检索结果-南通市图书馆

Sirolimus-eluting cobalt alloyed stents in treating patients with coronary artery disease:six-month angiographic and one-year clinical follow-up result A prospective,historically controlled,multi-center clinical study

在线全文

学校读者我要写书评

暂无评论

Chinese Medical Journal 2007年第7期120卷 533-538页

作者： ZHANG Qi XU Bo YANG Yue-jin ZHANG Rui-yan LI Jian-ping qiao shu-bin ZHANG Jian-sheng HU Jian QIN Xue-wen HONG Tao CHEN Ji-lin HUO Yong SHEN Wei-feng GAO Run-lin Department of Cardiology Ruijin Hospital School of Medicine Shanghai Jiaotong University Shanghai 200025 China Department of Cardiology Cardiovascular Institute and Fuwal Hospital Chinese Academy of Medical Sciences ＆ Peking Union Medical College Beijing 100037 China Department of Cardiology Peking University First Hospital Beijing 100034 China

Background The emergence of drug-eluting stents （DES） has dramatically reduced the incidence of in-stent restenosis This study was conducted to evaluate the safety and efficacy of sirolimus-eluUng cobalt-chrome stents （Firebird 2） for treating patients with coronary artery disease. Methods Sixty-seven patients with de novo or non-stented restenostic coronary lesions were chosen to receive the Firebird 2 stent as the final treatment （Firebird 2 group）. Another 49 consecutive patients were implanted with bare cobalt alloyed stents （Driver, Medtronic） within the previous six months and served as historical controls （control group）. Baseline clinical characteristics, angiographic features, procedural results, 30-day, 6-month and 12-month clinical follow-up regarding the occurrence of major adverse cardiac events （MACE）, as well as the primary endpoint of late lumen loss at 6-month angiographic follow-up were compared between the two groups. Results The demographic characteristics were similar between the two groups despite more patients in the Firebird 2 group who underwent previous percutaneous coronary intervention （22.4% vs 8.2%, P=0.0418） and who had diabetes mellitus （29.9% vs 12.2%, P=0.0253）. In the Firebird 2 group, the mean diameter of the reference vessel was smaller （（2.79±0.46） mm vs （2.98±0.49） mm, P=0.0175） and more stents were implanted for each lesion （1.28±0.52 vs 1.10±0.30, P=0.0060）. Other angiographic, procedural results and the device success rate were similar between the two groups. The MACE rate at 30-day and 3-month was the same, but significantly fewer MACE occurred in the Firebird 2 group at 6- and 12-month follow-up （1.5% vs 12.2% at 6 month, P=0.0168; 1.5% vs 26.5% at 12 month, P〈0.0001）. The primary endpoint of late lumen loss at 6-month angiographic follow-up was significantly reduced in the Firebird 2 group （in-stent：（0.05±0.09） mm vs （0.98±0.61） mm; in-segment：（0.05±0.18） mm vs （0.72±0.59） mm; P〈0.0001） than the control group. One patient in the Firebird 2 group had in-segment re

关键词： instrumentation coronary angiography sirolimus stents treatment outcome

Effect of siRNAs on HSV-1 Plaque Formation and Relative Expression Levels of RR mRNA

在线全文

学校读者我要写书评

暂无评论

Virologica Sinica 2011年第1期26卷 40-46页

作者： Zhe Ren Shen Li qiao-li Wang Yang-fei Xiang Yun-xia Cui Yi-fei Wang Ren-bin Qi Da-xiang Lu shu-min Zhang Pei-zhuo Zhang Biomedicine research and development center of Jinan University Guangdong Guangzhou 510632 China Medical College of Jinan University Guangdong Guangzhou 510632 China National Engineering Research Center of Genetic Medicine Guangdong Guangzhou 510632 China National Institute for the Control of Pharmaceutical and Biological Products Beijing 100050China Shanghai GenePharma Co. Ltd Shanghai 201203 China

RNA interference (RNAi) is a process by which introduced small interfering RNA (siRNA) can cause the specific degradation of mRNA with identical sequences. The human herpes simplex virus type 1 (HSV-1) RR is composed of two distinct homodimeric subunits encoded by UL39 and UL40,respectively. In this study,we applied siRNAs targeting the UL39 and UL40 genes of HSV-1. We showed that synthetic siRNA silenced effectively and specifically UL39 and UL40 mRNA expression and inhibited HSV-1 replication. Our work offers new possibilities for RNAi as a genetic tool for inhibition of HSV-1 replication.

