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Thermal noise-driven resonant sensors

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Microsystems & Nanoengineering 2024年第3期10卷 259-271页

作者： Yan qiao Alaaeldin Elhady Mohamed Arabi Eihab Abdel-Rahman Wenming Zhang School of Mechanical Engineering Shanghai Jiao Tong UniversityShanghaiChina Department of Systems Design Engineering University of WaterlooWaterlooONCanada

MEMS/NEMS resonant sensors hold promise for minute mass and force ***,one major challenge is that conventional externally driven sensors inevitably encounter undesired intrinsic noise,which imposes a fundamental limitation upon their signal-to-noise ratio(SNR)and,consequently,the ***,this restriction becomes increasingly pronounced as sensors shrink to the *** this work,we propose a counterintuitive paradigm shift that turns intrinsic thermal noise from an impediment to a constituent of the sensor by harvesting it as the driving force,obviating the need for external actuation and realizing‘noise-driven’*** sensors employ the dynamically amplified response to thermal noise at resonances for stimulus *** demonstrate that lightly damped and highly compliant nano-structures with high aspect ratios are promising candidates for this class of *** overcome the phase incoherence of the drive force,three noise-enabled quantitative sensing mechanisms are *** validated our sensor paradigm by experimental demonstrating noise-driven pressure and temperature ***-driven sensors offer a new opportunity for delivering practical NEMS sensors that can function at room temperature and under ambient pressure,and a development that suggests a path to cheaper,simpler,and low-power-consumption sensors.

关键词： noise resonant overcome

Emerging mechanisms and implications of c GAS-STING signaling in cancer immunotherapy strategies

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Cancer Biology & Medicine 2024年第1期21卷 45-64页

作者： Jiawen Zhang Sihui Yu qiao Peng Ping Wang Lan Fang Tongji University Cancer Center Shanghai Tenth People’s HospitalSchool of MedicineTongji UniversityShanghai 200072China Reproductive Medicine Center Department of Obstetrics and GynecologyShanghai General HospitalShanghai Jiao Tong University School of MedicineShanghai 201620China Department of Obstetrics and Gynecology Zhongshan HospitalFudan UniversityShanghai 200032China

The intricate interplay between the human immune system and cancer development underscores the central role of immunotherapy in cancer *** this landscape,the innate immune system,a critical sentinel protecting against tumor incursion,is a key *** cyclic GMP-AMP synthase(c GAS)and stimulator of interferon genes(STING)pathway has been found to be a linchpin of innate immunity:activation of this signaling pathway orchestrates the production of type I interferon(IFN-α/β),thus fostering the maturation,differentiation,and mobilization of immune effectors in the tumor ***,STING activation facilitates the release and presentation of tumor antigens,and therefore is an attractive target for cancer *** strategies to activate the STING pathway,including use of pharmacological agonists,have made substantial advancements,particularly when combined with immune checkpoint *** approaches have shown promise in preclinical and clinical settings,by enhancing patient survival *** review describes the evolving understanding of the c GAS-STING pathway's involvement in tumor biology and ***,this review explores classical and non-classical STING agonists,providing insights into their mechanisms of action and potential for optimizing immunotherapy *** challenges and complexities,the c GAS-STING pathway,a promising avenue for enhancing cancer treatment efficacy,has the potential to revolutionize patient outcomes.

关键词： cGAS-STING pathway type I interferon cyclic dinucleotide STING agonist cancer immunotherapy

Emerging clinical relevance of microbiome in cancer:promising biomarkers and therapeutic targets

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Protein & Cell 2024年第4期15卷 239-260页

作者： Jia-Hao Dai Xi-Rong Tan Han qiao Na Liu State Key Laboratory of Oncology in South China Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and TherapyGuangdong Provincial Clinical Research Center for CancerSun Yat-sen University Cancer CenterGuangzhou 510050China

The profound influence of microbiota in cancer initiation and progression has been under the spotlight for years,leading to numerous researches on cancer microbiome entering clinical *** promising biomarkers and therapeutic targets,the critical involvement of microbiota in cancer clinical practice has been increasingly ***,recent progress in this field is *** describe the potential of tumor-associated microbiota as effective diagnostic and prognostic biomarkers,*** addition,we highlight the relationship between microbiota and the therapeutic efficacy,toxicity,or side effects of commonly utilized treatments for cancer,including chemotherapy,radiotherapy,and *** that microbial factors influence the cancer treatment outcome,we further summarize some dominating microbial interventions and discuss the hidden risks of these *** review aims to provide an overview of the applications and advancements of microbes in cancer clinical relevance.

