检索结果-南通市图书馆

Effects of fi laricidal drugs on longevity and enzyme activities of the microfilariae of Setaria cervi in white rats

引用

Asian Pacific Journal of Tropical Biomedicine 2015年第9期5卷 691-695页

作者： Haytham Ahmed Zakai Wajihullah Khan Faculty of Applied Medical Sciences King Abdulaziz University Section of Parasitology Department of Zoology Aligarh Muslim University

Objective: To analyse the efficacy of diethylcarbamazine(DEC), tetramisole and chlorpromazine on the longevity and activity of glucose-6-phosphatase and succinate dehydrogenase in the microi lariae recovered from the peripheral circulation of the rats before and after the ***: Setaria cer vi worms were implanted in white rats via laparotomy and microfilaraemic rats were divided into 4 groups. Groups 1, 2 and 3 were treated with DEC, tetramisole and chlorpromazine respectively, while Group 4 served as infected control. Longevity of microi lariae and dif erential leucocyte counts were recorded till the disappearance of microi lariae from peripheral blood. Glucose-6-phosphatase and succinate dehydrogenase enzymes were localized in the microi lariae recovered from normal and treated ***: The microi lariae survived for 48 days in untreated rats while survival was reduced to 15, 21 and 27 days after treatment with DEC, tetramisole and chlorpromazine, respectively. Eosinophils and neutrophils increased during 2nd and 3rd weeks, whereas the lymphocytes increased during 4-7 weeks. DEC treatment resulted in slight decrease in the localization of succinate dehydrogenase but not in glucose-6-phosphatase. Tetramisole and chlorpromazine treatment did not show any appreciable change in the localization of both the above enzymes. Conclusions: DEC proved the most ef ective drug which cleared the microi laraemia within 15 days and reduced the activity of succinate dehydrogenase to some extent followed by tetramisole and chlorpromazine which took more time for the clearance of microi lariae and had no ef ect on the localization of both glucose-6-phosphatase and succinate dehydrogenase.

关键词： Drugs Microi lariae Longevity Enzyme activities Setaria cervi

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

In vitro antifilarial activity of Azadirachta indica aqueous extract through reactive oxygen species enhancement

引用

Asian Pacific Journal of Tropical Medicine 2014年第11期7卷 841-848页

作者： Niladri Mukherjee Prasanta Saini Suprabhat Mukherjee Priya Roy Santi P.Sinha Babu Parasitology Laboratory Department of Zoology(Centre for Advanced Studies)Visva-Bharati University

Objective:To evaluate an aqueous preparation from the Azadirachta indica leaves(AEA) against Setaria cervi(***),a model filarial ***:In vitro efficacy of AEA was evaluated against *** through estimation of relative motility value,dye exclusion test and MTT *** morphological alterations were monitored using conventional microscopic techniques in microfilariae and haematoxylin-eosin stained sections of AEA-treated ***:Enhancement of reactive oxygen species in *** treated with AEA was established through alteration in the activity of glutathione S-transferase,superoxide dismutase,catalase,peroxidase and level of superoxide anion and reduced ***:In vitro filaricidal activity of AEA is possibly through disturbing redox homeostasis by down-regulating and altering the level of some key antioxidants and regulatory enzymes like reduced glutathione,glutathione S-transferase,superoxide dismutase,catalase and glutathione peroxidase of ***.

关键词： Azadirachta indica Setaria cervi Antifilarial Reactive oxygen species

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Antifilarial activity of ethyl acetate extract of Vitex negundo leaves in vitro

引用

Asian Pacific Journal of Tropical Medicine 2013年第9期6卷 689-692页

作者： KN Sahare V Singh Department of Microbiology Barkatullah University

Objective:To evaluate the possible antifilarial effect of ethyl acetate extract of Vitex negundo(Verhenaceae)leaves against Selaria cervi filarial parasite in ***:In vitro screening was done by the method of motility inhibition and NTT reduction assay with concentralions of0.03 to 1.00 mg/mL for 2 to 24 h incubation periods respectively,for possible antifilarial effect by comparing with ***:In motility assay,complete inhibition of motility was observed and in MTT reduction assay which gave>50%reduction for concentrations 0.20,0.50and 1.00 mg/mL at 10,6 and 2 h incubation periods respectively in a dose dependent manner(P<0.05).An antifilarial effect imparted by plant extract was found to be a function of their relative *** concentration(IC_(50))for the plant extract was found to be 0.16mg/***:The present study recorded significant antifilarial effect of Vitex negundo plant extract and contributed toward the development of database for novel drug candidates for lymphatic fllariasis.

关键词： Antifilarial activity In vitro assay Medicinal plant Setaria cervi Vitex negundo

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：