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Environmental Effects of Groundwater Development in Xuzhou City, China

Journal of China University of Mining and Technology 2006年第1期16卷 13-16页

作者： HAN Bao-ping LIU Xi-kun ZHU Xue-qiang feng qi-yan sun Xiao-fei School of Environmental Science and Spatial Informatics China University of Mining ＆ Technology Xuzhou Jiangsu 221008 China

Xuzhou City is located in the most northwestern portion of Jiangsu Province, P. R. China. Karst groundwater in the Ordovician and Cambrian Limestone aquifers is the main source of water supply. There are 527 wells in urban areas to exploit the karst groundwater, yielding up to 35 000 m^3 per day. After 1978, urbanization and industrialization of Xuzhou City have continued at a greatly accelerated pace; the population increased from 670 700 （1978） to 1 645 500 （2002）, its GDP from 0.71 × 10^9 $ to 42.7× 10^9 $ and the urban area from 184 km^2 to 1,038 km^2 （built-up city area from 41.3 km^2 to 81.9 km^2）. The volume of karst groundwater withdrawal increased yearly before the operation of a supply plant of surface water in 1992, from 3.85x 10^7 m^3（1978） to 1.34× 10^8 m^3 （1991） and now maintained at 0.1× 10^9 m^3 （2002）. Intensive overexploitation of karst groundwater has caused a continuous descending of the piezometric level and the area of the depression cone increases year after year. These changes have increased the vulnerability of the karst groundwater system and have induced environmental problems such as depletion of water resources, water quality deterioration, groundwater contamination and karst collapse. The largest buried depth of karst groundwater is up to 100 m in the dry season in some areas, while 66 exhausted wells have been abandoned. A change in the thickness of the unsaturated zone due to the drawdown of the piezometric level has caused a change of the chemical environment which has an impact on the physical state and major chemical compositions in groundwater. The contents of Ca^2＋, Mg^2＋, NO3^-, SO4^2- and C1^- in karst groundwater has increased significantly, total hardness （CaCO3 content） rises annually in most pumping wells and exceeds the Standard of Drinking Water of P.R. China. Point source pollution and belt-like pollution along the rivers has caused water quality deterioration. The sudden loss of buoyant support due to rapid drawdown of

关键词： Xuzhou City karst groundwater vulnerability of groundwater environmental problem

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Knockdown of DEAD-box 51 inhibits tumor growth of esophageal squamous cell carcinoma via the PI3K/AKT pathway

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World Journal of Gastroenterology 2022年第4期28卷 464-478页

作者： Dong-Xin Hu qi-feng sun Lin Xu Hong-Da Lu Fan Zhang Zhen-Miao Li Ming-Yan Zhang Department of Thoracic Surgery Shandong Provincial Hospital Affiliated to Shandong First Medical UniversityJinan 250000Shandong ProvinceChina Department of Gastroenterology Shandong Provincial Hospital Affiliated to Shandong First Medical UniversityJinan 250000Shandong ProvinceChina

BACKGROUND Esophageal squamous cell carcinoma(ESCC)is one of the most prevalent malignancies that seriously threaten people’s health ***-box helicase 51(DDX51)is a member of the DEAD-box(DDX)RNA helicase family,and drives or inhibits tumor progression in multiple cancer *** To determine whether DDX51 affects the biological behavior of *** The expression of DDX51 in ESCC tumor tissues and adjacent normal tissues was detected by Immunohistochemistry(IHC)analyses and quantitative PCR(qPCR).We knocked down DDX51 in ESCC cell lines by using a small interfering RNA(siRNA)*** proliferation,apoptosis,and mobility of DDX51 siRNAtransfected cells were *** effect of DDX51 on the phosphoinositide 3-kinase(PI3K)/AKT pathway was investigated by western blot analysis.A mouse xenograft model was established to investigate the effects of DDX51 knockdown on ESCC tumor *** DDX51 exhibited high expression in ESCC tissues compared with normal tissues and represented a poor prognosis in patients with *** of DDX51 induced inhibition of ESCC cell proliferation and promoted ***,DDX51 siRNA-expressing cells also exhibited lower migration and invasion *** into the underlying mechanisms suggested that DDX51 knock down induced inactivation of the PI3K/AKT pathway,including decreased phosphorylation levels of phosphate and tensin homolog,PI3K,AKT,and mammalian target of *** experiments demonstrated that the AKT activator insulin-like growth factor 1 could reverse the inhibitory effects of DDX51 on ESCC malignant ***,we injected DDX51 siRNA-transfected TE-1 cells into an animal model,which resulted in slower tumor *** Our study suggests for the first time that DDX51 promotes cancer cell proliferation by regulating the PI3K/AKT pathway;thus,DDX51 might be a therapeutic target for ESCC.

