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Communications in Theoretical Physics 2008年第8期50卷 497-500页

作者： ZHOU Jun XUE Chun-Hua qi Yi-Hong lou Sen-Yue Department of Physics Ningbo University Ningbo 315211 China Department of Optical Engineering Jiangsu University Zhenjiang 212013 China

The properties of controllable soliton switching in Kerr-type optical lattices with different modulation are investigated theoretically and simulated *** results show that the optical lattices can be available for all- optical soliton switching through utilization for length-scale competition *** through longitudinal exponential- asymptotic modulation for the linear refractive index,the properties of soliton switching in the optical lattices can be *** number of output channels of soliton switching can be controlled by the parameters such as incident angle,asymptotic rate of longitudinal modulation,guiding parameter and form factor.

关键词： nonlinear Schrodinger equation optical lattices soliton switching

Establishment of a Lateral Flow Dipstick Detection Method for Influenza A Virus Based on CRISPR/Cas12a System

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China CDC weekly 2024年第37期6卷 946-952,I0008页

作者： Xiaoyan Zhao Ximing Zheng Xiyong Yang qi Guo Yi Zhang Jun lou Department of Clinical Laboratory Zhumadian Central HospitalZhumadian CityHenan ProvinceChina Laboratory of Virology Beijing Key Laboratory of Etiology of Viral Diseases in ChildrenCapital Institute of PediatricsBeijingChina National Institute for Viral Disease Control and Prevention Chinese Center for Disease Control and PreventionBeijingChina

Objective:This study aimed to develop a rapid,visual PCR-CRISPR/Cas12-LFD method for detecting influenza A by utilizing the conserved region of the matrix protein ***:We crafted universal degradation primers and clustered regularly interspaced short palindromic repeats RNA(CRISPR RNA,crRNA)targeting the conserved matrix protein gene of the influenza virus(IFV),integrated with lateral flow dipstick(LFD)*** new PCR-CRISPR/Cas12-LFD approach was designed to determine its sensitivity and specificity through the analysis of various clinical samples collected in ***:The developed nucleic acid assay for influenza A viruses(IAV)demonstrated a sensitivity of 10 copies/μL without cross-reactivity with other respiratory *** of 82 clinical samples showed high concordance with results from fluorescent Polymerase Chain Reaction(PCR),achieving a kappa value of ***:A highly sensitive and specific PCRCRISPR/Cas12-LFD method has been successfully established for the detection of influenza A,offering a robust tool for its diagnosis and aiding in the prevention and control of this virus.

关键词： prevention diagnosis specificity

Intratumoral heterogeneity of hepatocellular carcinoma: From singlecell to population-based studies

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World Journal of Gastroenterology 2020年第26期26卷 3720-3736页

作者： qi Zhang Yu lou Xue-Li Bai Ting-Bo Liang Department of Hepatobiliary and Pancreatic Surgery the First Affiliated HospitalZhejiang University School of MedicineHangzhou 310003Zhejiang ProvinceChina Key Laboratory of Pancreatic Disease of Zhejiang Province Hangzhou 310003Zhejiang ProvinceChina Innovation Center for the Study of Pancreatic Diseases of Zhejiang Province Hangzhou 310003Zhejiang ProvinceChina Zhejiang Clinical Research Center of Hepatobiliary and Pancreatic Diseases Hangzhou 310003Zhejiang ProvinceChina

Hepatocellular carcinoma(HCC)is characterized by high heterogeneity in both intratumoral and interpatient *** interpatient heterogeneity is related to personalized therapy,intratumoral heterogeneity(ITH)largely influences the efficacy of therapies in *** contributes to tumor growth,metastasis,recurrence,and drug resistance and consequently limits the prognosis of patients with *** is an urgent need to understand the causes,characteristics,and consequences of tumor heterogeneity in HCC for the purposes of guiding clinical practice and improving ***,we summarize the studies and technologies that describe ITH in HCC to gain insight into the origin and evolutionary process of *** parallel,evidence is collected to delineate the dynamic relationship between ITH and the tumor *** suggest that conducting comprehensive studies of ITH using single-cell approaches in temporal and spatial dimensions,combined with population-based clinical trials,will help to clarify the clinical implications of ITH,develop novel intervention strategies,and improve patient prognosis.

