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Optimized online filter stack spectrometer for ultrashort X-ray pulses

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Nuclear Science and Techniques 2024年第5期35卷 85-98页

作者： Jia-Xing Wen Ge Ma ming-Hai Yu Yu-Chi Wu Yong-hong Yan Shao-Yi wang Huai-Zhong Gao Lu-Shan wang Yu-Gang Zhou Qiang li Yue Yang fang Tan xiao-Hui Zhang Jie Zhang Wen-Bo Mo Jing-qin Su Wei-min Zhou Yu-Qiu Gu ming Zeng Zong-qing Zhao Science and Technology on Plasma Physics Laboratory Laser Fusion Research CenterCAEPMianyang 621900China department of Engineering Physics Tsinghua UniversityBeijing 100084China Key Laboratory of Particle and Radiation Imaging(Tsinghua University) Ministry of EducationBeijing 100084China School of Information Engineering Southwest University of Science and TechnologyMianyang 621010China

Currently,with the advent of high-repetition-rate laser-plasma experiments,the demand for online diagnosis for the X-ray spectrum is increasing because the laser-plasma-generated X-ray spectrum is very important for characterizing electron dynamics and *** this study,scintillators and silicon PIN(P-type–intrinsic-N-type semiconductor)diodes were used to construct a wideband online filter stack *** X-ray sensor and filter arrangement was optimized using a genetic algorithm to minimize the condition number of the response ***,the unfolding error was significantly reduced based on numerical *** detector responses were quantitatively calibrated by irradiating the scintillator and PIN diode with various nuclides and comparing the measuredγ-ray peaks.A prototype 15-channel spectrometer was developed by integrating an X-ray detector with front-and back-end *** prototype spectrometer could record X-ray pulse signals at a repetition rate of 1 ***,an optimized spectrometer was employed to record the real-time spectra of laser-driven bremsstrahlung *** optimized spectrometer offers a compact solution for spectrum diagnostics of ultrashort X-ray pulses,exhibiting improved accuracy in terms of spectrum measurements and repetition rates,and could be widely used in next-generation high-repetition-rate high-power laser facilities.

关键词： Filter stack spectrometer Laser plasma diagnostics X-ray diagnostics Scintillator PIN diode

Clinicopathological Features and long-Term Prognostic Role of Human Epidermal Growth Factor Receptor-2 Low Expression in Chinese Patients with Early Breast Cancer:A Single-Institution Study

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Biomedical and Environmental Sciences 2024年第5期37卷 457-470页

作者： KONG Zi qing liU li Qun HUANG de qin wang Yu Tong li Jing Jie ZHANG Zheng wang Xi Xi liU Chuan ling ZHANG Ya Di SHAO Jia Kang ZHU Yi min CHEN Yi Meng liU Mei ZHAO Wei hong Medical School of Chinese PLA Beijing 100853China department of Medical Oncology the First Medical CenterGeneral Hospital of the Chinese People’s Liberation ArmyBeijing 100853China Nankai University School of Medicine Tianjin 300071China department of Medical Oncology the Fifth Medical CenterGeneral Hospital of the Chinese People’s Liberation ArmyBeijing 100039China department of Medical Oncology Xi'an Jiaotong UniversityXi’an 710061ShaanxiChina department of Pathology the Sixth Medical CenterGeneral Hospital of the Chinese People’s Liberation ArmyBeijing 100037China

Objective This study aimed to comprehensively analyze and compare the clinicopathological features and prognosis of Chinese patients with human epidermal growth factor receptor 2(HER2)-low early breast cancer(BC)and HER2-IHC0 *** Patients diagnosed with HER2-negative BC(N=999)at our institution between January2011 and december 2015 formed our study *** characteristics,association between estrogen receptor(ER)expression and HER2-low,and evolution of HER2 immunohistochemical(IHC)score were ***-Meier method and log-rank test were used to compare the long-term survival outcomes(5-year follow-up)between the HER2-IHC0 and HER2-low *** HER2-low BC group tended to demonstrate high expression of ER and more progesterone receptor(PgR)positivity than HER2-IHC0 BC group(P2-low status increased with increasing ER expression levels(Mantel-Haenszelχ^(2)test,Plonger overall survival(OS)in HER2-low BC group than in HER2-IHC0 group(P=0.007)in the whole cohort and the hormone receptor(HR)-negative *** were no significant differences between the two groups in terms of disease-free survival(DFS).The discordance rate of HER2 IHC scores between primary and metastatic sites was 36.84%.Conclusion HER2-low BC may not be regarded as a unique BC group in this population-based study due to similar clinicopathological features and prognostic roles.

