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CAGCN:Centrality-Aware Graph Convolution Network for Anomaly Detection in Industrial Control Systems

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Journal of Computer Science & Technology 2024年第4期39卷 967-983页

作者： Jun Yang yi-qiang Sheng Jin-Lin Wang Hong Ni National Network New Media Engineering Research Center Institute of AcousticsChinese Academy of SciencesBeijing 100190China School of Electronic Electrical and Communication EngineeringUniversity of Chinese Academy of SciencesBeijing 100049China

In industrial control systems,the utilization of deep learning based methods achieves improvements for anomaly ***,most current methods ignore the association of inner components in industrial control *** industrial control systems,an anomaly component may affect the neighboring components;therefore,the connective relationship can help us to detect anomalies *** this paper,we propose a centrality-aware graph convolution network(CAGCN)for anomaly detection in industrial control *** the traditional graph convolution network(GCN)model,we utilize the concept of centrality to enhance the ability of graph convolution networks to deal with the inner relationship in industrial control *** experiments show that compared with GCN,our CAGCN has a better ability to utilize this relationship between components in industrial control *** performances of the model are evaluated on the Secure Water Treatment(SWaT)dataset and the Water Distribution(WADI)dataset,the two most common industrial control systems datasets in the field of industrial anomaly *** experimental results show that our CAGCN achieves better results on precision,recall,and F1 score than the state-of-the-art methods.

关键词： graph convolution network(GCN) data mining network centrality anomaly detection industrial control system

Mechanistic study of lipid metabolism disorders in diabetic kidney disease treated with GLQMP based on network pharmacology,molecular docking and in vitro experiments

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Traditional Medicine Research 2024年第2期9卷 42-51页

作者： Shu-Man Liu Zi-Jie Yan Man Xiao yi-qiang Xie College of Traditional Chinese Medicine Hainan Medical UniversityHaikou 571199China Key Laboratory of Biochemistry and Molecular Biology Hainan Medical UniversityHaikou 571199China.

Background:In this study,we used network pharmacology and molecular docking combined with vitro experiments to explore the potential mechanism of action of Gualou Qumai pill(GLQMP)against ***:We screened effective compounds and drug targets using Chinese medicine systemic pharmacology database and analysis platform and Chinese medicine molecular mechanism bioinformatics analysis tools;and searched for DKD targets using human online Mendelian genetics and gene *** potential targets of GLQMP for DKD were obtained through the intersection of drug targets and disease *** software was applied to build herbal medicine-active compound-target-disease networks and analyze them;protein-protein interaction networks were analyzed using the STRING database platform;gene ontology and Kyoto Encyclopedia of Genes and Genomes were used for gene ontology and gene and genome encyclopedia to enrich potential targets using the DAVID database;and the AutoDock Vina 1.1.2 software for molecular docking of key targets with corresponding key *** vitro experiments were validated by CCK8,oil red O staining,TC,TG,RT-qPCR,and Western ***:Through network pharmacology analysis,a total of 99 potential therapeutic targets of GLQMP for DKD and the corresponding 38 active compounds were obtained,and 5 core compounds were *** constructing the protein-protein interaction network and performing network topology analysis,we found that PPARA and PPARG were the key targets,and then we molecularly docked these two key targets with the 38 active compounds,especially the 5 core compounds,and found that PPARA and PPARG had good binding ability with a variety of *** vitro experiments showed that GLQMP was able to ameliorate HK-2 cell injury under high glucose stress,improve cell viability,reduce TC and TG levels as well as decrease the accumulation of lipid droplets,and RT-qPCR and Western blot confirmed that GLQMP was able to promote the expressi

关键词： Gualou Qumai pill diabetic kidney disease disorder of lipid metabolism network pharmacology molecular docking

Aerosol deposition technology and its applications in batteries

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Nano Materials Science 2024年第1期6卷 24-37页

作者： Xinyu Wang Ramon Alberto Paredes Camacho Xiaoyu Xu Yumei Wang yi qiang Hans Kungl Ruediger-AEichel Yunfeng Zhang Li Lu National University of Singapore(Chongqing)Research Institute Chongqing401123PR China National University of Singapore Singapore117576 Fundamental Electrochemistry(IEK-9) Institute of Energy and Climate ResearchForschungszentrum Jülich52425JülichGermany

Aerosol deposition(AD)method is a kind of additive manufacturing technology for fabricating dense films such as metals and ceramics at room *** resolves the challenge of integrating ceramic films onto temperaturesensitive substrates,including metals,glasses,and *** should be emphasized that the AD is a spray coating technology that uses powder without thermal assistance to generate films with high *** to the traditional sputter-based approach,the AD shows several advantages in efficiency,convenience,better interfacial bonding and so ***,it opens some possibilities to the field of batteries,especially all-solidstate batteries(ASSBs)and draws much attention not only for research but also for large scale *** purpose of this work is to provide a critical review on the science and technology of AD as well as its applications in the field of *** process,mechanism and effective parameters of AD,and recent developments in AD applications in the field of batteries will be systematically reviewed so that a trend for AD will be finally provided.

