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Sex-biased single-cell genetic landscape in mice with autism spectrum disorder

Journal of Genetics and Genomics 2024年第3期51卷 338-351页

作者： qian zhang Yongjie Wang Jie Tao Ruixue Xia Yijie zhang Zhirui Liu Jiwei cheng Department of Neurology and Central Laboratory Putuo HospitalShanghai University of Traditional Chinese MedicineShanghai 200062China School of Pharmacy Hangzhou Normal UniversityHangzhouZhejiang 311121China Department of Respiratory and Critical Care Medicine Henan University Huaihe HospitalKaifengHenan 475099China

Autistic spectrum disorder(ASD)is a male-biased,heterogeneous neurodevelopmental disorder that affects approximately 1%e2%of the *** exposure to valproic acid(VPA)is a recognized risk factor for ASD,but the cellular and molecular basis of VPA-induced ASD at the single-cell resolution is ***,we aim to compare the cellular and molecular differences in the hippocampus between male and female prenatal mice with ASD at the single-cell transcriptomic *** transcriptomes of more than 45,000 cells are assigned to 12 major cell types,including neurons,glial cells,vascular cells,and immune *** type-specific genes with altered expression after prenatal VPA exposure are analyzed,and the largest number of differentially expressed genes(DEGs)are found in neurons,choroid plexus epithelial cells,and *** microglia,several pathways related to inflammation are found in both males and females,including the tumor necrosis factor(TNF),nuclear factor kappa B(NF-kB),toll-like receptor(TLR),and mitogen-activated protein kinase(MAPK)signaling pathways,which are important for the induction of autistic-like ***,we note that several X-linked genes,including Bex1,Bex3,and Gria3,were among the male-specific DEGs of *** pioneering study describes the landscape of the transcriptome in the hippocampus of autistic *** elucidation of sexual differences could provide innovative strategies for the prevention and treatment of ASD.

关键词： Autistic spectrum disorder(ASD) Sex Single cell Neurons Microglia

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Absorptive Nonlinearity in Er-Doped Optical Fiber

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Wuhan University Journal of Natural Sciences 1999年第2期4卷 56-59页

作者： Song, qian Li, Ji-xing zhang, Yuan-cheng Wuhan Univ Wuhan China

Optical absorptive nonlinearity in Er doped optical fiber has been discussed and measured at the window wavelength 1.55 μm for optical communications firstly. It is proposed that the mechanism of this absorptive nonlinearity is the induced absorption. The first order nonlinear absorptive coefficient and the imaginary part and the complex value of the third order susceptibility at that wavelength are obtained from the measured absorptive nonlinearity.

关键词： optical nonlinearity Er doped fiber optical absorption

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Critical scalarization and descalarization of black holes in a generalized scalar-tensor theory

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Science China(Physics,Mechanics & Astronomy) 2023年第10期66卷 44-52页

作者： Yunqi Liu cheng-Yong zhang qian Chen Zhoujian Cao Yu Tian Bin Wang Center for Gravitation and Cosmology College of Physical Science and TechnologyYangzhou UniversityYangzhou 225009China Department of Physics and Siyuan Laboratory Jinan UniversityGuangzhou 510632China School of Physical Sciences University of Chinese Academy of SciencesBeijing 100049China Department of Astronomy Beijing Normal UniversityBeijing 100875China School of Fundamental Physics and Mathematical Sciences Hangzhou Institute for Advanced StudyUniversity of Chinese Academy of SciencesHangzhou 310024China Institute of Theoretical Physics Chinese Academy of SciencesBeijing 100190China Shanghai Frontier Science Center for Gravitational Wave Detection Shanghai Jiao Tong UniversityShanghai 200240China

We study the critical dynamics in scalarization and descalarization in the fully nonlinear dynamical evolution in the class of theories with a scalar field coupling with both Gauss-Bonnet(GB) invariant and Ricci scalar. We explore the manner in which the GB term triggers black hole(BH) scalarization. A typical type Ⅰ critical phenomenon is observed, in which an unstable critical solution emerges at the threshold and acts as an attractor in the dynamical scalarization. For the descalarization, we reveal that a marginally stable attractor exists at the threshold of the first-order phase transition in shedding off BH hair. This is a new type Ⅰ critical phenomenon in the BH phase transition. Implications of these findings are discussed from the perspective of thermodynamic properties and perturbations for static solutions. We examine the effect of scalar-Ricci coupling on the hyperbolicity in the fully nonlinear evolution and observe that such coupling can suppress the elliptic region and enlarge parameter space in computations.