关键词： Hepatocellular carcinoma Tumor heterogeneity Tumor microenvironment Single-cell analysis Local immunity

Mechanical-force-promoted peptide assembly: a general method

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Nuclear Science and Techniques 2018年第9期29卷 192-196页

作者： Yue Yuan qi-qi-Ge Du Yu-Jiao Wang Jun Hu Shi-Tao lou Yi Zhang State Key Laboratory of Precision Spectroscopy East China Normal University Key Laboratory of Interfacial Physics and Technology Shanghai Institute of Applied Physics Chinese Academy of Sciences School of Life Sciences Inner Mongolia Agricultural University

A general method was developed for promoting peptide assembly and protein polymerization to form nanoscale patterns on various surfaces with an atomic force microscope(AFM) operated in a liquid. By scanning solid surfaces with an AFM tip, we showed that peptide monomers assemble at a higher rate in the tip-scanned area compared to other regions. The promotion is attributed to the mechanical force applied by the scanning tip. This kind of mechanical-force-promoted assembly was also observed with different peptides on various substrates. The force promoting peptide assembly provides a simple and practical solution for preparing and building peptide and protein architectures for future nanodevices.

关键词： Self-assembly Peptide Nanomechanical stimulus Support lipid bilayers Atomic force microscope

Sesquiterpene Esters from Salvia roborowskii

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Chinese Chemical Letters 2003年第11期14卷 1156-1158页

作者： Ya LI Ning lou Yan qi WU Xian Feng LIN Yu LI National Laboratory of Applied Organic Chemistry Lanzhou UniversityLanzhou 730000

Two new sesquiterpene esters, 3b, 6b, 8a-triacetyl-4b, 5a-epoxy -1- oxogermacr- 10(14)-ene (1) and 3b, 6b, 8a-triacetyl-4b, 5a-epoxygermacr-1(10)-ene (2) were isolated from the whole plant of Salvia roborowskii Maxim.... 详细信息

关键词： Salvia roborowskii Labiatae sesquiterpene germacrane.

Synthesis of stimuli-responsive pillararene-based supramolecular polymer materials for the detection and separation of metal ions

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Chinese Chemical Letters 2023年第5期34卷 268-273页

作者： Yongfu Li Xinyue lou Chunyu Wang Yan Wang Yu Jia qi Lin Yingwei Yang International Joint Research Laboratory of Nano-Micro Architecture Chemistry College of ChemistryJilin UniversityChangchun 130012China State Key Laboratory of Supramolecular Structure and Materials Institute of Theoretical ChemistryLaboratory of Theoretical and Computational ChemistryCollege of ChemistryJilin UniversityChangchun 130012China Key Laboratory of Eco-Functional Polymer Materials of the Ministry of Education Key Laboratory of Eco-Environmental Polymer Materials of Gansu ProvinceCollege of Chemistry and Chemical EngineeringNorthwest Normal UniversityLanzhou 730070China

A stimuli-responsive supramolecular polymer network(G-(CN)_(2)⊂BXDSP5)with aggregation-induced emission(AIE)properties has been efficiently constructed by host-guest interactions between pillar[5]arene derivative BXDSP5 and a homoditopic guest G-(CN)_(2),which shows not only excellent fluorescence properties due to the AIE effect but also desirable ion-sensing abilities in both solution and solid states,holding great potential in the applicable fluorescence detection for Fe^(3+).The resultant G-(CN)_(2)⊂BXDSP5 can be transformed into supramolecular polymer gel at high concentration via multiple noncovalent interactions,showing multi-stimuli-responsiveness in response to temperature change,mechanical force,and competitive ***,the xerogel of supramolecular polymer material has been successfully used to remove Fe^(3+)from water with high adsorption *** addition,an ionresponsive film based on supramolecular polymer has also been developed,which can serve as a practical and convenient fluorescence test kit for detecting Fe^(3+).