关键词： Aerosol deposition Room temperature impact consolidation Ceramic film All-solid-state battery Spray coating technology

砷在氮化-碳化法制备超细碳化钨粉过程中的细化机理

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Transactions of Nonferrous Metals Society of China 2024年第3期34卷 966-976页

作者：易志强谭敦强南昌大学物理与材料学院南昌330031 南昌大学国际材料创新研究院南昌330031

为了简化工艺制备超细WC粉末,在伸钨酸铵前驱体中添加一定量的As元素,采用氮化-碳化法系统研究As在超细WC粉制备过程中的作用机理。结果表明,当碳化温度均为1400℃,氮化温度从500℃升高到600℃,As含量从0增加到0.3%(质量分数)时,所制备... 详细信息

为了简化工艺制备超细WC粉末,在伸钨酸铵前驱体中添加一定量的As元素,采用氮化-碳化法系统研究As在超细WC粉制备过程中的作用机理。结果表明,当碳化温度均为1400℃,氮化温度从500℃升高到600℃,As含量从0增加到0.3%(质量分数)时,所制备的WC粉平均粒径从2.23μm减小到0.22μm,颗粒均匀性显著提高。As元素在氮化产物中以W_(2)O_(3)(AsO_(4))_(2)的形式存在,且容易在氮化产物(NH_(4))_(0.42)WC_(3)和WN表面富集或分布于两相之间,阻碍碳化过程中WC晶粒的长大,从而制备超细WC粉。

关键词：砷超细WC粉均匀性细化机理氮化碳化

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睡虎地汉简《日书·星官》及相关问题

文物 2024年第2期 76-83页

作者：伊强熊北生山东大学文学院湖北省文物考古研究院

睡虎地汉简《日书》中有一篇简文,与睡虎地秦简《日书》甲种《星》、《日书》乙种《官》以及孔家坡汉简《星官》内容相近。目前尚未发现篇名,暂据内容拟题为《星官》。本篇与同墓出土的《日书》其他竹简一样,残碎严重。经缀合得残简20余... 详细信息

睡虎地汉简《日书》中有一篇简文,与睡虎地秦简《日书》甲种《星》、《日书》乙种《官》以及孔家坡汉简《星官》内容相近。目前尚未发现篇名,暂据内容拟题为《星官》。本篇与同墓出土的《日书》其他竹简一样,残碎严重。经缀合得残简20余枚,另有内容相关的残片若干,如何定位尚待进一步推敲。

关键词：睡虎地秦简孔家坡汉简《日书》缀合星官竹简

基于经验知识的船舶螺旋桨水动力样本扩充方法及其在预报代理模型中的应用

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船舶力学 2024年第1期28卷 36-44页

作者：谢硕陈奕宏强以铭李亮中国船舶科学研究中心江苏无锡214082 深海技术科学太湖实验室江苏无锡214082 浙江大学航空航天学院杭州310027

近几年来,越来越多学者致力于采用机器学习进行船舶螺旋桨性能预报,但代理模型的预报效果往往受训练样本的数量和质量影响较大。目前船舶螺旋桨性能数据数量少且质量也不高,即数据对应参数分布较为集中,严重不均匀,这些问题都会影响代... 详细信息

近几年来,越来越多学者致力于采用机器学习进行船舶螺旋桨性能预报,但代理模型的预报效果往往受训练样本的数量和质量影响较大。目前船舶螺旋桨性能数据数量少且质量也不高,即数据对应参数分布较为集中,严重不均匀,这些问题都会影响代理模型预报的准确率与可靠性。为了解决这一实际困难,本文提出一种基于经验知识的样本扩充方法,并以船舶螺旋桨水动力性能的代理模型预报为例进行应用验证。结果表明:本文使用的样本扩充方法可以快速生成数据样本,可以一定程度上改善预报代理模型的可靠性,提升预报精度。

关键词：样本扩充经验知识机器学习船舶螺旋桨水动力性能代理模型

Exploring the molecular mechanism of Suoquan pill in the treatment of diabetic kidney disease based on network pharmacology,molecular docking,in vitro experiment

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Traditional Medicine Research 2024年第11期9卷 27-37页

作者： Zi-Jie Yan Yu Kang Shu-Man Liu Fang-Yu Wang Man Xiao yi-qiang Xie College of Traditional Chinese Medicine Hainan Medical UniversityHaikou 571199China Graduate School Heilongjiang Academy of Traditional Chinese MedicineHarbin 150001China Department of Pharmacology College of PharmacyHainan Medical UniversityHaikou 571199China Key Laboratory of Biochemistry and Molecular Biology Hainan Medical UniversityHaikou 571199China.

