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Increased Levels of p53 and PARP-1 in EL-4 Cells Probably Related with the Immune Adaptive Response Induced by Low Dose Ionizing Radiation in vitro

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Biomedical and Environmental Sciences 2010年第6期23卷 487-495页

作者： GUANG-HUI CHENG NING WU DE-fu JIANG HONG-GUANG ZHAO qian ZHANG JIAN-FENG wang SHou-LIANG GONG Department of Radiotherapy China-Japan Union Hospital Jilin University Changchun 130033 Jilin China Key Laboratory of Radiobiology Ministry of Health (School of Public Health Jilin University) Changchun 130021 Jilin China Department of Nuclear Medicine the First Hospital Jilin University Changchun 130021 Jilin China

Objective This paper is to explore the DNA repair mechanism of immune adaptive response （AR） induced by low dose radiation （LDR）, the changes of mRNA levels and protein expressions of p53, ATM, DNA-PK catalytic subunit （DNA-PKcs） and PARP-1 genes in the LDR-induced AR in EL-4 cells. Methods The apoptosis and cell cycle progression of EL-4 cells were detected by flow cytometry in 12 h after the cells received the pre-exposure of 0.075 Gy X-rays （inductive dose, D 1） and the succeeding high dose irradiation （challenge dose, D2; 1.0, 1.5, and 2.0 Gy X-rays, respectively） with or without wortmannin （inhibitor of ATM and DNA-PK） and 3-aminobenzamid （inhibitor of PARP-1）. And the protein expressions and mRNA levels related to these genes were detected with flow cytometry and reverse transcription-polymerase chain reaction in 12 h after irradiation with D2. Results The mRNA and protein expressions of p53 and PARP-1 in EL-4 cells in the D1 ＋ D2 groups were much lower than those in the D2 groups, and those of PARP-1 in the 3-AB ＋ D2 and the 3-AB ＋ D1 ＋ D2 groups were much lower than those in the D2 and the D1 ＋ D2 groups. The percentage of apoptotic EL-4 cells in the 3-AB ＋ D1 ＋ D2 groups was much higher than that in the D1 ＋ D2 groups, that in the G0/G1 and the G2 ＋ M phases was much higher, and that in the S phase were much lower. Although the ATM and DNA-PKcs mRNA and protein expressions in wortmannin ＋ D1 ＋ D2 groups were much lower than those in the D1 ＋ D2 groups, there were no significant changes in the apoptosis and cell cycle progression between the wortmannin ＋ D1 ＋ D2 and the D1 ＋ D2 groups. Conclusion PARP-1 and p53 might play important roles in AR induced by LDR.

关键词： Low dose radiation (LDR) Adaptive response (AR) DNA repair

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Influence of Exposure Pathways on Tissue Distribution and Health Impact of Polycyclic Aromatic Hydrocarbon Derivatives

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Environment & Health 2023年第3期1卷 150-167页

作者： Yu Zhang qian Hu Jiaqi fu Xinting Li Hongjun Mao Ting wang Tianjin Key Laboratory of Urban Transport Emission Research State Environmental Protection Key Laboratory of Urban Ambient Air Particulate Matter Pollution Prevention and ControlCollege of Environmental Science and EngineeringNankai UniversityTianjin 300071China

The oxygen(OPAHs),nitro(NPAHs),hydroxyl(OH-PAHs),and alkylated(APAHs)derivatives of polycyclic aromatic hydrocarbon(PAHs)are ubiquitous pollutants in the *** concentrations of NPAHs,OPAHs,OH-PAHs,and APAHs are lower than that of PAHs in the environment,but the carcinogenic abilities of the derivatives are usually 10 to 1,000-fold higher than that of parent *** are three main pathways for the exposure of polycyclic aromatic compounds to humans,including inhalation,direct contact,and *** exposure by inhalation,they are mainly distributed in the lungs,affecting lung function and causing inflammation,asthma,*** to the digestive system’s strong capacity for metabolism,intake of PAHs and the derivatives is primarily distributed in the digestive system and metabolized *** it may lead to dysplasia of these organs and even to *** skin is the primary site of direct contact with PAH *** derivatives can enter the bloodstream through all three contact pathways,thereby accumulating in various *** study aimed to summarize the influence of exposure pathways on tissue distribution and the health impact of PAH derivatives to provide references for future research and evaluation on public health.

