In vitro antifilarial activity of Azadirachta indica aqueous extract through reactive oxygen species enhancement

作     者：Niladri Mukherjee Prasanta Saini Suprabhat Mukherjee Priya Roy Santi P.Sinha Babu 

作者机构：Parasitology LaboratoryDepartment of Zoology(Centre for Advanced Studies)Visva-Bharati University 

出 版 物：《Asian Pacific Journal of Tropical Medicine》 (亚太热带医药杂志（英文版）)

年 卷 期：2014年第7卷第11期

页      面：841-848页

核心收录：

学科分类：1008[医学-中药学(可授医学、理学学位)] 1006[医学-中西医结合] 1002[医学-临床医学] 100602[医学-中西医结合临床] 10[医学] 

基　　金：the Department of Biotechnology,Ministry of Science and Technology(Grant No.BT/PR8779/Med/14/1282/2007) Council of Scientific and Industrial Research(CSIR)(Grant No.37/(1516)/11/EMR-H)Gove.of India.New Delhi for supporting this work by a grant 

主　　题：Azadirachta indica Setaria cervi Antifilarial Reactive oxygen species 

摘      要：Objective:To evaluate an aqueous preparation from the Azadirachta indica leaves(AEA) against Setaria cervi(***),a model filarial ***:In vitro efficacy of AEA was evaluated against *** through estimation of relative motility value,dye exclusion test and MTT *** morphological alterations were monitored using conventional microscopic techniques in microfilariae and haematoxylin-eosin stained sections of AEA-treated ***:Enhancement of reactive oxygen species in *** treated with AEA was established through alteration in the activity of glutathione S-transferase,superoxide dismutase,catalase,peroxidase and level of superoxide anion and reduced ***:In vitro filaricidal activity of AEA is possibly through disturbing redox homeostasis by down-regulating and altering the level of some key antioxidants and regulatory enzymes like reduced glutathione,glutathione S-transferase,superoxide dismutase,catalase and glutathione peroxidase of ***.