关键词： HER2 HER2-low Breast cancer Estrogen receptor Trastuzumab deruxtecan

Constructing highly safe and long-life calcium ion batteries based on hydratedvanadium oxide cathodes featuring a pillar structure

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Rare Metals 2024年第6期43卷 2597-2612页

作者： Chun-fang wang Shi-Wei Zhang Lan Huang Yuan-min Zhu Feng liu Jian-Chuan wang li-ming Tan Chun-Yi Zhi Cui-Ping Han Powder Metallurgy Research Institute Central South UniversityChangsha410083China Songshan Lake Materials Laboratory Dongguan 523808China Research Institute of Interdisciplinary Science and School of Materials Science and Engineering Dongguan University of TechnologyDongguan 523808China department of Materials Science and Engineering City University of Hong KongHong Kong 999077China Faculty of Materials Science and Energy Engineering/Institute of Technology for Carbon Neutrality Shenzhen Institute of Advanced TechnologyChinese Academy of SciencesShenzhen 518055China

Calcium-ion batteries(CIBs)have generated intense interest due to the growing demand for safer,cheaper,and large-scale energy storage ***,their development is still in its infancy,owing to the lack of suitable cathodes for sustaining reversiblc Ca^(2+)intercalation/***,layered H_(2)V_(3)O_(8)(HVO)with Zn^(2+)pre-insertion(ZHVO)is reported as a high-rate and highly durable cathode material for *** existence of Zn^(2+)and H_(2)O pillars could expand the interlayer spacing up to 1.8 nm,which is favorable for the diffusion of bulky Ca^(2+).The formation of Zn-O bonds facilitates electron transfer and enhances electrical ***,the ZHVO cathode achieves superior capacity performance(213.9 mAh·g^(-1)at 0.2 A·g^(-1))and long lifespan(78.3%for 1,000 cycles at 5 A·g^(-1))compared to pristine *** functional theory(DFT)calculations revealed that Zn^(2+)moved during Ca^(2+)intercalation,thereby reducing the diffusion energy barrier and facilitating Ca^(2+)***,a safe aqueous calcium ion cell was successfully assembled.

关键词： Multivalent batteries Calcium-ion batteries Layered structure Vanadium oxide Cathode materials

The In-Flight Realtime Trigger and Localization Software of GECAM

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Research in Astronomy and Astrophysics 2024年第10期24卷 11-24页

作者： xiao-Yun Zhao Shao-lin Xiong Xiang-Yang Wen Xin-Qiao li Ce Cai Shuo xiao Qi Luo Wen-Xi Peng Dong-Ya Guo Zheng-Hua An Ke Gong Jin-Yuan liao Yan-Qiu Zhang Yue Huang Lu li Xing Wen Fei Zhang Jing Duan Chen-Wei wang Dong-li Shi Peng Zhang Qi-Bin Yi Chao-Yang li Yan-Bing Xu xiao-Hua liang Ya-qing liu Da-li Zhang Xi-Lei Sun Fan Zhang Gang Chen Huan-Yu wang Sheng Yang xiao-Jing liu min Gao Mao-Shun li Jin-Zhou wang Xing Zhou Yi Zhao wang-Chen Xue Chao Zheng Jia-Cong liu Xing-Bo Han Jin-ling Qi Jia Huang Ke-Ke Zhang Can Chen Xiong-Tao Yang Dong-Jie Hou Yu-Sa wang Rui Qiao Xiang Ma xiao-Bo li Ping wang Xin-Ying Song li-ming Song Shi-Jie Zheng Bing li hong-Mei Zhang Yue Zhu Wei Chen Jian-Jian He Zhen Zhang Jin Hou hong-Jun wang Yan-Chao Hao Xiang-Yu wang Zong-Yuan Yang Zhi-long Wen Zhi Chang Yuan-Yuan Du Rui Gao xiao-Fei Lan Yan-Guo li Gang li Xu-fang li fang-Jun Lu hong Lu Bin Meng Feng Shi Hui wang Hui-Zhen wang Yu-Peng Xu Jia-Wei Yang Xue-Juan Yang Shuang-Nan Zhang Chao-Yue Zhang Cheng-Mo Zhang Zhi-Cheng Tang Cheng Cheng Key Laboratory of Particle Astrophysics Institute of High Energy PhysicsChinese Academy of SciencesBeijing 100049China University of Chinese Academy of Sciences Chinese Academy of SciencesBeijing 100049China School of Information Science and Technology Southwest Jiaotong UniversityChengdu 611756China Key Laboratory of Stellar and Interstellar Physics and department of Physics Xiangtan UniversityXiangtan 411105China Physics and Space Science College China West Normal UniversityNanchong 637002China department of Astronomy Beijing Normal UniversityBeijing 100875China Innovation Academy for Microsatellites of CAS Shanghai 201203China Changchun University of Science and Technology Changchun 130022China Chinese Academy of Sciences South America Center for Astronomy National Astronomical ObservatoriesCASBeijing 100101China