关键词： Aggregation-induced emission Host-guest chemistry Sensing and separation Stimuli-responsive materials Supramolecular polymer materials

Differences and identification on multi-time hydrocarbon generation of carboniferous-permian coaly source rocks in the Huanghua Depression,Bohai Bay Basin

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Petroleum Science 2024年第2期21卷 765-776页

作者： Jin-Jun Xu Xian-Gang Cheng Shu-Nan Peng Jun-Cai Jiang qi-Long Wu Da lou Fu-qi Cheng La-Mei Lin National Key Laboratory of Deep Oil and Gas China University of Petroleum(East China)Qingdao 266580ShandongChina PetroChina Dagang Oilfield Company Tianjin300280China

Coal is a solid combustible mineral,and coal-bearing strata have important hydrocarbon generation potential and contribute to more than 12%of the global hydrocarbon ***,the deposition and hydrocarbon evolution process of ancient coal-bearing strata is characterized by multiple geological times,leading to obvious distinctions in their hydrocarbon generation potential,geological processes,and production,which affect the evaluation and exploration of hydrocarbon resources derived from coaly source rocks *** study aimed to identify the differences on oil-generated parent macerals and the production of oil generated from different coaly source rocks and through different oil generation *** with the analysis of previous tectonic burial history and hydrocarbon generation history,high-temperature and high-pressure thermal simulation experiments,organic geochemistry,and organic petrology were performed on the Carboniferous-Permian(C-P)coaly source rocks in the Huanghua Depression,Bohai Bay *** oil-generated parent macerals of coal's secondary oil generation process(SOGP)were mainly hydrogen-rich collotelinite,collodetrinite,sporinite,and cutinite,while the oil-generated parent macerals of tertiary oil generation process(TOGP)were the remaining small amount of hydrogen-rich collotelinite,sporinite,and cutinite,as well as dispersed soluble organic matter and unexhausted residual *** with coal,the oil-generated parent macerals of coaly shale SOGP were mostly sporinite and *** part of hydrogen-poor vitrinite,lacking hydrocarbon-rich macerals,and macerals of the TOGP,in addition to some remaining cutinite and a small amount of crude oil and bitumen from SOGP contributed to the oil *** results indicated that the changes in oil yield had a good junction between SOGP and TOGP,both coal and coaly shale had higher SOGP aborted oil yield than TOGP starting yield,and coaly shale TOGP peak oil yield was low

关键词： Thermal simulation Multi-time oil generation processes Coaly source rock Carboniferous-permian Huanghua Depression

8周运动预适应增强脂肪干细胞治疗心肌梗死大鼠的效果

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中国组织工程研究 2025年第7期29卷 1363-1370页

作者：娄国张敏付常喜江苏经贸职业技术学院江苏省南京市211168 南京旅游职业学院江苏省南京市211100 徐州工程学院体育学院江苏省徐州市221008

背景:干细胞移植是心肌梗死的崭新疗法,然而梗死区域极其恶劣的微环境造成干细胞存活率低下并导致远期疗效甚微。运动预适应是一种通过运动诱导机体产生内源性保护效应的方式,可作为心脏康复预防与治疗的新策略。目的:评估运动预适应是... 详细信息

