Origanum vulgare *** extract alleviates finasteride-induced oxidative stress in mouse liver and kidney
作者机构：Department of Hepatobiliary and Vascular SurgeryJinan City People's HospitalJinanShandong Province271100China Department of HepatologyZhejiang University Ming Zhou HospitalNingboZhejiang Province315199China Department of General SurgeryWuxi Traditional Chinese Medicine Hospital Affiliated to Nanjing University of Traditional Chinese MedicineWuxiJiangsu Province214023China Biology DepartmentCollege of ScienceKing Khalid UniversityAbhaSaudi Arabia Zoology DepartmentCollege of ScienceDamanhour UniversityDamanhourEgypt Biology DepartmentCollege of ScienceJouf UniversityP.O.Box 2014SakakaAl-JoufSaudi Arabia Zoology DepartmentFaculty of ScienceFayoum UniversityFayoumEgypt
出 版 物：《Asian Pacific Journal of Tropical Biomedicine》 (亚太热带生物医学杂志（英文版）)
年 卷 期：2021年第11卷第5期
页 面：194-204页
核心收录：
学科分类：1008[医学-中药学(可授医学、理学学位)] 1006[医学-中西医结合] 100602[医学-中西医结合临床] 10[医学]
基 金：supported by King Khalid University Abha KSA through Research Group Project under grant number R.G.P.2/80/41 and Wuxi Municipal Health and Family Planning Commission(WXQ201832)
主 题：Kidney Liver Origanum vulgare L. Inflammation Antioxidant
摘 要：Objective:To investigate the hepatorenoprotective effects of Origanum vulgare *** finasteride-induced oxidative injury in the liver and kidney of ***:Liquid chromatography-electrospray ionization-tandem mass spectrometry(LC-ESI/MS)analysis was utilized to yield a fingerprint of Origanum vulgare polyphenolic *** BALB/c mice received 0.5 mL/day distilled water,finasteride(25 mg/kg/day for 10 d),and 100,200,or 400 mg/kg/day finasteride+Origanum vulgare extract with 6 mice per group for five *** day 36,liver and kidney function as well as pro-and antiinflammatory(IFN-γ,IL-12,IL-6,TNF-α,IL-1β,and IL-10)cytokines were *** total antioxidant status,nitric oxide(NO),and malondialdehyde levels as well as the activities of NO synthase and catalase were also *** study was conducted to assess the effect of Origanum vulgare extract on finasteride-induced renal and hepatic ***:Twenty-five major polyphenolic compounds were identified in the Origanum vulgare extract by LC-ESI/*** vulgare extract,especially at 200 and 400 mg/kg/day doses,significantly improved liver and kidney biochemical indices,decreased inflammatory cytokines,increased total antioxidant status and NO synthase and catalase activities,as well as decreased plasma NO and malondialdehyde levels in a dose-dependent manner as compared to the finasteride *** results further confirmed the protective effect of Origanum vulgare ***:Origanum vulgare extract ameliorates finasterideinduced hepatic and renal biochemical and histopathological alterations,and restores antioxidant/oxidant balance.
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