关键词： Esophageal squamous cell carcinoma DDX51 PI3K/AKT pathway Tumor growth Therapeutic target

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Origanum vulgare *** extract alleviates finasteride-induced oxidative stress in mouse liver and kidney

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Asian Pacific Journal of Tropical Biomedicine 2021年第5期11卷 194-204页

作者： qi-feng sun Shi-Xiang Chen Zhang-feng Tang Xiao-Yi Song Fa Jing Hao-Tian Wu Zhong-Yang Ding Attalla El-kott Diaa Massoud Heba Khalifa Department of Hepatobiliary and Vascular Surgery Jinan City People's HospitalJinanShandong Province271100China Department of Hepatology Zhejiang University Ming Zhou HospitalNingboZhejiang Province315199China Department of General Surgery Wuxi Traditional Chinese Medicine Hospital Affiliated to Nanjing University of Traditional Chinese MedicineWuxiJiangsu Province214023China Biology Department College of ScienceKing Khalid UniversityAbhaSaudi Arabia Zoology Department College of ScienceDamanhour UniversityDamanhourEgypt Biology Department College of ScienceJouf UniversityP.O.Box 2014SakakaAl-JoufSaudi Arabia Zoology Department Faculty of ScienceFayoum UniversityFayoumEgypt

Objective:To investigate the hepatorenoprotective effects of Origanum vulgare *** finasteride-induced oxidative injury in the liver and kidney of ***:Liquid chromatography-electrospray ionization-tandem mass spectrometry(LC-ESI/MS)analysis was utilized to yield a fingerprint of Origanum vulgare polyphenolic *** BALB/c mice received 0.5 mL/day distilled water,finasteride(25 mg/kg/day for 10 d),and 100,200,or 400 mg/kg/day finasteride+Origanum vulgare extract with 6 mice per group for five *** day 36,liver and kidney function as well as pro-and antiinflammatory(IFN-γ,IL-12,IL-6,TNF-α,IL-1β,and IL-10)cytokines were *** total antioxidant status,nitric oxide(NO),and malondialdehyde levels as well as the activities of NO synthase and catalase were also *** study was conducted to assess the effect of Origanum vulgare extract on finasteride-induced renal and hepatic ***:Twenty-five major polyphenolic compounds were identified in the Origanum vulgare extract by LC-ESI/*** vulgare extract,especially at 200 and 400 mg/kg/day doses,significantly improved liver and kidney biochemical indices,decreased inflammatory cytokines,increased total antioxidant status and NO synthase and catalase activities,as well as decreased plasma NO and malondialdehyde levels in a dose-dependent manner as compared to the finasteride *** results further confirmed the protective effect of Origanum vulgare ***:Origanum vulgare extract ameliorates finasterideinduced hepatic and renal biochemical and histopathological alterations,and restores antioxidant/oxidant balance.

关键词： Kidney Liver Origanum vulgare L. Inflammation Antioxidant

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城镇化影响农村生活能源消费的机制——基于中国1997～2012年省级面板数据的实证分析

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系统工程 2016年第12期34卷 70-75页

作者：李风琦孙凤英曹建华上海财经大学财经研究所上海200433 湖南省社会科学界联合会湖南长沙410003 中南林业科技大学湖南长沙410004

改革开放以来,我国城镇化率不断提高,城镇化对农村的影响日益多元和广泛深刻。本文将城镇化细分为经济城镇化、土地城镇化和人口城镇化等三个因素,并分析其影响农村生活能源消费的作用机制：经济城镇化中城镇GDP的影响是倒U型关系,即随... 详细信息

