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World Journal of Diabetes 2019年第6期10卷 333-340页

作者： Sofia Nahavandi Sarah Price priya Sumithran Elif Ilhan Ekinci The Royal Children’s Hospital Melbourne Parkville VIC 3052 Australia Department of Endocrinology Austin Health Repatriation Campus Heidelberg West Melbourne VIC 3081 Australia Department of Medicine Austin Health and the University of Melbourne (Austin Campus) Parkville Melbourne VIC 3084 Australia

Gestational diabetes mellitus (GDM) and large for gestational age (LGA) offspring are two common pregnancy complications. Connections also exist between the two conditions, including mutual maternal risk factors for the conditions and an increased prevalence of LGA offspring amongst pregnancies affected by GDM. Thus, it is important to elucidate potential shared underlying mechanisms of both LGA and GDM. One potential mechanistic link relates to macronutrient metabolism. Indeed, derangement of carbohydrate and lipid metabolism is present in GDM, and maternal biomarkers of glucose and lipid control are associated with LGA neonates in such pregnancies. The aim of this paper is therefore to reflect on the existing nutritional guidelines for GDM in light of our understanding of the pathophysiological mechanisms of GDM and LGA offspring. Lifestyle modification is first line treatment for GDM, and while there is some promise that nutritional interventions may favourably impact outcomes, there is a lack of definitive evidence that changing the macronutrient composition of the diet reduces the incidence of either GDM or LGA offspring. The quality of the available evidence is a major issue, and rigorous trials are needed to inform evidence-based treatment guidelines.

关键词： Gestational diabetes mellitus Large for gestational age Metabolism Biomarkers Glucose Lipids

Blood and CSF biomarkers for post-stroke epilepsy:a systematic review

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Acta Epileptologica 2022年第3期5卷 127-135页

作者： priya Dev Mareena Cyriac Kamalesh Chakravarty Abhishek Pathak Department of Neurology Institute of Medical ScienceBanaras Hindu UniversityVaranasi 221005India Department of Neurology PGIMERChandigarh 160012India

Post-stroke epilepsy is a common complication of ischemic stroke which adversely affects the prognosis of *** and radiological parameters cannot adequately predict the ***,the discovery of biomarkers is imperatively needed for predicting post-stroke *** conducted a systematic review of diagnostic and prognostic biomarkers for post-stroke epilepsy through a comprehensive literature search in different *** articles that met our inclusion criteria were assessed for quality using the modified Quality Assessment of Diagnostic Accuracy Studies *** eligible studies were included in this systematic *** of 22 assessed biomarkers,nine biomarkers showed significant association with post-stroke *** T allele of CD40(cluster of differentiation 40)−1C/T polymorphism,the CC genotype of TRPM6(transient receptor potential cation channel subfamily M member 6)rs2274924,the allele polymorphism of MAD2(mitochondrial aldehyde dehydrogenase 2),the mRNA level of interleukin-6(IL-6),the plasma level of endostatin,and the mRNA expression of IL-1βshow a positive correlation with post-stroke epilepsy;while S100 calcium-binding protein B,heat shock 70 kDa protein-8 and neuropeptide Y are inversely associated with post-stroke *** a small number of patients were recruited,further studies are needed to confirm their potential use for predicting post-stroke epilepsy.

关键词： Post-stroke epilepsy Biomarker Stroke Blood and CSF biomarker Systematic review

Statistical analysis of dynamic fibrils observed from NST/BBSO observations

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Research in Astronomy and Astrophysics 2018年第2期18卷 43-52页

作者： Thambaje Gopalan priya Jiang-Tao Su Jie Chen Yuan-Yong Deng Debi Prasad Choudhury Key Laboratory of Solar Activity National Astronomical Observatories Chinese Academy of Sciences Beijing 100012 China University of Chinese Academy of Sciences Beijing 100049 China State Key Laboratory for Space Weather Center for Space Science and Applied Research Chinese Academy of Sciences Beijing 100190 China California State University Northridge CA 91330 USA

We present the results obtained from the analysis of dynamic fibrils in NOAA active region （AR） 12132, using high resolution Ha observations from the New Solar Telescope operating at Big Bear Solar Observatory. The dynamic fibrils are seen to be moving up and down, and most of these dynamic fibrils are periodic and have a jet-like appearance. We found from our observations that the fibrils follow almost perfect parabolic paths in many cases. A statistical analysis on the properties of the parabolic paths showing an analysis on deceleration, maximum velocity, duration and kinetic energy of these fibrils is presented here. We found the average maximum velocity to be around 15 km s-1 and mean deceleration to be around 100 m s-2. The observed deceleration appears to be a fraction of gravity of the Sun and is not compatible with the path of ballistic motion due to gravity of the Sun. We found a positive correlation between deceleration and maximum velocity. This correlation is consistent with simulations done earlier on magnetoacoustic shock waves propagating upward.