Realtime trigger and localization of bursts are the key functions of GECAM,an all-sky gamma-ray monitor launched on 2020 december *** developed a multifunctional trigger and localization software operating in the CPU of the GECAM Electronic *** onboard software has the following features:high trigger efficiency for real celestial bursts with a suppression of false triggers caused by charged particle bursts and background fluctuation,dedicated localization algorithm optimized for both short and long bursts,and low time latency of the trigger information which is downlinked through the Global Short Message Communication service of the global BeiDou navigation *** paper provides a detailed description of the design and development of the trigger and localization software system for *** covers the general design,workflow,the main functions,and the algorithms used in the *** paper also includes on-ground trigger tests using simulated gamma-ray bursts generated by a dedicated X-ray tube,as well as an overview of the performance for real celestial bursts during its in-orbit operation.

关键词： telescopes instrumentation:detectors methods:observational

Small-molecule agents for cancer immunotherapy

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Acta Pharmaceutica Sinica B 2024年第3期14卷 905-952页

作者： fang wang Kai Fu Yujue wang Can Pan Xueping wang Zeyu liu Chuan Yang Ying Zheng xiaopeng li Yu Lu Kenneth Kin Wah To Chenglai Xia Jianye Zhang Zhi Shi Zeping Hu min Huang liwu Fu State Key Laboratory of Oncology in South China Collaborative Innovation Center for Cancer MedicineGuangdong Esophageal Cancer InstituteGuangdong Provincial Clinical Research Center for CancerSun Yat-sen University Cancer CenterGuangzhou 510060China School of Pharmaceutical Sciences Tsinghua-Peking Center for Life SciencesBeijing Frontier Research Center for Biological StructureTsinghua UniversityBeijing 100084China State Key Laboratory of Drug Research Shanghai Institute of Materia MedicaChinese Academy of SciencesShanghai 201203China department of Cell Biology&Institute of Biomedicine National Engineering Research Center of Genetic MedicineMOE Key Laboratory of Tumor Molecular BiologyGuangdong Provincial Key Laboratory of Bioengineering MedicineCollege of Life Science and TechnologyJinan UniversityGuangzhou 510632China Guangzhou Municipal and Guangdong Provincial Key Laboratory of Molecular Target&Clinical Pharmacology NMPA and State Key Laboratory of Respiratory DiseaseSchool of Pharmaceutical Sciences and the Fifth Affiliated HospitalGuangzhou Medical UniversityGuangzhou 511436China School of Pharmacy The Chinese University of Hong KongHong Kong 999077China Affiliated Foshan Maternity and Child Healthcare Hospital Southern Medical UniversityFoshan 528000China

Cancer immunotherapy,exemplified by the remarkable clinical benefits of the immune checkpoint blockade and chimeric antigen receptor T-cell therapy,is revolutionizing cancer *** induce long-term tumor regression and overall survival benefit in many types of *** the advances in our knowledge about the tumor immune microenvironment,remarkable progress has been made in the development of small-molecule drugs for *** molecules targeting PRR-associated pathways,immune checkpoints,oncogenic signaling,metabolic pathways,cytokine/chemokine signaling,and immune-related kinases have been extensively *** of smallmolecule immunotherapeutic drugs and their combinations with other antitumor modalities are under active clinical investigations to overcome immune tolerance and circumvent immune checkpoint inhibitor ***,we review the latest development of small-molecule agents for cancer immunotherapy by targeting defined pathways and highlighting their progress in recent clinical investigations.