改革开放以来,我国城镇化率不断提高,城镇化对农村的影响日益多元和广泛深刻。本文将城镇化细分为经济城镇化、土地城镇化和人口城镇化等三个因素,并分析其影响农村生活能源消费的作用机制：经济城镇化中城镇GDP的影响是倒U型关系,即随着城镇经济不断发展,农村生活能源消费量先增加,达到峰值后再下降。农村GDP的影响是正向的;土地城镇化的影响是随着区域经济的发展从负转向正;人口城镇化的影响为正且相对较小。为验证理论假说,以我国1997~2012年省级面板数据,建立全国、东部、中部和西部区域的固定（随机）效应模型分析,并在实证分析基础上提出政策建议。

关键词：城镇化农村生活能源机制研究

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Depression mechanism of sulfite ions on sphalerite and Pb^(2+)activated sphalerite in the flotation separation of galena from sphalerite

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International Journal of Minerals,Metallurgy and Materials 2025年第2期32卷 335-345页

作者： feng Zhang Chenyang Zhang Linlin Wu Wei sun Hongliang Zhang Jianhua Chen Yong Pei Songjiang Li Engineering Research Center of Ministry of Education for Carbon Emission Reduction in Metal Resource Exploitation and Utilization Hunan International Joint Research Center for Efficient and Clean Utilization of Critical Metal Mineral ResourcesSchool of Minerals Processing and BioengineeringCentral South UniversityChangsha 410083China State Key Laboratory of Mineral Processing Beijing General Research Institute of Mining&MetallurgyBeijing 100160China Hunan Provincial Key Laboratory of Micro&Nano Materials Interfaces Science College of Chemistry and Chemical EngineeringCentral South UniversityChangsha 410083China School of Resources Environment and MaterialsGuangxi UniversityNanning 530004China Department of Chemistry Xiangtan UniversityXiangtan 411105China China Railway Resource Group Co.Ltd Beijing 102300China

The depression mechanism of sulfite ions on sphalerite and Pb^(2+)activated sphalerite in the flotation separation of galena from sphalerite still lacked in-depth ***,the depression mechanism of sulfite ions on sphalerite and Pb^(2+)activated sphalerite in the flotation separation of galena from sphalerite was further systematically investigated with experiments and density functional theory(DFT)*** X-ray photoelectric spectroscopy(XPS)results,DFT calculation results,and frontier molecular orbital analysis indicated that sulfite ions were difficult to be adsorbed on sphalerite surface,suggesting that sulfite ions achieved depression effects on sphalerite through other non-adsorption ***,the oxygen content in the surface of sphalerite treated with sulfite ions in creased,which enhanced the hydrophilicity of the sphalerite and further increased the difference in hydrophilicity between sphalerite and ***,sulfite ions were chelated with lead ions to form PbSO_(3)in *** hydrophilic PbSO_(3)was more easily adsorbed on sphalerite than *** interaction between sulfite ions and lead ions could effectively inhibit the activation of *** addition the UV spectrum showed that after adding sulfite ions,the peak of perxanthate in the sphalerite treated xanthate solution was significantly stronger than that in the galena with xanthate solution,indicating that xanthate interacted more readily with sulfite ions and oxygen mo lecules within the sphalerite system,leading to the formation of ***,sulfite ions hardly depressed the flotation of ga lena and could promote the flotation of galena to some *** study deepened the understanding of the depression mechanism o sulfite ions on sphalerite and Pb^(2+)activated sphalerite.

关键词： sphalerite galena sulfite ion density functional theory depression mechanism

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Flexible molecules dedicate to release strain of inverted inorganic perovskite solar cell

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Journal of Energy Chemistry 2025年第1期100卷 87-93页

作者： Hongrui sun Sanlong Wang Pengyang Wang Yali Liu Shanshan qi Biao Shi Ying Zhao Xiaodan Zhang Institute of Photoelectronic Thin Film Devices and Technology Renewable Energy Conversion and Storage Center State Key Laboratory of Photovoltaic Materials and CellsNankai University Key Laboratory of Photoelectronic Thin Film Devices and Technology of Tianjin Haihe Laboratory of Sustainable Chemical Transformations Engineering Research Center of Thin Film Photoelectronic Technology of Ministry of Education Collaborative Innovation Center of Chemical Science and Engineering (Tianjin)

