Mechanical-force-promoted peptide assembly: a general method

作     者：Yue Yuan Qi-Qi-Ge Du Yu-Jiao Wang Jun Hu Shi-Tao Lou Yi Zhang 

作者机构：State Key Laboratory of Precision Spectroscopy East China Normal University Key Laboratory of Interfacial Physics and TechnologyShanghai Institute of Applied Physics Chinese Academy of Sciences School of Life Sciences Inner Mongolia Agricultural University 

出 版 物：《Nuclear Science and Techniques》 (核技术（英文）)

年 卷 期：2018年第29卷第9期

页      面：192-196页

核心收录：

学科分类：08[工学] 0807[工学-动力工程及工程热物理] 0827[工学-核科学与技术] 0703[理学-化学] 0702[理学-物理学] 0801[工学-力学（可授工学、理学学位）] 

基　　金：supported by the National Natural Science Foundation of China(No.11674344) the National Basic Research Program of China(973 program,No.2013CB932801) the Key Research Program of Frontier Sciences,Chinese Academy of Sciences(No.QYZDJ-SSW-SLH019-2) 

主　　题：Self-assembly Peptide Nanomechanical stimulus Support lipid bilayers Atomic force microscope 

摘      要：A general method was developed for promoting peptide assembly and protein polymerization to form nanoscale patterns on various surfaces with an atomic force microscope(AFM) operated in a liquid. By scanning solid surfaces with an AFM tip, we showed that peptide monomers assemble at a higher rate in the tip-scanned area compared to other regions. The promotion is attributed to the mechanical force applied by the scanning tip. This kind of mechanical-force-promoted assembly was also observed with different peptides on various substrates. The force promoting peptide assembly provides a simple and practical solution for preparing and building peptide and protein architectures for future nanodevices.