关键词： Sun: sunspots-oscillation -- Sun: magnetic fields -- Sun: chromosphere

Hepatic Hemangioendothelioma: An update

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World Journal of Gastrointestinal Oncology 2020年第3期12卷 248-266页

作者： Mayur Virarkar Mohammed Saleh Radwan Diab Melissa Taggart Peeyush Bhargava priya Bhosale Department of Diagnostic Radiology The University of Texas MD Anderson Cancer CenterHoustonTX 77030United States Department of Pathology The University of Texas MD Anderson Cancer CenterHoustonTX 77030United States Department of Radiology The University of Medical BranchGalvestonTX 77555United States

Primary epithelioid hemangioendotheliomas of the liver(EHL)are rare tumors with a low *** molecular background of EHL is still under investigation,with WWTR1-CAMPTA1 mutation may function as a tumor ***,this tumor is misdiagnosed with angiosarcoma,cholangiocarcinomas,metastatic carcinoma,and hepatocellular carcinoma(sclerosing variant).Characteristic features on imaging modalities such as ultrasound,computed tomography,magnetic resonance imaging and positron emission tomography/computed tomography guide in diagnosis and ***“halo sign”and the“lollipop sign”on computed tomography and magnetic resonance imaging are described in the ***,there are no standardized guidelines for treating EHL with treatment options are broad including:chemotherapy,ablation,surgery and liver transplantation with inconsistent results.

关键词： Epithelioid hemangioendotheliomas Halo sign Lollipop sign Angiosarcoma Cholangiocarcinomas Hepatocellular carcinoma

Synthesis and electrochemical properties of environmental free Lglutathione grafted graphene oxide/ZnO nanocomposite for highly selective piroxicam sensing

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Journal of Pharmaceutical Analysis 2021年第1期11卷 48-56页

作者： N.Dhanalakshmi T.priya S.Thennarasu S.Sivanesan N.Thinakaran Environmental Research Lab PG and Research Department of ChemistryAlagappa Government Arts CollegeKaraikudi630003Tamil NaduIndia School of Chemistry Bharathidasan UniversityThiruchirapalli620024Tamil NaduIndia Department of Applied Science and Technology AC TechAnna UniversityChennai25India

A simple and reliable strategy was proposed to engineer the glutathione grafted graphene oxide/ZnO nanocomposite(glutathione-GO/ZnO)as electrode material for the high-performance piroxicam *** prepared glutathione-GO/ZnO nanocomposite was well characterized by X-ray diffraction(XRD),Fourier transform infrared spectrum(FTIR),X-ray photoelectron spectroscopy(XPS),field emission scanning electron microscopy(FE-SEM),cyclic voltammetry(CV),electrochemical impedance spectroscopy(EIS)and differential pulse voltammetry(DPV).The novel nanocomposite modified electrode showed the highest electrocatalytic activity towards piroxicam(oxidation potential is 0.52 V).Under controlled experimental parameters,the proposed sensor exhibited good linear responses to piroxicam concentrations ranging from 0.1 to 500 μ*** detection limit and sensitivity were calculated as 1.8 μM and 0.2 μA/μM·cm^(2),***,it offered excellent selectivity,reproducibility,and long-term stability and can effectively ignore the interfering candidates commonly existing in the pharmaceutical tablets and human fluids even at a higher ***,the reported sensor was successfully employed to the direct determination of piroxicam in practical samples.

关键词： Reduced graphene oxide Glutathione ZnO Piroxicam Electrochemical sensing

Subthreshold behavior of AlInSb/InSb high electron mobility transistors

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Chinese Physics B 2015年第7期24卷 360-364页

作者： S.Theodore Chandra N.B.Balamurugan G.Lakshmi priya S.Manikandan Department of Electronics and Communication Engineering Thiagarajar College of Engineering

We propose a scaling theory for single gate Al In Sb/In Sb high electron mobility transistors（HEMTs） by solving the two-dimensional（2D） Poisson equation. In our model, the effective conductive path effect（ECPE） is taken into account to overcome the problems arising from the device scaling. The potential in the effective conducting path is developed and a simple scaling equation is derived. This equation is solved to obtain the minimum channel potential Φdeff,minand the new scaling factor α to model the subthreshold behavior of the HEMTs. The developed model minimizes the leakage current and improves the subthreshold swing degradation of the HEMTs. The results of the analytical model are verified by numerical simulation with a Sentaurus TCAD device simulator.