关键词： Cancer immunotherapy Small-molecule agents Immune checkpoints Oncogenic signaling Metabolic pathways Cytokine/chemokine signaling Antitumor immunity Tumor immune microenvironment

Diagnosis and treatment of refractory infectious diseases using nanopore sequencing technology:Three case reports

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World Journal of Clinical Cases 2024年第22期12卷 5208-5216页

作者： qing-Mei deng Jian Zhang Yi-Yong Zhang min Jia Du-Shan Ding Yu-qin fang hong-Zhi wang hong-Cang Gu Science Island Branch Graduate School of University of Science and Technology of ChinaHefei 230031Anhui ProvinceChina Institute of Health and Medical Technology Hefei Institutes of Physical ScienceChinese Academy of ScienceHefei 230031Anhui ProvinceChina Medical Pathology Center Hefei Cancer HospitalChinese Academy of SciencesHefei 230031Anhui ProvinceChina

BACKGROUND Infectious diseases are still one of the greatest threats to human health,and the etiology of 20%of cases of clinical fever is unknown;therefore,rapid identification of pathogens is highly *** culture methods are only able to detect a limited number of pathogens and are time-consuming;serologic detection has window periods,false-positive and false-negative problems;and nucleic acid molecular detection methods can detect several known pathogens only ***-generation nanopore sequencing technology provides new options for identifying *** SUMMARY Case 1:The patient was admitted to the hospital with abdominal pain for three days and cessation of defecation for five days,accompanied by cough and *** sequencing of the drainage fluid revealed the presence of orallike bacteria,leading to a clinical diagnosis of bronchopleural *** sodium sulbactam treatment was *** 2:The patient was admitted to the hospital with fever and headache,and CT revealed lung *** treatment for Streptococcus pneumoniae,identified through nanopore sequencing of cerebrospinal fluid,was *** 3:The patient was admitted to our hospital with intermittent fever and an enlarged neck mass that had persisted for more than six *** antibacterial treatment,her symptoms *** nanopore sequencing results indicate that voriconazole treatment is effective for Aspergillus *** patient was diagnosed with mixed cell type classical Hodgkin's lymphoma with *** Three-generation nanopore sequencing technology allows for rapid and accurate detection of pathogens in human infectious diseases.

关键词： Nanopore sequencing technology Third-generation sequencing technology Infection Pathogen Case report

Effect and Safety of Herbal Medicine Foot Baths in Patients with Diabetic Peripheral Neuropathy:A Multicenter Double-Blind Randomized Controlled Trial

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Chinese Journal of Integrative Medicine 2024年第3期30卷 195-202页