关键词： PAH derivatives concentration tissue distribution exposure pathway health impact

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A Two-dimensional Dual-pore Covalent Organic Framework for Efficient Iodine Capture

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Chemical Research in Chinese Universities 2022年第2期38卷 472-477页

作者： WEN Zhongliang wang Shenglin fu Siyao qian Jiaying YAN qianqian XU Huanjun ZUO Kaiming SU Xiaofang ZENG Chaoyuan GAO Yanan Key Laboratory of Ministry of Education for Advanced Materials in Tropical Island Resources Hainan UniversityHaikou 570228P.R.China

Effectively capturing volatile radioiodine generated during the nuclear fission process is considered to be a safe way to the utilization of nuclear power. Here we report a new two-dimensional covalent organic framework(2D COF), ETTA-PyTTA-COF, as a highly efficient iodine adsorbent, which is constructed through the condensation reaction between 4,4’,4’’,4’’’-(ethene-1,1,2,2-tetrayl)-tetrabenzaldehyde(ETTA) and 1,3,6,8-tetrakis(4-aminophenyl)pyrene(PyTTA). The ETTA-PyTTA-COF possesses a permanent 1D channel porous structure with a high Brunauer-Emmet-Teller(BET) surface area of 1519 m2/g and excellent chemical and thermal stability. It shows ultrahigh iodine adsorption capability, which can reach up to 4.6 g/g in vapor owing to its high BET surface area, large π-conjugated structure and plenty of imine groups in the skeleton of the COF as effective iodine sorption sites.

关键词： Covalent organic framework Iodine capture Porous material Adsorbent Nuclear energy

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Laser-rewritable room temperature phosphorescence based on in-situ polymerized tartaric acid

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Science China Chemistry 2024年第9期67卷 3029-3038页

作者： Tuo-Yu Zhou Tai-Wen Li Hai-fu Zhang Rui-Lin Chai qian Zhao Penglin Zhang Guang-Yue Li qian-Wen wang Chang Li Yu Shu Zhi Fan Sheng-Hua Li College of Chemical Engineering and Materials Science College of SciencesTianjin University of Science&TechnologyTianjin 300457China College of Chemical Engineering North China University of Science and TechnologyTangshan 063210China Tianjin Key Laboratory of Multiplexed Identification for Port Hazardous Chemicals Tianjin University of Science&TechnologyTianjin 300457China

Organic room temperature phosphorescence(RTP)materials have potential applications in information technology and ***,the precise control of the afterglow in reversible manners remains challenging for organic ***,we report a kind of organic RTP material fabricated by simple heating mixtures of tartaric acid(TA)and aromatic acids,which can switch their phosphorescence by *** mixtures show tunable phosphorescence from indigo to orange with phosphorescence efficiency of up to 53.99% due to locking different organic luminogens by the TA-formed matrix through the noncovalent *** afterglow of those materials lasts a few seconds and disappears by water fumigation,which can be repeated in response to wet/heat *** drop-casting those materials on glass slides,a laser-repatternable phosphorescence is achieved by facile laser direct writing and quenched by water *** results open the opportunity for the design of smart stimuli-responsive phosphorescence materials from sustainable natural products.

关键词： room temperature phosphorescence tunable afterglows tartaric acid laser direct writing stimuli-response

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Engineering Multi‑field‑coupled Synergistic Ion Transport System Based on the Heterogeneous Nanofluidic Membrane for High‑Efficient Lithium Extraction

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Nano-Micro Letters 2023年第8期15卷 436-449页

作者： Lin fu Yuhao Hu Xiangbin Lin Qingchen wang Linsen Yang Weiwen Xin Shengyang Zhou Yongchao qian Xiang‑Yu Kong Lei Jiang Liping Wen CAS Key Laboratory of Bio‑Inspired Materials and Interfacial Science Technical Institute of Physics and ChemistryChinese Academy of SciencesBeijing 100190People’s Republic of China School of future Technology University of Chinese Academy of SciencesBeijing 100049People’s Republic of China Qingdao Institute of Bioenergy and Bioprocess Technology Chinese Academy of SciencesQingdao 266101People’s Republic of China