关键词： scaling theory subthreshold behavior effective conducting path effect short channel effect

Pathophysiology of alcoholic pancreatitis:An overview

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World Journal of Gastroenterology 2006年第46期12卷 7421-7427页

作者： Parimal Chowdhury priya Gupta Department of Physiology and Biophysics University of Arkansas for Medical sciences Little Rock Arkansas United States

Use of alcohol is a worldwide habit regardless of socio- economic background. Heavy alcohol consumption is a potential risk factor for induction of pancreatitis. The current review cites the updated literature on the alcohol metabolism, its effects on gastrointestinal and pancreatic function and in causing pancreatic injury, genetic predisposition of alcohol induced pancreatitis. Reports describing prospective mechanisms of action of alcohol activating the signal transduction pathways, induction of oxidative stress parameters through the development of animal models are being presented.

关键词： Alcohol Metabolism Pancreatic function Pancreatitis Mechanism of action

Spin Hall effect in prototype Rashba ferroelectrics GeTe and SnTe

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npj Computational Materials 2020年第1期6卷 1607-1613页

作者： Haihang Wang priya Gopal Silvia Picozzi Stefano Curtarolo Marco Buongiorno Nardelli Jagoda Sławińska Department of Physics University of North TexasDentonTX 76203USA Consiglio Nazionale delle Ricerche Istituto SPINUOS L’AquilaSede di lavoro CNR-SPIN c/o Univ.G.D’Annunzio66100 ChietiItaly Center for Autonomous Materials Design Duke UniversityDurhamNC 27708USA Materials Science Electrical EngineeringPhysics and ChemistryDuke UniversityDurhamNC 27708USA

Ferroelectric Rashba semiconductors(FERSCs)have recently emerged as a promising class of spintronics *** peculiar coupling between spin and polar degrees of freedom responsible for several exceptional properties,including ferroelectric switching of Rashba spin texture,suggests that the electron’s spin could be controlled by using only electric *** this regard,recent experimental studies revealing charge-to-spin interconversion phenomena in two prototypical FERSCs,GeTe and SnTe,appear extremely ***,by employing density functional theory calculations,we investigate spin Hall effect(SHE)in these materials and show that it can be large either in ferroelectric or paraelectric *** further explore the compatibility between doping required for the practical realization of SHE in semiconductors and polar distortions which determine Rashba-related phenomena in FERSCs,but which could be suppressed by free charge carriers.

关键词： structure Rashba ferroelectric

Determination of the chromospheric quiet network element area index and its variation between 2008 and 2011

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Research in Astronomy and Astrophysics 2012年第2期12卷 201-211页

作者： Jagdev Singh Ravindra Belur Selvendran Raju Kumaravel Pichaimani Muthu priyal Thambaje Gopalan priya Amareswari Kotikalapudi Indian Institute of Astrophysics Koramangala

In general, it is believed that plages and sunspots are the main contribu- tors to solar irradiance. There are small-scale structures on the Sun with intermediate magnetic fields that could also contribute to solar irradiance, but it has not yet been quantified how many of these small scale structures contribute and how much this varies over the solar cycle. We used Ca II K images obtained from the telescope at the Kodaikanal observatory. We report a method to separate the network elements from the background structure and plage regions, and compute the changes in the network element area index during the minimum phase of the solar cycle and part of the as- cending phase of cycle 24. The measured area occupied by the network elements is about 30% and the plages cover less than 1% of the solar disk during the observation period from February 2008 to 2011. During the extended period of minimum activity, it is observed that the network element area index decreases by about 7% compared to the area occupied by the network elements in 2008. A long term study of the network element area index is required to understand the variations over the solar cycle.

关键词： Sun: network - Sun: Ca-K - Sun: solar cycle

In vitro antifilarial activity of Azadirachta indica aqueous extract through reactive oxygen species enhancement

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Asian Pacific Journal of Tropical Medicine 2014年第11期7卷 841-848页

作者： Niladri Mukherjee Prasanta Saini Suprabhat Mukherjee priya Roy Santi P.Sinha Babu Parasitology Laboratory Department of Zoology(Centre for Advanced Studies)Visva-Bharati University

Objective:To evaluate an aqueous preparation from the Azadirachta indica leaves(AEA) against Setaria cervi(***),a model filarial ***:In vitro efficacy of AEA was evaluated against *** through estimation of relative motility value,dye exclusion test and MTT *** morphological alterations were monitored using conventional microscopic techniques in microfilariae and haematoxylin-eosin stained sections of AEA-treated ***:Enhancement of reactive oxygen species in *** treated with AEA was established through alteration in the activity of glutathione S-transferase,superoxide dismutase,catalase,peroxidase and level of superoxide anion and reduced ***:In vitro filaricidal activity of AEA is possibly through disturbing redox homeostasis by down-regulating and altering the level of some key antioxidants and regulatory enzymes like reduced glutathione,glutathione S-transferase,superoxide dismutase,catalase and glutathione peroxidase of ***.

关键词： Azadirachta indica Setaria cervi Antifilarial Reactive oxygen species