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Genetic association of autoimmune hepatitis and human leucocyte antigen in German patients

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world Journal of Gastroenterology 2006年第34期12卷 5513-5516页

作者： Andreas Teufel Markus wrns Arndt weinmann Catherine Centner Anja Piendl Ansgar w Lohse Peter R Galle Stephan Kanzler Department of Medicine I Johannes Gutenberg University Mainz Germany Department of Medicine I University of Hamburg Germany

AIM: To report on our large German collective and updated data of 142 patients with autoimmune hepatitis (AIH) type 1. METHODS: Key investigations performed were liver biopsy, serum autoantibodies as well as serum markers such as IgG and elevated transaminases. Antinuclear antigen (ANA) and smooth muscle antigen (SMA) autoantibodies characterized type 1 AIH. Type 3 (AIH) was solely characterized by the occurrence of soluble liver antigen/liver-pancreas antigen (SLA/LP) autoantibodies either with or without ANA or SMA autoantibodies. RESULTS: Most prevalent HLAs were A2 (68 patients, 48%), B8 (63 patients, 44%), C7 (90 patients, 63%), DR3 (49 patients, 38%), DR4 (49 patients, 38%) and DQ2 (42 patients, 30%). Compared to the Italian and North American patients, we found fewer patients with a DQ2 subtype. Furthermore, the B8-DR3-DQ2 human leucocyte antigen (HLA) was also less prominent compared to the North American patients. However, prevalences of B8, DR3, DR4, DR7, DR11 and DR13 were comparable to the Italian and North American patients. Furthermore, we report on an additional subgroup of patients with SLA/LP positive AIH. Generally, in this subgroup of patients the same HLA subtypes were favoured as the AIH type 1. CONCLUSION: Although HLA subtypes were comparable between these three collectives, the German patients were distinct from the Italian and North American patients with respect to DQ2 and from the North American patients with respect to B8-DR3-DQ2HLA. A clinical correlation, e.g. difference in severity or treatability of AIH type 1, has yet to be determined.

关键词： Autoimmune hepatitis Human leucocyte antigen Immunogenetics

Forty hours with a traumatic carotid transection： A diagnostic caveat and review of the contemporary management of penetrating neck trauma

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Chinese Journal of Traumatology 2018年第2期21卷 118-121页

作者： Eugene ng Ian Campbell Andrew Choong Allan Kruger Philip J. walker Department of Vascular Surgery Royal Brisbane & Women's Hospital Herston QLD 4006 Brisbane Australia

Although penetrating neck trauma （PNT） is uncommon, it is associated with the significant morbidity and mortality. The management of PNT has changed significantly over the past 50 years. A radiological assessment now is a vital part of the management with a traditional surgical exploration. A 22 years old male was assaulted by a screwdriver and sustained multiple penetrating neck injuries. A contrast CT scan revealed a focal pseudoaneurysm in the left common carotid artery bulb. There was no active bleeding or any other vascular injuries and the patient remained haemodynamically stable. In view of these findings, he was initially managed conservatively without an open surgical exploration. However, the patient was noted to have an acute drop in his hemoglobin count overnight post injury and the catheter directed angiography showed active bleeding from the pseudoaneurysm. Surgical exploration 40 hours follow.ng the initial injury revealed a penetrating injury through both arterial walls of the left carotid bulb which was repaired with a great saphenous vein patch. A percutaneous drain was inserted in the carotid tri- angle and a course of intravenous antibiotics for five days was commenced. The patient recovered well with no complications and remained asymptomatic at five months followup.

关键词： Penetrating neck trauma Management penetrating neck trauma Investigation penetrating neck trauma Assessment penetrating neck trauma

Npac Is A Co-factor of Histone H3K36me3 and Regulates Transcriptional Elongation in Mouse Embryonic Stem Cells

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Genomics, Proteomics & Bioinformatics 2022年第1期20卷 110-128页

作者： Sue Yu Jia Li Guanxu Ji Zhen Long ng Jiamin Siew wan Ning Lo Ying Ye Yuan Yuan Chew Yun Chau Long wensheng Zhang Ernesto Guccione Yuin Han Loh Zhi-Hong Jiang Henry Yang qiang wu Department of Biochemistry Yong Loo Lin School of MedicineNational University of SingaporeSingapore 117597Singapore Cancer Science Institute of Singapore Centre for Translational MedicineSingapore 117599Singapore The State Key Laboratory of Quality Research in Chinese Medicine Macao University of Science and TechnologyMacao Special Administrative Region 999078China Cam-Su Genomic Resource Center Soochow UniversitySuzhou 215123China Institute of Molecular and Cell Biology Singapore 138673Singapore