关键词：基因表达水平单纯疱疹病毒 siRNA RNA干扰斑块 mRNA降解复制工具 RNA沉默

Apelin对血管紧张素Ⅱ诱导的心肌细胞肥大的作用及其机制

在线全文

学校读者我要写书评

暂无评论

中国循环杂志 2014年第9期29卷 733-737页

作者：周颖陈游洲乔树宾北京协和医学院中国医学科学院国家心血管病中心阜外心血管病医院冠心病诊治中心北京市100037

目的：探讨Apelin对血管紧张素Ⅱ（AngⅡ）诱导的心肌细胞肥大的作用及其细胞内信号转导机制。方法：培养1-3 d新生Sprague-Dawley大鼠心肌细胞,给予AngⅡ刺激。在此基础上给予不同浓度Apelin。测定[3H]亮氨酸掺入量、细胞表面积以及总... 详细信息

目的：探讨Apelin对血管紧张素Ⅱ（AngⅡ）诱导的心肌细胞肥大的作用及其细胞内信号转导机制。方法：培养1-3 d新生Sprague-Dawley大鼠心肌细胞,给予AngⅡ刺激。在此基础上给予不同浓度Apelin。测定[3H]亮氨酸掺入量、细胞表面积以及总蛋白表达量评价心肌细胞肥大程度。免疫印迹法测定细胞B型尿钠肽、β肌球蛋白重链、活化T细胞的核因子3、钙调神经磷酸酶、磷酸化钙调神经磷酸酶、钙调蛋白激酶Ⅱ、磷酸化钙调蛋白激酶Ⅱ的蛋白表达水平。逆转录-聚合酶链反应法测定B型尿钠肽和β肌球蛋白重链mRNA表达水平。结果：Apelin可以抑制AngⅡ诱导的心肌细胞肥大,其作用呈剂量依赖性。同时,Apelin可以抑制AngⅡ诱导的B型尿钠肽和β肌球蛋白重链mRNA表达水平、B型尿钠肽和β肌球蛋白重链、活化T细胞的核因子3、磷酸化钙调神经磷酸酶、钙调蛋白激酶Ⅱ和磷酸化钙调蛋白激酶Ⅱ的蛋白表达水平升高,且均与Apelin浓度呈剂量依赖性。结论：Apelin可以抑制AngⅡ诱导的心肌细胞肥大,其机制与Ca2＋依赖的钙调神经磷酸酶信号转导通路有关。

关键词：血管紧张素Ⅱ 心肌细胞肥大钙调神经磷酸酶钙调蛋白依赖的蛋白激酶Ⅱ

Clinical characteristics of early and late drug-eluting stent in-stent restenosis and mid-term prognosis after repeated percutaneous coronary intervention

在线全文

学校读者我要写书评

暂无评论

Chinese Medical Journal 2020年第22期133卷 2674-2681页

作者： Jian-Feng Zheng Ting-Ting Guo Yuan Tian Yong Wang Xiao-Ying Hu Yue Chang Hong Qiu Ke-Fei Dou Yi-Da Tang Jin-Qing Yuan Yong-Jian Wu Hong-bing Yan shu-bin qiao Bo Xu Yue-Jin Yang Run-Lin Gao Department of Cardiology Fuwai HospitalNational Center for Cardiovascular DiseasesChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100037China Department of Cardiology Urumqi Friendship HospitalUrumqiXinjiang 830049China