The global carbon neutrality strategy brings a wave of rechargeable lithium‐ion batteries technique development and induces an ever-growing consumption and demand for lithium(Li).Among all the Li exploitation,extracting Li from spent LIBs would be a strategic and perspective approach,especially with the low energy consumption and eco-friendly membrane separation ***,current membrane separation systems mainly focus on monotonous membrane design and structure optimization,and rarely further consider the coordination of inherent structure and applied external field,resulting in limited ion ***,we propose a heterogeneous nanofluidic membrane as a platform for coupling multi-external fields(i.e.,lightinduced heat,electrical,and concentration gradient fields)to construct the multi-field-coupled synergistic ion transport system(MSITS)for Li-ion extraction from spent *** Li flux of the MSITS reaches 367.4 mmol m^(−2)h^(−1),even higher than the sum flux of those applied individual fields,reflecting synergistic enhancement for ion transport of the multi-field-coupled *** from the adaptation of membrane structure and multi-external fields,the proposed system exhibits ultrahigh selectivity with a Li^(+)/Co^(2+)factor of 216,412,outperforming previous *** based on nanofluidic membrane proves to be a promising ion transport strategy,as it could accelerate ion transmembrane transport and alleviate the ion concentration polarization *** work demonstrated a collaborative system equipped with an optimized membrane for high-efficient Li extraction,providing an expanded strategy to investigate the other membrane-based applications of their common similarities in core concepts.

关键词： Nanofluids Ion separation Lithium extraction Synergistic effect Spent lithium-ion battery

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Self-induced birefringence of white-light continuum generated by interaction of focused femtosecond laser pulses with fused silica

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High Power Laser Science and Engineering 2020年第2期8卷 71-76页

作者： J.qian G.D.wang K.Y.Lou D.Y.Shen Q.fu Q.Z.Zhao State Key Laboratory of High Field Laser Physics Shanghai Institute of Optics and Fine MechanicsChinese Academy of SciencesShanghai 201800China Center of Materials Science and Optoelectronics Engineering University of Chinese Academy of SciencesBeijing 100049China

White-light continuum can be induced by the interaction of intense femtosecond laser pulses with condensed *** using two orthogonal polarizers,a self-induced birefringence of continuum is observed when focusing femtosecond laser pulses into bulk fused *** is,the generated white-light continuum is synchronously modulated anisotropically while propagating in fused ***-resolved detection confirms that self-induced birefringence of continuum shows a growth and saturation feature with time *** adjusting laser energy,the transmitted intensity of continuum modulated by self-induced birefringence also varies *** analysis with time evolution indicates that it is the focused femtosecond laser pulses that induce anisotropic microstructures in bulk fused silica,and the anisotropic structures at the same time modulate the generated continuum.

关键词： femtosecond laser pulses fused silica self-induced birefringence white-light continuum

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Computational study on the half-metallicity in transition metal-oxide-incorporated 2D g-C3N4 nanosheets

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Frontiers of physics 2018年第3期13卷 45-52页

作者： qian Gao Hui-Li wang Li-fu Zhang Shuang-Lin Hu Zhen-Peng Hu School of Physics Nankai Institute of Nuclear Physics and Chemistry China University Tianjin 300071 China Academy of Engineering Physics Mianyang 621900 China

In this study, based on the first-principles calculations, we systematically investigated the electronic and magnetic properties of the transition metal-oxide-incorporated 2D g-C3N4 nanosheet （labeled C3N4- TM-O, TM - Sc-Mn）. The results suggest that the TM-O binds to g-CaN4 nanosheets strongly for all systems. We found that the 2D C3N4-TM-O framework is ferromagnetic for TM = Sc, Ti, V, Cr, while it is antiferromagnetic for TM = Mn. All the ferromagnetic systems exhibit the half-metallic property. furthermore, Monte Carlo simulations based on the Heisenberg model suggest that the Curie temperatures （To） of the CaN4-TM-O （TM --- Sc, Ti, V, Cr） framework are 169 K, 68 K, 203 K, and 190 K, respectively. Based on Bader charge analysis, we found that the origin of the half-metallicity at Fermi energy can be partially attributed to the transfer of electrons from TM atoms to the g-C3N4 nanosheet. In addition, we found that not only electrons but also holes can induce half-metallicity for 2D g-C3N4 nanosheets, which may help to understand the origin of half-metallicity for graphitic carbon nitride.