Chromatin modification contributes to pluripotency maintenance in embryonic stem cells(ESCs).However,the related mechanisms remain ***,we show that Npac,a"reader"of histone H3 lysine 36 trimethylation(H3K36me3),is required to maintain mouse ESC(mESC)pluripotency since knockdown of Npac causes mESC *** of Npac in mouse embryonic fibroblasts(MEFs)inhibits reprogramming ***,our chromatin immunoprecipitation followed by sequencing(ChIP-seq)results of Npac reveal that Npac co-localizes with histone H3K36me3 in gene bodies of actively transcribed genes in ***,we find that Npac interacts with positive transcription elongation factor b(p-TEFb),Ser2-phosphorylated RNA PolⅡ(RNA PolⅡSer2P),and Ser5-phosphorylated RNA PolⅡ(RNA PolⅡSer5 P).Furthermore,depletion of Npac disrupts transcriptional elongation of the pluripotency genes Nanog and *** together,we propose that Npac is essential for the transcriptional elongation of pluripotency genes by recruiting p-TEFb and interacting with RNA PolⅡSer2P and Ser5P.

关键词： Npac Pluripotency Reprogramming Histone H3K36me3 Transcriptional elongation

Compact Dual-Frequency Fiber Laser Accelerometer with Sub-μg Resolution

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Photonic Sensors 2016年第2期6卷 115-120页

作者： qian CAO Long JIN Yizhi liang Linghao CHEng Bai-Ou GUAN Guangdong Provincial Key Laboratory of Optical Fiber Sensing and Communications Institute of PhotonicsTechnology Jinan University Guangzhou 510632 China

we demonstrate a compact and high-resolution dual-polarization fiber laser accelerometer. A spring-mass like scheme is constructed by fixing a 10-gram proof mass on the laser cavity to transduce applied vibration into beat-frequency change. The loading is located at the intensity maximum of intracavity light to maximize the optical response. The detection limit reaches 107 ng/Hz1/2 at 200 Hz. The working bandwidth ranges from 60 Hz to 600 Hz.

关键词： Dual-frequency fiber lasers fiber Bragg grating photonic accelerometers

Serological diagnosis of nasopharyngeal carcinoma by enzyme linked immunosorbant assay:optimization,standardization and diagnostic criteria

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Chinese Medical Journal 1998年第6期000卷 51-56页

作者： M.H. ng, H.L. Chen, R.X. Luo, K.H. Chan, P.C.Y. woo, J.S.T. Sham, J. Huang, w.H.Seto P. Smith and B.E. Griffin Department of Microbiology The University of Hong Kong Hong Kong China Department of Biology Shantou University Shantou China Department of Microbiology Queen Mary Hospital Hong Kong China Department of Microbiology and Department of Radiation Oncology The University of Hong Kong Hong Kong China Department of Virology Royal Postgraduate Medical School University of London London United Kingdom

Objectives To produce an enzyme linked immunosorbant assay (ELISA) to detect antibodies against Epstein Barr virus (EBV) specified nuclear antigen 1 (EBNA 1) and the 18kD EBV matrix protein, and to determine and optimize its sensitivity and specificity for the diagnosis of nasopharyngeal carcinoma (NPC).Methods we used a combination of highly purified glutathione transferase fusion proteins of the 40kD carboxy domain of EBNA1 and the 18kD EBV matrix protein for coating ELISA plates. In three separate studies, we tested for IgA antibodies in serum specimens from 28 EBV seronegative donors, 284 EBV seropositive donors and 160 newly diagnosed NPC patients. By comparing the sensitivity and specificity of diagnosis obtained for different cutoff values, we derived several quantitative parameters to evaluate assay performance, establish objective diagnostic criteria which optimize the intrinsic diagnostic capability of the assay and assess the significance of individual test results, respectively. Optimum cutoff optical density (OD) is defined as the cutoff OD where sensitivity of the assay equals its specificity, and resolution of the assay is indicated by the value of sensitivity (or specificity) determined at the optimum cutoff OD. Diagnosis of NPC was achieved by setting a cutoff zone at +/-20% of this *** All the EBV seronegative donors tested were not reactive, and most of the EBV seropositive donors were weakly reactive, while the majority of NPC patients were moderately or strongly reactive. while the assay was thus shown to be specific for EBV, there was an overlap in the level of these serum antibodies between few individuals of the two latter groups. It was shown that the assay performed equally well in two separate studies conducted under different testing conditions and using different collections of sera in that assay resolution determined on these occasions were 86% and 87% respectively. Diagnosis of NPC can be achieved at the same expected sensiti

关键词： Serological diagnosis of nasopharyngeal carcinoma by enzyme linked immunosorbant assay

The revival of thermal utilization from the Sun: interfacial solar vapor generation

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National Science Review 2019年第3期6卷 562-578页

作者： Lin Zhou Xiuqiang Li George w.Ni Shining Zhu Jia Zhu National Laboratory of Solid State Microstructures College of Engineering and Applied Sciences School of Physics Key Laboratory of Intelligent Optical Sensing and Manipulation Ministry of Education Collaborative Innovation Center of Advanced Microstructures Nanjing University Department of Mechanical Engineering Massachusetts Institute of Technology

Since solar energy is the ultimate energy resource and a significant amount of global energy utilization goes through heat, there have been persistent efforts for centuries to develop devices and systems for solar–thermal conversion. Most recently, interfacial solar vapor generation, as an emerging concept of solar–thermal conversion, has gained significant attention for its great potentials in various fields such as desalination, sterilization, catalysis, etc. with the advances of rationally designed materials and structures and photon and thermal management at the nanoscale, interfacial solar vapor generation has demonstrated both thermodynamic and kinetical advantages over conventional strategies. In this review, we aim to illustrate the definition, mechanism and figures of merit of interfacial solar vapor generation, and to summarize the development progress of relevant materials and applications, as well as to provide a prospective view of the future.