关键词： microbiome cancer diagnosis prognosis therapy

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绵阳市大气污染物浓度变化特征及相关性分析

地球环境学报 2021年第2期12卷 183-191,201页

作者：杜娟宋鹏程龙平黄强乔君喜西南科技大学城市学院绵阳621010 绵阳市环境监测中心站绵阳621010

随着我国工业化、城市化和机动化的高速发展,大气环境质量越来越受民众关注,我国已建成国控-省控-市控-县控四级环境空气自动监测网络,监测项目包括SO_(2)、NO_(2)、CO、O_(3)、PM_(2.5)和PM_(10)。基于2018年绵阳市环境空气监测数据、... 详细信息

随着我国工业化、城市化和机动化的高速发展,大气环境质量越来越受民众关注,我国已建成国控-省控-市控-县控四级环境空气自动监测网络,监测项目包括SO_(2)、NO_(2)、CO、O_(3)、PM_(2.5)和PM_(10)。基于2018年绵阳市环境空气监测数据、颗粒物化学组分及气象资料分析上述6个监测项目年均、季度、月均、日均及每日最大小时浓度变化特征,并进一步探讨污染物浓度与气象条件的相关性,结合颗粒物化学组分对产生原因进行剖析。结果表明:绵阳市冬季环境空气质量较差,夏季相对较好。Pearson相关性分析表明:SO_(2)、NO_(2)、CO和颗粒物(PM_(2.5)和PM_(10))之间存在显著相关性,冬季PM_(2.5)与SO_(2)、NO_(2)的相关系数分别为0.610和0.635,PM_(10)与SO_(2)、NO_(2)的相关系数分别为0.655和0.655,颗粒物主要化学组分为硫酸盐、硝酸盐、铵盐和二次有机气溶胶,颗粒物二次转化尤为明显,冬季需重点管控颗粒物;春季和夏季O_(3)与PM_(2.5)、PM_(10)呈显著正相关,需做好颗粒物和O_(3)的协同管控。O_(3)每日最大小时浓度多集中在13∶00-18∶00,其他污染物每日最大小时浓度多集中于08∶00-12∶00和20∶00-24∶00,同时NO_(2)在20∶00-24∶00出现每日最大小时浓度的频次占67.1%,控制机动车等污染源排放尤为重要。

关键词：绵阳市环境空气质量气象条件相关性分析

Dynamic response of mountain tunnel,bridge,and embankment along the Sichuan-Tibet transportation corridor to active fault based on model tests

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Journal of Mountain Science 2024年第1期21卷 182-199页

作者： HUANG Beixiu qiao Sijia CHEN Xulei LI Lihui QI Shengwen Key Laboratory of Shale Gas and Geoengineering Institute of Geology and GeophysicsChinese Academy of SciencesBeijing 100029China Innovation Academy for Earth Science Chinese Academy of SciencesBeijing 100029China College of Earth and Planetary Sciences University of Chinese Academy of SciencesBeijing 100049China

The Sichuan-Tibet transportation corridor is prone to numerous active faults and frequent strong *** extensive studies have individually explored the effect of active faults and strong earthquakes on different engineering structures,their combined effect remains *** research employed multiple physical model tests to investigate the dynamic response of various engineering structures,including tunnels,bridges,and embankments,under the simultaneous influence of cumulative earthquakes and stick-slip misalignment of an active *** prototype selected for this study was the Kanding No.2 tunnel,which crosses the Yunongxi fault zone within the Sichuan-Tibet transportation *** results demonstrated that the tunnel,bridge,and embankment exhibited amplification in response to the input seismic wave,with the amplification effect gradually decreasing as the input peak ground acceleration(PGA)*** PGAs of different engineering structures were weakened by the fault rupture ***,the misalignment of the active fault may decrease the overall stiffness of the engineering structure,leading to more severe damage,with a small contribution from seismic ***,the seismic vibration effect might be enlarged with the height of the engineering structure,and the tunnel is supposed to have a smaller PGA and lower dynamic earth pressure compared to bridges and embankments in strong earthquake zones crossing active *** findings contribute valuable insights for evaluating the dynamic response of various engineering structures crossing an active fault and provide an experimental reference for secure engineering design in the challenging conditions of the Sichuan-Tibet transportation corridor.