Background:The mechanism and characteristics of early and late drug-eluting stent in-stent restenosis(DES-ISR)have not been fully clarified.Whether there are different outcomes among those patients being irrespective of their repeated treatments remain a knowledge gap.Methods:A total of 250 patients who underwent initial stent implantation in our hospital,and then were readmitted to receive treatment for the reason of recurrent significant DES-ISR in 2016 were involved.The patients were categorized as early ISR(<12 months;E-ISR;n=32)and late ISR(≥12 months;L-ISR;n=218).Associations between patient characteristics and clinical performance,as well as clinical outcomes after a repeated percutaneous coronary intervention(PCI)were evaluated.Primary composite endpoint of major adverse cardiac events(MACEs)included cardiac death,non-fatal myocardial infarction(MI),or target lesion revascularization(TLR).Results:Most baseline characteristics are similar in both groups,except for the period of ISR,initial pre-procedure thrombolysis in myocardial infarction,and some serum biochemical indicators.The incidence of MACE(37.5%vs.5.5%;P<0.001)and TLR(37.5%vs.5.0%;P<0.001)is higher in the E-ISR group.After multivariate analysis,E-ISR(odds ratio[OR],13.267;[95%CI 4.984-35.311];P<0.001)and left ventricular systolic dysfunction(odds ratio[OR],6.317;[95%CI 1.145-34.843];P=0.034)are the independent predictors for MACE among DES-ISR patients in the mid-term follow-up of 12 months.Conclusions:Early ISR and left ventricular systolic dysfunction are associated with MACE during the mid-term follow-up period for DES-ISR patients.The results may benefit the risk stratification and secondary prevention for DES-ISR patients in clinical practice.

关键词： In-stent restenosis Neointimal hyperplasia Risk factors Drug-eluting stent

ST-elevated acute myocardial infarction happening 1 month post stent implantation： late thrombosis in-stents or new lesions？

在线全文

学校读者我要写书评

暂无评论

Chinese Medical Journal 2009年第14期122卷 1610-1614页

作者： SONG Guang-yuan YANG Yue-jin XU Bo LI Jian-jun GAO Run-lin qiao shu-bin YUAN Jin-qing TANG Yi-da YOU Shi-jie PEI Han-jun ZHAO Zhen-yan WANG Xi-mei WU Yong-jian Center of Coronary Heart Disease Center of Interventional Therapy Cardiovascular Institute & Fuwai Hospital Peking Union Medical College and Chinese Academy of Medical Sciences Beijing 100037 China

Background ST-elevated acute myocardial infarction （STEAMI） happening in the first month post percutaneous coronary intervention （PCI） is almost related to acute thrombosis or subacute thrombosis in-stents. This study aimed to investigate the possible causes of myocardial infarction one month later. Methods Patients who had a history of successful PCI, and received coronary angiography or re-PCI due to STEAMI were included in this study. The AMI-related lesions and previous angiographic findings such as the number of lesions, the degree of the stenosis, the type of stents and acute results of last PCI were recorded. If the AMI-related lesion was localized in-stents or at the edge of stents （distance apart from the edge 〈5 mm）, it was defined to be late thrombosis; otherwise as a new-lesion induced AMI. Results One hundred and ninety-two patients aged 40-79 years were included in this study. New lesions, as the cause of STEAMI, were found in 144 patients （Group A, 75%）, and late thrombosis in 48 patients （Group B, 25%）. Almost all newly built thromboses were found at the sites of previous insignificant lesions （diameter stenosis 〈50%）. There was a significant difference in the average time from previous PCI to AMI （（30.1±12.4） vs （20.3±11.9） months） between the two groups. Diabetes mellitus （DM） and drug-eluting stent （DES） utilization were associated with markedly higher morbidity of late thrombosis in adjusted Logistic regression （hazard ratio （HR） 3.4, 95% confidence interval （C/） 1.1-10.9 and 5.3, 95% Cl 1.1-26.5）. Conclusions STEAMIs happening 1 month after PCI are more likely to develop from previous insignificant lesion rupture than from late thrombosis in-stents. Moreover, DM and DES are associated with the high incidence of late thrombosis, which may indicate that intensive antiplatelet therapy should be considered in patients with diabetes.