关键词： solar vapor generation solar absorber solar evaporator interfacial heating

Human pluripotent stem cells:tools for regenerative medicine

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Biomaterials Translational 2021年第4期2卷 294-300页

作者： Peter w.Andrews The Centre for Stem Cell Biology The School of BioscienceThe University of SheffieldSheffieldUK

Human embryonic stem cells and induced pluripotent stem cells,together denoted as pluripotent stem cells have opened up unprecedented opportunities for developments in human healthcare over the past 20 *** much about the properties and behaviour of these cells required to underpin their applications has been discovered over this time,a number of issues *** brief review considers the history of these developments and some of the underlying biology,pointing out some of the problems still to be resolved,particularly in relation to their genetic stability and possible malignancy.

关键词： embryonic stem cell induced pluripotent stem cell human pluripotency differentiation

原发性开角型青光眼视神经损害进展与眼压波动及视盘旁萎缩弧扩大的关系

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眼科 2012年第1期21卷 39-42页

作者：张亚琴徐亮张莉李建军首都医科大学附属北京同仁医院北京同仁眼科中心北京市眼科研究所 100005

目的分析原发性开角型青光眼(POAG)视神经损害进展的相关危险因素。设计回顾性病例系列。研究对象北京同仁医院眼科门诊确诊的POAG、随访3年以上、眼底照片及眼压资料完整的患者115例(197眼)。方法将患者初次就诊和末次就诊的眼底图片... 详细信息

目的分析原发性开角型青光眼(POAG)视神经损害进展的相关危险因素。设计回顾性病例系列。研究对象北京同仁医院眼科门诊确诊的POAG、随访3年以上、眼底照片及眼压资料完整的患者115例(197眼)。方法将患者初次就诊和末次就诊的眼底图片在计算机图像处理软件下进行图像配准,通过叠加闪烁对比观察眼底病变的细微改变。平均随访(56.6±14.8)个月。青光眼视神经损害进展的标准为盘沿丢失进展或伴有视网膜神经纤维层缺损进展。主要指标可能导致青光眼视神经损害进展的多因素Logistic回归分析。结果视神经损害进展98眼,未进展99眼,进展率49.75%。单因素Logistic回归分析显示视神经损害进展与眼压波动(P=0.000)、峰值眼压(P=0.001)及随访时间(P=0.041)有关;卡方检验显示视神经损害进展与盘沿出血(P=0.02)及视盘旁萎缩弧扩大(P=0.000)有关。多因素Logistic回归分析显示视神经损害进展与眼压波动(P=0.000)及视盘旁萎缩弧扩大(P=0.000)有关。视神经损害进展组与未进展组相比,眼压波动明显大,前者眼压波动值平均为(2.87±1.29)(0.89～7.21),后者眼压波动值平均为(2.11±0.94)(0.25～4.97);并且视盘旁萎缩弧扩大的比例明显增高,视神经损害进展组无β区萎缩弧者5眼(5.1%),有β区萎缩弧扩大者75眼(76.53%)。结论除峰值眼压外,过大的眼压波动及β区萎缩弧扩大是POAG视神经损害进展的重要危险因素。

关键词：原发性开角型青光眼眼压波动萎缩弧

New Chinese Military History, 1839-1951： what＇s the Story？

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Frontiers of History in China 2018年第1期13卷 90-126页

作者： Charles w. Hayford Independent Scholar

Since 1990, New Chinese Military History in the west has remedied scholarly neglect of Chinese warfare and changed the usual stories of modern China. These studies disproved Orientalist assumptions of a unique ＂Chinese way of war＂ or a strategic culture that avoided aggressive confrontation. Scholars also challenge the assumption that Confucian immobility led to a clash of civilizations and decisive defeat in the Opium wars, First Sino-Japanese war, and Boxer war of 1900. In fact, qing officials were quick and successful in creating a new military regime. New military histories of the warlords, the Sino-Japanese wars, and the Chinese Civil war show that developing new types of warfare was central in creating the new nation. All these wars split the country into factions that were supported by outside powers： they were internationalized civil wars. The article also asks how the choice of terms, labels, and categories shapes interpretations and political messages.

关键词： historiography New Military History New Chinese MilitaryHistory war warfare Opium wars Taiping Rebellion Boxer Uprising Sino-Japanese war war of Resistance world war Two in Asia