The tensile strain in inorganic perovskite films induced by thermal annealing is one of the primary factors contributing to the inefficiency and instability of inorganic perovskite solar cells （IPSCs）,which reduces the defect formation ***,a flexible molecule 5-maleimidovaleric acid （5-MVA） was introduced as a strain buffer to release the residual strain of *** anhydride and carboxyl groups in 5-MVA interact strongly with the uncoordinated Pb2+through Lewis acid-base reaction,thus tightly“pull”the perovskite *** in-between soft carbon chain increased the structural flexibility of CsPbI2.85Br0.15perovskite materials,which effectively relieved the intrinsic internal strain of CsPbI2.85Br0.15,resisted the corrosion of external strain,and also reduced the formation of defects such as VIand *** addition,the introduction of 5-MVA improved crystal quality,passivated residual defects,and narrowed energy level ***,power conversion efficiency （PCE） of NiOxbased inverted IPSCs increased from 19.25% to 20.82% with the open-circuit voltage enhanced from 1.164 V to 1.230 *** release of strain also improved the stability of CsPbI2.85Br0.15perovskite films and devices.

关键词： Inverted inorganic perovskite solar cells Flexible molecules Strain release Crystallization Energy barrier High PCE

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Metal nanoparticles decorated CoFe-(oxy)hydroxysulfides nanosheets fabricated by a general strategy for electrocatalytic water splitting

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Journal of Energy Chemistry 2025年第1期100卷 26-38页

作者： Xiaodong Yang Haochen Shen Xiaoming Xiao Zhichao Li qi Zhou Wei Yang Bin Jiang Yongli sun Luhong Zhang Zhenhua Yan School of Chemical Engineering and Technology Tianjin University Key Laboratory of Advanced Energy Materials Chemistry (Ministry of Education) Nankai University

This study presents a novel method to fabricate metal-decorated,sulfur-doped layered double hydroxides （M/SLDH） through spontaneous redox and sulfurization *** developed Ag/SLDH and Pt/SLDH catalysts with abundant heterogeneous interfaces and hierarchical nanostructures demonstrated outstanding oxygen evolution reaction （OER） and hydrogen evolution reaction （HER） performance,achieving low overpotentials of 212 and 35 mV at 10 mA cm-2in 1 M KOH,*** both anode and cathode in water splitting,they required only 1.47 V to reach 10 mA cm-2and exhibited high structural robustness,maintaining stability at 1000 mA cm-2for 300 ***-situ Raman analysis revealed that the synergistic effects of metal nanoparticles and S doping significantly promote the transformation into the S-Co1-xFexOOH layer,which serves as the active phase for water ***,ultraviolet photoelectron spectroscopy （UPS） and density functional theory （DFT） analyses indicated that incorporating metal nanoparticles and S doping increase electron density near the Fermi level and reduce reaction energy barriers,thus enhancing intrinsic OER and HER *** study provides a scalable strategy for synthesizing high-performance electrocatalysts for water splitting,with promising potential for broader applications.

关键词： LDH Spontaneous reaction Metal nanoparticles Water splitting

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Meningeal lymphatic vessel crosstalk with central nervous system immune cells in aging and neurodegenerative diseases

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Neural Regeneration Research 2025年第3期20卷 763-778页

作者： Minghuang Gao Xinyue Wang Shijie Su Weicheng feng Yaona Lai Kongli Huang Dandan Cao qi Wang Science and Technology Innovation Center Guangzhou University of Chinese MedicineGuangzhouGuangdong ProvinceChina Institute of Clinical Pharmacology Guangzhou University of Chinese MedicineGuangzhouGuangdong ProvinceChina The Sixth Affiliated Hospital Sun Yat-sen UniversityGuangzhouGuangdong ProvinceChina