关键词： Dynamic response Engineering structure Sichuan-Tibet transportation corridor Active fault Earthquake Model test

Tailoring the austenite characteristics via dual nanoparticles to synergistically optimize the strength-ductility in cold rolled medium Mn steel

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Journal of Materials Science & Technology 2024年第2期169卷 158-171页

作者： Qizhe Ye Haokai Dong Qinyi Guo Yishuang Yu Lijie qiao Yu Yan Beijing Advanced Innovation Center for Materials Genome Engineering Corrosion and Protection CenterInstitute for Advanced Materials and TechnologyUniversity of Science and Technology BeijingBeijing 100083China School of Mechanical and Automotive Engineering South China University of TechnologyGuangzhou 510641China School of Metallurgical and Ecological Engineering University of Science and Technology BeijingBeijing 100083China School of Biomedical Engineering Shanghai Jiao Tong UniversityShanghai 200240China

In this work,we proposed a novel Cu/θdual nanoparticles strategy to tailor the austenite characteris-tics of a medium Mn steel via a tempering-annealing process to optimize the mechanical *** explored the effects of Cu-rich particles and cementite precipitated in the tempering process on the austenite reversion during the subsequent annealing *** experiments and numerical simula-tions verified that the austenite inherited from cementite had a finer size and a higher Mn enrichment compared with the austenite originating from the tempered martensite *** addition,quantitative evaluations revealed that the pinning effect exerted by the Cu-rich particles could significantly hinder theα/γinterface migration and the recrystallized grain growth,thereby further refining the final *** contributions from the effects of dual nanoprecipitates on the austenite reversion,the heterogeneous austenite grains inherited from varying nucleation sites ensured the sustained and gradual deformation-induced martensite and twinning ***,the Cu-added steels subjected to a tempering-annealing process achieved synergetic enhancement of the tensile strength from 1055 MPa to 1250 MPa and elongation from 33%to 45%.This strategy may provide new guidance for the development and alloy design of high-performance medium Mn steels.

关键词： Dual nanoparticles Medium Mn steel Tempering-annealing process Austenite reversion Mechanical properties

Facile low-temperature supercritical carbonization method to prepare high-loading nickel single atom catalysts for efficient photodegradation of tetracycline

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Journal of Environmental Sciences 2024年第4期138卷 373-384页

作者： Han qiao Lirong Zheng Shiwen Hu Gang Tang Hongri Suo Chongxuan Liu School of Environment Harbin Institute of TechnologyHarbin 150090China State Environmental Protection Key Laboratory of Integrated Surface Water-Groundwater Pollution Control School of Environmental Science and EngineeringSouthern University of Science and TechnologyShenzhen 518055China Beijing Synchrotron Radiation Facility(BSRF) Institute of High Energy PhysicsChinese Academy of SciencesBeijing 100049China

Environmental photocatalysis is a promising technology for treating antibiotics in *** this study,a supercritical carbonization method was developed to synthesize a single-atom photocatalyst with a high loading of Ni(above 5 wt.%)anchored on a carbonnitrogen-silicate substrate for the efficient photodegradation of a ubiquitous environmental contaminant of tetracycline(TC).The photocatalyst was prepared from an easily obtained metal-biopolymer-inorganic supramolecular hydrogel,followed by supercritical drying and carbonization *** low-temperature(300℃)supercritical ethanol treatment prevents the excessive structural degradation of hydrogel and greatly reduces the metal clustering and aggregation,which contributed to the high Ni *** characterizations confirmed that Ni was present at isolated sites and stabilized by Ni-N and Ni-O bonds in a Ni-(N/O)_(6)-C/SiC configuration.A 5%Ni-C-Si catalyst,which performed the best among the studied catalysts,exhibited a wide visible light response with a narrow bandgap of 1.45 eV that could efficiently and repeatedly catalyze the oxidation of TC with a conversion rate of almost 100% within 40 *** reactive species trapping experiments and electron spin resonance(ESR)tests demonstrated that the h+,and·O_(2)-were mainly responsible for TC *** TC degradation mechanism and possible reaction pathways were provided ***,this study proposed a novel strategy to synthesize a high metal loading singleatom photocatalyst that can efficiently remove TC with high concentrations,and this strategy might be extended for synthesis of other carbon-based single-atom catalysts with valuable properties.

