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The emerging role of nitric oxide in the synaptic dysfunction of vascular dementia

Neural Regeneration Research 2025年第2期20卷 402-415页

作者： Xiaorong Zhang Zhiying Chen Yinyi Xiong qin zhou Ling-Qiang Zhu Dan Liu Department of Pathology Affiliated Hospital of Jiujiang UniversityJiujiangJiangxi ProvinceChina Jiujiang Clinical Precision Medicine Research Center JiujiangJiangxi ProvinceChina Center for Cognitive Science and Transdisciplinary Studies Jiujiang UniversityJiangxi ProvinceChina Department of Neurology Affiliated Hospital of Jiujiang UniversityJiujiangJiangxi ProvinceChina Department of Rehabilitation Affiliated Hospital of Jiujiang UniversityJiujiangJiangxi ProvinceChina Department of Pathophysiology School of Basic MedicineTongji Medical CollegeHuazhong University of Science and TechnologyWuhanHubei ProvinceChina

With an increase in global aging,the number of people affected by cerebrovascular diseases is also increasing,and the incidence of vascular dementia-closely related to cerebrovascular risk-is increasing at an epidemic ***,few therapeutic options exist that can markedly improve the cognitive impairment and prognosis of vascular dementia *** in Alzheimer’s disease and other neurological disorders,synaptic dysfunction is recognized as the main reason for cognitive *** oxide is one of the ubiquitous gaseous cellular messengers involved in multiple physiological and pathological processes of the central nervous ***,nitric oxide has been implicated in regulating synaptic plasticity and plays an important role in the pathogenesis of vascular *** review introduces in detail the emerging role of nitric oxide in physiological and pathological states of vascular dementia and summarizes the diverse effects of nitric oxide on different aspects of synaptic dysfunction,neuroinflammation,oxidative stress,and blood-brain barrier dysfunction that underlie the progress of vascular ***,we propose that targeting the nitric oxide-sGC-cGMP pathway using certain specific approaches may provide a novel therapeutic strategy for vascular dementia.

关键词： endoplasmic reticulum stress endothelial nitric oxide synthase gene therapy nitric oxide NO-sGC-cGMP pathway synaptic dysfunction vascular dementia

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Influence of Parameters of Optical Fibers on Optical Soliton Interactions

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Chinese Physics Letters 2022年第1期39卷 7-10页

作者： qin zhou School of Mathematical and Physical Sciences Wuhan Textile UniversityWuhan 430200China

The interaction between optical solitons is of great significance for studying interaction between light and matter and development of all-optical devices, and is conducive to the design of integrated optical path. Optical soliton interactions for the nonlinear Schr¨odinger equation are investigated to improve the communication quality and system integration. Solutions of the equation are derived and used to analyze the interaction of two *** suggestions are put forward to weaken their interactions.

关键词： interaction solitons equation

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非货币激励因素对中小学教师工作满意度的影响——基于云贵川渝的调查

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教师教育学报 2025年第1期12卷 106-115页

作者：周琴郭瑜琦西南大学教师教育学院重庆400715

教师工作满意度是影响教师工作效能、促进教师可持续发展的重要因素。研究采用TALIS 2018教师问卷对云贵川渝4个省份的中小学教师展开抽样调查。数据分析显示,该地区教师工作满意度处于较高水平,但内部群体间存在显著性差异。回归分析发... 详细信息

教师工作满意度是影响教师工作效能、促进教师可持续发展的重要因素。研究采用TALIS 2018教师问卷对云贵川渝4个省份的中小学教师展开抽样调查。数据分析显示,该地区教师工作满意度处于较高水平,但内部群体间存在显著性差异。回归分析发现,云贵川渝4省份中小学教师工作满意度受工资薪酬以及其他非货币因素的影响。比较分析发现,云贵川渝初中教师对工资薪酬的接受度高于上海同行,但对社会认可、媒体关注等非货币激励因素的认可程度却低于上海教师,从而使其工作满意度整体水平低于上海。研究认为,坚持教育家精神铸魂强师的同时提升教师工作满意度,需要在巩固提高工资薪酬水平的基础上,进一步从优化教师工作体验、提高教师学历、打通职业晋升渠道、营造尊师重教良好氛围等非货币因素着手,在满足教师内在需求的同时,为加快教育现代化、建设教育强国、办好人民满意的教育提供有力支撑。