关键词： percutaneous coronary intervention acute myocardial infarction late thrombosis diabetes mellitus

注射用左旋泮托拉唑钠对家兔胚胎-胎仔发育的毒性

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

华西药学杂志 2019年第1期34卷 43-46页

作者：蔡鸣舒斌乔红群刘晶江苏省药物研究所江苏南京210009 南京工业大学江苏南京211816

目的考察静脉给予注射用左旋泮托拉唑钠对家兔胚胎-胎仔发育的影响。方法将孕兔随机分为正常组、阳性组(10 mg·kg^(-1)注射用环磷酰胺)和注射用左旋泮托拉唑钠低、中、高剂量组(15、30、60 mg·kg^(-1))及注射用右旋泮托拉唑钠组(60 mg... 详细信息

目的考察静脉给予注射用左旋泮托拉唑钠对家兔胚胎-胎仔发育的影响。方法将孕兔随机分为正常组、阳性组(10 mg·kg^(-1)注射用环磷酰胺)和注射用左旋泮托拉唑钠低、中、高剂量组(15、30、60 mg·kg^(-1))及注射用右旋泮托拉唑钠组(60 mg·kg^(-1)),在妊娠期(GD)6～18 d时静脉注射给药,于GD29处死家兔,记录各项指标。结果与空白组比较,左旋泮托拉唑钠组和右旋泮托拉唑钠组孕兔在孕期内的体质量增加量明显下降;泮托拉唑钠左、右旋体均未对妊娠结局产生明显影响,亦未对胎兔顶臀长、体质量、性别比产生明显影响;60 mg·kg^(-1)泮托拉唑钠左旋体和右旋体均可对胎兔的骨骼发育产生明显的不利影响。结论在试验条件下,静脉给予孕兔30 mg·kg^(-1)注射用左旋泮托拉唑钠未见明显胚胎-胎仔毒性,其对母体的无可见不良作用水平剂量为30 mg·kg^(-1)。

关键词：泮托拉唑钠质子泵抑制剂左旋体右旋体家兔胚胎-胎仔发育毒性手性药物 Me—too药物环磷酰胺安全性评价生殖毒性无可见不良作用剂量水平(NOAEL)

Electrophysiological Evidence of Gender differences in Chinese words recognition

在线全文

学校读者我要写书评

暂无评论

Electrophysiological Evidence of Gender differences in Chine...

Statins as candidate therapeutic agents for coronavirus disease 2019(COVID-19)

2005 International Conference on Neural Networks and Brain(ICNN&B’05)

作者： Wang Xiang Yao shu-qiao Liu Ding Wang Xiao-yan Chen bin Wu Da-xing Cheng Zao-huo The Medical Psychological department of Second Xiangya Hospital Central South University

ISBN: (纸本)0780394224;9780780394223

＜正＞Event-related potentials were recorded in order to study gender difference in the brain processes of verbal recognition memory.15 male and 15 female healthy volunteers received a Chinese words recognition task.Both males and females showed a positive-going parietal old/new effect,but females demonstrated larger P500 amplitudes and shorter P500 latency than males.Furthermore,the parietal old/new effect of males was significantly left-lateralized,while that of females showed more bilateral pattern.Only males elicited obvious frontally distributed old/new effect between 250 and 350 ms,which was negative-going and right-lateralized. These findings suggested that gender differences did exist in the recognition processing of Chinese words.Some of the gender differences could be interpreted as reflecting different strengths and speed of brain activation and others could be interpreted as reflecting the involvement of different neural structures.In addition,males and females may use different strategies to make correct discrimination.