Meningeal lymphatic vessels form a relationship between the nervous system and periphery, which is relevant in both health and disease. Meningeal lymphatic vessels not only play a key role in the drainage of brain metabolites but also contribute to antigen delivery and immune cell activation. The advent of novel genomic technologies has enabled rapid progress in the characterization of myeloid and lymphoid cells and their interactions with meningeal lymphatic vessels within the central nervous system. In this review, we provide an overview of the multifaceted roles of meningeal lymphatic vessels within the context of the central nervous system immune network, highlighting recent discoveries on the immunological niche provided by meningeal lymphatic vessels. Furthermore, we delve into the mechanisms of crosstalk between meningeal lymphatic vessels and immune cells in the central nervous system under both homeostatic conditions and neurodegenerative diseases, discussing how these interactions shape the pathological outcomes. Regulation of meningeal lymphatic vessel function and structure can influence lymphatic drainage, cerebrospinal fluid-borne immune modulators, and immune cell populations in aging and neurodegenerative disorders, thereby playing a key role in shaping meningeal and brain parenchyma immunity.

关键词： central nervous system meningeal lymphatic vessels immunity myeloid cells lymphatic cells neurodegenerative disease

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A matrix metalloproteinase-responsive hydrogel system controls angiogenic peptide release for repair of cerebral ischemia/reperfusion injury

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Neural Regeneration Research 2025年第2期20卷 503-517页

作者： qi Liu Jianye Xie Runxue Zhou Jin Deng Weihong Nie Shuwei sun Haiping Wang Chunying Shi Department of Human Anatomy Histology and EmbryologySchool of Basic MedicineQingdao UniversityQingdaoShandong ProvinceChina Department of Neurology The Affiliated Hospital of Qingdao UniversityQingdaoShandong ProvinceChina Department of General Practice The Affiliated Hospital of Qingdao UniversityQingdaoShandong ProvinceChina

Vascular endothelial growth factor and its mimic peptide KLTWQELYQLKYKGI(QK)are widely used as the most potent angiogenic factors for the treatment of multiple ischemic ***,conventional topical drug delivery often results in a burst release of the drug,leading to transient retention(inefficacy)and undesirable diffusion(toxicity)in ***,a drug delivery system that responds to changes in the microenvironment of tissue regeneration and controls vascular endothelial growth factor release is crucial to improve the treatment of ischemic *** metalloproteinase-2(MMP-2)is gradually upregulated after cerebral ***,vascular endothelial growth factor mimic peptide QK was self-assembled with MMP-2-cleaved peptide PLGLAG(TIMP)and customizable peptide amphiphilic(PA)molecules to construct nanofiber hydrogel ***-TIMP-QK was found to control the delivery of QK by MMP-2 upregulation after cerebral ischemia/reperfusion and had a similar biological activity with vascular endothelial growth factor in *** results indicated that PA-TIMP-QK promoted neuronal survival,restored local blood circulation,reduced blood-brain barrier permeability,and restored motor *** findings suggest that the self-assembling nanofiber hydrogel PA-TIMP-QK may provide an intelligent drug delivery system that responds to the microenvironment and promotes regeneration and repair after cerebral ischemia/reperfusion injury.

关键词： angiogenesis biomaterial blood-brain barrier cerebral ischemia/reperfusion injury control release drug delivery inflammation QK peptides matrix metalloproteinase-2 neuroprotection self-assembling nanofiber hydrogel

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机场道面管理的评价模型

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同济大学学报（自然科学版） 2004年第6期32卷 731-735页

作者：暨育雄阚胜男冯奇孙立军同济大学道路与交通工程教育部重点实验室上海200092

根据我国机场道面的实际状况 ,构建了适用于水泥混凝土道面管理的 4个评价模型———损坏状况评价、结构强度评价、平整度评价和抗滑评价模型 .通过这 4个评价模型 ,可以对机场道面的调查检测数据进行评价分析 ,了解机场道面的整个使用... 详细信息

根据我国机场道面的实际状况 ,构建了适用于水泥混凝土道面管理的 4个评价模型———损坏状况评价、结构强度评价、平整度评价和抗滑评价模型 .通过这 4个评价模型 ,可以对机场道面的调查检测数据进行评价分析 ,了解机场道面的整个使用状况 ,为确定养护措施。

关键词：机场道面水泥混凝土道面评价模型惰性点理论道面管理系统

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