关键词：中小学教师工作满意度工资非货币激励双因素理论

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Procreating Tiles of Double Commutative-Step Digraphs

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Acta Mathematicae Applicatae Sinica 2008年第2期24卷 185-194页

作者： Jian-qin zhou Telecommunication School Hangzhou Dianzi University Hangzhou 310018 China Department of Computer Science Anhui University of Technology Ma'anshan 243002 China

Double commutative-step digraph generalizes the double-loop digraph. A double commutative-step digraph can be represented by an L-shaped tile, which periodically tessellates the plane. Given an initial tile L（l, h, x, y）, Aguil5 et al. define a discrete iteration L（p） = L（l ＋ 2p, h ＋ 2p, x ＋ p, y ＋ p）, p = 0, 1, 2,..., over L-shapes （equivalently over double commutative-step digraphs）, and obtain an orbit generated by L（l, h, x,y）, which is said to be a procreating k-tight tile if L（p）（p = 0, 1, 2, ~ ~ ~ ） are all k-tight tiles. They classify the set of L-shaped tiles by its behavior under the above-mentioned discrete dynamics and obtain some procreating tiles of double commutative-step digraphs. In this work, with an approach proposed by Li and Xu et al., we define some new discrete iteration over L-shapes and classify the set of tiles by the procreating condition. We also propose some approaches to find infinite families of realizable k-tight tiles starting from any realizable k-tight L-shaped tile L（l, h, x, y）, 0 ≤ y - x ≤ 2k ＋ 2. As an example, we present an infinite family of 3-tight optimal double-loop networks to illustrate our approaches.

关键词： Double-loop digraph double commutative-step digraph L-shaped tile procreate infinite family

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Screening-Assisted Dynamic Multiple Testing with False Discovery Rate Control

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Journal of Systems Science & Complexity 2023年第2期36卷 716-754页

作者： MUSHTAQ Iram zhou qin ZI Xuemin School of Statistics and Data Science LPMC and KLMDASRNankai UniversityTianjin 300071China School of Mathematics and Statistics Jiangsu Normal UniversityXuzhou 221116China School of Science Tianjin University of Technology and EducationTianjin 300350China

In the era of big data,high-dimensional data always arrive in streams,making timely and accurate decision *** has become particularly important to rapidly and sequentially identify individuals whose behavior deviates from the *** at identifying as many irregular behavioral patterns as possible,the authors develop a large-scale dynamic testing system in the framework of false discovery rate(FDR)*** fully exploiting the sequential feature of datastreams,the authors propose a screening-assisted procedure that filters streams and then only tests streams that pass the filter at each time point.A data-driven optimal screening threshold is derived,giving the new method an edge over existing *** some mild conditions on the dependence structure of datastreams,the FDR is shown to be strongly controlled and the suggested approach for determining screening thresholds is asymptotically *** studies show that the proposed method is both accurate and powerful,and a real-data example is used for illustrative purpose.

关键词： Change-point false discovery rate high-dimensional datastreams large-scale inference sequential analysis weak dependence structure

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Multiple Change Points Detection in High-Dimensional Multivariate Regression

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Journal of Systems Science & Complexity 2022年第6期35卷 2278-2301页

作者： MA Xiaoyan zhou qin ZI Xuemin School of Statistics and Data Science LPMC and KLMDASRNankai UniversityTianjin 300071China School of Mathematics and Statistics Jiangsu Normal UniversityXuzhou 221116China School of Science Tianjin University of Technology and EducationTianjin 300222China

This paper considers the problem of detecting structural changes in a high-dimensional regression setting. The structural parameters are subject to abrupt changes of unknown magnitudes at unknown locations. The authors propose a new procedure that minimizes a penalized least-squares loss function via a dynamic programming algorithm for estimating the locations of change points. To alleviate the computational burden, the authors adopt a prescreening procedure by eliminating a large number of irrelevant points before implementing estimation procedure. The number of change points is determined via Schwarz’s information criterion. Under mild assumptions, the authors establish the consistency of the proposed estimators, and further provide error bounds for estimated parameters which achieve almost-optimal rate. Simulation studies show that the proposed method performs reasonably well in terms of estimation accuracy, and a real data example is used for illustration.

