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Asian Pacific Journal of Tropical Medicine 2012年第5期5卷 385-390页

作者： Aashish S Morani Subhash L Bodhankar V Mohan prasad a thakurdesai Department of Pharmacology Poona College of PharmacyBharati Vidyapeeth Deemed UniversityErandwanePaud Road.Pune-411038India

Objective:To evaluate the effects of the standardized extract of fenugreek(Trigonella foenumgraecum ***:Leguminasae) seed(IND01) in animal models of peripheral neuropathy. Methods:IND01 was prepared from fenugreek seeds and standardized by high performance liquid chromatography to a marker compound,*** effects of daily oral administration of IND01(50,100 and 200 mg/kg) were studied in rats after partial sciatic nerve ligation(PSNL) and sciatic nerve crush injury(SNCI) during 30-days *** measurements on thermal hyperalgesia(TH),motor function test(MFT) score and motor nerve conduction velocity (MNCV) were ***:IND01 offered sustained protection against TH and deranged MFT scores in both models from 7-day *** days of daily oral administration of IND01 restored MNCV reduction in rats with SNCI but not with ***:IND01 was found to be effective in rat models of painful peripheral neuropathy.

关键词： Trigonella foenum-graecum L. Peripheral nervous system diseases Peripheral neuropathy Neuropathic pain Sciatic nerve lesions Rat

Add-on therapy of herbal formulation rich in standardized fenugreek seed extract in type 2 diabetes mellitus patients with insulin therapy: An efficacy and safety study

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Asian Pacific Journal of Tropical Biomedicine 2018年第9期8卷 446-455页

作者： Amit Kandhare Uday Phadke Abhay Mane prasad thakurdesai Sunil Bhaskaran Department of Scientific Affairs Indus Biotech Private Limited Ruby Hall Clinic Tulip Opp.Camp Education Society's High School

Objective: To assess the safety and efficacy of herbal formulation rich in standardized fenugreek seed extract(IND-2) add-on therapy in type 2 diabetes mellitus(T2DM) patients who were on insulin treatment in prospective, single arm, open-label, uncontrolled, multicentre ***: T2DM patients(n=30) with aged 18-80 years who were stabilized on insulin treatment with fasting blood sugar(FBS) level between 100-140 mg/dL received IND-2 capsules(700 mg, thrice a day) for 16 *** primary endpoints were an assessment of FBS at week 2, 4, 6, 8, 12 and *** end-points include post-prandial blood sugar level, glycosylated Hb(HbA1c), reduction in the dose of insulin and number of hypoglycemic attacks, and improvement in lipid profile at various *** and adverse events(AEs) were also assessed during the ***: Study was completed in twenty T2DM patients, and there was no significant reduction in FBS and post-prandial blood sugar level after addon therapy of ***, add-on therapy of IND-2 significantly reduced(P<0.01) the HbA1c values, requirements of insulin and hypoglycemic events as compared with *** cholesterol, high-density lipoproteins-cholesterol, and low-density lipoproteincholesterol levels were significantly increased(P<0.01) after IND-2 add-on *** weight and safety outcomes did not differ significantly in IND-2 add-on therapy group at week ***, add-on therapy of IND-2 did not produce any serious adverse ***: The results of present investigation suggest that add-on therapy of IND-2 with insulin in T2DM patients improves glycaemic control through a decrease in levels of HbA1c and number of insulin doses needed per day without an increase in body weight and risk of ***, IND-2 may provide a safe and well-tolerated add-on therapy option for the management of T2DM.

关键词： Add-on therapy Dietary supplement Glycaemic control HbA1c Standardized fenugreek seed extract Type 2 diabetes

Protective effect of aqueous extract of Feronia elephantum correa leaves on thioacetamide induced liver necrosis in diabetic rats

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Asian Pacific Journal of Tropical Biomedicine 2012年第9期2卷 691-695页

作者： Prashant Sharma Subhash L Bodhankar prasad a thakurdesai Department of Pharmacology Poona College of PharmacyBharati Deemed Vidyapeeth University

Objective:To evalueate hepatoprotective effects Feronia elephantum(***)correa against thioacctamide(TA)induced liver necrosis in diabetic ***:Male wistar rats were made diabetic with alloxan(160 mg/kg)on day 0 of the *** were intoxicated with hepatotoxicant(thioacetamide,300 mg/kg,ip)on day 9 of study to produce liver *** of 7 day daily once administration(day 2 to day 9)of EF(400 and 800 mg/kg,po)were evaluated on necorosis of liver in terms of mortality,liver volume,liver weight,serum aspartate aminotransferase(AST)and serum alanine transaminase(ALT),and histopathology of liver sections(for signs of necorosis and inflammation)on day-9 of the *** groups of rats with treated only with alloxan(DA control),thioacetamide(TA control)and both(TA+DA control)were ***:FE significantly lowered the mortality rate and showed improvement in liver function parameters in TA-induced diabetic rats without change in liver weight,volume and serum glucose ***:FE showed promising activity against TA-induced liver necorsis in diabetic rats and so might be useful for prevention of liver complications in DM.