作者： HUANG Hao-yue liN Yu-ping WEI Hua FU Yu ZHOU Yue-hong fang Zhao-hui QIU xiao-tang wang Mei li qing-bo li Shan-shan wang Shi-dong DAI fang liU Zhen-jie ZHAO ling WEN Jian-xuan WU li-yan ZENG Hui-yan ZHANG Jin-ming LU Qi-yun HE liu SONG Wei SUN Lu LUO Lu-lu HE Jia-li XIE Wen-wen liANG qing-shun HUANG Yuan ZHU Sheng-ling long Jie-er GAO Zhi-juan WEN Ze-huai li Chun-ji OUYANG Wen-wei li Geng WU ming-hui li An-xiang HUANG Jin-zhu Sanjoy K Paul TANG Xian-yu FAN Guan-jie department of Endocrinology Guangdong Provincial Hospital of Chinese MedicineGuangzhou510120China The Second Clinical College of Guangzhou University of Chinese Medicine Guangzhou510120China department of Endocrinology The Second Affiliated Hospital of Guangzhou University of Chinese MedicineGuangzhou510120China Guangdong Provincial Academy of Chinese Medical Sciences Guangzhou510120China department of Endocrinology The First Affiliated Hospital of Henan University of Chinese MedicineZhengzhou450000China department of Endocrinology Liuyang Hospital of Chinese MedicineChangsha410000China department of Endocrinology The First Affiliated Hospital of Anhui University of Chinese MedicineHefei230000China department of Endocrinology Hainan Provincial Hospital of Traditional Chinese MedicineHaikou570100China department of Endocrinology The Affiliated Hospital of Liaoning University of Traditional Chinese MedicineShenyang110000China department of Geriatric Luoyang No.1 Hospital of Traditional Chinese MedicineLuoyangHenan Province471000China department of Endocrinology The Second Affiliated Hospital of Guizhou University of Traditional Chinese MedicineGuiyang550000China department of Endocrinology Beijing University of Chinese Medicine Affiliated Dongzhimen HospitalBeijing100000China department of Endocrinology The First Affiliated Hospital of Guizhou University of Traditional Chinese MedicineGuiyang550000China Melbourne EpiCentre The University of Melbourne and Melbourne HealthMelbourne3013Australia

Objective:To evaluate the effect and safety of foot baths with Tangbi Waixi decoction(TW)in treating patients with diabetic peripheral neuropathy(DPN).Methods:It is a multicenter double-blinded randomized controlled *** with DPN were recruited between November 18,2016 and May 30,2018 from 8 hospitals in *** patients received basic treatments for glycemic *** received foot baths with TW herbal granules either 66.9 g(intervention group)or 6.69 g(control group)for 30 min once a day for 2 weeks and followed by a 2-week rest,as a therapeutic *** the Toronto Clinical Scoring System total score(TCSS-TS)6 points,the patients received a total of 3 therapeutic courses(for 12 weeks)and were followed up for 12 *** primary outcome was change in TCSS-TS score at 12 and 24 *** outcomes included changes in bilateral motor nerve conduction velocity(MNCV)and sensory nerve conduction velocity(SNCV)of the median and common peroneal *** was also ***:Totally 632 patients were enrolled,and 317 and 315 were randomized to the intervention and control groups,*** the 12-week intervention,patients in both groups showed significant declines in TCSSTS scores,and significant increases in MNCV and SNCV of the median and common peroneal nerves compared with pre-treatment(P2 weeks and the increase of SNCV of median nerve at 24 weeks in the control group were greater than those in the intervention group(P0.05),and no serious adverse event was related with ***:Treatment of TW foot baths was safe and significantly benefitted patients with DPN.A low dose of TW appeared to be more effective than a high dose.(Registry *** CTR-IOR-16009331)

关键词： diabetic peripheral neuropathy herbal medicine foot baths Chinese medicine randomized controlled trial Tangbi Waixi decoction

Artificial intelligence for geoscience:Progress,challenges,and perspectives

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The Innovation 2024年第5期5卷 136-160,135页