背景:干细胞移植是心肌梗死的崭新疗法,然而梗死区域极其恶劣的微环境造成干细胞存活率低下并导致远期疗效甚微。运动预适应是一种通过运动诱导机体产生内源性保护效应的方式,可作为心脏康复预防与治疗的新策略。目的:评估运动预适应是否能够增强大鼠心肌梗死后脂肪干细胞移植的心脏保护效应,探讨血管生成在其中的作用机制。方法:6周龄雄性SD大鼠随机分为对照组、造模组、干细胞组以及干细胞运动组。利用冠状动脉闭塞术制作急性心肌梗死模型,对照组同期行假手术;干细胞运动组于造模前进行8周有氧运动,造模后30 min进行脂肪干细胞移植;干细胞组仅进行脂肪干细胞移植。干细胞移植后1 d和7 d,利用免疫印迹法测定心肌总Akt(t-Akt)、磷酸化Akt(p-Akt)、血管内皮生长因子(VEGF)、总内皮型一氧化氮合酶(t-eNOS)和磷酸化内皮型一氧化氮合酶(p-eNOS)蛋白表达量,计算p-Akt/t-Akt和p-eNOS/t-eNOS比值;4周后利用彩色多普勒超声诊断系统检测心脏结构与功能以及心肌血流量,TTC染色法检测心肌梗死面积,Masson染色法检测心肌间质胶原沉积,免疫荧光染色法测定心肌毛细血管密度,TUNEL染色法评估心肌细胞凋亡。结果与结论:(1)干细胞移植后4周:与对照组比较,造模组左心室缩短分数、左心室射血分数、心肌毛细血管密度和心肌血流量下降(P0.05);与造模组比较,干细胞组上述指标均无显著性变化(P>0.05),干细胞运动组磷酸化p-Akt蛋白表达量以及p-Akt/t-Akt比值上调(P0.05),干细胞运动组p-Akt、VEGF、p-eNOS蛋白表达量以及p-Akt/t-Akt、p-eNOS/t-eNOS比值升高(P<0.05)。结果表明:运动预适应可增强脂肪干细胞对心肌梗死大鼠心脏重塑的治疗效果,其机制与促进心肌血管生成并增加血流灌注有关。

关键词：干细胞脂肪干细胞运动预适应心肌梗死血管生成心脏重塑血流灌注

Optimal Dual-Channel Dynamic Pricing of Perishable Items under Different Attenuation Coefficients of Demands

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Journal of Systems Science and Systems Engineering 2021年第1期30卷 44-58页

作者： Zhenkai lou Fujun Hou Xuming lou School of Management and Economics Beijing Institute of TechnologyBeijing100081China School of Economics and Management Xi’an University of Posts and TelecommunicationsXi’an710061China

This paper discusses optimal dual-channel dynamic pricing of a retailer who sells perishable products in a finite *** type of product which is equipped with different attenuation coefficients of demands on different sales channels is *** demand functions for the two channels are proposed according to attenuation coefficients of demands,and then a decision model is constructed,which can be handled *** is shown that the sales price and the sales quantity of the channel which possesses more market shares are both higher than the ones of the other channel at each sales *** importantly,by analyzing the reasonability of the obtained solution,a necessary and sufficient condition is proposed to guarantee that both of the two channels will not stop selling through the entire *** also propose an approach by the elimination method to deal with cases in which some channel stops ***,we demonstrate that the channel which possesses more market shares is the optimal option when only one channel ***,numerical examples are presented to investigate the change of sales prices of the two channels under different market potential demands.

关键词： Dual-channel pricing multi-stage pricing attenuation coefficients of demands stop selling

Charybdis japonica genome provides insights into desiccation adaptation and sex-determining region

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Zoological Research 2022年第6期43卷 927-930页

作者： Zhi-qiang Han Tian-Xiang Gao Fang-Rui lou qi Liu Fishery College Zhejiang Ocean UniversityZhoushanZhejiang 316022China School of Ocean Yantai UniversityYantaiShandong 264001China Wuhan Onemore-tech Co. Ltd.WuhanHubei 430076China

DEAR EDITOR, Shore swimming crabs, such as Charybdis japonica, predominantly inhabit the intertidal zones and exhibit high tolerance to desiccation. Here, we present the first chromosome-level C. japonica genome, containing 51 pseudochromosomes, with a revised genome length of 1 431.02 Mb and scaffold N50 size of 29.67 Mb. In addition.

关键词： revised dis des