Background:Diabetic kidney disease(DKD)is a microvascular complication of diabetes mellitus and is the main cause of end-stage renal *** pills(SQP)has a variety of pharmacological activities and multiple therapeutic effects,and it is used clinically as a basic formula for the treatment of ***:Public databases were used to identify SQP compounds and the potential targets of SQP and DKD.A drug-component-therapeutic target network was ***-protein interaction network analysis,Gene Ontology functional analysis,and Kyoto Encyclopedia of Genes and Genomes pathway enrichment analysis were used to analyse the potential molecular mechanisms of SQP based on common targets of drugs and *** docking simulations were conducted to confirm the binding abity of the core compounds to key *** efficacy and predicted molecular mechanisms of SQP were validated using cell counting kit-8 assay,flow cytometry,and western blotting with HK-2 cells as a ***:Network pharmacology analysis showed that 26 compounds and 207 potential targets of SQP were involved in the treatment of DKD;boldine,denudatin B,pinocembrin,kaempferoid,and quercetin were considered core compounds,and epidermal growth factor receptor(EGFR)and proto-oncogene,non-receptor tyrosine kinase(SRC)were considered key *** Ontology enrichment analysis indicated that protein phosphorylation and negative regulation of apoptotic processes are important biological processes in the treatment of DKD by *** docking confirmed the excellent binding abilities of boldine,denudatin B,kaempferide,and quercetin to EGFR and *** results of in vitro experiments showed that treatment with an ethanolic extract of SQP significantly protected HK-2 cells from high glucose-induced cell *** addition,the SQP ethanol extract inhibited the phosphorylation of EGFR and SRC,suppressed the apoptosis rate,and regulated apoptosis-related proteins in HK-2 cells under hig

关键词： traditional Chinese medicine diabetic kidney disease Suoquan pill network analysis molecular docking

城市轨道交通道岔区振动源强特征与减振措施效果试验研究

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铁道科学与工程学报 2024年第5期21卷 1854-1865页

作者：易强赵磊高原王树国中国铁道科学研究院集团有限公司铁道建筑研究所北京100081

城市轨道交通道岔区结构状态复杂且存在固有不平顺,从而导致环境振动噪声增强。为探明岔区振动产生机理以及不同减振措施对道岔区振动源强的影响规律,以普通整体道床、减振器扣件以及钢弹簧浮置板道岔为试验对象,分别于岔前、转辙器轮... 详细信息

城市轨道交通道岔区结构状态复杂且存在固有不平顺,从而导致环境振动噪声增强。为探明岔区振动产生机理以及不同减振措施对道岔区振动源强的影响规律,以普通整体道床、减振器扣件以及钢弹簧浮置板道岔为试验对象,分别于岔前、转辙器轮载过渡区、转辙器跟端、连接部分以及辙叉区5个断面布置测点,测试岔区不同位置隧道壁垂向与横向振动响应,并从频域、时频域以及Z振级角度分析不同减振道岔的源强特征。试验结果表明:普通整体道床道岔区振动源强主频位于50~100 Hz,与区间线路相似。但由于左右轨下刚度差异,辙叉区P2共振主频存在双峰值特征,且辙叉区存在有害空间,导致隧道壁50~200 Hz振动响应幅值较高,振动源强相对于其他断面增大3~5 dB。虽然转辙器区也存在轮载过渡,但转辙器区隧道壁垂向振动并未表现出明显的加剧。岔区隧道壁横向振动不可忽视,减振扣件区段隧道壁横向振动甚至高于垂向振动。减振扣件和钢弹簧浮置板道岔均可抑制50 Hz以上的隧道壁振动,但减振扣件使得车辆簧下质量-道岔P2共振频率降低至40 Hz,从而在该频率位置存在较高振动响应峰值。采用分频最大振级以及最大Z振级进行对比,道岔减振器扣件减振量相对较低,而钢弹簧浮置板减振效果良好,减振量在15 dB左右。试验研究结果可为城市轨道交通道岔区振动控制提供参考。

关键词：城市轨道交通道岔振动源强减振措施 Z振级

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多约束排队系统的随机模拟与统计分析

数学的实践与认识 2024年第3期54卷 112-123页

作者：卢一强战略支援部队信息工程大学河南郑州450000

将排队系统文献中出现的负顾客、重试可修、N-策略、工作性休假、可反馈等概念看作是在基本排队系统基础上增加的约束条件.在详细分析各种约束条件的基础上,我们依照多约束排队系统中各个离散事件发生的时间顺序,给出了多约束排队系统... 详细信息

将排队系统文献中出现的负顾客、重试可修、N-策略、工作性休假、可反馈等概念看作是在基本排队系统基础上增加的约束条件.在详细分析各种约束条件的基础上,我们依照多约束排队系统中各个离散事件发生的时间顺序,给出了多约束排队系统的随机模拟算法;运用数理统计的方法,得到了各种排队系统评价指标的估计;并通过模拟例子,研究了复杂多约束排队系统的统计特性.

关键词：多约束排队系统统计模拟离散事件调度法排队论指标的估计