关键词： half-metallicity first-principles g-C3N4 Curie-temperature

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Structures of SARS-CoV-2 spike protein alert noteworthy sites for the potential approaching variants

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Virologica Sinica 2022年第6期37卷 938-941页

作者： Xiaorui Xing Lei wang Zhen Cui wangjun fu Tao Zheng Lili Qin Pingju Ge Aidong qian Nan wang Shuai Yuan College of Veterinary Medicine Jilin Agricultural UniversityChangchun130118China College of Animal Science and Technology Jilin Provincial Engineering Research Center of Animal ProbioticsKey Lab of Animal ProductionProduct Quality and SecurityJoint Laboratory of Modern Agricultural Technology International CooperationMinistry of EducationJilin Agricultural UniversityChangchun130118China CAS Key Laboratory of Infection and Immunity National Laboratory of MacromoleculesInstitute of BiophysicsChinese Academy of SciencesBeijing100101China University of Chinese Academy of Sciences Beijing100101China Acrobiosystems Beijing100101China State Key Laboratory of Virology Wuhan Institute of VirologyChinese Academy of SciencesWuhan430071China

Dear Editor,The COVID-19 pandemic, which is caused by severe acute respiratory syndrome coronavirus 2(SARS-CoV-2), has led to millions of lives lost worldwide. The trimeric spike protein(S) decorating the membrane surface of the infectious virion is responsible for the attachment and entry by binding to the receptor angiotensin-converting enzyme 2(ACE2) in the early replication cycle(Zhou P. et al., 2020). Two subunits S1 and S2 are included in the trimeric glycoprotein.

关键词： ACE2 al. acute

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Vitreous substitutes: challenges and directions

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International Journal of Ophthalmology(English edition) 2015年第3期8卷 437-440页

作者： qian-Ying Gao Yue fu Yan-Nian Hui State Key Laboratory of Ophthalmology Zhongshan Ophthalmic Center Sun Yat-sen University Department of Ophthalmology Xijing Hospital the Fourth Military Medical University

The natural vitreous body has a fine structure and complex functions. The imitation of the natural vitreous body by vitreous substitutes is a challenging work for both researchers and ophthalmologists. Gases, silicone oil, heavy silicone oil and hydrogels, particularly the former two vitreous substitutes are clinically widely used with certain complications. Those, however, are not real artificial vitreous due to lack of structure and function like the natural vitreous body. This article reviews the situations, challenges, and future directions in the development of vitreous substitutes, particularly the experimental and clinical use of a new artificial foldable capsular vitreous body.

关键词： vitreous substitute artificial vitreous foldable capsular vitreous body silicone oil

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Transcriptional regulation of flavonoid biosynthesis in Artemisia annua by AaYABBY5

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Horticulture Research 2021年第1期8卷 3381-3395页

作者： Sadaf-Ilyas Kayani qian Shen Saeed-ur Rahman Xueqing fu Yongpeng Li Chen wang Danial Hassani Kexuan Tang Joint International Research Laboratory of Metabolic and Developmental Sciences Plant Biotechnology Research CenterFudan-SJTU-Nottingham Plant Biotechnology R&D CenterSchool of Agriculture and BiologyShanghai Jiao Tong University200240 ShanghaiChina

Artemisia annua is a medicinal plant rich in terpenes and flavonoids with useful biological activities such as antioxidant,anticancer,and antimalarial *** transcriptional regulation of flavonoid biosynthesis in *** has not been *** this study,we identified a YABBY family transcription factor,AaYABBY5,as a positive regulator of anthocyanin and total flavonoid contents in ***5 was selected based on its similar expression pattern to the phenylalanine ammonia lyase(PAL),chalcone synthase(CHS),chalcone isomerase(CHI),and flavonol synthase(FLS)genes.A transient dual-luciferase assay in Nicotiana bethamiana with the AaYABBY5 effector showed a significant increase in the activity of the downstream LUC gene,with reporters AaPAL,AaCHS,AaCHI,and *** yeast one-hybrid system further confirmed the direct activation of these promoters by *** expression analysis of stably transformed AaYABBY5 overexpression,AaYABBY5 antisense,and control plants revealed a significant increase in the expression of AaPAL,AaCHS,AaCHI,AaFLS,AaFSII,AaLDOX,and AaUFGT in AaYABBY5 overexpression ***,their total flavonoid content and anthocyanin content were also found to ***5 antisense plants showed a significant decrease in the expression of flavonoid biosynthetic genes,as well as a decrease in anthocyanin and total flavonoid *** addition,phenotypic analysis revealed deep purple-pigmented stems,an increase in the leaf lamina size,and higher trichome densities in AaYABBY5 overexpression ***,these data proved that AaYABBY5 is a positive regulator of flavonoid biosynthesis in *** study provides candidate transcription factors for the improvement of flavonoid concentrations in *** and can be further extended to elucidate its mechanism of regulating trichome development.

关键词： transformed ammonia transient

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