关键词： Gender difference Recognition Event-related potentials（ERPs） Old/new effects

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

Chinese Medical Journal 2021年第4期134卷 407-409页

作者： Sheng-De Li shu-Yang Zhang bin Peng Department of Neurology Peking Union Medical College HospitalPeking Union Medical College and Chinese Academy of Medical SciencesBeijing 100730China Department of Cardiology Peking Union Medical College HospitalPeking Union Medical College and Chinese Academy of Medical SciencesBeijing 100730China

Statins are 3-hydroxy-3-methyl glutaryl(HMG)-coenzyme A(CoA)reductase inhibitors,acting on the rate-limiting enzyme for the conversion of HMG-CoA to L-mevalonate to reduce cholesterol biosynthesis.Apart from reducing cardiovascular events by lowering low-density lipoprotein cholesterol concentrations,pleiotropic cholesterol-independent functions of statins,including immunomodulatory and anti-inflammatory effects,are increasingly recognized.

关键词： cholesterol cardiovascular therapeutic

Impact of Body Mass Index on the Clinical Outcomes after Percutaneous Coronary Intervention in Patients ≥75 Years Old

在线全文

学校读者我要写书评

暂无评论

Chinese Medical Journal 2015年第5期128卷 638-643页

作者： Pei-Yuan He Yue-Jin Yang shu-bin qiao Bo Xu Min Yao Yong-Jian Wu Yuan Wu Jin-Qing Yuan Jue Chen Hai-Bo Liu Jun Dai Wei Li Yi-Da Tang Jin-Gang Yang Run-Lin Gao Department of Cardiology Cardiovascular Institute and Fuwai Hospital National Center for Cardiovascular Diseases Chinese Academy of Medical Sciences and Peking Union Medical College Beijing 100037 China Medical Research and Biometrics Center Cardiovascular Institute and Fuwai Hospital National Center for Cardiovascular Diseases Chinese Academy of Medical Sciences and Peking Union Medical College Beijing 100037 China

Background：The impact of body mass index （BMI） on the clinical outcomes after percutaneous coronary intervention （PCI） in patients ≥75 years old remained unclear.Methods：A total of 1098 elderly patients undergoing PCI with stent implantation were recruited.Patients were divided into four groups by the value of BMI：Underweight （〈20.0 kg/m^2）,normal weight （20.0-24.9 kg/m^2）,overweight （25.0-29.9 kg/m^2） and obese （≥30.0 kg/m^2）.Major clinical outcomes after PCI were compared between the groups.The primary endpoint was defined as in-hospital major adverse cardiovascular events （MACEs）,which included death,myocardial infarction （MI） and target vessel revascularization.The secondary endpoint was defined as 1 year death.Logistic regression analysis was performed to adjust for the potential confounders.Results：Totally,1077 elderly patients with available BMIs were included in the analysis.Patients of underweight,normal weight,overweight and obese accounted for 5.6%,45.4%,41.5% and 7.5% of the population,respectively.Underweight patients were more likely to attract ST-segment elevation MI,and get accompanied with anemia or renal dysfunction.Meanwhile,they were less likely to achieve thrombolysis in MI 3 grade flow after PCI,and receive beta-blocker,angiotensin converting enzyme inhibitor or angiotensin receptor blocker after discharge.In underweight,normal weight,overweight and obese patients,in-hospital MACE were 1.7%,2.7%,3.8%,and 3.7% respectively （P =0.68）,and 1 year mortality rates were 5.0%,3.9%,5.1% and 3.7% （P =0.80）,without significant difference between the groups.Multivariate regression analysis showed that the value of BMI was not associated with in-hospital MACE in patients at 75 years old.Conclusions：The BMI ＂obese paradox＂ was not found in patients ≥75 years old.It was suggested that BMI may not be a sensitive predictor of adverse cardiovascular events in elderly patients.

关键词： Aged Angioplasty Body Mass Index Outcomes