关键词： black hole(de)scalarization dynamical critical behavior marginally attractor

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Effects of Huatan Tongluo decoction on vascular endothelial growth factor receptor 2 expression in synovial tissues of rats with collagen-induced arthritis

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Journal of Traditional Chinese Medicine 2019年第2期39卷 191-198页

作者： Chen Jinchun Qiu Mingshan Li Yihan zhang qian zhang Yiyan Lin Shuangjie zhang Shaohong qian Lixia Gao Hai Li Liang-cheng Department of Rheumatology Xiamen Hospital of Traditional Chinese Medicinethe Eighth Affiliated Hospital of Beijing University of Chinese Medicine Affiliated Hospital of Fujian University of Traditional Chinese Medicine School of Pharmaceutical Sciences Xiamen University Health and Human Service Department Xianyue Hospital

OBJECTIVE: To determine the therapeutic effect and potential mechanism of Huatan Tongluo decoction on rats with collagen-induced ***: Forty specific pathogen-free Wistar rats were selected, and 10 were randomly selected as the control(group 1). The remaining rats were injected intradermally with emulsified type Ⅱ bovine collagen at the tail base and back, followed by a booster 7 d post first immunization. After establishing collagen-induced arthritis(CIA), rats were randomly divided into three groups(n = 10). The rats were treated orally for 30 d as follows: group 1, saline; group 2, model(saline); group 3, tripterygium polyglycoside(TP; 7.81 mg/kg, positive control);group 4, Huatan Tongluo decoction(HTTL; 7.5 g/kg). Body weight, ankle swelling and arthritis index were measured over the course of the study. The rats were sacrificed 30 d after treatment. Morphological changes in the synovium were observed by hematoxylin and eosin staining. Pannus formation and synovial thickness in the left ankle were observed by color Doppler ultrasoundVascular endothelial growth factor(VEGF) and VEGFR2 protein levels were measured by ***/VEGFR2 mRNA levels were measured by real-time quantitative polymerase chain ***: Compared with the model group, a significantly lower arthritis index was observed in the positive control group(P < 0.05) and HTTL group(P < 0.01), after treatment. Both positive control and HTTL reduced intra-articular pannus formation and synovial thickening. Furthermore, VEGF mRNA,and VEGFR2 protein and mRNA levels were significantly downregulated(P < 0.05) in the treatment ***: Inhibition of the expression of VEGF and VEGFR2 in synovial tissues and the formation of pannus and synovial hyperplasia may be part of the mechanism of HTTL for relieving the symptoms of rheumatoid arthritis in CIA rats.

关键词： Arthritis,experimental Tripterygium Vascular endothelial growth factor A Vascular endothelial growth factor receptor-2 Huatan Tongluo decocti on

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Confinement of Fe atoms between MoS_(2) interlayers drives phase transition for improved reactivity in Fenton-like reactions

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Nano Research 2024年第3期17卷 1132-1139页

作者： Yibing Sun Yu Zhou Hongchao Li Chuan Wang Xuan zhang qian Ma Yingchun cheng Jieshu qian Bingcai Pan Jiangsu Key Laboratory of Chemical Pollution Control and Resources Reuse School of Environmental and Biological EngineeringNanjing University of Science and TechnologyNanjing 210094China Key Laboratory of Flexible Electronics and Institute of Advanced Materials Jiangsu National Synergetic Innovation Center for Advanced MaterialsNanjing Tech UniversityNanjing 211816China Department of General Dentistry Affiliated Stomatological Hospital of Nanjing Medical UniversityJiangsu Province Key Laboratory of Oral DiseasesNanjing 210029China Research Center for Environmental Nanotechnology(ReCENT) State Key Laboratory of Pollution Control and Resources ReuseSchool of EnvironmentNanjing UniversityNanjing 210023China

Phase manipulation of MoS_(2) from thermodynamically stable 2H phase to the unstable but more reactive 1T phase represents a crucial strategy for improving the reactivity in many *** widely adopted wet chemistry approach uses intercalating entities especially alkali metal ions to achieve the phase transition;however,these entities are normally inert for the target ***,we describe the first use of iron atoms for the intercalation of 2H-MoS_(2) layers,driving the partial transition from 2H to 1T ***,in the peroxymonosulfate(PMS)-based Fenton-like reactions,the interlayered confinement of Fe atoms not only activates the inert basal plane,but also adds more reactive Fe sites for the formation of metal-PMS complex as primary reactive species for pollutant *** the degradation of a model pollutant carbamazepine(CBZ),the Fe-intercalated MoS_(2) exhibits a first order rate constant 13.3 times higher than 2H-MoS_(2).This strategy is a new direction for manipulating the phase composition and boosting the catalytic reactivity of MoS_(2)-based catalysts in various scenarios,including environmental remediation and energy applications.