关键词： Carbon-based single-atom catalyst Nickel Photocatalytic degradation Tetracycline Visible light

Paleogene transgression process and environmental evolution in the deepwater area of the Baiyun Depression in the northern South China Sea

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Acta Oceanologica Sinica 2024年第4期43卷 15-24页

作者： Peijun qiao Yuchi Cui Qiong Ma Qiang Yu Lei Shao State Key Laboratory of Marine Geology Tongji UniversityShanghai 200092China CNOOC Energy Technology&Services-Drilling&Production Co. CNOOC Central Laboratory Shenzhen BranchGuangdong 516000China

Multiple borehole samples are collected from the Baiyun Depression in deep-water area of the northern South China Sea(SCS)in an effort to reconstruct transgression processes during the Paleogene based on palynalgal *** study indicates that the Baiyun Depression generated a large group of palynopore assemblages and fluvial/lacustrine-related algae during the early and middle Eocene when the Wenchang Formation was *** entire depression was dominated by fluvial and lacustrine facies before *** eastern and southeastern sags transitioned to shallow marine environment by generating a large abundance of marine dinoflagellates during the Enping deposition of the late ***,the southern uplift zone simply yielded fluvial/lacustrine-related palynopores and algae,and was dominated by the fluvial and lacustrine environment during the early stage of the Enping Formation,prior to shifting into transitional setting in the later *** sags remained extensive fluvial and delta facies without existence of marine *** was until the depositional stage of the Zhuhai Formation(Oligocene)that the overall depression was strongly impacted from transgression *** eastern and southeastern sags were mainly under deep marine setting on a continental slope while northwestern and southern areas developed transitional *** distribution and accumulation patterns varied greatly among sub-sags,the overall Baiyun Depression was characterized by widespread development of marine *** should be noted that the northwestern sag also partly generated large-scale river delta *** to the eustatic rise and change of SCS spreading axis,the overall Baiyun Depression was mostly influenced by the deep marine environment on a continental slope during the early *** northwestern sag and southern uplift zone were found plentiful marine *** summary,transgression initiated from the ea

关键词： South China Sea Paleogene transgression sedimentary environment plant ecology

Impact Force Localization and Reconstruction via ADMM-based Sparse Regularization Method

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Chinese Journal of Mechanical Engineering 2024年第3期37卷 170-188页

作者： Yanan Wang Lin Chen Junjiang Liu Baijie qiao Weifeng He Xuefeng Chen National Key Lab of Aerospace Power System and Plasma Technology Xi’an Jiaotong UniversityXi’an 710049China School of Mechanical Engineering Xi’an Jiaotong UniversityXi’an 710049China

In practice,simultaneous impact localization and time history reconstruction can hardly be achieved,due to the illposed and under-determined problems induced by the constrained and harsh measuring *** l_(1) regularization can be used to obtain sparse solutions,it tends to underestimate solution amplitudes as a biased *** address this issue,a novel impact force identification method with l_(p) regularization is proposed in this paper,using the alternating direction method of multipliers(ADMM).By decomposing the complex primal problem into sub-problems solvable in parallel via proximal operators,ADMM can address the challenge *** mitigate the sensitivity to regularization parameters,an adaptive regularization parameter is derived based on the K-sparsity ***,an ADMM-based sparse regularization method is developed,which is capable of handling l_(p) regularization with arbitrary p values using adaptively-updated *** effectiveness and performance of the proposed method are validated on an aircraft skin-like composite ***,an investigation into the optimal p value for achieving high-accuracy solutions via l_(p) regularization is *** turns out that l_(0.6)regularization consistently yields sparser and more accurate solutions for impact force identification compared to the classic l_(1) regularization *** impact force identification method proposed in this paper can simultaneously reconstruct impact time history with high accuracy and accurately localize the impact using an under-determined sensor configuration.

关键词： Impact force identification Non-convex sparse regularization Alternating direction method of multipliers Proximal operators