关键词： Feronia elephantum correa Hepatic necrosis Diabetes mellitus Thioacetamide

Anti-inflammatory and anti-arthritic activity of type-A procyanidine polyphenols from bark of Cinnamomum zeylanicum in rats

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Food Science and Human Wellness 2013年第2期2卷 59-67页

作者： Sachin Vetal Subhash L.Bodhankar Vishwaraman Mohan prasad A.thakurdesai Department of Pharmacology Poona College of PharmacyBharati Vidyapeeth Deemed UniversityErandwanePune 411038India Indus Biotech Private Limited 1Rahul ResidencyOff Salunke Vihar RoadKondhwaPune 411048India

Type-A procyanidine polyphenols(TAPP)are reported to have immunomodulatory and anti-inflammatory potential in *** objective of present work is to evaluate potential of TAPP extracted from Cinnamon(Cinnamomum zeylanicum)bark in animal models of inflammation and rheumatoid arthritis in ***-induced rat paw edema(CPE)and adjuvant induced established arthritis(AIA),in rats were used as the experimental models for inflammation and arthritis *** activity was evaluated in Randall–Selitto assay in AIA *** showed significant anti-inflammatory effect at dose of 4,8 and 25 mg/kg,*** not at 2 mg/kg,*** in CPE *** dose of 8 mg/kg,*** selected for the evaluation of anti-arthritic activity in AIA ***(8 mg/kg,p.o.,daily from day-12 to day-21)treatment in established arthritic rats showed significant reversal of changes induced in AIA with respect to body weight drop(cachexia),ankle diameter,arthritic score,serum C-reactive protein(CRP)***,TAPP was found to be non-ulcerogenic as compared to AIA control ***,TAPP did not show analgesic effect on AIA-induced pain as seen in Randall–Selitto *** conclusion,TAPP showed disease-modifying potential in animal models of inflammation and arthritis in rats.©2013 Beijing Academy of Food *** and hosting by Elsevier *** rights reserved.

关键词： Type-A procyanidine polyphenols Cinnamon bark Anti-inflammatory Rheumatoid arthritis

Beneficial effects of fenugreek glycoside supplementation in male subjects during resistance training: A randomized controlled pilot study

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Journal of Sport and Health Science 2016年第2期5卷 176-182页

作者： Sachin Wankhede Vishwaraman Mohan prasad thakurdesai Department of Microbiology Smt.Kashibai Navale Medical College Department of Scientific Affairs Indus Biotech Private Limited

Purpose： To evaluate the efficacy and safety of the glycoside fraction of fenugreek （Trigonellafoenum-graecum） seeds （Fenu-FG） on physiologi- cal parameters related to muscle anabolism, androgenic hormones, and body fat in healthy male subjects during an 8-week resistance training program using a prospective, randomized, double-blind, placebo controlled design. Methods： Sixty healthy male subjects were randomized to ingest capsules of Fenu-FG （1 capsule of 300 rag, twice per day） or the matching placebo at a 1：1 ratio. The subjects participated in a supervised 4-day per week resistance-training program for 8 weeks. The outcome measurements were recorded at recruitment （baseline） and at the end of the treatment （8 weeks）. The efficacy outcome included serum testosterone （total and free） levels, muscle strength and repetitions to failure, metabolic markers for anabolic activity （serum creatinine and blood urea nitrogen）, and % body fat. The standard safety measurements such as adverse events monitoring, vital signs, hematology, biochemistry, and urinalysis were performed. Results： Fenu-FG supplementation demonstrated significant anabolic and androgenic activity as compared with the placebo. Fenu-FG treated subjects showed significant improvements in body fat without a reduction in muscle strength or repetitions to failure. The Fenu-FG supplemen- tation was found to be safe and well-tolerated. Conclusion： Fenu-FG supplementation showed beneficial effects in male subjects during resistance training without any clinical side effects.

