray analysis screened out 5686 differentially expressed *** of them,nine selected lncRNAs verified by qPCR,the expression levels of NR20420 and lnc-GCH1-2:3 in the ACI group were significantly higher than that in the healthy volunteers(HVT)*** operating characteristic(ROC)analysis showed that the sensitivity and specificity of NR20420 were 85.7% and 84.6% in patients with total anterior circulation infarction(TACI)respectively,while the sensitivity and specificity of lnc-GCH1-2:3 were 85.7% and 82.1%.Multivariate logistic regression showed that NR20420 was a significantly independent diagnostic factor for ***,the elevated expression levels of NR20420 and lnc-GCH1-2:3 were also associated with the poor prognosis of ***:Our study clearly illustrated that the elevated expression levels of circulating NR20420 and lnc-GCH1-2:3 could predict the stroke classification with high sensitivity and specificity and the poor prognosis of patients with ACI.

关键词： Acute Cerebral Infarction long non-coding RNAs biomarker neurobiology

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The biology of bone morphogenetic protein signaling pathway in cerebrovascular system

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Chinese Neurosurgical Journal 2021年第4期7卷 281-288页

作者： Haishuang Tang Xiaoxi Zhang Gaici Xue Fengfeng Xu Qingsong Wang Pengfei Yang Bo Hong Yi Xu qinghai huang Jianmin Liu Qiao Zuo Department of Neurosurgery Changhai HospitalNaval Military Medical University168 Changhai RoadShanghai 200433People’s Republic of China Naval Medical Center of PLA Naval Military Medical UniversityShanghai 200050People’s Republic of China Department of Cardiology the First Medical CentreChinese PLA General HospitalBeijing 100853People’s Republic of China

Bone morphogenetic protein belongs to transcription growth factor superfamilyβ;bone morphogenetic protein signal pathway regulates cell proliferation,differentiation,and apoptosis among different *** system supplies sufficient oxygen and blood into brain to maintain its normal *** disorder of cerebrovascular system will result into serious cerebrovascular diseases,which is gradually becoming a major threat to human health in modern *** recent decades,many studies have revealed the underlying biology and mechanism of bone morphogenetic protein signal pathway played in cerebrovascular *** review will discuss the relationship between the two aspects,aiming to provide new perspective for non-invasive treatment and basic research of cerebrovascular diseases.

关键词： Bone morphogenetic protein Hemodynamic Neovascularization Cerebrovascular diseases

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Treatment delay from aneurysmal subarachnoid hemorrhage to endovascular treatment:a high-volume hospital experience

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Chinese Neurosurgical Journal 2021年第4期7卷 258-264页

作者： Xiaoxi Zhang Haishuang Tang Qiao Zuo Gaici Xue Guoli Duan Yi Xu Bo Hong Rui Zhao Pengfei Yang Jianmin Liu qinghai huang Department of Neurosurgery Changhai HospitalNaval Military Medical University168 Changhai RdShanghai 200433People’s Republic of China Naval Medical Center of PLA Naval Military Medical UniversityShanghai 200050People’s Republic of China

Background:Early treatment for patients with aneurysmal subarachnoid hemorrhage(aSAH)could significantly reduce the risk of re-bleeding and improve clinical *** assessed the different time intervals from the initial hemorrhage,admission,and endovascular treatment and identified the risk factors contributing to ***:Between February 2017 and December 2019,422 consecutive aSAH patients treated in a high-volume hospital were collected and *** factors contributing to admission delay and treatment delay were analyzed with univariate and multivariate ***:One hundred twenty-two(28.9%)were admitted to the high-volume hospital at the day of symptom onset and 386(91.5%)were treated with endovascular management at the same day of *** multivariate analysis found that younger age(P=0.022,OR=0.981,95%CI 0.964–0.997)and good Fisher score(P=0.002,OR=0.420,95%CI 0.245–0.721)were independent risk factors of admission *** was found to be related with treatment *** analysis(OR(95%CI))showed that higher age 1.027(1.004–1.050),poorer Fisher score 3.496(1.993–6.135),larger aneurysmal size 1.112(1.017–1.216),and shorter interval between onset to admission 1.845(1.018–3.344)were independent risk factors of poorer clinical ***:Treatment delay was mainly caused by pre-hospital delay including delayed admission and delayed *** experience showed that cerebrovascular team could provide early treatment for aSAH *** age and good Fisher score were significantly related with admission ***,admission delay was further significantly correlated with better clinical outcome.