关键词： confinement MoS_(2) Fe atoms Fenton-like reactions hydrogen evolution reaction

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Comprehensive understanding and rational regulation of microenvironment for gas-involving electrochemical reactions

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Carbon Energy 2023年第7期5卷 70-99页

作者： Qiyang cheng Mengfan Wang Jiajie Ni Lifang zhang Yu cheng Xi Zhou Yufeng Cao Tao qian chenglin Yan School of Chemistry and Chemical Engineering Nantong UniversityNantongChina Key Laboratory of Core Technology of High Specific Energy Battery and Key Materials for Petroleum and Chemical Industry College of EnergySoochow UniversitySuzhouChina Light Industry Institute of Electrochemical Power Sources Soochow UniversitySuzhouChina

Substantial progress has been made in the understanding of gas-involving electrochemical reactions recently for the sake of clean,renewable,and efficient energy ***,the specific influence mechanism of the microenvironment at the reaction interface on the electrocatalytic performance(activity,selectivity,and durability)remains ***,we provide a comprehensive understanding of the interfacial microenvironment of gas-involving electrocatalysis,including carbon dioxide reduction reaction and nitrogen reduction reaction,and classify the factors affecting the reaction thermodynamics and kinetics into gas diffusion,proton supply,and electron *** categorization allows a systematic survey of the literature focusing on electrolyzer-level(optimization of the device,control of the experimental condition,and design of the working electrode),electrolytelevel(increase of gas solubility,regulation of proton supply,and substitution of anodic reaction),and electrocatalyst-level strategies(promotion of gas affinity,adjustment of hydrophobicity,and enhancement of conductivity),aiming to retrieve the correlations between the microenvironment and electrochemical ***,priorities for future studies are suggested to support the comprehensive improvement of next-generation gas-involving electrochemical reactions.

关键词： CO_(2)RR electrocatalysis microenvironment NRR three-phase interface

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Effects of imidazolium-based ionic liquids on the isobaric vapor–liquid equilibria of methanol+dimethyl carbonate azeotropic systems

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Chinese Journal of Chemical Engineering 2020年第3期28卷 766-776页

作者： Songsong Chen Li Dong Junping zhang Weiguo cheng Feng Huo qian Su Wei Hua Beijing Key Laboratory of Ionic Liquids Clean Process CAS Key Laboratory of Green Process and EngineeringState Key Laboratory of Multiphase Complex SystemsInstitute of Process EngineeringChinese Academy of Sciences.Beijing 100090China School of Chemical Engineering University of Chinese Academy of SciencesBeijing 100049China SINOPEC Beijing Yanshan CompanyBeijing 102500China Dalian National Laboratory for Clean Energy Dalian 116023China

The separation of methanol(MeOH)and dimethyl carbonate(DMC)is important but difficult due to the formation of an azeotropic *** this work,isobaric vapor–liquid equilibrium(VLE)data for the ternary systems containing different imidazolium–based ionic liquids(ILs),***+DMC+1-butyl-3-methy-limidazolium bis[(trifluoromethyl)sulfonyl]imide([Bmim][Tf2N]),MeOH+DMC+1-ethyl-3-methyl-imidazolium bis[(trifluoromethyl)sulfonyl]imide([Emim][Tf2N]),and MeOH+DMC+1-ethyl-3-methylimidazolium hexafluorophosphate([Emim][PF6])were measured at 101.3 *** mole fraction of IL was varied from0.05 to *** experimental data were correlated with the NRTL and Wilson equations,*** results show that imidazolium-based ILs were beneficial to improve the relative volatility of MeOH to DMC,and[Bmim][Tf2 N]showed a much more excellent performance on the activity coefficient of *** interaction energies of system components were calculated using Gaussian program,and the effects of cation and anion on the separation coefficient of the azeotropic system were discussed.

关键词： Vapor liquid equilibria Ionic liquid Azeotrope Separation Interaction energy

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Prescribed-Time Fully Distributed Nash Equilibrium Seeking Strategy in Networked Games

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IEEE/CAA Journal of Automatica Sinica 2024年第1期11卷 261-263页

作者： cheng qian Lei Ding the Institute of Advanced Technology for Carbon Neutrality College of Automation&the College of Artificial Intelligence Nanjing University of Posts and TelecommunicationsNanjing 210023China IEEE

Dear Editor, This letter is concerned with prescribed-time fully distributed Nash equilibrium seeking for networked games under directed graphs. An adaptive algorithm is proposed to ensure the convergence of all players to the Nash equilibrium without requiring any knowledge of global parameters. Moreover, it is theoretically proved that the convergence time of the proposed seeking strategy can be predefined based on practical requirements. Finally, a numerical example is presented to validate the effectiveness of the proposed method.