作者： Tianjie Zhao Sheng wang Chaojun Ouyang min Chen Chenying liu Jin Zhang long Yu Fei wang Yong Xie Jun li fang wang Sabine Grunwald Bryan MWong Fan Zhang Zhen Qian Yongjun Xu Chengqing Yu Wei Han Tao Sun Zezhi Shao Tangwen Qian Zhao Chen Jiangyuan Zeng Huai Zhang Husi Letu Bing Zhang li wang Lei Luo Chong Shi hongjun Su hongsheng Zhang Shuai Yin Ni Huang Wei Zhao Nan li Chaolei Zheng Yang Zhou Changping Huang defeng Feng qingsong Xu Yan Wu Danfeng hong Zhenyu wang Yinyi lin Tangtang Zhang Prashant Kumar Antonio Plaza Jocelyn Chanussot Jiabao Zhang Jiancheng Shi lizhe wang Aerospace Information Research Institute Chinese Academy of SciencesBeijing 100094China School of Computer Science China University of GeosciencesWuhan 430078China State Key Laboratory of Mountain Hazards and Engineering Resilience Institute of Mountain Hazards and EnvironmentChinese Academy of SciencesChengdu 610299China Key Laboratory of Virtual Geographic Environment(ministry of Education of PRC) Nanjing Normal UniversityNanjing 210023China Data Science in Earth Observation Technical University of Munich80333 MunichGermany The National Key Laboratory of Water Disaster Prevention Yangtze Institute for Conservation and DevelopmentHohai UniversityNanjing 210098China Institute of Computing Technology Chinese Academy of SciencesBeijing 100190China School of Geographical Sciences Nanjing University of Information Science and TechnologyNanjing 210044China State Key Laboratory of Soil and Sustainable Agriculture Institute of Soil ScienceChinese Academy of SciencesNanjing 210008China Soil Water and Ecosystem Sciences DepartmentUniversity of FloridaPO Box 110290GainesvilleFLUSA Materials Science Engineering Program Cooperating Faculty Member in the department of Chemistry and department of Physics Astronomy University of CaliforniaCaliforniaRiversideCA 92521USA Institute of Remote Sensing and Geographical Information System School of Earth and Space SciencesPeking UniversityBeijing 100871China Key Laboratory of Computational Geodynamics University of Chinese Academy of SciencesBeijing 100049China International Research Center of Big Data for Sustainable development Goals Beijing 100094China College of Geography and Remote Sensing Hohai UniversityNanjing 211100China department of Geography The University of Hong KongHong Kong 999077SARChina Jiangsu Key Laboratory of Atmospheric Environment Monitoring and Pollution Control Nanjing 210044China School of Environmental Science and Engineering Nanjing University of Information Science&TechnologyNanjing 210044China Collaborative Inno

This paper explores the evolution of geoscientific inquiry,tracing the progression from traditional physics-based models to modern data-driven approaches facilitated by significant advancements in artificial intelligence(AI)and data collection *** models,which are grounded in physical and numerical frameworks,provide robust explanations by explicitly reconstructing underlying physical ***,their limitations in comprehensively capturing Earth’s complexities and uncertainties pose challenges in optimization and real-world *** contrast,contemporary data-driven models,particularly those utilizing machine learning(ML)and deep learning(DL),leverage extensive geoscience data to glean insights without requiring exhaustive theoretical *** techniques have shown promise in addressing Earth science-related ***,challenges such as data scarcity,computational demands,data privacy concerns,and the“black-box”nature of AI models hinder their seamless integration into *** integration of physics-based and data-driven methodologies into hybrid models presents an alternative *** models,which incorporate domain knowledge to guide AI methodologies,demonstrate enhanced efficiency and performance with reduced training data *** review provides a comprehensive overview of geoscientific research paradigms,emphasizing untapped opportunities at the intersection of advanced AI techniques and *** examines major methodologies,showcases advances in large-scale models,and discusses the challenges and prospects that will shape the future landscape of AI in *** paper outlines a dynamic field ripe with possibilities,poised to unlock new understandings of Earth’s complexities and further advance geoscience exploration.

关键词： Earth utilizing landscape

Incidence and prognosis of olfactory and gustatory dysfunctions related to SARS-CoV-2 Omicron strain infection in China:A national multicenter survey of 35,566 individuals

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World Journal of Otorhinolaryngology-Head and Neck Surgery 2024年第2期10卷 113-120页