关键词： Consistency dynamic programming low-rank structure multi-task learning nuclear norm

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Numerical analysis of a Neumann boundary control problem with a stochastic parabolic equation

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Science China Mathematics 2023年第9期66卷 2133-2156页

作者： qin zhou Binjie Li School of Mathematics Sichuan UniversityChengdu 610064China School of Mathematics&Information China West Normal UniversityNanchong 637002China

We analyze the discretization of a Neumann boundary control problem with a stochastic parabolic equation, where additive noise occurs in the Neumann boundary condition. The convergence is established for general filtr... 详细信息

关键词： Neumann boundary control stochastic parabolic equation Q-Wiener process boundary noise discretization convergence

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Temperature effect on photolysis decomposing of perfluorooctanoic acid

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Journal of Environmental Sciences 2016年第4期28卷 126-133页

作者： Tiliang Zhang Gang Pan qin zhou Research Center for Eco-Environmental Sciences Chinese Academy of Sciences

Perfluorooctanoic acid（PFOA）is recalcitrant to degrade and ***,the effect of temperature on the photolytic decomposition of PFOA was *** decomposition of PFOA was enhanced from 34% to 99% in 60 min of exposure when the temperature was increased from 25 to 85℃ under UV light（201–600 nm）.The limited degree of decomposition at 25℃ was due to low quantum yield,which was increased by a factor of 12 at 85℃.Under the imposed conditions,the defluorination ratio increased from 8% at 25℃ to 50% at85℃ in 60 *** of perfluorinated carboxylic acids（PFCAs,C7–C5）,PFCAs（C4–C3）and TFA（trifluoroacetic acid,C2）accelerated and attained a maximum within 30 to 90 min at 85℃.However,these reactions did not occur at 25℃ despite extended irradiation to180 *** was decomposed in a step-wise process by surrendering one *** each cyclical process,increased temperature enhanced the quantum yields of irradiation and reactions between water molecules and intermediates *** energy consumption for removing eachμmol of PFOA was reduced from 82.5 k J at 25℃ to 10.9 k J at 85℃ using *** coupled with heat achieved high rates of PFOA degradation and defluorination.

关键词： Perfluorooctanoic acid PFOA Photolysis Temperature effect

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TWO IMPROVED ALGORITHMS AND IMPLEMENTATION FOR A SINGULARLY PERTURBED PROBLEM ON MOVING MESHES

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Journal of Systems Science & Complexity 2011年第6期24卷 1232-1240页

作者： qin zhou Yanping CHEN Yin YANG School of Mathematics Hunan International Economics University Changsha 410205 China School of Mathematical Sciences South China Normal University Guangzhou 510631 China School of Mathematics and Computational Science Xiangtan University Xiangtan 411105 China

This paper applies a difference scheme to a singularly perturbed problem. The authors provide two algorithms on moving mesh methods by using Richardson extrapolation which can improve the accuracy of numerical solution. In traditional algorithms of moving meshes, the initial mesh is a uniform mesh. The authors change it to Bakhvalov-Shishkin mesh, and prove that it improves efficiency by numerical experiments. Finally, the results of the two algorithms are analyzed.

关键词： Algorithm equidistribution principle moving mesh method Richardson extrapolation singularly perturbed problem.

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Asymptotical Behaviors for Neumann Boundary Problem with Singular Data

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Acta Mathematica Sinica,English Series 2019年第4期35卷 463-480页

作者： Tao ZHANG Chun qin zhou School of Mathematical Sciences Shanghai Jiao Tong University

In this paper, we will analyze the blow-up behaviors for solutions to the Laplacian equation with exponential Neumann boundary condition. In particular, the boundary value is with a kind of singular data. We show a Brezis–Merle type concentration-compactness theorem, calculate the blow up value at the blow-up point, and give a point-wise estimate for the profile of the solution sequence at the blow-up point.

关键词： Exponential Neumann boundary condition singular data blow up analysis profile of the solution sequence

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