关键词： Intracranial aneurysm Rupture Coiling with stent placement Procedure-related complication Safety

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颅内未破裂动脉瘤患者神经心理状况及其干预的研究进展

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中国脑血管病杂志 2020年第8期17卷 477-481页

作者：曾张伟闫亚洲黄清海海军军医大学第一附属医院神经外科上海200433

颅内未破裂动脉瘤是常见的脑血管病之一,无论是随访观察、开颅手术夹闭或血管内介入治疗均存在风险,可能造成患者发生神经心理改变。作者主要通过分析颅内未破裂动脉瘤患者的焦虑和抑郁状况以及其随时间、治疗方式不同而产生的变化对患... 详细信息

颅内未破裂动脉瘤是常见的脑血管病之一,无论是随访观察、开颅手术夹闭或血管内介入治疗均存在风险,可能造成患者发生神经心理改变。作者主要通过分析颅内未破裂动脉瘤患者的焦虑和抑郁状况以及其随时间、治疗方式不同而产生的变化对患者神经心理状态影响的特点,以及心理干预的价值等进行文献综述。

关键词：颅内未破裂动脉瘤开颅手术夹闭血管介入治疗焦虑抑郁心理干预综述

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Safety and efficacy of stent-assisted coiling for acutely ruptured wide-necked intracranial aneurysms:comparison of LVIS stents with laser-cut stents

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Chinese Neurosurgical Journal 2021年第2期7卷 116-125页

作者： Gaici Xue Qiao Zuo Xiaoxi Zhang Haishuang Tang Rui Zhao Qiang Li Yibin Fang Pengfei Yang Bo Hong Yi Xu qinghai huang Jianmin Liu Department of Neurosurgery General Hospital of Southern Theatre Command of PLA111 Liuhua RoadGuangzhou 510010China Department of Neurosurgery Changhai HospitalNaval Medical University168 Changhai RoadShanghai 200433China

Background:To compare the safety and efficacy of LVIS stent-assisted coiling with those of laser-cut stent-assisted coiling for the treatment of acutely ruptured wide-necked intracranial ***:Patients with acutely ruptured wide-necked intracranial aneurysms treated with LVIS stent-assisted coiling(LVIS stent group)and laser-cut stent-assisted coiling(laser-cut stent group)were retrospectively reviewed from January 2014 to December *** score matching was used to adjust for potential differences in age,sex,aneurysm location,aneurysm size,neck width,Hunt-Hess grade,and modified Fisher *** procedure-related complications and clinical and angiographic follow-up outcomes were *** and multivariate analyses were performed to determine the associations between procedure-related complications and potential risk ***:A total of 142 patients who underwent LVIS stent-assisted coiling and 93 patients who underwent laser-cut stent-assisted coiling were enrolled after 1:2 propensity score *** angiographic follow-up outcomes showed that the LVIS stent group had a slightly higher complete occlusion rate and lower recurrence rate than the laser-cut stent group(92.7%vs 80.6%;3.7%vs 9.7%,P=0.078).The clinical outcomes at discharge and follow-up between the two groups demonstrated no significant differences(P=0.495 and P=0.875,respectively).The rates of intraprocedural thrombosis,postprocedural thrombosis,postoperative early rebleeding,and procedure-related death were 0.7%(1/142),1.4%(2/142),2.8%(4/142),and 2.1%(3/142)in the LVIS stent group,respectively,and 4.3%(4/93),2.2%(2/93),1.1%(1/93),and 3.2%(3/93)in the laser-cut stent group,respectively(P=0.082,0.649,0.651,and 0.683).Nevertheless,the rates of overall procedure-related complications and intraprocedural rupture in the LVIS stent group were significantly lower than those in the laser-cut stent group(5.6%vs 14.0%,P=0.028;0.7%vs 6.5%,P=0.016).Multivariate an

关键词： Ruptured intracranial aneurysm LVIS stent Laser-cut stent Propensity score matching

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