作者： Meng-Fan liu Rui-Xia Ma Xian-Bao Cao Hua Zhang Shui-hong Zhou Wei-hong Jiang Yan Jiang Jing-Wu Sun qin-Tai Yang Xue-Zhong li Ya-Nan Sun li Shi min wang Xi-Cheng Song Fu-Quan Chen xiao-Shu Zhang hong-Quan Wei Shao-qing Yu Dong-Dong Zhu Luo Ba Zhi-Wei Cao Xu-Ping xiao Xin Wei Zhi-hong lin Feng-hong Chen Chun-Guang Shan Guang-Ke wang Jing Ye Shen-hong Qu Chang-qing Zhao Zhen-lin wang Hua-Bin li Feng liu xiao-Bo Cui Sheng-Nan Ye Zheng liu Yu Xu xiao Cai Wei Huang Ru-Xin Zhang Yu-lin Zhao Guo-Dong Yu Guang-Gang Shi Mei-Ping Lu Yang Shen Yu-Tong Zhao Jia-hong Pei Shao-Bing Xie long-Gang Yu Ye-Hai liu Shao-Wei Gu Yu-Cheng Yang Lei Cheng Jian-Feng liu Graduate School of Beijing University of Chinese Medicine BeijingChina department of Otorhinolaryngology Head and Neck Surgery China-Japan Friendship HospitalBeijingChina department of Otorhinolaryngology Head and Neck Surgery The First People's Hospital of YinchuanYinchuanChina department of Otorhinolaryngology The First People's Hospital of Yunnan ProvinceKunmingChina department of Otorhinolaryngology The First Affiliated Hospital of Xinjiang Medical UniversityUrumqiChina department of Otorhinolaryngology Head and Neck Surgery The First Affiliated Hospital of Zhejiang University School of MedicineHangzhouChina department of Otorhinolaryngology Head and Neck Surgery Xiangya Hospital Central South UniversityChangshaChina department of Otorhinolaryngology Head and Neck Surgery The Affiliated Hospital of Qingdao UniversityQingdaoChina department of Otorhinolaryngology Head and Neck Surgery The First Affiliated Hospital of USTCHefeiChina department of Otorhinolaryngology Head and Neck Surgery The Third Affiliated Hospital of Sun Yat-sen UniversityGuangzhouChina department of Otorhinolaryngology Head and Neck Surgery Qilu Hospital of Shandong UniversityJinanChina department of Otorhinolaryngology Head and Neck Surgery The Second Affiliated Hospital of Harbin Medical UniversityHarbinChina department of Otolaryngology The Second Hospital of Shandong UniversityShandong UniversityJinanChina department of Otorhinolaryngology Head and Neck Surgery Peking University People's HospitalBeijingChina department of Otorhinolaryngology Head and Neck Surgery Yantai Yuhuangding HospitalQingdao UniversityYantaiChina department of Otorhinolaryngology Head and Neck Surgery Xijing HospitalThe Fourth Military Medical UniversityXi'anChina Gansu Provincial Center for Disease Control and Prevention LanzhouChina department of Otorhinolaryngology Head and Neck Surgery The First Affiliated Hospital of China Medical UniversityShenyangChina department of Otorhinolaryngology Head and Neck Surgery Tongji Hospit

Objective:This cross-sectional study aimed to determine the epidemiology of olfactory and gustatory dysfunctions related to COVID-19 in ***:This study was conducted by 45 tertiary Grade-A hospitals in *** and offline questionnaire data were obtained from patients infected with COVID-19 between december 28,2022,and February 21,*** collected information included basic demographics,medical history,smoking and drinking history,vaccination history,changes in olfactory and gustatory functions before and after infection,and other postinfection symptoms,as well as the duration and improvement status of olfactory and gustatory ***:Complete questionnaires were obtained from 35,566 *** overall incidence of olfactory and taste dysfunction was 67.75%.Being female or being a cigarette smoker increased the likelihood of developing olfactory and taste *** received four doses of the vaccine or having good oral health or being a alcohol drinker decreased the risk of such *** infection,the average olfactory and taste VAS scores were 8.41 and 8.51,respectively;after infection,they decreased to 3.69 and 4.29 and recovered to 5.83 and 6.55 by the time of the *** median duration of dysosmia and dysgeusia was 15 and 12 days,respectively,with 0.5%of patients having symptoms lasting for more than 28 *** overall self-reported improvement rate was 59.16%.Recovery was higher in males,never smokers,those who received two or three vaccine doses,and those that had never experienced dental health issues,or chronic accompanying ***:The incidence of dysosmia and dysgeusia following infection with the SARS-CoV-2 virus is high in *** and prognosis are influenced by several factors,including sex,SARS-CoV-2 vaccination,history of head-facial trauma,nasal and oral health status,smoking and drinking history,and the persistence of accompanying symptoms.

关键词： epidemiologic studies incidence olfactory disorders prognosis SARS-CoV-2 taste disorders