关键词： parameters seeking prescribed

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淫羊藿苷预处理增强人牙周膜干细胞对M1型巨噬细胞的影响

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中国组织工程研究 2025年第7期29卷 1328-1335页

作者：喻婷吕冬梅邓浩孙涛程钎西南医科大学口颌面修复重建和再生泸州市重点实验室四川省泸州市646000 西南医科大学口腔医学研究所四川省泸州市646000 西南医科大学附属口腔医院正畸科四川省泸州市646000 西南医科大学口腔医学院四川省泸州市646000

背景:人牙周膜干细胞对M1型巨噬细胞促炎功能有一定抑制作用,具有抗炎等药理活性的淫羊藿苷是否能增强人牙周膜干细胞对M1型巨噬细胞的抑制作用尚不明确。目的:探究淫羊藿苷预处理人牙周膜干细胞后对M1型巨噬细胞的影响。方法:分离培养... 详细信息

背景:人牙周膜干细胞对M1型巨噬细胞促炎功能有一定抑制作用,具有抗炎等药理活性的淫羊藿苷是否能增强人牙周膜干细胞对M1型巨噬细胞的抑制作用尚不明确。目的:探究淫羊藿苷预处理人牙周膜干细胞后对M1型巨噬细胞的影响。方法:分离培养原代人牙周膜干细胞,并进行鉴定。对THP-1细胞进行诱导,采用免疫荧光染色及PCR进行M1型巨噬细胞鉴定。用含浓度10^(-7),10^(-6),10^(-5),10^(-4)mol/L淫羊藿苷的α-MEM完全培养基培养人牙周膜干细胞1,3,5,7 d,采用CCK-8法筛选合适的淫羊藿苷浓度进行实验。将α-MEM完全培养基、未处理的人牙周膜干细胞α-MEM条件培养基及淫羊藿苷预处理24 h的人牙周膜干细胞α-MEM条件培养基与RPMI-1640完全培养基以1∶1的比例对M1型巨噬细胞进行条件培养,分别为对照组、未处理组及预处理组,24 h后RT-PCR法检测M1型巨噬细胞炎症因子的mRNA表达情况;ELISA法检测M1型巨噬细胞炎症因子的蛋白表达情况;Western blot检测M1/M2型巨噬细胞表面标记物及核转录因子κB通路相关蛋白的表达。结果与结论:(1)CCK-8检测结果显示,10^(-7),10^(-6),10^(-5),10^(-4)mol/L淫羊藿苷对人牙周膜干细胞均无细胞毒性,且从第5天起,各浓度都提高了细胞活力,促进细胞增殖,选择10^(-4)mol/L淫羊藿苷进行后续实验。(2)RT-PCR法及ELISA检测结果显示,与对照组相比,未处理组及预处理组均降低了M1型巨噬细胞白细胞介素1β、白细胞介素6及肿瘤坏死因子α的表达与分泌(P<0.05),且预处理组低于未处理组(P<0.05)。(3)Western blot检测结果显示,与未处理组相比,预处理组CD86的表达明显降低(P<0.05);与对照组相比,未处理组和预处理组M2型巨噬细胞表面标志物CD206的表达均升高(P<0.01),且预处理组明显高于未处理组(P<0.01);M1型巨噬细胞经24 h条件培养后,与对照组相比,核转录因子κB/P65的表达在未处理组和预处理组均有降低(P<0.01),p-IκBα的表达仅在预处理组降低(P<0.01);与未处理组相比,预处理组核转录因子κB/P65和p-IκBα的表达均显著降低(P<0.05),而IκBα在3组中的表达差异无显著性意义。(4)上述结果证实,淫羊藿苷增强了人牙周膜干细胞对M1型巨噬细胞的抑制作用,此作用可能与抑制了巨噬细胞的核转录因子κB信号通路相关。

关键词：人牙周膜干细胞淫羊藿苷巨噬细胞条件培养基共培养表面标志物炎症因子抗炎核转录因子κB信号通路

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Pseudoelasticity and elastocaloric effect of Fe_(75.5)Ga_(24.5) single crystal

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Rare Metals 2023年第6期42卷 1989-1993页

作者： Kang-Yi Xu Jing-Min Wang qian Yu Chi zhang cheng-Bao Jiang Key Laboratory of Aerospace Materials and Performance(Ministry of Education) School of Materials Science and EngineeringBeihang UniversityBeijing100191China

-,-and -oriented single crystals of Fe_(75.5)Ga_(24.5) alloy were prepared by optical float zone melting *** pseudoelasticity behavior and elastocaloric effect of the single crystals were investigated,as well as the associate microstructures.D0_(3) phase structure was realized by solution treatment at 800 0C and annealed at 600℃ for 10 *** compressive deformation behavior exhibits significant dependence on the crystalline *** pseudoelasticity with recoverable strain up to 5% is obtained by compression along *** pseudoelasticity disappears after five deformation *** temperature change is simultaneously detected during the pseudoelasticity,especially during loading process.

关键词： FeGa Pseudoelasticity Elastocaloric effect

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