关键词： Anabolic Androgenic Fenugreek seeds Glycosides Randomized controlled study Resistance training

BALINIT~——我们的目标是提高您的生产力

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工具技术 2006年第1期40卷 12-13页

作者： prasad R.thakurdesai 巴尔查斯涂层(苏州)有限公司市场部

巴尔查斯公司是世界一流的涂层供应商,作为UNAXIS集团中最具活力的一员,拥有世界领先的镀膜和真空技术.巴尔查斯长期致力于开发各种涂层及涂层工艺、销售系统以及生产设备,并且是唯一一家通过其目前设在欧洲、美洲和亚洲拥有70多个涂层... 详细信息

巴尔查斯公司是世界一流的涂层供应商,作为UNAXIS集团中最具活力的一员,拥有世界领先的镀膜和真空技术.巴尔查斯长期致力于开发各种涂层及涂层工艺、销售系统以及生产设备,并且是唯一一家通过其目前设在欧洲、美洲和亚洲拥有70多个涂层中心的全球网络向世界各地的客户提供涂层服务的公司.巴尔查斯拥有世界领先的涂层设备,作为工具和精密元件耐磨涂层的供应者已经有27年之久.巴尔查斯的真空涂层系统广泛应用在提高各种工具和精密元件的性能上,效果十分显著.在金属切削、冲压成型和塑料模具等应用方面,巴尔查斯涂层在极大提高硬度的同时,能显著减少摩擦,提高生产能力,从而降低生产成本.实践证明,在使用巴尔查斯涂层后,汽车发动机、传动设备和水压系统精密部件的使用寿命被显著延长.

关键词：生产力涂层工艺生产设备销售系统全球网络涂层设备世界供应商公司集团

Prophylactic effects of asiaticoside-based standardized extract of Centella asiatica(L.) Urban leaves on experimental migraine: Involvement of 5HT1A/1B receptors

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Chinese Journal of Natural Medicines 2015年第4期13卷 274-282页

作者： Vijeta Bobade Subhash L.Bodhankar Urmila Aswar Vishwaraman Mohan prasad thakurdesai Department of Pharmacology Poona College of Pharmacy Bharati Vidyapeeth Deemed University Department of Pharmacology Sinhgad Institute of Pharmacy Indus Biotech Private Limited 1 Rahul residency Kondhwa Pune-411026 India

The present study aimed at evaluation of prophylactic efficacy and possible mechanisms of asiaticoside （AS） based standardized extract of Centella asiatica （L.） Urban leaves （INDCA） in animal models of migraine. The effects of oral and intranasal （i.n.） pretreatment of INDCA （acute and 7-days subacute） were evaluated against nitroglycerine （NTG, 10 mg·kg^-1, i.p.） and bradykinin （BK, 10 μg, intra-arterial） induced hyperalgesia in rats. Tail flick latencies （from 0 to 240 rain） post-NTG treatment and the number of vocalizations post-BK treatment were recorded as a measure of hyperalgesia. Separate groups of rats for negative （Normal） and positive （sumatriptan, 42 *** ^-1, s.c.） controls were included. The interaction of 1NDCA with selective 5-HT1A, 5-HT1B, and 5-HTI D receptor antagonists （NAN-190, Isamoltane hemifumarate, and BRL-15572 respectively） against NTG-induced hyperalgesia was also evaluated. Acute and sub-acute pre-treatment of INDCA [10 and 30 ***^-1 （oral） and 100 μg/rat （i.n.） showed significant anti-nociception activity, and reversal of the NTG-induced hypera｜gesia and brain 5-HT concentration decline. Oral pre-treatment with INDCA （30 mg·kg ^-1, 7 d） showed significant reduction in the number of vocalization. The anti-nociceptive effects of INDCA were blocked by 5-HTIA and 5-HT1B but not 5-HT1D receptor antagonists. In conclusion, 1NDCA demonstrated promising anti-nociceptive effects in animal models of migraine, probably through 5-HT1A/1B medicated action.

关键词： Centella asiatica (L.) Urban Experimental migraine Anti-nociception Serotonin, 5HTI A and 5HT1B receptors

Corrigendum to “Beneficial effects of fenugreek glycoside supplementation in male subjects during resistance training: A randomized controlled pilot study” [J Sport Health Sci 5(2016) 176à182]

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Journal of Sport and Health Science 2018年第2期7卷 251-251页

作者： Sachin Wankhede Vishwaraman Mohan prasad thakurdesai Department of Microbiology Smt. Kashibai Navale Medical College

The authors regret the error in the unit of"free testosterone"in Table 2(Page 179)and Section 3.2(Page 180)as"ng/dL"instead of the correct unit"pg/mL".Taged PThe authors would like to apologise for any inconvenience c... 详细信息

关键词： A randomized controlled pilot study Beneficial effects of fenugreek glycoside supplementation in male subjects during resistance training Corrigendum to J Sport Health Sci 5